MersV1, Ncbi, Merge, bibRecord, 000E84

[In vitro anti-HIV activity of phosphorothioate alpha-anomeric oligodeoxynucleotides].

Identifieur interne : 000E84 ( Ncbi/Merge ); précédent : 000E83; suivant : 000E85

[In vitro anti-HIV activity of phosphorothioate alpha-anomeric oligodeoxynucleotides].

Auteurs : B. Rayner ; M. Matsukura ; F. Morvan ; J S Cohen ; J L Imbach

Source :

Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie [ 0764-4469 ] ; 1989.

RBID : pubmed:2516764

Descripteurs français

KwdFr :
- Dépression chimique, Humains, Lymphocytes T (immunologie), Lymphocytes T (microbiologie), Oligonucléotides (pharmacologie), Oligonucléotides antisens, Séquence nucléotidique, Techniques in vitro, Thionucléotides (pharmacologie), VIH (Virus de l'Immunodéficience Humaine) ().
MESH :
- immunologie : Lymphocytes T.
- microbiologie : Lymphocytes T.
- pharmacologie : Oligonucléotides, Thionucléotides.
- Dépression chimique, Humains, Oligonucléotides antisens, Séquence nucléotidique, Techniques in vitro, VIH (Virus de l'Immunodéficience Humaine).

English descriptors

KwdEn :
- Base Sequence, Depression, Chemical, HIV (drug effects), Humans, In Vitro Techniques, Oligonucleotides (pharmacology), Oligonucleotides, Antisense, T-Lymphocytes (immunology), T-Lymphocytes (microbiology), Thionucleotides (pharmacology).
MESH :
- chemical , pharmacology : Oligonucleotides, Thionucleotides.
- drug effects : HIV.
- immunology : T-Lymphocytes.
- microbiology : T-Lymphocytes.
- Base Sequence, Depression, Chemical, Humans, In Vitro Techniques, Oligonucleotides, Antisense.

Abstract

Oligonucleotide analogs consisting exclusively of alpha-anomeric deoxynucleoside units bridged with phosphorothioate linkages have been synthesized and tested in vitro as antiviral agents against human immunodeficiency virus (HIV) in human T cells. Two 28-mers, an homopolymer alpha-S-dC28 and an oligomer alpha-S-anti-rev complementary to the initiation site of the regulatory viral gene rev exhibited antiviral activities comparable to those reported for the corresponding beta-anomeric phosphorothioate analogs. In contrast, a nuclease-resistant homopolymer, alpha-dC28 was inactive. Their preliminary results would indicate that the origin of oligonucleotide phosphorothioate anti-HIV activity is not exclusively correlated with their higher nuclease resistance.

PubMed: 2516764

Links toward previous steps (curation, corpus...)

to stream PubMed, to step Corpus: 002A48
to stream PubMed, to step Curation: 002A48
to stream PubMed, to step Checkpoint: 002875

Links to Exploration step

pubmed:2516764

Le document en format XML

<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">[In vitro anti-HIV activity of phosphorothioate alpha-anomeric oligodeoxynucleotides].</title>
<author><name sortKey="Rayner, B" sort="Rayner, B" uniqKey="Rayner B" first="B" last="Rayner">B. Rayner</name>
<affiliation><nlm:affiliation>Laboratoire de Chimie bio-organique, U.A. n 488, C.N.R.S., Université de Montpellier-II.</nlm:affiliation>
<wicri:noCountry code="subField">Université de Montpellier-II</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Matsukura, M" sort="Matsukura, M" uniqKey="Matsukura M" first="M" last="Matsukura">M. Matsukura</name>
</author>
<author><name sortKey="Morvan, F" sort="Morvan, F" uniqKey="Morvan F" first="F" last="Morvan">F. Morvan</name>
</author>
<author><name sortKey="Cohen, J S" sort="Cohen, J S" uniqKey="Cohen J" first="J S" last="Cohen">J S Cohen</name>
</author>
<author><name sortKey="Imbach, J L" sort="Imbach, J L" uniqKey="Imbach J" first="J L" last="Imbach">J L Imbach</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PubMed</idno>
<date when="1989">1989</date>
<idno type="RBID">pubmed:2516764</idno>
<idno type="pmid">2516764</idno>
<idno type="wicri:Area/PubMed/Corpus">002A48</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">002A48</idno>
<idno type="wicri:Area/PubMed/Curation">002A48</idno>
<idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">002A48</idno>
<idno type="wicri:Area/PubMed/Checkpoint">002875</idno>
<idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">002875</idno>
<idno type="wicri:Area/Ncbi/Merge">000E84</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en">[In vitro anti-HIV activity of phosphorothioate alpha-anomeric oligodeoxynucleotides].</title>
<author><name sortKey="Rayner, B" sort="Rayner, B" uniqKey="Rayner B" first="B" last="Rayner">B. Rayner</name>
<affiliation><nlm:affiliation>Laboratoire de Chimie bio-organique, U.A. n 488, C.N.R.S., Université de Montpellier-II.</nlm:affiliation>
<wicri:noCountry code="subField">Université de Montpellier-II</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Matsukura, M" sort="Matsukura, M" uniqKey="Matsukura M" first="M" last="Matsukura">M. Matsukura</name>
</author>
<author><name sortKey="Morvan, F" sort="Morvan, F" uniqKey="Morvan F" first="F" last="Morvan">F. Morvan</name>
</author>
<author><name sortKey="Cohen, J S" sort="Cohen, J S" uniqKey="Cohen J" first="J S" last="Cohen">J S Cohen</name>
</author>
<author><name sortKey="Imbach, J L" sort="Imbach, J L" uniqKey="Imbach J" first="J L" last="Imbach">J L Imbach</name>
</author>
</analytic>
<series><title level="j">Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie</title>
<idno type="ISSN">0764-4469</idno>
<imprint><date when="1989" type="published">1989</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Base Sequence</term>
<term>Depression, Chemical</term>
<term>HIV (drug effects)</term>
<term>Humans</term>
<term>In Vitro Techniques</term>
<term>Oligonucleotides (pharmacology)</term>
<term>Oligonucleotides, Antisense</term>
<term>T-Lymphocytes (immunology)</term>
<term>T-Lymphocytes (microbiology)</term>
<term>Thionucleotides (pharmacology)</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Dépression chimique</term>
<term>Humains</term>
<term>Lymphocytes T (immunologie)</term>
<term>Lymphocytes T (microbiologie)</term>
<term>Oligonucléotides (pharmacologie)</term>
<term>Oligonucléotides antisens</term>
<term>Séquence nucléotidique</term>
<term>Techniques in vitro</term>
<term>Thionucléotides (pharmacologie)</term>
<term>VIH (Virus de l'Immunodéficience Humaine) ()</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Oligonucleotides</term>
<term>Thionucleotides</term>
</keywords>
<keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>HIV</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Lymphocytes T</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>T-Lymphocytes</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiologie" xml:lang="fr"><term>Lymphocytes T</term>
</keywords>
<keywords scheme="MESH" qualifier="microbiology" xml:lang="en"><term>T-Lymphocytes</term>
</keywords>
<keywords scheme="MESH" qualifier="pharmacologie" xml:lang="fr"><term>Oligonucléotides</term>
<term>Thionucléotides</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Base Sequence</term>
<term>Depression, Chemical</term>
<term>Humans</term>
<term>In Vitro Techniques</term>
<term>Oligonucleotides, Antisense</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Dépression chimique</term>
<term>Humains</term>
<term>Oligonucléotides antisens</term>
<term>Séquence nucléotidique</term>
<term>Techniques in vitro</term>
<term>VIH (Virus de l'Immunodéficience Humaine)</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Oligonucleotide analogs consisting exclusively of alpha-anomeric deoxynucleoside units bridged with phosphorothioate linkages have been synthesized and tested in vitro as antiviral agents against human immunodeficiency virus (HIV) in human T cells. Two 28-mers, an homopolymer alpha-S-dC28 and an oligomer alpha-S-anti-rev complementary to the initiation site of the regulatory viral gene rev exhibited antiviral activities comparable to those reported for the corresponding beta-anomeric phosphorothioate analogs. In contrast, a nuclease-resistant homopolymer, alpha-dC28 was inactive. Their preliminary results would indicate that the origin of oligonucleotide phosphorothioate anti-HIV activity is not exclusively correlated with their higher nuclease resistance.</div>
</front>
</TEI>
<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">2516764</PMID>
<DateCompleted><Year>1990</Year>
<Month>04</Month>
<Day>26</Day>
</DateCompleted>
<DateRevised><Year>2014</Year>
<Month>11</Month>
<Day>20</Day>
</DateRevised>
<Article PubModel="Print"><Journal><ISSN IssnType="Print">0764-4469</ISSN>
<JournalIssue CitedMedium="Print"><Volume>310</Volume>
<Issue>3</Issue>
<PubDate><Year>1989</Year>
</PubDate>
</JournalIssue>
<Title>Comptes rendus de l'Academie des sciences. Serie III, Sciences de la vie</Title>
<ISOAbbreviation>C. R. Acad. Sci. III, Sci. Vie</ISOAbbreviation>
</Journal>
<ArticleTitle>[In vitro anti-HIV activity of phosphorothioate alpha-anomeric oligodeoxynucleotides].</ArticleTitle>
<Pagination><MedlinePgn>61-4</MedlinePgn>
</Pagination>
<Abstract><AbstractText>Oligonucleotide analogs consisting exclusively of alpha-anomeric deoxynucleoside units bridged with phosphorothioate linkages have been synthesized and tested in vitro as antiviral agents against human immunodeficiency virus (HIV) in human T cells. Two 28-mers, an homopolymer alpha-S-dC28 and an oligomer alpha-S-anti-rev complementary to the initiation site of the regulatory viral gene rev exhibited antiviral activities comparable to those reported for the corresponding beta-anomeric phosphorothioate analogs. In contrast, a nuclease-resistant homopolymer, alpha-dC28 was inactive. Their preliminary results would indicate that the origin of oligonucleotide phosphorothioate anti-HIV activity is not exclusively correlated with their higher nuclease resistance.</AbstractText>
</Abstract>
<AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Rayner</LastName>
<ForeName>B</ForeName>
<Initials>B</Initials>
<AffiliationInfo><Affiliation>Laboratoire de Chimie bio-organique, U.A. n 488, C.N.R.S., Université de Montpellier-II.</Affiliation>
</AffiliationInfo>
</Author>
<Author ValidYN="Y"><LastName>Matsukura</LastName>
<ForeName>M</ForeName>
<Initials>M</Initials>
</Author>
<Author ValidYN="Y"><LastName>Morvan</LastName>
<ForeName>F</ForeName>
<Initials>F</Initials>
</Author>
<Author ValidYN="Y"><LastName>Cohen</LastName>
<ForeName>J S</ForeName>
<Initials>JS</Initials>
</Author>
<Author ValidYN="Y"><LastName>Imbach</LastName>
<ForeName>J L</ForeName>
<Initials>JL</Initials>
</Author>
</AuthorList>
<Language>fre</Language>
<PublicationTypeList><PublicationType UI="D004740">English Abstract</PublicationType>
<PublicationType UI="D016428">Journal Article</PublicationType>
</PublicationTypeList>
<VernacularTitle>Activité anti-VIH in vitro d'oligodésoxynucléotides phosphorothioates d'anomérie alpha.</VernacularTitle>
</Article>
<MedlineJournalInfo><Country>France</Country>
<MedlineTA>C R Acad Sci III</MedlineTA>
<NlmUniqueID>8503078</NlmUniqueID>
<ISSNLinking>0764-4469</ISSNLinking>
</MedlineJournalInfo>
<ChemicalList><Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D009841">Oligonucleotides</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D016376">Oligonucleotides, Antisense</NameOfSubstance>
</Chemical>
<Chemical><RegistryNumber>0</RegistryNumber>
<NameOfSubstance UI="D013873">Thionucleotides</NameOfSubstance>
</Chemical>
</ChemicalList>
<CitationSubset>IM</CitationSubset>
<CitationSubset>X</CitationSubset>
<MeshHeadingList><MeshHeading><DescriptorName UI="D001483" MajorTopicYN="N">Base Sequence</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D003864" MajorTopicYN="N">Depression, Chemical</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006678" MajorTopicYN="N">HIV</DescriptorName>
<QualifierName UI="Q000187" MajorTopicYN="Y">drug effects</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D066298" MajorTopicYN="N">In Vitro Techniques</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D009841" MajorTopicYN="N">Oligonucleotides</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D016376" MajorTopicYN="N">Oligonucleotides, Antisense</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013601" MajorTopicYN="N">T-Lymphocytes</DescriptorName>
<QualifierName UI="Q000276" MajorTopicYN="N">immunology</QualifierName>
<QualifierName UI="Q000382" MajorTopicYN="N">microbiology</QualifierName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D013873" MajorTopicYN="N">Thionucleotides</DescriptorName>
<QualifierName UI="Q000494" MajorTopicYN="Y">pharmacology</QualifierName>
</MeshHeading>
</MeshHeadingList>
</MedlineCitation>
<PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>1989</Year>
<Month>1</Month>
<Day>1</Day>
</PubMedPubDate>
<PubMedPubDate PubStatus="medline"><Year>1989</Year>
<Month>1</Month>
<Day>1</Day>
<Hour>0</Hour>
<Minute>1</Minute>
</PubMedPubDate>
<PubMedPubDate PubStatus="entrez"><Year>1989</Year>
<Month>1</Month>
<Day>1</Day>
<Hour>0</Hour>
<Minute>0</Minute>
</PubMedPubDate>
</History>
<PublicationStatus>ppublish</PublicationStatus>
<ArticleIdList><ArticleId IdType="pubmed">2516764</ArticleId>
</ArticleIdList>
</PubmedData>
</pubmed>
<affiliations><list></list>
<tree><noCountry><name sortKey="Cohen, J S" sort="Cohen, J S" uniqKey="Cohen J" first="J S" last="Cohen">J S Cohen</name>
<name sortKey="Imbach, J L" sort="Imbach, J L" uniqKey="Imbach J" first="J L" last="Imbach">J L Imbach</name>
<name sortKey="Matsukura, M" sort="Matsukura, M" uniqKey="Matsukura M" first="M" last="Matsukura">M. Matsukura</name>
<name sortKey="Morvan, F" sort="Morvan, F" uniqKey="Morvan F" first="F" last="Morvan">F. Morvan</name>
<name sortKey="Rayner, B" sort="Rayner, B" uniqKey="Rayner B" first="B" last="Rayner">B. Rayner</name>
</noCountry>
</tree>
</affiliations>
</record>

Pour manipuler ce document sous Unix (Dilib)

EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Ncbi/Merge

HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000E84 | SxmlIndent | more

HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 000E84 | SxmlIndent | more

Pour mettre un lien sur cette page dans le réseau Wicri

{{Explor lien
   |wiki=    Sante
   |area=    MersV1
   |flux=    Ncbi
   |étape=   Merge
   |type=    RBID
   |clé=     pubmed:2516764
   |texte=   [In vitro anti-HIV activity of phosphorothioate alpha-anomeric oligodeoxynucleotides].
}}

Pour générer des pages wiki

HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i   -Sk "pubmed:2516764" \
       | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd   \
       | NlmPubMed2Wicri -a MersV1

This area was generated with Dilib version V0.6.33.
Data generation: Mon Apr 20 23:26:43 2020. Site generation: Sat Mar 27 09:06:09 2021

	Serveur d'exploration MERS
	Attention, ce site est en cours de développement ! Attention, site généré par des moyens informatiques à partir de corpus bruts. Les informations ne sont donc pas validées.

Serveur d'exploration MERS

[In vitro anti-HIV activity of phosphorothioate alpha-anomeric oligodeoxynucleotides].

[In vitro anti-HIV activity of phosphorothioate alpha-anomeric oligodeoxynucleotides].

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki