Emerging Developments on Pathogenicity, Molecular Virulence, Epidemiology and Clinical Symptoms of Current Middle East Respiratory Syndrome Coronavirus (MERS-CoV)
Identifieur interne : 000E08 ( Main/Exploration ); précédent : 000E07; suivant : 000E09Emerging Developments on Pathogenicity, Molecular Virulence, Epidemiology and Clinical Symptoms of Current Middle East Respiratory Syndrome Coronavirus (MERS-CoV)
Auteurs : Kannan Subbaram [Arabie saoudite] ; Hemalatha Kannan [Éthiopie] ; Mansour Khalil Gatasheh [Arabie saoudite]Source :
- Hayati [ 1978-3019 ] ; 2017.
Abstract
Middle East respiratory syndrome coronavirus (MERS-CoV) is a recently reported virus that is associated with severe, life threatening and rapidly spreading primarily respiratory illness called the Middle East respiratory syndrome. MERS-CoV possesses a unique positive-sense single-stranded RNA and can undergo rapid mutation in the viral genome. This results in antigenic switching and genetic variation, finally leading to the emergence of novel and new MERS-CoV subtypes which are uncontrollable by vaccines. Researchers are also finding difficulties to sort out therapeutic intervention strategies for MERS-CoV. This virus can spread from human to human, but transmission from dromedary camels to humans plays a crucial epidemiological significance. Dromedary camel acts as “gene mixing vessels” for MERS-CoV and these virus particles undergo rapid change in them. Viral receptors called dipeptidyl peptidase-4 are important receptors for attachment and spread of MERS-CoV in humans. The current method of laboratory confirmation is through real-time polymerase chain reaction on bronchoalveolar lavage, sputum and tracheal aspirates. Unfortunately, till today there are no definite anti-viral drugs available for MERS-CoV.
Url:
DOI: 10.1016/j.hjb.2017.08.001
PubMed: NONE
PubMed Central: 7104923
Affiliations:
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Clinical Symptoms of Current Middle East Respiratory Syndrome Coronavirus (MERS-CoV)</title><author><name sortKey="Subbaram, Kannan" sort="Subbaram, Kannan" uniqKey="Subbaram K" first="Kannan" last="Subbaram">Kannan Subbaram</name><affiliation wicri:level="1"><nlm:aff id="aff1">Department of Preparatory (Biology), Al-Ghad International Colleges for Applied Medical Sciences, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Preparatory (Biology), Al-Ghad International Colleges for Applied Medical Sciences, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Kannan, Hemalatha" sort="Kannan, Hemalatha" uniqKey="Kannan H" first="Hemalatha" last="Kannan">Hemalatha Kannan</name><affiliation wicri:level="1"><nlm:aff id="aff2">Department of Laboratory Sciences & Pathology, Jimma University, Ethiopia</nlm:aff><country xml:lang="fr">Éthiopie</country><wicri:regionArea>Department of Laboratory Sciences & Pathology, Jimma University</wicri:regionArea><wicri:noRegion>Jimma University</wicri:noRegion></affiliation></author><author><name sortKey="Khalil Gatasheh, Mansour" sort="Khalil Gatasheh, Mansour" uniqKey="Khalil Gatasheh M" first="Mansour" last="Khalil Gatasheh">Mansour Khalil Gatasheh</name><affiliation wicri:level="1"><nlm:aff id="aff3">Department of Clinical Laboratory Sciences, Al-Ghad International Colleges for Applied Medical Sciences, Riyadh, Saudi Arabia</nlm:aff><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Clinical Laboratory Sciences, Al-Ghad International Colleges for Applied Medical Sciences, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author></analytic><series><title level="j">Hayati</title><idno type="ISSN">1978-3019</idno><idno type="eISSN">2086-4094</idno><imprint><date when="2017">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Middle East respiratory syndrome coronavirus (MERS-CoV) is a recently reported virus that is associated with severe, life threatening and rapidly spreading primarily respiratory illness called the Middle East respiratory syndrome. MERS-CoV possesses a unique positive-sense single-stranded RNA and can undergo rapid mutation in the viral genome. This results in antigenic switching and genetic variation, finally leading to the emergence of novel and new MERS-CoV subtypes which are uncontrollable by vaccines. Researchers are also finding difficulties to sort out therapeutic intervention strategies for MERS-CoV. This virus can spread from human to human, but transmission from dromedary camels to humans plays a crucial epidemiological significance. Dromedary camel acts as “gene mixing vessels” for MERS-CoV and these virus particles undergo rapid change in them. Viral receptors called dipeptidyl peptidase-4 are important receptors for attachment and spread of MERS-CoV in humans. The current method of laboratory confirmation is through real-time polymerase chain reaction on bronchoalveolar lavage, sputum and tracheal aspirates. 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Al-Thani</name></author><author><name sortKey="Al Marri, S A" uniqKey="Al Marri S">S.A. Al-Marri</name></author><author><name sortKey="Alhajri, M M" uniqKey="Alhajri M">M.M. AlHajri</name></author><author><name sortKey="Haagmans, B L" uniqKey="Haagmans B">B.L. Haagmans</name></author><author><name sortKey="Koopman, M P" uniqKey="Koopman M">M.P. Koopman</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Song, F" uniqKey="Song F">F. Song</name></author><author><name sortKey="Fux, R" uniqKey="Fux R">R. Fux</name></author><author><name sortKey="Provacia, L B" uniqKey="Provacia L">L.B. Provacia</name></author><author><name sortKey="Volz, A" uniqKey="Volz A">A. Volz</name></author><author><name sortKey="Eickmann, M" uniqKey="Eickmann M">M. Eickmann</name></author><author><name sortKey="Becker, S" uniqKey="Becker S">S. Becker</name></author><author><name sortKey="Osterhaus, A D" uniqKey="Osterhaus A">A.D. 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Gorbalenya</name></author><author><name sortKey="Snijder, E J" uniqKey="Snijder E">E.J. Snijder</name></author><author><name sortKey="Fouchier, R A" uniqKey="Fouchier R">R.A. Fouchier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="World Health Organization" uniqKey="World Health Organization">World Health Organization</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="World Health Organization" uniqKey="World Health Organization">World Health Organization</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zaki, A M" uniqKey="Zaki A">A.M. Zaki</name></author><author><name sortKey="Van Boheemen, S" uniqKey="Van Boheemen S">S. van Boheemen</name></author><author><name sortKey="Bestebroer, T M" uniqKey="Bestebroer T">T.M. Bestebroer</name></author><author><name sortKey="Osterhaus, A D" uniqKey="Osterhaus A">A.D. Osterhaus</name></author><author><name sortKey="Fouchier, A M" uniqKey="Fouchier A">A.M. Fouchier</name></author></analytic></biblStruct></listBibl></div1></back></TEI><affiliations><list><country><li>Arabie saoudite</li><li>Éthiopie</li></country></list><tree><country name="Arabie saoudite"><noRegion><name sortKey="Subbaram, Kannan" sort="Subbaram, Kannan" uniqKey="Subbaram K" first="Kannan" last="Subbaram">Kannan Subbaram</name></noRegion><name sortKey="Khalil Gatasheh, Mansour" sort="Khalil Gatasheh, Mansour" uniqKey="Khalil Gatasheh M" first="Mansour" last="Khalil Gatasheh">Mansour Khalil Gatasheh</name></country><country name="Éthiopie"><noRegion><name sortKey="Kannan, Hemalatha" sort="Kannan, Hemalatha" uniqKey="Kannan H" first="Hemalatha" last="Kannan">Hemalatha Kannan</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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