Emerging Developments on Pathogenicity, Molecular Virulence, Epidemiology and Clinical Symptoms of Current Middle East Respiratory Syndrome Coronavirus (MERS-CoV).
Identifieur interne : 002784 ( Ncbi/Curation ); précédent : 002783; suivant : 002785Emerging Developments on Pathogenicity, Molecular Virulence, Epidemiology and Clinical Symptoms of Current Middle East Respiratory Syndrome Coronavirus (MERS-CoV).
Auteurs : Kannan Subbaram [Arabie saoudite] ; Hemalatha Kannan [Éthiopie] ; Mansour Khalil Gatasheh [Arabie saoudite]Source :
- Hayati : journal of biosciences [ 1978-3019 ] ; 2017.
Abstract
Middle East respiratory syndrome coronavirus (MERS-CoV) is a recently reported virus that is associated with severe, life threatening and rapidly spreading primarily respiratory illness called the Middle East respiratory syndrome. MERS-CoV possesses a unique positive-sense single-stranded RNA and can undergo rapid mutation in the viral genome. This results in antigenic switching and genetic variation, finally leading to the emergence of novel and new MERS-CoV subtypes which are uncontrollable by vaccines. Researchers are also finding difficulties to sort out therapeutic intervention strategies for MERS-CoV. This virus can spread from human to human, but transmission from dromedary camels to humans plays a crucial epidemiological significance. Dromedary camel acts as "gene mixing vessels" for MERS-CoV and these virus particles undergo rapid change in them. Viral receptors called dipeptidyl peptidase-4 are important receptors for attachment and spread of MERS-CoV in humans. The current method of laboratory confirmation is through real-time polymerase chain reaction on bronchoalveolar lavage, sputum and tracheal aspirates. Unfortunately, till today there are no definite anti-viral drugs available for MERS-CoV.
DOI: 10.1016/j.hjb.2017.08.001
PubMed: 32288937
Links toward previous steps (curation, corpus...)
- to stream PubMed, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000D38
- to stream PubMed, to step Curation: Pour aller vers cette notice dans l'étape Curation :000D38
- to stream PubMed, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :000D23
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :002784
Links to Exploration step
pubmed:32288937Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Emerging Developments on Pathogenicity, Molecular Virulence, Epidemiology and Clinical Symptoms of Current Middle East Respiratory Syndrome Coronavirus (MERS-CoV).</title><author><name sortKey="Subbaram, Kannan" sort="Subbaram, Kannan" uniqKey="Subbaram K" first="Kannan" last="Subbaram">Kannan Subbaram</name><affiliation wicri:level="1"><nlm:affiliation>Department of Preparatory (Biology), Al-Ghad International Colleges for Applied Medical Sciences, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Preparatory (Biology), Al-Ghad International Colleges for Applied Medical Sciences, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Kannan, Hemalatha" sort="Kannan, Hemalatha" uniqKey="Kannan H" first="Hemalatha" last="Kannan">Hemalatha Kannan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Laboratory Sciences & Pathology, Jimma University, Ethiopia.</nlm:affiliation><country xml:lang="fr">Éthiopie</country><wicri:regionArea>Department of Laboratory Sciences & Pathology, Jimma University</wicri:regionArea><wicri:noRegion>Jimma University</wicri:noRegion></affiliation></author><author><name sortKey="Khalil Gatasheh, Mansour" sort="Khalil Gatasheh, Mansour" uniqKey="Khalil Gatasheh M" first="Mansour" last="Khalil Gatasheh">Mansour Khalil Gatasheh</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Laboratory Sciences, Al-Ghad International Colleges for Applied Medical Sciences, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Clinical Laboratory Sciences, Al-Ghad International Colleges for Applied Medical Sciences, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PubMed</idno><date when="2017">2017</date><idno type="RBID">pubmed:32288937</idno><idno type="pmid">32288937</idno><idno type="doi">10.1016/j.hjb.2017.08.001</idno><idno type="wicri:Area/PubMed/Corpus">000D38</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000D38</idno><idno type="wicri:Area/PubMed/Curation">000D38</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000D38</idno><idno type="wicri:Area/PubMed/Checkpoint">000D23</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000D23</idno><idno type="wicri:Area/Ncbi/Merge">002784</idno><idno type="wicri:Area/Ncbi/Curation">002784</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Emerging Developments on Pathogenicity, Molecular Virulence, Epidemiology and Clinical Symptoms of Current Middle East Respiratory Syndrome Coronavirus (MERS-CoV).</title><author><name sortKey="Subbaram, Kannan" sort="Subbaram, Kannan" uniqKey="Subbaram K" first="Kannan" last="Subbaram">Kannan Subbaram</name><affiliation wicri:level="1"><nlm:affiliation>Department of Preparatory (Biology), Al-Ghad International Colleges for Applied Medical Sciences, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Preparatory (Biology), Al-Ghad International Colleges for Applied Medical Sciences, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author><author><name sortKey="Kannan, Hemalatha" sort="Kannan, Hemalatha" uniqKey="Kannan H" first="Hemalatha" last="Kannan">Hemalatha Kannan</name><affiliation wicri:level="1"><nlm:affiliation>Department of Laboratory Sciences & Pathology, Jimma University, Ethiopia.</nlm:affiliation><country xml:lang="fr">Éthiopie</country><wicri:regionArea>Department of Laboratory Sciences & Pathology, Jimma University</wicri:regionArea><wicri:noRegion>Jimma University</wicri:noRegion></affiliation></author><author><name sortKey="Khalil Gatasheh, Mansour" sort="Khalil Gatasheh, Mansour" uniqKey="Khalil Gatasheh M" first="Mansour" last="Khalil Gatasheh">Mansour Khalil Gatasheh</name><affiliation wicri:level="1"><nlm:affiliation>Department of Clinical Laboratory Sciences, Al-Ghad International Colleges for Applied Medical Sciences, Riyadh, Saudi Arabia.</nlm:affiliation><country xml:lang="fr">Arabie saoudite</country><wicri:regionArea>Department of Clinical Laboratory Sciences, Al-Ghad International Colleges for Applied Medical Sciences, Riyadh</wicri:regionArea><wicri:noRegion>Riyadh</wicri:noRegion></affiliation></author></analytic><series><title level="j">Hayati : journal of biosciences</title><idno type="ISSN">1978-3019</idno><imprint><date when="2017" type="published">2017</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Middle East respiratory syndrome coronavirus (MERS-CoV) is a recently reported virus that is associated with severe, life threatening and rapidly spreading primarily respiratory illness called the Middle East respiratory syndrome. MERS-CoV possesses a unique positive-sense single-stranded RNA and can undergo rapid mutation in the viral genome. This results in antigenic switching and genetic variation, finally leading to the emergence of novel and new MERS-CoV subtypes which are uncontrollable by vaccines. Researchers are also finding difficulties to sort out therapeutic intervention strategies for MERS-CoV. This virus can spread from human to human, but transmission from dromedary camels to humans plays a crucial epidemiological significance. Dromedary camel acts as "gene mixing vessels" for MERS-CoV and these virus particles undergo rapid change in them. Viral receptors called dipeptidyl peptidase-4 are important receptors for attachment and spread of MERS-CoV in humans. The current method of laboratory confirmation is through real-time polymerase chain reaction on bronchoalveolar lavage, sputum and tracheal aspirates. Unfortunately, till today there are no definite anti-viral drugs available for MERS-CoV.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Ncbi/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 002784 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 002784 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= MersV1
|flux= Ncbi
|étape= Curation
|type= RBID
|clé= pubmed:32288937
|texte= Emerging Developments on Pathogenicity, Molecular Virulence, Epidemiology and Clinical Symptoms of Current Middle East Respiratory Syndrome Coronavirus (MERS-CoV).
}}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i -Sk "pubmed:32288937" \
| HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd \
| NlmPubMed2Wicri -a MersV1
| This area was generated with Dilib version V0.6.33. |  |