Emerging Developments on Pathogenicity, Molecular Virulence, Epidemiology and Clinical Symptoms of Current Middle East Respiratory Syndrome Coronavirus (MERS-CoV)
Identifieur interne : 002C23 ( Ncbi/Checkpoint ); précédent : 002C22; suivant : 002C24Emerging Developments on Pathogenicity, Molecular Virulence, Epidemiology and Clinical Symptoms of Current Middle East Respiratory Syndrome Coronavirus (MERS-CoV)
Auteurs : Kannan Subbaram [Arabie saoudite] ; Hemalatha Kannan [Éthiopie] ; Mansour Khalil Gatasheh [Arabie saoudite]Source :
- Hayati [ 1978-3019 ] ; 2017.
Abstract
Middle East respiratory syndrome coronavirus (MERS-CoV) is a recently reported virus that is associated with severe, life threatening and rapidly spreading primarily respiratory illness called the Middle East respiratory syndrome. MERS-CoV possesses a unique positive-sense single-stranded RNA and can undergo rapid mutation in the viral genome. This results in antigenic switching and genetic variation, finally leading to the emergence of novel and new MERS-CoV subtypes which are uncontrollable by vaccines. Researchers are also finding difficulties to sort out therapeutic intervention strategies for MERS-CoV. This virus can spread from human to human, but transmission from dromedary camels to humans plays a crucial epidemiological significance. Dromedary camel acts as “gene mixing vessels” for MERS-CoV and these virus particles undergo rapid change in them. Viral receptors called dipeptidyl peptidase-4 are important receptors for attachment and spread of MERS-CoV in humans. The current method of laboratory confirmation is through real-time polymerase chain reaction on bronchoalveolar lavage, sputum and tracheal aspirates. Unfortunately, till today there are no definite anti-viral drugs available for MERS-CoV.
Url:
DOI: 10.1016/j.hjb.2017.08.001
PubMed: NONE
PubMed Central: 7104923
Affiliations:
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<front><div type="abstract" xml:lang="en"><p>Middle East respiratory syndrome coronavirus (MERS-CoV) is a recently reported virus that is associated with severe, life threatening and rapidly spreading primarily respiratory illness called the Middle East respiratory syndrome. MERS-CoV possesses a unique positive-sense single-stranded RNA and can undergo rapid mutation in the viral genome. This results in antigenic switching and genetic variation, finally leading to the emergence of novel and new MERS-CoV subtypes which are uncontrollable by vaccines. Researchers are also finding difficulties to sort out therapeutic intervention strategies for MERS-CoV. This virus can spread from human to human, but transmission from dromedary camels to humans plays a crucial epidemiological significance. Dromedary camel acts as “gene mixing vessels” for MERS-CoV and these virus particles undergo rapid change in them. Viral receptors called dipeptidyl peptidase-4 are important receptors for attachment and spread of MERS-CoV in humans. The current method of laboratory confirmation is through real-time polymerase chain reaction on bronchoalveolar lavage, sputum and tracheal aspirates. Unfortunately, till today there are no definite anti-viral drugs available for MERS-CoV.</p>
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<affiliations><list><country><li>Arabie saoudite</li>
<li>Éthiopie</li>
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<tree><country name="Arabie saoudite"><noRegion><name sortKey="Subbaram, Kannan" sort="Subbaram, Kannan" uniqKey="Subbaram K" first="Kannan" last="Subbaram">Kannan Subbaram</name>
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<name sortKey="Khalil Gatasheh, Mansour" sort="Khalil Gatasheh, Mansour" uniqKey="Khalil Gatasheh M" first="Mansour" last="Khalil Gatasheh">Mansour Khalil Gatasheh</name>
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<country name="Éthiopie"><noRegion><name sortKey="Kannan, Hemalatha" sort="Kannan, Hemalatha" uniqKey="Kannan H" first="Hemalatha" last="Kannan">Hemalatha Kannan</name>
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