High production of interleukin‐10 and interferon‐γ in influenza‐associated MERS in the early phase
Identifieur interne : 000026 ( Istex/Curation ); précédent : 000025; suivant : 000027High production of interleukin‐10 and interferon‐γ in influenza‐associated MERS in the early phase
Auteurs : Shinichiro Morichi [Japon] ; Hisashi Kawashima [Japon] ; Hiroaki Ioi [Japon] ; Gaku Yamanaka [Japon] ; Yasuyo Kashiwagi [Japon] ; Akinori Hoshika [Japon]Source :
- Pediatrics International [ 1328-8067 ] ; 2012-08.
Abstract
Mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) occurs in various diseases and pathologies, and the clinical symptoms are not consistent with the impaired region. The mechanism of the region specificity is unclear. We investigated the cytokine profiling in cerebrospinal fluid (CSF) and serum obtained from a child with MERS during influenza infection, and compared them with those of serious another serious type of influenza‐associated encephalopathy. There was no elevation of Interleukin (IL)‐1β, which induces convulsion. The inhibitory cytokines of IL‐10 and IFN‐γ were elevated in the early phase in CSF. Comparing them with other patients, the elevation of the cytokine levels were generally mild. Considering that the prognosis of this MERS case was favorable and high levels of inhibitory cytokines including IL‐10 and IFN‐γ might work to localize the lesion and to prevent sequelae.
Url:
DOI: 10.1111/j.1442-200X.2011.03483.x
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000026
Links to Exploration step
ISTEX:62076921C50133203DD99C9C78AED4C9EC06B590Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">High production of interleukin‐10 and interferon‐γ in influenza‐associated MERS in the early phase</title><author><name sortKey="Morichi, Shinichiro" sort="Morichi, Shinichiro" uniqKey="Morichi S" first="Shinichiro" last="Morichi">Shinichiro Morichi</name><affiliation wicri:level="1"><mods:affiliation>Department of Pediatrics, Tokyo Medical University, Tokyo, Japan</mods:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pediatrics, Tokyo Medical University, Tokyo</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: shinichiro‐m@hotmail.co.jp</mods:affiliation><country wicri:rule="url">Japon</country></affiliation></author><author><name sortKey="Kawashima, Hisashi" sort="Kawashima, Hisashi" uniqKey="Kawashima H" first="Hisashi" last="Kawashima">Hisashi Kawashima</name><affiliation wicri:level="1"><mods:affiliation>Department of Pediatrics, Tokyo Medical University, Tokyo, Japan</mods:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pediatrics, Tokyo Medical University, Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Ioi, Hiroaki" sort="Ioi, Hiroaki" uniqKey="Ioi H" first="Hiroaki" last="Ioi">Hiroaki Ioi</name><affiliation wicri:level="1"><mods:affiliation>Department of Pediatrics, Tokyo Medical University, Tokyo, Japan</mods:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pediatrics, Tokyo Medical University, Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Yamanaka, Gaku" sort="Yamanaka, Gaku" uniqKey="Yamanaka G" first="Gaku" last="Yamanaka">Gaku Yamanaka</name><affiliation wicri:level="1"><mods:affiliation>Department of Pediatrics, Tokyo Medical University, Tokyo, Japan</mods:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pediatrics, Tokyo Medical University, Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Kashiwagi, Yasuyo" sort="Kashiwagi, Yasuyo" uniqKey="Kashiwagi Y" first="Yasuyo" last="Kashiwagi">Yasuyo Kashiwagi</name><affiliation wicri:level="1"><mods:affiliation>Department of Pediatrics, Tokyo Medical University, Tokyo, Japan</mods:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pediatrics, Tokyo Medical University, Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Hoshika, Akinori" sort="Hoshika, Akinori" uniqKey="Hoshika A" first="Akinori" last="Hoshika">Akinori Hoshika</name><affiliation wicri:level="1"><mods:affiliation>Department of Pediatrics, Tokyo Medical University, Tokyo, Japan</mods:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pediatrics, Tokyo Medical University, Tokyo</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:62076921C50133203DD99C9C78AED4C9EC06B590</idno><date when="2012" year="2012">2012</date><idno type="doi">10.1111/j.1442-200X.2011.03483.x</idno><idno type="url">https://api.istex.fr/ark:/67375/WNG-SS6VDV5V-1/fulltext.pdf</idno><idno type="wicri:Area/Istex/Corpus">000026</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000026</idno><idno type="wicri:Area/Istex/Curation">000026</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main">High production of interleukin‐10 and interferon‐γ in influenza‐associated MERS in the early phase</title><author><name sortKey="Morichi, Shinichiro" sort="Morichi, Shinichiro" uniqKey="Morichi S" first="Shinichiro" last="Morichi">Shinichiro Morichi</name><affiliation wicri:level="1"><mods:affiliation>Department of Pediatrics, Tokyo Medical University, Tokyo, Japan</mods:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pediatrics, Tokyo Medical University, Tokyo</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>E-mail: shinichiro‐m@hotmail.co.jp</mods:affiliation><country wicri:rule="url">Japon</country></affiliation></author><author><name sortKey="Kawashima, Hisashi" sort="Kawashima, Hisashi" uniqKey="Kawashima H" first="Hisashi" last="Kawashima">Hisashi Kawashima</name><affiliation wicri:level="1"><mods:affiliation>Department of Pediatrics, Tokyo Medical University, Tokyo, Japan</mods:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pediatrics, Tokyo Medical University, Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Ioi, Hiroaki" sort="Ioi, Hiroaki" uniqKey="Ioi H" first="Hiroaki" last="Ioi">Hiroaki Ioi</name><affiliation wicri:level="1"><mods:affiliation>Department of Pediatrics, Tokyo Medical University, Tokyo, Japan</mods:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pediatrics, Tokyo Medical University, Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Yamanaka, Gaku" sort="Yamanaka, Gaku" uniqKey="Yamanaka G" first="Gaku" last="Yamanaka">Gaku Yamanaka</name><affiliation wicri:level="1"><mods:affiliation>Department of Pediatrics, Tokyo Medical University, Tokyo, Japan</mods:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pediatrics, Tokyo Medical University, Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Kashiwagi, Yasuyo" sort="Kashiwagi, Yasuyo" uniqKey="Kashiwagi Y" first="Yasuyo" last="Kashiwagi">Yasuyo Kashiwagi</name><affiliation wicri:level="1"><mods:affiliation>Department of Pediatrics, Tokyo Medical University, Tokyo, Japan</mods:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pediatrics, Tokyo Medical University, Tokyo</wicri:regionArea></affiliation></author><author><name sortKey="Hoshika, Akinori" sort="Hoshika, Akinori" uniqKey="Hoshika A" first="Akinori" last="Hoshika">Akinori Hoshika</name><affiliation wicri:level="1"><mods:affiliation>Department of Pediatrics, Tokyo Medical University, Tokyo, Japan</mods:affiliation><country xml:lang="fr">Japon</country><wicri:regionArea>Department of Pediatrics, Tokyo Medical University, Tokyo</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j" type="main">Pediatrics International</title><title level="j" type="alt">PEDIATRICS INTERNATIONAL</title><idno type="ISSN">1328-8067</idno><idno type="eISSN">1442-200X</idno><imprint><biblScope unit="vol">54</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="536">536</biblScope><biblScope unit="page" to="538">538</biblScope><biblScope unit="page-count">3</biblScope><publisher>Blackwell Publishing Asia</publisher><pubPlace>Melbourne, Australia</pubPlace><date type="published" when="2012-08">2012-08</date></imprint><idno type="ISSN">1328-8067</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">1328-8067</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) occurs in various diseases and pathologies, and the clinical symptoms are not consistent with the impaired region. The mechanism of the region specificity is unclear. We investigated the cytokine profiling in cerebrospinal fluid (CSF) and serum obtained from a child with MERS during influenza infection, and compared them with those of serious another serious type of influenza‐associated encephalopathy. There was no elevation of Interleukin (IL)‐1β, which induces convulsion. The inhibitory cytokines of IL‐10 and IFN‐γ were elevated in the early phase in CSF. Comparing them with other patients, the elevation of the cytokine levels were generally mild. Considering that the prognosis of this MERS case was favorable and high levels of inhibitory cytokines including IL‐10 and IFN‐γ might work to localize the lesion and to prevent sequelae.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Istex/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000026 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Curation/biblio.hfd -nk 000026 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= MersV1
|flux= Istex
|étape= Curation
|type= RBID
|clé= ISTEX:62076921C50133203DD99C9C78AED4C9EC06B590
|texte= High production of interleukin‐10 and interferon‐γ in influenza‐associated MERS in the early phase
}}
| This area was generated with Dilib version V0.6.33. |  |