High production of interleukin‐10 and interferon‐γ in influenza‐associated MERS in the early phase
Identifieur interne : 000026 ( Istex/Corpus ); précédent : 000025; suivant : 000027High production of interleukin‐10 and interferon‐γ in influenza‐associated MERS in the early phase
Auteurs : Shinichiro Morichi ; Hisashi Kawashima ; Hiroaki Ioi ; Gaku Yamanaka ; Yasuyo Kashiwagi ; Akinori HoshikaSource :
- Pediatrics International [ 1328-8067 ] ; 2012-08.
Abstract
Mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) occurs in various diseases and pathologies, and the clinical symptoms are not consistent with the impaired region. The mechanism of the region specificity is unclear. We investigated the cytokine profiling in cerebrospinal fluid (CSF) and serum obtained from a child with MERS during influenza infection, and compared them with those of serious another serious type of influenza‐associated encephalopathy. There was no elevation of Interleukin (IL)‐1β, which induces convulsion. The inhibitory cytokines of IL‐10 and IFN‐γ were elevated in the early phase in CSF. Comparing them with other patients, the elevation of the cytokine levels were generally mild. Considering that the prognosis of this MERS case was favorable and high levels of inhibitory cytokines including IL‐10 and IFN‐γ might work to localize the lesion and to prevent sequelae.
Url:
DOI: 10.1111/j.1442-200X.2011.03483.x
Links to Exploration step
ISTEX:62076921C50133203DD99C9C78AED4C9EC06B590Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">High production of interleukin‐10 and interferon‐γ in influenza‐associated MERS in the early phase</title>
<author><name sortKey="Morichi, Shinichiro" sort="Morichi, Shinichiro" uniqKey="Morichi S" first="Shinichiro" last="Morichi">Shinichiro Morichi</name>
<affiliation><mods:affiliation>Department of Pediatrics, Tokyo Medical University, Tokyo, Japan</mods:affiliation>
</affiliation>
<affiliation><mods:affiliation>E-mail: shinichiro‐m@hotmail.co.jp</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Kawashima, Hisashi" sort="Kawashima, Hisashi" uniqKey="Kawashima H" first="Hisashi" last="Kawashima">Hisashi Kawashima</name>
<affiliation><mods:affiliation>Department of Pediatrics, Tokyo Medical University, Tokyo, Japan</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Ioi, Hiroaki" sort="Ioi, Hiroaki" uniqKey="Ioi H" first="Hiroaki" last="Ioi">Hiroaki Ioi</name>
<affiliation><mods:affiliation>Department of Pediatrics, Tokyo Medical University, Tokyo, Japan</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Yamanaka, Gaku" sort="Yamanaka, Gaku" uniqKey="Yamanaka G" first="Gaku" last="Yamanaka">Gaku Yamanaka</name>
<affiliation><mods:affiliation>Department of Pediatrics, Tokyo Medical University, Tokyo, Japan</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Kashiwagi, Yasuyo" sort="Kashiwagi, Yasuyo" uniqKey="Kashiwagi Y" first="Yasuyo" last="Kashiwagi">Yasuyo Kashiwagi</name>
<affiliation><mods:affiliation>Department of Pediatrics, Tokyo Medical University, Tokyo, Japan</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Hoshika, Akinori" sort="Hoshika, Akinori" uniqKey="Hoshika A" first="Akinori" last="Hoshika">Akinori Hoshika</name>
<affiliation><mods:affiliation>Department of Pediatrics, Tokyo Medical University, Tokyo, Japan</mods:affiliation>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">ISTEX</idno>
<idno type="RBID">ISTEX:62076921C50133203DD99C9C78AED4C9EC06B590</idno>
<date when="2012" year="2012">2012</date>
<idno type="doi">10.1111/j.1442-200X.2011.03483.x</idno>
<idno type="url">https://api.istex.fr/ark:/67375/WNG-SS6VDV5V-1/fulltext.pdf</idno>
<idno type="wicri:Area/Istex/Corpus">000026</idno>
<idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000026</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title level="a" type="main">High production of interleukin‐10 and interferon‐γ in influenza‐associated MERS in the early phase</title>
<author><name sortKey="Morichi, Shinichiro" sort="Morichi, Shinichiro" uniqKey="Morichi S" first="Shinichiro" last="Morichi">Shinichiro Morichi</name>
<affiliation><mods:affiliation>Department of Pediatrics, Tokyo Medical University, Tokyo, Japan</mods:affiliation>
</affiliation>
<affiliation><mods:affiliation>E-mail: shinichiro‐m@hotmail.co.jp</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Kawashima, Hisashi" sort="Kawashima, Hisashi" uniqKey="Kawashima H" first="Hisashi" last="Kawashima">Hisashi Kawashima</name>
<affiliation><mods:affiliation>Department of Pediatrics, Tokyo Medical University, Tokyo, Japan</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Ioi, Hiroaki" sort="Ioi, Hiroaki" uniqKey="Ioi H" first="Hiroaki" last="Ioi">Hiroaki Ioi</name>
<affiliation><mods:affiliation>Department of Pediatrics, Tokyo Medical University, Tokyo, Japan</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Yamanaka, Gaku" sort="Yamanaka, Gaku" uniqKey="Yamanaka G" first="Gaku" last="Yamanaka">Gaku Yamanaka</name>
<affiliation><mods:affiliation>Department of Pediatrics, Tokyo Medical University, Tokyo, Japan</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Kashiwagi, Yasuyo" sort="Kashiwagi, Yasuyo" uniqKey="Kashiwagi Y" first="Yasuyo" last="Kashiwagi">Yasuyo Kashiwagi</name>
<affiliation><mods:affiliation>Department of Pediatrics, Tokyo Medical University, Tokyo, Japan</mods:affiliation>
</affiliation>
</author>
<author><name sortKey="Hoshika, Akinori" sort="Hoshika, Akinori" uniqKey="Hoshika A" first="Akinori" last="Hoshika">Akinori Hoshika</name>
<affiliation><mods:affiliation>Department of Pediatrics, Tokyo Medical University, Tokyo, Japan</mods:affiliation>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j" type="main">Pediatrics International</title>
<title level="j" type="alt">PEDIATRICS INTERNATIONAL</title>
<idno type="ISSN">1328-8067</idno>
<idno type="eISSN">1442-200X</idno>
<imprint><biblScope unit="vol">54</biblScope>
<biblScope unit="issue">4</biblScope>
<biblScope unit="page" from="536">536</biblScope>
<biblScope unit="page" to="538">538</biblScope>
<biblScope unit="page-count">3</biblScope>
<publisher>Blackwell Publishing Asia</publisher>
<pubPlace>Melbourne, Australia</pubPlace>
<date type="published" when="2012-08">2012-08</date>
</imprint>
<idno type="ISSN">1328-8067</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">1328-8067</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) occurs in various diseases and pathologies, and the clinical symptoms are not consistent with the impaired region. The mechanism of the region specificity is unclear. We investigated the cytokine profiling in cerebrospinal fluid (CSF) and serum obtained from a child with MERS during influenza infection, and compared them with those of serious another serious type of influenza‐associated encephalopathy. There was no elevation of Interleukin (IL)‐1β, which induces convulsion. The inhibitory cytokines of IL‐10 and IFN‐γ were elevated in the early phase in CSF. Comparing them with other patients, the elevation of the cytokine levels were generally mild. Considering that the prognosis of this MERS case was favorable and high levels of inhibitory cytokines including IL‐10 and IFN‐γ might work to localize the lesion and to prevent sequelae.</div>
</front>
</TEI>
<istex><corpusName>wiley</corpusName>
<keywords><teeft><json:string>mers</json:string>
<json:string>cytokine</json:string>
<json:string>splenial</json:string>
<json:string>encephalopathy</json:string>
<json:string>mers patient</json:string>
<json:string>sequela</json:string>
<json:string>convulsion</json:string>
<json:string>early phase</json:string>
<json:string>reversible splenial lesion</json:string>
<json:string>cytokine level</json:string>
<json:string>pediatrics</json:string>
<json:string>callosum</json:string>
<json:string>inflammatory cytokine</json:string>
<json:string>corpus callosum</json:string>
<json:string>pediatric</json:string>
<json:string>transient splenial lesion</json:string>
<json:string>interleukin</json:string>
<json:string>lesion</json:string>
<json:string>splenial lesion</json:string>
<json:string>inhibitory cytokine</json:string>
<json:string>cytokine profile</json:string>
<json:string>author pediatrics international</json:string>
<json:string>other encephalopathy</json:string>
<json:string>inflammatory</json:string>
<json:string>prognosis</json:string>
<json:string>case report</json:string>
<json:string>generalized clonic convulsion</json:string>
<json:string>white matter</json:string>
<json:string>other patient</json:string>
<json:string>high level</json:string>
<json:string>control patient</json:string>
<json:string>cerebrospinal fluid</json:string>
<json:string>control group</json:string>
<json:string>tumor necrosis factor</json:string>
<json:string>region specificity</json:string>
<json:string>similar level</json:string>
<json:string>clinical course</json:string>
<json:string>cytokine expression</json:string>
<json:string>vascular endothelial disorder</json:string>
<json:string>clinical symptom</json:string>
<json:string>viral infection</json:string>
<json:string>several cytokine</json:string>
</teeft>
</keywords>
<author><json:item><name>Shinichiro Morichi</name>
<affiliations><json:string>Department of Pediatrics, Tokyo Medical University, Tokyo, Japan</json:string>
<json:string>E-mail: shinichiro‐m@hotmail.co.jp</json:string>
</affiliations>
</json:item>
<json:item><name>Hisashi Kawashima</name>
<affiliations><json:string>Department of Pediatrics, Tokyo Medical University, Tokyo, Japan</json:string>
</affiliations>
</json:item>
<json:item><name>Hiroaki Ioi</name>
<affiliations><json:string>Department of Pediatrics, Tokyo Medical University, Tokyo, Japan</json:string>
</affiliations>
</json:item>
<json:item><name>Gaku Yamanaka</name>
<affiliations><json:string>Department of Pediatrics, Tokyo Medical University, Tokyo, Japan</json:string>
</affiliations>
</json:item>
<json:item><name>Yasuyo Kashiwagi</name>
<affiliations><json:string>Department of Pediatrics, Tokyo Medical University, Tokyo, Japan</json:string>
</affiliations>
</json:item>
<json:item><name>Akinori Hoshika</name>
<affiliations><json:string>Department of Pediatrics, Tokyo Medical University, Tokyo, Japan</json:string>
</affiliations>
</json:item>
</author>
<subject><json:item><lang><json:string>eng</json:string>
</lang>
<value>influenza‐associated encephalopathy (IAE)</value>
</json:item>
<json:item><lang><json:string>eng</json:string>
</lang>
<value>interferon‐γ</value>
</json:item>
<json:item><lang><json:string>eng</json:string>
</lang>
<value>interleukin‐10</value>
</json:item>
<json:item><lang><json:string>eng</json:string>
</lang>
<value>MERS</value>
</json:item>
</subject>
<articleId><json:string>PED3483</json:string>
</articleId>
<arkIstex>ark:/67375/WNG-SS6VDV5V-1</arkIstex>
<language><json:string>eng</json:string>
</language>
<originalGenre><json:string>caseStudy</json:string>
</originalGenre>
<abstract>Mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) occurs in various diseases and pathologies, and the clinical symptoms are not consistent with the impaired region. The mechanism of the region specificity is unclear. We investigated the cytokine profiling in cerebrospinal fluid (CSF) and serum obtained from a child with MERS during influenza infection, and compared them with those of serious another serious type of influenza‐associated encephalopathy. There was no elevation of Interleukin (IL)‐1β, which induces convulsion. The inhibitory cytokines of IL‐10 and IFN‐γ were elevated in the early phase in CSF. Comparing them with other patients, the elevation of the cytokine levels were generally mild. Considering that the prognosis of this MERS case was favorable and high levels of inhibitory cytokines including IL‐10 and IFN‐γ might work to localize the lesion and to prevent sequelae.</abstract>
<qualityIndicators><score>5.42</score>
<pdfWordCount>1800</pdfWordCount>
<pdfCharCount>11754</pdfCharCount>
<pdfVersion>1.3</pdfVersion>
<pdfPageCount>3</pdfPageCount>
<pdfPageSize>595.276 x 805.039 pts</pdfPageSize>
<pdfWordsPerPage>600</pdfWordsPerPage>
<pdfText>true</pdfText>
<refBibsNative>true</refBibsNative>
<abstractWordCount>135</abstractWordCount>
<abstractCharCount>919</abstractCharCount>
<keywordCount>4</keywordCount>
</qualityIndicators>
<title>High production of interleukin‐10 and interferon‐γ in influenza‐associated MERS in the early phase</title>
<pmid><json:string>22830540</json:string>
</pmid>
<genre><json:string>case-report</json:string>
</genre>
<host><title>Pediatrics International</title>
<language><json:string>unknown</json:string>
</language>
<doi><json:string>10.1111/(ISSN)1442-200X</json:string>
</doi>
<issn><json:string>1328-8067</json:string>
</issn>
<eissn><json:string>1442-200X</json:string>
</eissn>
<publisherId><json:string>PED</json:string>
</publisherId>
<volume>54</volume>
<issue>4</issue>
<pages><first>536</first>
<last>538</last>
<total>3</total>
</pages>
<genre><json:string>journal</json:string>
</genre>
</host>
<namedEntities><unitex><date><json:string>2012</json:string>
<json:string>6-7-1</json:string>
</date>
<geogName></geogName>
<orgName><json:string>Tokyo Medical University</json:string>
<json:string>Department of Pediatrics, Tokyo Medical University</json:string>
<json:string>Akinori Hoshika Department of Pediatrics, Tokyo Medical University, Tokyo, Japan Abstract Mild</json:string>
<json:string>Japan Pediatric Society</json:string>
<json:string>Japan Pediatric Society We</json:string>
<json:string>The Authors Pediatrics International</json:string>
</orgName>
<orgName_funder></orgName_funder>
<orgName_provider></orgName_provider>
<persName><json:string>Electroencephalogram</json:string>
<json:string>Case</json:string>
<json:string>Shinichiro Morichi</json:string>
</persName>
<placeName><json:string>Japan</json:string>
<json:string>Tokyo</json:string>
</placeName>
<ref_url></ref_url>
<ref_bibl><json:string>Morichi et al.</json:string>
</ref_bibl>
<bibl></bibl>
</unitex>
</namedEntities>
<ark><json:string>ark:/67375/WNG-SS6VDV5V-1</json:string>
</ark>
<categories><wos><json:string>1 - science</json:string>
<json:string>2 - pediatrics</json:string>
</wos>
<scienceMetrix><json:string>1 - health sciences</json:string>
<json:string>2 - clinical medicine</json:string>
<json:string>3 - pediatrics</json:string>
</scienceMetrix>
<scopus><json:string>1 - Health Sciences</json:string>
<json:string>2 - Medicine</json:string>
<json:string>3 - Pediatrics, Perinatology, and Child Health</json:string>
</scopus>
<inist><json:string>1 - sciences appliquees, technologies et medecines</json:string>
<json:string>2 - sciences biologiques et medicales</json:string>
<json:string>3 - sciences medicales</json:string>
</inist>
</categories>
<publicationDate>2012</publicationDate>
<copyrightDate>2012</copyrightDate>
<doi><json:string>10.1111/j.1442-200X.2011.03483.x</json:string>
</doi>
<id>62076921C50133203DD99C9C78AED4C9EC06B590</id>
<score>1</score>
<fulltext><json:item><extension>pdf</extension>
<original>true</original>
<mimetype>application/pdf</mimetype>
<uri>https://api.istex.fr/ark:/67375/WNG-SS6VDV5V-1/fulltext.pdf</uri>
</json:item>
<json:item><extension>zip</extension>
<original>false</original>
<mimetype>application/zip</mimetype>
<uri>https://api.istex.fr/ark:/67375/WNG-SS6VDV5V-1/bundle.zip</uri>
</json:item>
<istex:fulltextTEI uri="https://api.istex.fr/ark:/67375/WNG-SS6VDV5V-1/fulltext.tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main">High production of interleukin‐10 and interferon‐γ in influenza‐associated MERS in the early phase</title>
<title level="a" type="short">Cytokine profiling of influenza‐associated MERS in the early phase</title>
</titleStmt>
<publicationStmt><authority>ISTEX</authority>
<publisher>Blackwell Publishing Asia</publisher>
<pubPlace>Melbourne, Australia</pubPlace>
<availability><licence>© 2012 The Authors. Pediatrics International © 2012 Japan Pediatric Society</licence>
</availability>
<date type="published" when="2012-08"></date>
</publicationStmt>
<notesStmt><note type="content-type" subtype="case-report" source="caseStudy" scheme="https://content-type.data.istex.fr/ark:/67375/XTP-29919SZJ-6">case-report</note>
<note type="publication-type" subtype="journal" scheme="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</note>
</notesStmt>
<sourceDesc><biblStruct type="case-report"><analytic><title level="a" type="main">High production of interleukin‐10 and interferon‐γ in influenza‐associated MERS in the early phase</title>
<title level="a" type="short">Cytokine profiling of influenza‐associated MERS in the early phase</title>
<author xml:id="author-0000" role="corresp"><persName><forename type="first">Shinichiro</forename>
<surname>Morichi</surname>
</persName>
<affiliation><orgName type="division">Department of Pediatrics</orgName>
<orgName type="institution">Tokyo Medical University</orgName>
<address><addrLine>Tokyo</addrLine>
<addrLine>Japan</addrLine>
<country key="JP" xml:lang="en">JAPAN</country>
</address>
</affiliation>
</author>
<author xml:id="author-0001"><persName><forename type="first">Hisashi</forename>
<surname>Kawashima</surname>
</persName>
<affiliation><orgName type="division">Department of Pediatrics</orgName>
<orgName type="institution">Tokyo Medical University</orgName>
<address><addrLine>Tokyo</addrLine>
<addrLine>Japan</addrLine>
<country key="JP" xml:lang="en">JAPAN</country>
</address>
</affiliation>
</author>
<author xml:id="author-0002"><persName><forename type="first">Hiroaki</forename>
<surname>Ioi</surname>
</persName>
<affiliation><orgName type="division">Department of Pediatrics</orgName>
<orgName type="institution">Tokyo Medical University</orgName>
<address><addrLine>Tokyo</addrLine>
<addrLine>Japan</addrLine>
<country key="JP" xml:lang="en">JAPAN</country>
</address>
</affiliation>
</author>
<author xml:id="author-0003"><persName><forename type="first">Gaku</forename>
<surname>Yamanaka</surname>
</persName>
<affiliation><orgName type="division">Department of Pediatrics</orgName>
<orgName type="institution">Tokyo Medical University</orgName>
<address><addrLine>Tokyo</addrLine>
<addrLine>Japan</addrLine>
<country key="JP" xml:lang="en">JAPAN</country>
</address>
</affiliation>
</author>
<author xml:id="author-0004"><persName><forename type="first">Yasuyo</forename>
<surname>Kashiwagi</surname>
</persName>
<affiliation><orgName type="division">Department of Pediatrics</orgName>
<orgName type="institution">Tokyo Medical University</orgName>
<address><addrLine>Tokyo</addrLine>
<addrLine>Japan</addrLine>
<country key="JP" xml:lang="en">JAPAN</country>
</address>
</affiliation>
</author>
<author xml:id="author-0005"><persName><forename type="first">Akinori</forename>
<surname>Hoshika</surname>
</persName>
<affiliation><orgName type="division">Department of Pediatrics</orgName>
<orgName type="institution">Tokyo Medical University</orgName>
<address><addrLine>Tokyo</addrLine>
<addrLine>Japan</addrLine>
<country key="JP" xml:lang="en">JAPAN</country>
</address>
</affiliation>
</author>
<idno type="istex">62076921C50133203DD99C9C78AED4C9EC06B590</idno>
<idno type="ark">ark:/67375/WNG-SS6VDV5V-1</idno>
<idno type="DOI">10.1111/j.1442-200X.2011.03483.x</idno>
<idno type="unit">PED3483</idno>
<idno type="toTypesetVersion">file:PED.PED3483.pdf</idno>
</analytic>
<monogr><title level="j" type="main">Pediatrics International</title>
<title level="j" type="alt">PEDIATRICS INTERNATIONAL</title>
<idno type="pISSN">1328-8067</idno>
<idno type="eISSN">1442-200X</idno>
<idno type="book-DOI">10.1111/(ISSN)1442-200X</idno>
<idno type="book-part-DOI">10.1111/ped.2012.54.issue-4</idno>
<idno type="product">PED</idno>
<idno type="publisherDivision">ST</idno>
<imprint><biblScope unit="vol">54</biblScope>
<biblScope unit="issue">4</biblScope>
<biblScope unit="page" from="536">536</biblScope>
<biblScope unit="page" to="538">538</biblScope>
<biblScope unit="page-count">3</biblScope>
<publisher>Blackwell Publishing Asia</publisher>
<pubPlace>Melbourne, Australia</pubPlace>
<date type="published" when="2012-08"></date>
</imprint>
</monogr>
</biblStruct>
</sourceDesc>
</fileDesc>
<encodingDesc><schemaRef type="ODD" url="https://xml-schema.delivery.istex.fr/tei-istex.odd"></schemaRef>
<appInfo><application ident="pub2tei" version="1.0.10" when="2019-12-20"><label>pub2TEI-ISTEX</label>
<desc>A set of style sheets for converting XML documents encoded in various scientific publisher formats into a common TEI format.
<ref target="http://www.tei-c.org/">We use TEI</ref>
</desc>
</application>
</appInfo>
</encodingDesc>
<profileDesc><abstract xml:lang="en" style="main"><head>Abstract</head>
<p>Mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) occurs in various diseases and pathologies, and the clinical symptoms are not consistent with the impaired region. The mechanism of the region specificity is unclear. We investigated the cytokine profiling in cerebrospinal fluid (CSF) and serum obtained from a child with MERS during influenza infection, and compared them with those of serious another serious type of influenza‐associated encephalopathy. There was no elevation of Interleukin (IL)‐1β, which induces convulsion. The inhibitory cytokines of IL‐10 and IFN‐γ were elevated in the early phase in CSF. Comparing them with other patients, the elevation of the cytokine levels were generally mild. Considering that the prognosis of this MERS case was favorable and high levels of inhibitory cytokines including IL‐10 and IFN‐γ might work to localize the lesion and to prevent sequelae.</p>
</abstract>
<textClass><keywords xml:lang="en"><term xml:id="k1">influenza‐associated encephalopathy (IAE)</term>
<term xml:id="k2">interferon‐γ</term>
<term xml:id="k3">interleukin‐10</term>
<term xml:id="k4">MERS</term>
</keywords>
<keywords rend="tocHeading1"><term>PATIENT REPORTS</term>
</keywords>
</textClass>
<langUsage><language ident="en"></language>
</langUsage>
</profileDesc>
<revisionDesc><change when="2019-12-20" who="#istex" xml:id="pub2tei">formatting</change>
</revisionDesc>
</teiHeader>
</istex:fulltextTEI>
<json:item><extension>txt</extension>
<original>false</original>
<mimetype>text/plain</mimetype>
<uri>https://api.istex.fr/ark:/67375/WNG-SS6VDV5V-1/fulltext.txt</uri>
</json:item>
</fulltext>
<metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration>
<istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Asia</publisherName>
<publisherLoc>Melbourne, Australia</publisherLoc>
</publisherInfo>
<doi origin="wiley" registered="yes">10.1111/(ISSN)1442-200X</doi>
<issn type="print">1328-8067</issn>
<issn type="electronic">1442-200X</issn>
<idGroup><id type="product" value="PED"></id>
<id type="publisherDivision" value="ST"></id>
</idGroup>
<titleGroup><title type="main" sort="PEDIATRICS INTERNATIONAL">Pediatrics International</title>
</titleGroup>
</publicationMeta>
<publicationMeta level="part" position="08104"><doi origin="wiley">10.1111/ped.2012.54.issue-4</doi>
<numberingGroup><numbering type="journalVolume" number="54">54</numbering>
<numbering type="journalIssue" number="4">4</numbering>
</numberingGroup>
<coverDate startDate="2012-08">August 2012</coverDate>
</publicationMeta>
<publicationMeta level="unit" type="caseStudy" position="19" status="forIssue"><doi origin="wiley">10.1111/j.1442-200X.2011.03483.x</doi>
<idGroup><id type="unit" value="PED3483"></id>
</idGroup>
<countGroup><count type="pageTotal" number="3"></count>
</countGroup>
<titleGroup><title type="tocHeading1">PATIENT REPORTS</title>
</titleGroup>
<copyright>© 2012 The Authors. Pediatrics International © 2012 Japan Pediatric Society</copyright>
<eventGroup><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:3.1.6 mode:FullText" date="2012-07-26"></event>
<event type="firstOnline" date="2012-07-26"></event>
<event type="publishedOnlineFinalForm" date="2012-07-26"></event>
<event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-06"></event>
<event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.3.4 mode:FullText" date="2015-02-25"></event>
</eventGroup>
<numberingGroup><numbering type="pageFirst" number="536">536</numbering>
<numbering type="pageLast" number="538">538</numbering>
</numberingGroup>
<correspondenceTo>Shinichiro Morichi, MD, Department of Pediatrics, Tokyo Medical University 6‐7‐1 Nishishinjuku, Shinjuku‐ku, Tokyo 160‐0023, Japan. Email: <email normalForm="shinichiro-m@hotmail.co.jp">shinichiro‐m@hotmail.co.jp</email>
</correspondenceTo>
<linkGroup><link type="toTypesetVersion" href="file:PED.PED3483.pdf"></link>
</linkGroup>
</publicationMeta>
<contentMeta><unparsedEditorialHistory>Received 7 April 2010; revised 26 July 2011; accepted 6 September 2011.</unparsedEditorialHistory>
<countGroup><count type="figureTotal" number="2"></count>
<count type="tableTotal" number="1"></count>
<count type="formulaTotal" number="0"></count>
<count type="referenceTotal" number="14"></count>
<count type="wordTotal" number="1316"></count>
<count type="linksPubMed" number="0"></count>
<count type="linksCrossRef" number="0"></count>
</countGroup>
<titleGroup><title type="main">High production of interleukin‐10 and interferon‐γ in influenza‐associated MERS in the early phase</title>
<title type="shortAuthors">S Morichi <i>et al</i>
.</title>
<title type="short">Cytokine profiling of influenza‐associated MERS in the early phase</title>
</titleGroup>
<creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1" corresponding="yes"><personName><givenNames>Shinichiro</givenNames>
<familyName>Morichi</familyName>
</personName>
</creator>
<creator creatorRole="author" xml:id="cr2" affiliationRef="#a1"><personName><givenNames>Hisashi</givenNames>
<familyName>Kawashima</familyName>
</personName>
</creator>
<creator creatorRole="author" xml:id="cr3" affiliationRef="#a1"><personName><givenNames>Hiroaki</givenNames>
<familyName>Ioi</familyName>
</personName>
</creator>
<creator creatorRole="author" xml:id="cr4" affiliationRef="#a1"><personName><givenNames>Gaku</givenNames>
<familyName>Yamanaka</familyName>
</personName>
</creator>
<creator creatorRole="author" xml:id="cr5" affiliationRef="#a1"><personName><givenNames>Yasuyo</givenNames>
<familyName>Kashiwagi</familyName>
</personName>
</creator>
<creator creatorRole="author" xml:id="cr6" affiliationRef="#a1"><personName><givenNames>Akinori</givenNames>
<familyName>Hoshika</familyName>
</personName>
</creator>
</creators>
<affiliationGroup><affiliation xml:id="a1" countryCode="JP"><unparsedAffiliation>Department of Pediatrics, Tokyo Medical University, Tokyo, Japan</unparsedAffiliation>
</affiliation>
</affiliationGroup>
<keywordGroup xml:lang="en"><keyword xml:id="k1">influenza‐associated encephalopathy (IAE)</keyword>
<keyword xml:id="k2">interferon‐γ</keyword>
<keyword xml:id="k3">interleukin‐10</keyword>
<keyword xml:id="k4">MERS</keyword>
</keywordGroup>
<abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title>
<p>Mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) occurs in various diseases and pathologies, and the clinical symptoms are not consistent with the impaired region. The mechanism of the region specificity is unclear. We investigated the cytokine profiling in cerebrospinal fluid (CSF) and serum obtained from a child with MERS during influenza infection, and compared them with those of serious another serious type of influenza‐associated encephalopathy. There was no elevation of Interleukin (IL)‐1β, which induces convulsion. The inhibitory cytokines of IL‐10 and IFN‐γ were elevated in the early phase in CSF. Comparing them with other patients, the elevation of the cytokine levels were generally mild. Considering that the prognosis of this MERS case was favorable and high levels of inhibitory cytokines including IL‐10 and IFN‐γ might work to localize the lesion and to prevent sequelae.</p>
</abstract>
</abstractGroup>
</contentMeta>
</header>
</component>
</istex:document>
</istex:metadataXml>
<mods version="3.6"><titleInfo lang="en"><title>High production of interleukin‐10 and interferon‐γ in influenza‐associated MERS in the early phase</title>
</titleInfo>
<titleInfo type="abbreviated" lang="en"><title>Cytokine profiling of influenza‐associated MERS in the early phase</title>
</titleInfo>
<titleInfo type="alternative" contentType="CDATA" lang="en"><title>High production of interleukin‐10 and interferon‐γ in influenza‐associated MERS in the early phase</title>
</titleInfo>
<name type="personal"><namePart type="given">Shinichiro</namePart>
<namePart type="family">Morichi</namePart>
<affiliation>Department of Pediatrics, Tokyo Medical University, Tokyo, Japan</affiliation>
<affiliation>E-mail: shinichiro‐m@hotmail.co.jp</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Hisashi</namePart>
<namePart type="family">Kawashima</namePart>
<affiliation>Department of Pediatrics, Tokyo Medical University, Tokyo, Japan</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Hiroaki</namePart>
<namePart type="family">Ioi</namePart>
<affiliation>Department of Pediatrics, Tokyo Medical University, Tokyo, Japan</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Gaku</namePart>
<namePart type="family">Yamanaka</namePart>
<affiliation>Department of Pediatrics, Tokyo Medical University, Tokyo, Japan</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Yasuyo</namePart>
<namePart type="family">Kashiwagi</namePart>
<affiliation>Department of Pediatrics, Tokyo Medical University, Tokyo, Japan</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">Akinori</namePart>
<namePart type="family">Hoshika</namePart>
<affiliation>Department of Pediatrics, Tokyo Medical University, Tokyo, Japan</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<typeOfResource>text</typeOfResource>
<genre type="case-report" displayLabel="caseStudy" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-29919SZJ-6">case-report</genre>
<originInfo><publisher>Blackwell Publishing Asia</publisher>
<place><placeTerm type="text">Melbourne, Australia</placeTerm>
</place>
<dateIssued encoding="w3cdtf">2012-08</dateIssued>
<edition>Received 7 April 2010; revised 26 July 2011; accepted 6 September 2011.</edition>
<copyrightDate encoding="w3cdtf">2012</copyrightDate>
</originInfo>
<language><languageTerm type="code" authority="rfc3066">en</languageTerm>
<languageTerm type="code" authority="iso639-2b">eng</languageTerm>
</language>
<physicalDescription><extent unit="figures">2</extent>
<extent unit="tables">1</extent>
<extent unit="formulas">0</extent>
<extent unit="references">14</extent>
<extent unit="linksCrossRef">0</extent>
<extent unit="words">1316</extent>
</physicalDescription>
<abstract lang="en">Mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) occurs in various diseases and pathologies, and the clinical symptoms are not consistent with the impaired region. The mechanism of the region specificity is unclear. We investigated the cytokine profiling in cerebrospinal fluid (CSF) and serum obtained from a child with MERS during influenza infection, and compared them with those of serious another serious type of influenza‐associated encephalopathy. There was no elevation of Interleukin (IL)‐1β, which induces convulsion. The inhibitory cytokines of IL‐10 and IFN‐γ were elevated in the early phase in CSF. Comparing them with other patients, the elevation of the cytokine levels were generally mild. Considering that the prognosis of this MERS case was favorable and high levels of inhibitory cytokines including IL‐10 and IFN‐γ might work to localize the lesion and to prevent sequelae.</abstract>
<subject lang="en"><genre>keywords</genre>
<topic>influenza‐associated encephalopathy (IAE)</topic>
<topic>interferon‐γ</topic>
<topic>interleukin‐10</topic>
<topic>MERS</topic>
</subject>
<relatedItem type="host"><titleInfo><title>Pediatrics International</title>
</titleInfo>
<genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre>
<identifier type="ISSN">1328-8067</identifier>
<identifier type="eISSN">1442-200X</identifier>
<identifier type="DOI">10.1111/(ISSN)1442-200X</identifier>
<identifier type="PublisherID">PED</identifier>
<part><date>2012</date>
<detail type="volume"><caption>vol.</caption>
<number>54</number>
</detail>
<detail type="issue"><caption>no.</caption>
<number>4</number>
</detail>
<extent unit="pages"><start>536</start>
<end>538</end>
<total>3</total>
</extent>
</part>
</relatedItem>
<relatedItem type="references" displayLabel="cit1"><titleInfo><title>Acute encephalopathy associated with influenza and other viral infections</title>
</titleInfo>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Mizuguchi</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">H</namePart>
<namePart type="family">Yamanouchi</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">T</namePart>
<namePart type="family">Ichiyama</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Shiomi</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Mizuguchi M, Yamanouchi H, Ichiyama T, Shiomi M. Acute encephalopathy associated with influenza and other viral infections. Acta Neurol. Scand. Suppl. 2007; 115: 45–6. Review.</note>
<part><date>2007</date>
<detail type="volume"><caption>vol.</caption>
<number>115</number>
</detail>
<extent unit="pages"><start>45</start>
<end>6</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Acta Neurol. Scand. Suppl.</title>
</titleInfo>
<part><date>2007</date>
<detail type="volume"><caption>vol.</caption>
<number>115</number>
</detail>
<extent unit="pages"><start>45</start>
<end>6</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit2"><titleInfo><title>[Studies on the epidemiology and pathogenesis of encephalitis/encephalopathy occurring during the clinical course of influenza.]</title>
</titleInfo>
<name type="personal"><namePart type="given">T</namePart>
<namePart type="family">Morishima</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>book-chapter</genre>
<relatedItem type="host"><titleInfo><title>[2000–2002 General Report of the Research Committee for Research on Emerging and Re‐Emerging Diseases.]</title>
</titleInfo>
<originInfo><publisher>Ministry of Health, Labor and Welfare</publisher>
</originInfo>
<part><date>2003</date>
<extent unit="pages"><start>1</start>
<end>23</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit3"><titleInfo><title>Transient splenial lesion of the corpus callosum in clinically mild influenza‐associated encephalitis/encephalopathy</title>
</titleInfo>
<name type="personal"><namePart type="given">N</namePart>
<namePart type="family">Bulakbasi</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Kocaoglu</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">C</namePart>
<namePart type="family">Tayfun</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">T</namePart>
<namePart type="family">Ucoz</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Bulakbasi N, Kocaoglu M, Tayfun C, Ucoz T. Transient splenial lesion of the corpus callosum in clinically mild influenza‐associated encephalitis/encephalopathy. Am. J. Neuroradiol. 2006; 27: 156–8.</note>
<part><date>2006</date>
<detail type="volume"><caption>vol.</caption>
<number>27</number>
</detail>
<extent unit="pages"><start>156</start>
<end>8</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Am. J. Neuroradiol.</title>
</titleInfo>
<part><date>2006</date>
<detail type="volume"><caption>vol.</caption>
<number>27</number>
</detail>
<extent unit="pages"><start>156</start>
<end>8</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit4"><titleInfo><title>A case of isolated and transient splenial lesion of the corpus callosum associated with disseminated Staphylococcus aureus infection</title>
</titleInfo>
<name type="personal"><namePart type="given">JM</namePart>
<namePart type="family">Hong</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">IS</namePart>
<namePart type="family">Joo</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Hong JM, Joo IS. A case of isolated and transient splenial lesion of the corpus callosum associated with disseminated Staphylococcus aureus infection. J. Neurol. Sci. 2006; 250: 156–8.</note>
<part><date>2006</date>
<detail type="volume"><caption>vol.</caption>
<number>250</number>
</detail>
<extent unit="pages"><start>156</start>
<end>8</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J. Neurol. Sci.</title>
</titleInfo>
<part><date>2006</date>
<detail type="volume"><caption>vol.</caption>
<number>250</number>
</detail>
<extent unit="pages"><start>156</start>
<end>8</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit5"><titleInfo><title>Reversible MR findings of hemolytic uremic syndrome with mild encephalopathy</title>
</titleInfo>
<name type="personal"><namePart type="given">H</namePart>
<namePart type="family">Ogura</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Takaoka</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Kishi</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Ogura H, Takaoka M, Kishi M et al. Reversible MR findings of hemolytic uremic syndrome with mild encephalopathy. Am. J. Neuroradiol. 1998; 19: 1144–5.</note>
<part><date>1998</date>
<detail type="volume"><caption>vol.</caption>
<number>19</number>
</detail>
<extent unit="pages"><start>1144</start>
<end>5</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Am. J. Neuroradiol.</title>
</titleInfo>
<part><date>1998</date>
<detail type="volume"><caption>vol.</caption>
<number>19</number>
</detail>
<extent unit="pages"><start>1144</start>
<end>5</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit6"><titleInfo><title>Transient splenial lesion of the corpus callosum associated with antiepileptic drugs: Evaluation by diffusion‐weighted MR imaging</title>
</titleInfo>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Maeda</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">T</namePart>
<namePart type="family">Shiroyama</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">H</namePart>
<namePart type="family">Tsukahara</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">T</namePart>
<namePart type="family">Shimono</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">S</namePart>
<namePart type="family">Aoki</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">K</namePart>
<namePart type="family">Takeda</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Maeda M, Shiroyama T, Tsukahara H, Shimono T, Aoki S, Takeda K. Transient splenial lesion of the corpus callosum associated with antiepileptic drugs: Evaluation by diffusion‐weighted MR imaging. Eur. Radiol. 2003; 13: 1902–6.</note>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>13</number>
</detail>
<extent unit="pages"><start>1902</start>
<end>6</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Eur. Radiol.</title>
</titleInfo>
<part><date>2003</date>
<detail type="volume"><caption>vol.</caption>
<number>13</number>
</detail>
<extent unit="pages"><start>1902</start>
<end>6</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit7"><titleInfo><title>Transient splenial lesion of the corpus callosum after acute withdrawal antiepileptic drugs: A case report</title>
</titleInfo>
<name type="personal"><namePart type="given">K</namePart>
<namePart type="family">Honda</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">J</namePart>
<namePart type="family">Nishimiya</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">H</namePart>
<namePart type="family">Sato</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Honda K, Nishimiya J, Sato H et al. Transient splenial lesion of the corpus callosum after acute withdrawal antiepileptic drugs: A case report. Magn. Reson. Med. Sci. 2006; 5: 211–15.</note>
<part><date>2006</date>
<detail type="volume"><caption>vol.</caption>
<number>5</number>
</detail>
<extent unit="pages"><start>211</start>
<end>15</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Magn. Reson. Med. Sci.</title>
</titleInfo>
<part><date>2006</date>
<detail type="volume"><caption>vol.</caption>
<number>5</number>
</detail>
<extent unit="pages"><start>211</start>
<end>15</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit8"><titleInfo><title>Encephalopathy with a reversible splenial lesion is associated with hyponatremia</title>
</titleInfo>
<name type="personal"><namePart type="given">J</namePart>
<namePart type="family">Takanashi</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">H</namePart>
<namePart type="family">Tada</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Maeda</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Suzuki</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">H</namePart>
<namePart type="family">Terada</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">AJ</namePart>
<namePart type="family">Barkovich</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Takanashi J, Tada H, Maeda M, Suzuki M, Terada H, Barkovich AJ. Encephalopathy with a reversible splenial lesion is associated with hyponatremia. Brain Dev. 2009; 31: 217–20.</note>
<part><date>2009</date>
<detail type="volume"><caption>vol.</caption>
<number>31</number>
</detail>
<extent unit="pages"><start>217</start>
<end>20</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Brain Dev.</title>
</titleInfo>
<part><date>2009</date>
<detail type="volume"><caption>vol.</caption>
<number>31</number>
</detail>
<extent unit="pages"><start>217</start>
<end>20</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit9"><titleInfo><title>Oxidative stress in patients with clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS)</title>
</titleInfo>
<name type="personal"><namePart type="given">R</namePart>
<namePart type="family">Miyata</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">N</namePart>
<namePart type="family">Tanuma</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Hayashi</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Miyata R, Tanuma N, Hayashi M et al. Oxidative stress in patients with clinically mild encephalitis/encephalopathy with a reversible splenial lesion (MERS). Brain Dev. 2011. doi:10.1016/j.braindev.2011.04.004</note>
<part><date>2011</date>
</part>
<relatedItem type="host"><titleInfo><title>Brain Dev.</title>
</titleInfo>
<part><date>2011</date>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit10"><titleInfo><title>Cytokine storm in avian influenza</title>
</titleInfo>
<name type="personal"><namePart type="given">D</namePart>
<namePart type="family">Us</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Us D. Cytokine storm in avian influenza. Mikrobiyol. Bul. 2008; 42: 365–80.</note>
<part><date>2008</date>
<detail type="volume"><caption>vol.</caption>
<number>42</number>
</detail>
<extent unit="pages"><start>365</start>
<end>80</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Mikrobiyol. Bul.</title>
</titleInfo>
<part><date>2008</date>
<detail type="volume"><caption>vol.</caption>
<number>42</number>
</detail>
<extent unit="pages"><start>365</start>
<end>80</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit11"><titleInfo><title>Induction of proinflammatory cytokines in human macrophages by influenza A(H5N1) viruses: A mechanism for the unusual severity of human disease?</title>
</titleInfo>
<name type="personal"><namePart type="given">CY</namePart>
<namePart type="family">Cheung</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">LL</namePart>
<namePart type="family">Poon</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">AS</namePart>
<namePart type="family">Lau</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Cheung CY, Poon LL, Lau AS et al. Induction of proinflammatory cytokines in human macrophages by influenza A(H5N1) viruses: A mechanism for the unusual severity of human disease? Lancet 2002; 360: 1831–7.</note>
<part><date>2002</date>
<detail type="volume"><caption>vol.</caption>
<number>360</number>
</detail>
<extent unit="pages"><start>1831</start>
<end>7</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Lancet</title>
</titleInfo>
<part><date>2002</date>
<detail type="volume"><caption>vol.</caption>
<number>360</number>
</detail>
<extent unit="pages"><start>1831</start>
<end>7</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit12"><titleInfo><title>[Chemokines as mediators for intracellular communication in the brain.]</title>
</titleInfo>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Minami</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Satoh</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Minami M, Satoh M. [Chemokines as mediators for intracellular communication in the brain.] Nihon Yakurigaku Zasshi 2000; 115: 193–200 (in Japanese).</note>
<part><date>2000</date>
<detail type="volume"><caption>vol.</caption>
<number>115</number>
</detail>
<extent unit="pages"><start>193</start>
<end>200</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>Nihon Yakurigaku Zasshi</title>
</titleInfo>
<part><date>2000</date>
<detail type="volume"><caption>vol.</caption>
<number>115</number>
</detail>
<extent unit="pages"><start>193</start>
<end>200</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit13"><titleInfo><title>Murine astrocytes express a functional chemokine receptor</title>
</titleInfo>
<name type="personal"><namePart type="given">S</namePart>
<namePart type="family">Tanabe</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Heesen</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">MA</namePart>
<namePart type="family">Berman</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Tanabe S, Heesen M, Berman MA et al. Murine astrocytes express a functional chemokine receptor. J. Neurosci. 1997; 17: 6522–8.</note>
<part><date>1997</date>
<detail type="volume"><caption>vol.</caption>
<number>17</number>
</detail>
<extent unit="pages"><start>6522</start>
<end>8</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J. Neurosci.</title>
</titleInfo>
<part><date>1997</date>
<detail type="volume"><caption>vol.</caption>
<number>17</number>
</detail>
<extent unit="pages"><start>6522</start>
<end>8</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<relatedItem type="references" displayLabel="cit14"><titleInfo><title>Functional expression of the CXC‐chemokine receptor‐4/fusin on mouse microglial cells and astrocytes</title>
</titleInfo>
<name type="personal"><namePart type="given">S</namePart>
<namePart type="family">Tanabe</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">M</namePart>
<namePart type="family">Heesen</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">I</namePart>
<namePart type="family">Yoshizawa</namePart>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<genre>journal-article</genre>
<note type="citation/reference">Tanabe S, Heesen M, Yoshizawa I et al. Functional expression of the CXC‐chemokine receptor‐4/fusin on mouse microglial cells and astrocytes. J. Immunol. 1997; 159: 905–11.</note>
<part><date>1997</date>
<detail type="volume"><caption>vol.</caption>
<number>159</number>
</detail>
<extent unit="pages"><start>905</start>
<end>11</end>
</extent>
</part>
<relatedItem type="host"><titleInfo><title>J. Immunol.</title>
</titleInfo>
<part><date>1997</date>
<detail type="volume"><caption>vol.</caption>
<number>159</number>
</detail>
<extent unit="pages"><start>905</start>
<end>11</end>
</extent>
</part>
</relatedItem>
</relatedItem>
<identifier type="istex">62076921C50133203DD99C9C78AED4C9EC06B590</identifier>
<identifier type="ark">ark:/67375/WNG-SS6VDV5V-1</identifier>
<identifier type="DOI">10.1111/j.1442-200X.2011.03483.x</identifier>
<identifier type="ArticleID">PED3483</identifier>
<accessCondition type="use and reproduction" contentType="copyright">© 2012 The Authors. Pediatrics International © 2012 Japan Pediatric Society</accessCondition>
<recordInfo><recordContentSource authority="ISTEX" authorityURI="https://loaded-corpus.data.istex.fr" valueURI="https://loaded-corpus.data.istex.fr/ark:/67375/XBH-L0C46X92-X">wiley</recordContentSource>
<recordOrigin>Converted from (version ) to MODS version 3.6.</recordOrigin>
<recordCreationDate encoding="w3cdtf">2019-11-16</recordCreationDate>
</recordInfo>
</mods>
<json:item><extension>json</extension>
<original>false</original>
<mimetype>application/json</mimetype>
<uri>https://api.istex.fr/ark:/67375/WNG-SS6VDV5V-1/record.json</uri>
</json:item>
</metadata>
<serie></serie>
</istex>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/MersV1/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000026 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 000026 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= MersV1 |flux= Istex |étape= Corpus |type= RBID |clé= ISTEX:62076921C50133203DD99C9C78AED4C9EC06B590 |texte= High production of interleukin‐10 and interferon‐γ in influenza‐associated MERS in the early phase }}
![]() | This area was generated with Dilib version V0.6.33. | ![]() |