High production of interleukin‐10 and interferon‐γ in influenza‐associated MERS in the early phase
Identifieur interne : 000026 ( Istex/Corpus ); précédent : 000025; suivant : 000027High production of interleukin‐10 and interferon‐γ in influenza‐associated MERS in the early phase
Auteurs : Shinichiro Morichi ; Hisashi Kawashima ; Hiroaki Ioi ; Gaku Yamanaka ; Yasuyo Kashiwagi ; Akinori HoshikaSource :
- Pediatrics International [ 1328-8067 ] ; 2012-08.
Abstract
Mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) occurs in various diseases and pathologies, and the clinical symptoms are not consistent with the impaired region. The mechanism of the region specificity is unclear. We investigated the cytokine profiling in cerebrospinal fluid (CSF) and serum obtained from a child with MERS during influenza infection, and compared them with those of serious another serious type of influenza‐associated encephalopathy. There was no elevation of Interleukin (IL)‐1β, which induces convulsion. The inhibitory cytokines of IL‐10 and IFN‐γ were elevated in the early phase in CSF. Comparing them with other patients, the elevation of the cytokine levels were generally mild. Considering that the prognosis of this MERS case was favorable and high levels of inhibitory cytokines including IL‐10 and IFN‐γ might work to localize the lesion and to prevent sequelae.
Url:
DOI: 10.1111/j.1442-200X.2011.03483.x
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ISTEX:62076921C50133203DD99C9C78AED4C9EC06B590Le document en format XML
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The mechanism of the region specificity is unclear. We investigated the cytokine profiling in cerebrospinal fluid (CSF) and serum obtained from a child with MERS during influenza infection, and compared them with those of serious another serious type of influenza‐associated encephalopathy. There was no elevation of Interleukin (IL)‐1β, which induces convulsion. The inhibitory cytokines of IL‐10 and IFN‐γ were elevated in the early phase in CSF. Comparing them with other patients, the elevation of the cytokine levels were generally mild. Considering that the prognosis of this MERS case was favorable and high levels of inhibitory cytokines including IL‐10 and IFN‐γ might work to localize the lesion and to prevent sequelae.</div></front></TEI><istex><corpusName>wiley</corpusName><keywords><teeft><json:string>mers</json:string><json:string>cytokine</json:string><json:string>splenial</json:string><json:string>encephalopathy</json:string><json:string>mers patient</json:string><json:string>sequela</json:string><json:string>convulsion</json:string><json:string>early phase</json:string><json:string>reversible splenial lesion</json:string><json:string>cytokine level</json:string><json:string>pediatrics</json:string><json:string>callosum</json:string><json:string>inflammatory cytokine</json:string><json:string>corpus callosum</json:string><json:string>pediatric</json:string><json:string>transient splenial lesion</json:string><json:string>interleukin</json:string><json:string>lesion</json:string><json:string>splenial lesion</json:string><json:string>inhibitory cytokine</json:string><json:string>cytokine profile</json:string><json:string>author pediatrics international</json:string><json:string>other encephalopathy</json:string><json:string>inflammatory</json:string><json:string>prognosis</json:string><json:string>case report</json:string><json:string>generalized clonic convulsion</json:string><json:string>white matter</json:string><json:string>other patient</json:string><json:string>high level</json:string><json:string>control patient</json:string><json:string>cerebrospinal fluid</json:string><json:string>control group</json:string><json:string>tumor necrosis factor</json:string><json:string>region specificity</json:string><json:string>similar level</json:string><json:string>clinical course</json:string><json:string>cytokine expression</json:string><json:string>vascular endothelial disorder</json:string><json:string>clinical symptom</json:string><json:string>viral infection</json:string><json:string>several cytokine</json:string></teeft></keywords><author><json:item><name>Shinichiro Morichi</name><affiliations><json:string>Department of Pediatrics, Tokyo Medical University, Tokyo, Japan</json:string><json:string>E-mail: shinichiro‐m@hotmail.co.jp</json:string></affiliations></json:item><json:item><name>Hisashi Kawashima</name><affiliations><json:string>Department of Pediatrics, Tokyo Medical University, Tokyo, Japan</json:string></affiliations></json:item><json:item><name>Hiroaki Ioi</name><affiliations><json:string>Department of Pediatrics, Tokyo Medical University, Tokyo, Japan</json:string></affiliations></json:item><json:item><name>Gaku Yamanaka</name><affiliations><json:string>Department of Pediatrics, Tokyo Medical University, Tokyo, Japan</json:string></affiliations></json:item><json:item><name>Yasuyo Kashiwagi</name><affiliations><json:string>Department of Pediatrics, Tokyo Medical University, Tokyo, Japan</json:string></affiliations></json:item><json:item><name>Akinori Hoshika</name><affiliations><json:string>Department of Pediatrics, Tokyo Medical University, Tokyo, Japan</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>influenza‐associated encephalopathy (IAE)</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>interferon‐γ</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>interleukin‐10</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>MERS</value></json:item></subject><articleId><json:string>PED3483</json:string></articleId><arkIstex>ark:/67375/WNG-SS6VDV5V-1</arkIstex><language><json:string>eng</json:string></language><originalGenre><json:string>caseStudy</json:string></originalGenre><abstract>Mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) occurs in various diseases and pathologies, and the clinical symptoms are not consistent with the impaired region. 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Pediatrics International © 2012 Japan Pediatric Society</copyright><eventGroup><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:3.1.6 mode:FullText" date="2012-07-26"></event><event type="firstOnline" date="2012-07-26"></event><event type="publishedOnlineFinalForm" date="2012-07-26"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:3.8.8" date="2014-02-06"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.3.4 mode:FullText" date="2015-02-25"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="536">536</numbering><numbering type="pageLast" number="538">538</numbering></numberingGroup><correspondenceTo>Shinichiro Morichi, MD, Department of Pediatrics, Tokyo Medical University 6‐7‐1 Nishishinjuku, Shinjuku‐ku, Tokyo 160‐0023, Japan. Email: <email normalForm="shinichiro-m@hotmail.co.jp">shinichiro‐m@hotmail.co.jp</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:PED.PED3483.pdf"></link></linkGroup></publicationMeta><contentMeta><unparsedEditorialHistory>Received 7 April 2010; revised 26 July 2011; accepted 6 September 2011.</unparsedEditorialHistory><countGroup><count type="figureTotal" number="2"></count><count type="tableTotal" number="1"></count><count type="formulaTotal" number="0"></count><count type="referenceTotal" number="14"></count><count type="wordTotal" number="1316"></count><count type="linksPubMed" number="0"></count><count type="linksCrossRef" number="0"></count></countGroup><titleGroup><title type="main">High production of interleukin‐10 and interferon‐γ in influenza‐associated MERS in the early phase</title><title type="shortAuthors">S Morichi <i>et al</i>.</title><title type="short">Cytokine profiling of influenza‐associated MERS in the early phase</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1" corresponding="yes"><personName><givenNames>Shinichiro</givenNames><familyName>Morichi</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a1"><personName><givenNames>Hisashi</givenNames><familyName>Kawashima</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a1"><personName><givenNames>Hiroaki</givenNames><familyName>Ioi</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a1"><personName><givenNames>Gaku</givenNames><familyName>Yamanaka</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a1"><personName><givenNames>Yasuyo</givenNames><familyName>Kashiwagi</familyName></personName></creator><creator creatorRole="author" xml:id="cr6" affiliationRef="#a1"><personName><givenNames>Akinori</givenNames><familyName>Hoshika</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="JP"><unparsedAffiliation>Department of Pediatrics, Tokyo Medical University, Tokyo, Japan</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">influenza‐associated encephalopathy (IAE)</keyword><keyword xml:id="k2">interferon‐γ</keyword><keyword xml:id="k3">interleukin‐10</keyword><keyword xml:id="k4">MERS</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><title type="main">Abstract</title><p>Mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) occurs in various diseases and pathologies, and the clinical symptoms are not consistent with the impaired region. The mechanism of the region specificity is unclear. We investigated the cytokine profiling in cerebrospinal fluid (CSF) and serum obtained from a child with MERS during influenza infection, and compared them with those of serious another serious type of influenza‐associated encephalopathy. There was no elevation of Interleukin (IL)‐1β, which induces convulsion. The inhibitory cytokines of IL‐10 and IFN‐γ were elevated in the early phase in CSF. Comparing them with other patients, the elevation of the cytokine levels were generally mild. Considering that the prognosis of this MERS case was favorable and high levels of inhibitory cytokines including IL‐10 and IFN‐γ might work to localize the lesion and to prevent sequelae.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>High production of interleukin‐10 and interferon‐γ in influenza‐associated MERS in the early phase</title></titleInfo><titleInfo type="abbreviated" lang="en"><title>Cytokine profiling of influenza‐associated MERS in the early phase</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>High production of interleukin‐10 and interferon‐γ in influenza‐associated MERS in the early phase</title></titleInfo><name type="personal"><namePart type="given">Shinichiro</namePart><namePart type="family">Morichi</namePart><affiliation>Department of Pediatrics, Tokyo Medical University, Tokyo, Japan</affiliation><affiliation>E-mail: shinichiro‐m@hotmail.co.jp</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hisashi</namePart><namePart type="family">Kawashima</namePart><affiliation>Department of Pediatrics, Tokyo Medical University, Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Hiroaki</namePart><namePart type="family">Ioi</namePart><affiliation>Department of Pediatrics, Tokyo Medical University, Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Gaku</namePart><namePart type="family">Yamanaka</namePart><affiliation>Department of Pediatrics, Tokyo Medical University, Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Yasuyo</namePart><namePart type="family">Kashiwagi</namePart><affiliation>Department of Pediatrics, Tokyo Medical University, Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Akinori</namePart><namePart type="family">Hoshika</namePart><affiliation>Department of Pediatrics, Tokyo Medical University, Tokyo, Japan</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="case-report" displayLabel="caseStudy" authority="ISTEX" authorityURI="https://content-type.data.istex.fr" valueURI="https://content-type.data.istex.fr/ark:/67375/XTP-29919SZJ-6">case-report</genre><originInfo><publisher>Blackwell Publishing Asia</publisher><place><placeTerm type="text">Melbourne, Australia</placeTerm></place><dateIssued encoding="w3cdtf">2012-08</dateIssued><edition>Received 7 April 2010; revised 26 July 2011; accepted 6 September 2011.</edition><copyrightDate encoding="w3cdtf">2012</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><extent unit="figures">2</extent><extent unit="tables">1</extent><extent unit="formulas">0</extent><extent unit="references">14</extent><extent unit="linksCrossRef">0</extent><extent unit="words">1316</extent></physicalDescription><abstract lang="en">Mild encephalitis/encephalopathy with a reversible splenial lesion (MERS) occurs in various diseases and pathologies, and the clinical symptoms are not consistent with the impaired region. The mechanism of the region specificity is unclear. We investigated the cytokine profiling in cerebrospinal fluid (CSF) and serum obtained from a child with MERS during influenza infection, and compared them with those of serious another serious type of influenza‐associated encephalopathy. There was no elevation of Interleukin (IL)‐1β, which induces convulsion. The inhibitory cytokines of IL‐10 and IFN‐γ were elevated in the early phase in CSF. Comparing them with other patients, the elevation of the cytokine levels were generally mild. Considering that the prognosis of this MERS case was favorable and high levels of inhibitory cytokines including IL‐10 and IFN‐γ might work to localize the lesion and to prevent sequelae.</abstract><subject lang="en"><genre>keywords</genre><topic>influenza‐associated encephalopathy (IAE)</topic><topic>interferon‐γ</topic><topic>interleukin‐10</topic><topic>MERS</topic></subject><relatedItem type="host"><titleInfo><title>Pediatrics International</title></titleInfo><genre type="journal" authority="ISTEX" authorityURI="https://publication-type.data.istex.fr" valueURI="https://publication-type.data.istex.fr/ark:/67375/JMC-0GLKJH51-B">journal</genre><identifier type="ISSN">1328-8067</identifier><identifier type="eISSN">1442-200X</identifier><identifier type="DOI">10.1111/(ISSN)1442-200X</identifier><identifier type="PublisherID">PED</identifier><part><date>2012</date><detail type="volume"><caption>vol.</caption><number>54</number></detail><detail type="issue"><caption>no.</caption><number>4</number></detail><extent unit="pages"><start>536</start><end>538</end><total>3</total></extent></part></relatedItem><relatedItem type="references" displayLabel="cit1"><titleInfo><title>Acute encephalopathy associated with influenza and other viral infections</title></titleInfo><name type="personal"><namePart type="given">M</namePart><namePart type="family">Mizuguchi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">H</namePart><namePart type="family">Yamanouchi</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">T</namePart><namePart type="family">Ichiyama</namePart><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">M</namePart><namePart type="family">Shiomi</namePart><role><roleTerm type="text">author</roleTerm></role></name><genre>journal-article</genre><note type="citation/reference">Mizuguchi M, Yamanouchi H, Ichiyama T, Shiomi M. 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