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The effects of silica on lymph nodes and vessels—a possible mechanism in the pathogenesis of non-filarial endemic elephantiasis

Identifieur interne : 00EE18 ( Main/Exploration ); précédent : 00EE17; suivant : 00EE19

The effects of silica on lymph nodes and vessels—a possible mechanism in the pathogenesis of non-filarial endemic elephantiasis

Auteurs : N. C. M. Fyfe [Royaume-Uni] ; E. W. Price [Royaume-Uni]

Source :

Transactions of The Royal Society of Tropical Medicine and Hygiene [ 0035-9203 ] ; 1985.

RBID : ISTEX:AF7004CF468F3B109BC6912EBF2A584A0DB79265

Descripteurs français

KwdFr :
- Animaux, Facteurs temps, Femelle, Lapins, Lymphoedème (), Lymphographie, Macrophages (anatomopathologie), Mâle, Noeuds lymphatiques (), Noeuds lymphatiques (anatomopathologie), Silice (effets indésirables), Système lymphatique (), Système lymphatique (anatomopathologie), Éléphantiasis (), Éléphantiasis (anatomopathologie).
MESH :
- anatomopathologie : Macrophages, Noeuds lymphatiques, Système lymphatique, Éléphantiasis.
- effets indésirables : Silice.
- Animaux, Facteurs temps, Femelle, Lapins, Lymphoedème, Lymphographie, Mâle, Noeuds lymphatiques, Système lymphatique, Éléphantiasis.

English descriptors

KwdEn :
- Animals, Elephantiasis (chemically induced), Elephantiasis (pathology), Female, Lymph Nodes (drug effects), Lymph Nodes (pathology), Lymphatic System (drug effects), Lymphatic System (pathology), Lymphedema (chemically induced), Lymphography, Macrophages (pathology), Male, Rabbits, Silicon Dioxide (adverse effects), Time Factors.
MESH :
- chemical , adverse effects : Silicon Dioxide.
- chemically induced : Elephantiasis, Lymphedema.
- drug effects : Lymph Nodes, Lymphatic System.
- pathology : Elephantiasis, Lymph Nodes, Lymphatic System, Macrophages.
- Animals, Female, Lymphography, Male, Rabbits, Time Factors.

Abstract

Non-filarial tropical elephantiasis, which occurs in certain volcanic areas of the world, has been postulated to be an obstructive lymphopathy due to the fibrogenic effects of silica absorbed through the plantar skin of bare-footed people. Animal experiments involving the direct intralymphatic injection of fine silica particles have been carried out in order to assess the extent to which this substance can engender lymphatic obstruction and to determine its main site of action. Intralymphatic silica provoked an immediate and intense macrophage reaction with later fibrosis both within lymph vessels and to a lesser extent within lymph nodes. Lymphography indicated that the consequent obstruction resulted more from the effects of silica on vessels than on nodes.

Url:

DOI: 10.1016/0035-9203(85)90180-4

Affiliations:

Royaume-Uni

Le document en format XML

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<term>Lymph Nodes (pathology)</term>
<term>Lymphatic System (drug effects)</term>
<term>Lymphatic System (pathology)</term>
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<front><div type="abstract">Non-filarial tropical elephantiasis, which occurs in certain volcanic areas of the world, has been postulated to be an obstructive lymphopathy due to the fibrogenic effects of silica absorbed through the plantar skin of bare-footed people. Animal experiments involving the direct intralymphatic injection of fine silica particles have been carried out in order to assess the extent to which this substance can engender lymphatic obstruction and to determine its main site of action. Intralymphatic silica provoked an immediate and intense macrophage reaction with later fibrosis both within lymph vessels and to a lesser extent within lymph nodes. Lymphography indicated that the consequent obstruction resulted more from the effects of silica on vessels than on nodes.</div>
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The effects of silica on lymph nodes and vessels—a possible mechanism in the pathogenesis of non-filarial endemic elephantiasis

The effects of silica on lymph nodes and vessels—a possible mechanism in the pathogenesis of non-filarial endemic elephantiasis

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

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Pour manipuler ce document sous Unix (Dilib)

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