The effects of silica on lymph nodes and vessels—a possible mechanism in the pathogenesis of non-filarial endemic elephantiasis
Identifieur interne : 006930 ( Istex/Curation ); précédent : 006929; suivant : 006931The effects of silica on lymph nodes and vessels—a possible mechanism in the pathogenesis of non-filarial endemic elephantiasis
Auteurs : N. C. M. Fyfe [Royaume-Uni] ; E. W. Price [Royaume-Uni]Source :
- Transactions of the Royal Society of Tropical Medicine and Hygiene [ 0035-9203 ] ; 1985.
Abstract
Non-filarial tropical elephantiasis, which occurs in certain volcanic areas of the world, has been postulated to be an obstructive lymphopathy due to the fibrogenic effects of silica absorbed through the plantar skin of bare-footed people. Animal experiments involving the direct intralymphatic injection of fine silica particles have been carried out in order to assess the extent to which this substance can engender lymphatic obstruction and to determine its main site of action. Intralymphatic silica provoked an immediate and intense macrophage reaction with later fibrosis both within lymph vessels and to a lesser extent within lymph nodes. Lymphography indicated that the consequent obstruction resulted more from the effects of silica on vessels than on nodes.
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DOI: 10.1016/0035-9203(85)90180-4
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Fyfe</name><affiliation wicri:level="1"><mods:affiliation>Department of Surgery, St. Thomas' Hospital Medical School, London U.K.</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Surgery, St. Thomas' Hospital Medical School</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>London School of Tropical Medicine and Hygiene, Keppel St., London WC1E 7HT U.K.</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>London School of Tropical Medicine and Hygiene, Keppel St.</wicri:regionArea></affiliation></author><author><name sortKey="Price, E W" sort="Price, E W" uniqKey="Price E" first="E. W." last="Price">E. W. 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C. M." last="Fyfe">N. C. M. Fyfe</name><affiliation wicri:level="1"><mods:affiliation>Department of Surgery, St. Thomas' Hospital Medical School, London U.K.</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Surgery, St. Thomas' Hospital Medical School</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>London School of Tropical Medicine and Hygiene, Keppel St., London WC1E 7HT U.K.</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>London School of Tropical Medicine and Hygiene, Keppel St.</wicri:regionArea></affiliation></author><author><name sortKey="Price, E W" sort="Price, E W" uniqKey="Price E" first="E. W." last="Price">E. W. Price</name><affiliation wicri:level="1"><mods:affiliation>Department of Surgery, St. Thomas' Hospital Medical School, London U.K.</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>Department of Surgery, St. Thomas' Hospital Medical School</wicri:regionArea></affiliation><affiliation wicri:level="1"><mods:affiliation>London School of Tropical Medicine and Hygiene, Keppel St., London WC1E 7HT U.K.</mods:affiliation><country xml:lang="fr">Royaume-Uni</country><wicri:regionArea>London School of Tropical Medicine and Hygiene, Keppel St.</wicri:regionArea></affiliation></author></analytic><monogr></monogr><series><title level="j">Transactions of the Royal Society of Tropical Medicine and Hygiene</title><title level="j" type="abbrev">TRSTMH</title><idno type="ISSN">0035-9203</idno><imprint><publisher>ELSEVIER</publisher><date type="published" when="1985">1985</date><biblScope unit="volume">79</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="645">645</biblScope><biblScope unit="page" to="651">651</biblScope></imprint><idno type="ISSN">0035-9203</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0035-9203</idno></seriesStmt></fileDesc><profileDesc><textClass></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Non-filarial tropical elephantiasis, which occurs in certain volcanic areas of the world, has been postulated to be an obstructive lymphopathy due to the fibrogenic effects of silica absorbed through the plantar skin of bare-footed people. Animal experiments involving the direct intralymphatic injection of fine silica particles have been carried out in order to assess the extent to which this substance can engender lymphatic obstruction and to determine its main site of action. Intralymphatic silica provoked an immediate and intense macrophage reaction with later fibrosis both within lymph vessels and to a lesser extent within lymph nodes. Lymphography indicated that the consequent obstruction resulted more from the effects of silica on vessels than on nodes.</div></front></TEI></record>Pour manipuler ce document sous Unix (Dilib)
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