The effects of silica on lymph nodes and vessels—a possible mechanism in the pathogenesis of non-filarial endemic elephantiasis
Identifieur interne : 005232 ( Istex/Corpus ); précédent : 005231; suivant : 005233The effects of silica on lymph nodes and vessels—a possible mechanism in the pathogenesis of non-filarial endemic elephantiasis
Auteurs : N. C. M. Fyfe ; E. W. PriceSource :
- Transactions of The Royal Society of Tropical Medicine and Hygiene [ 0035-9203 ] ; 1985.
Abstract
Non-filarial tropical elephantiasis, which occurs in certain volcanic areas of the world, has been postulated to be an obstructive lymphopathy due to the fibrogenic effects of silica absorbed through the plantar skin of bare-footed people. Animal experiments involving the direct intralymphatic injection of fine silica particles have been carried out in order to assess the extent to which this substance can engender lymphatic obstruction and to determine its main site of action. Intralymphatic silica provoked an immediate and intense macrophage reaction with later fibrosis both within lymph vessels and to a lesser extent within lymph nodes. Lymphography indicated that the consequent obstruction resulted more from the effects of silica on vessels than on nodes.
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DOI: 10.1016/0035-9203(85)90180-4
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<front><div type="abstract">Non-filarial tropical elephantiasis, which occurs in certain volcanic areas of the world, has been postulated to be an obstructive lymphopathy due to the fibrogenic effects of silica absorbed through the plantar skin of bare-footed people. Animal experiments involving the direct intralymphatic injection of fine silica particles have been carried out in order to assess the extent to which this substance can engender lymphatic obstruction and to determine its main site of action. Intralymphatic silica provoked an immediate and intense macrophage reaction with later fibrosis both within lymph vessels and to a lesser extent within lymph nodes. Lymphography indicated that the consequent obstruction resulted more from the effects of silica on vessels than on nodes.</div>
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Department of Surgery, St. Thomas' Hospital Medical School, London U.K.</aff>
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<p>Non-filarial tropical elephantiasis, which occurs in certain volcanic areas of the world, has been postulated to be an obstructive lymphopathy due to the fibrogenic effects of silica absorbed through the plantar skin of bare-footed people. Animal experiments involving the direct intralymphatic injection of fine silica particles have been carried out in order to assess the extent to which this substance can engender lymphatic obstruction and to determine its main site of action. Intralymphatic silica provoked an immediate and intense macrophage reaction with later fibrosis both within lymph vessels and to a lesser extent within lymph nodes. Lymphography indicated that the consequent obstruction resulted more from the effects of silica on vessels than on nodes.</p>
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<label>Tjernberg, 1962</label>
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<person-group person-group-type="author">
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<given-names>B.</given-names>
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</person-group>
<article-title>Lymphography, An animal study on the diagnosis of VX2 carcinoma and inflammation</article-title>
<source><italic>Acta Radiologica, Stockholm</italic>
, Suppl.</source>
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</nlm-citation>
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<year>1970</year>
<publisher-loc>London and New York</publisher-loc>
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</nlm-citation>
</ref>
</ref-list>
</back>
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<mods version="3.6"><titleInfo><title>The effects of silica on lymph nodes and vessels—a possible mechanism in the pathogenesis of non-filarial endemic elephantiasis</title>
</titleInfo>
<titleInfo type="alternative" contentType="CDATA"><title>The effects of silica on lymph nodes and vessels—a possible mechanism in the pathogenesis of non-filarial endemic elephantiasis</title>
</titleInfo>
<name type="personal"><namePart type="given">N.C.M.</namePart>
<namePart type="family">Fyfe</namePart>
<affiliation>Department of Surgery, St. Thomas' Hospital Medical School, London U.K.</affiliation>
<affiliation>London School of Tropical Medicine and Hygiene, Keppel St., London WC1E 7HT U.K.</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<name type="personal"><namePart type="given">E.W.</namePart>
<namePart type="family">Price</namePart>
<affiliation>Department of Surgery, St. Thomas' Hospital Medical School, London U.K.</affiliation>
<affiliation>London School of Tropical Medicine and Hygiene, Keppel St., London WC1E 7HT U.K.</affiliation>
<role><roleTerm type="text">author</roleTerm>
</role>
</name>
<typeOfResource>text</typeOfResource>
<genre type="research-article" displayLabel="research-article"></genre>
<originInfo><publisher>Royal Society of Tropical Medicine and Hygiene</publisher>
<dateIssued encoding="w3cdtf">1985</dateIssued>
<copyrightDate encoding="w3cdtf">1985</copyrightDate>
</originInfo>
<physicalDescription><internetMediaType>text/html</internetMediaType>
</physicalDescription>
<abstract>Non-filarial tropical elephantiasis, which occurs in certain volcanic areas of the world, has been postulated to be an obstructive lymphopathy due to the fibrogenic effects of silica absorbed through the plantar skin of bare-footed people. Animal experiments involving the direct intralymphatic injection of fine silica particles have been carried out in order to assess the extent to which this substance can engender lymphatic obstruction and to determine its main site of action. Intralymphatic silica provoked an immediate and intense macrophage reaction with later fibrosis both within lymph vessels and to a lesser extent within lymph nodes. Lymphography indicated that the consequent obstruction resulted more from the effects of silica on vessels than on nodes.</abstract>
<relatedItem type="host"><titleInfo><title>Transactions of The Royal Society of Tropical Medicine and Hygiene</title>
</titleInfo>
<titleInfo type="abbreviated"><title>Trans R Soc Trop Med Hyg</title>
</titleInfo>
<genre type="journal">journal</genre>
<identifier type="ISSN">0035-9203</identifier>
<identifier type="eISSN">1878-3503</identifier>
<identifier type="PublisherID">trstmh</identifier>
<identifier type="PublisherID-hwp">trstmh</identifier>
<part><date>1985</date>
<detail type="volume"><caption>vol.</caption>
<number>79</number>
</detail>
<detail type="issue"><caption>no.</caption>
<number>5</number>
</detail>
<extent unit="pages"><start>645</start>
<end>651</end>
</extent>
</part>
</relatedItem>
<identifier type="istex">AF7004CF468F3B109BC6912EBF2A584A0DB79265</identifier>
<identifier type="DOI">10.1016/0035-9203(85)90180-4</identifier>
<recordInfo><recordContentSource>OUP</recordContentSource>
</recordInfo>
</mods>
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