Podoconiosis: non-infectious geochemical elephantiasis
Identifieur interne : 007377 ( Main/Curation ); précédent : 007376; suivant : 007378Podoconiosis: non-infectious geochemical elephantiasis
Auteurs : Gail Davey [Éthiopie] ; Fasil Tekola [Éthiopie] ; Melanie J. Newport [Royaume-Uni]Source :
- Transactions of The Royal Society of Tropical Medicine and Hygiene [ 0035-9203 ] ; 2007-12.
Descripteurs français
- KwdFr :
- MESH :
- anatomopathologie : Éléphantiasis.
- diagnostic : Éléphantiasis.
- Diagnostic différentiel, Femelle, Humains, Mâle, Santé en zone rurale, Sol, Éléphantiasis.
- Pascal (Inist)
- Wicri :
- topic : Homme.
English descriptors
- KwdEn :
- MESH :
- chemical : Soil.
- diagnosis : Elephantiasis.
- pathology : Elephantiasis.
- prevention & control : Elephantiasis.
- Diagnosis, Differential, Female, Humans, Male, Rural Health.
Abstract
This article reviews peer-reviewed publications and book chapters on the history, epidemiology, genetics, ecology, pathogenesis, pathology and management of podoconiosis (endemic non-filarial elephantiasis). Podoconiosis is a non-infectious geochemical elephantiasis caused by exposure of bare feet to irritant alkalic clay soils. It is found in at least 10 countries in tropical Africa, Central America and northwest India, where such soils coexist with high altitude, high seasonal rainfall and low income. Podoconiosis develops in men and women working barefoot on irritant soils, with signs becoming apparent in most patients by the third decade of life. Colloid-sized silicate particles appear to enter through the skin, are taken up into macrophages in the lower limb lymphatics and cause endolymphangitis and obliteration of the lymphatic lumen. Genetic studies provide evidence for high heritability of susceptibility to podoconiosis. The economic burden is significant in affected areas dependent on subsistence farming. Podoconiosis is unique in being an entirely preventable non-communicable disease. Primary prevention entails promoting use of footwear in areas of irritant soil; early stages are reversible given good foot hygiene, but late stages result in considerable economic and social difficulties, and require extended periods of elevation and occasionally nodulectomy.
Url:
DOI: 10.1016/j.trstmh.2007.08.013
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<front><div type="abstract">This article reviews peer-reviewed publications and book chapters on the history, epidemiology, genetics, ecology, pathogenesis, pathology and management of podoconiosis (endemic non-filarial elephantiasis). Podoconiosis is a non-infectious geochemical elephantiasis caused by exposure of bare feet to irritant alkalic clay soils. It is found in at least 10 countries in tropical Africa, Central America and northwest India, where such soils coexist with high altitude, high seasonal rainfall and low income. Podoconiosis develops in men and women working barefoot on irritant soils, with signs becoming apparent in most patients by the third decade of life. Colloid-sized silicate particles appear to enter through the skin, are taken up into macrophages in the lower limb lymphatics and cause endolymphangitis and obliteration of the lymphatic lumen. Genetic studies provide evidence for high heritability of susceptibility to podoconiosis. The economic burden is significant in affected areas dependent on subsistence farming. Podoconiosis is unique in being an entirely preventable non-communicable disease. Primary prevention entails promoting use of footwear in areas of irritant soil; early stages are reversible given good foot hygiene, but late stages result in considerable economic and social difficulties, and require extended periods of elevation and occasionally nodulectomy.</div>
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<affiliation wicri:level="1"><country xml:lang="fr">Éthiopie</country>
<wicri:regionArea>Department of Community Health, Addis Ababa University, P.O. Box 9806, Addis Ababa</wicri:regionArea>
<wicri:noRegion>Addis Ababa</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Newport, Melanie J" sort="Newport, Melanie J" uniqKey="Newport M" first="Melanie J." last="Newport">Melanie J. Newport</name>
<affiliation wicri:level="4"><country xml:lang="fr">Royaume-Uni</country>
<wicri:regionArea>Brighton and Sussex Medical School, University of Sussex, Falmer, Brighton BN1 9PS</wicri:regionArea>
<orgName type="university">Université du Sussex</orgName>
<placeName><settlement type="city">Brighton</settlement>
<settlement type="town">Falmer</settlement>
<region type="nation">Angleterre</region>
<region nuts="2" type="region">Sussex de l'Est</region>
</placeName>
</affiliation>
</author>
</analytic>
<monogr></monogr>
<series><title level="j">Transactions of The Royal Society of Tropical Medicine and Hygiene</title>
<title level="j" type="abbrev">Trans R Soc Trop Med Hyg</title>
<idno type="ISSN">0035-9203</idno>
<idno type="eISSN">1878-3503</idno>
<imprint><publisher>Royal Society of Tropical Medicine and Hygiene</publisher>
<date type="published" when="2007-12">2007-12</date>
<biblScope unit="volume">101</biblScope>
<biblScope unit="issue">12</biblScope>
<biblScope unit="page" from="1175">1175</biblScope>
<biblScope unit="page" to="1180">1180</biblScope>
</imprint>
<idno type="ISSN">0035-9203</idno>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><idno type="ISSN">0035-9203</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Diagnosis, Differential</term>
<term>Elephantiasis</term>
<term>Elephantiasis (diagnosis)</term>
<term>Elephantiasis (pathology)</term>
<term>Elephantiasis (prevention & control)</term>
<term>Female</term>
<term>Geochemical</term>
<term>Humans</term>
<term>Male</term>
<term>Non-filarial elephantiasis</term>
<term>Podoconiosis</term>
<term>Review</term>
<term>Rural Health</term>
<term>Soil</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Diagnostic différentiel</term>
<term>Femelle</term>
<term>Humains</term>
<term>Mâle</term>
<term>Santé en zone rurale</term>
<term>Sol</term>
<term>Éléphantiasis ()</term>
<term>Éléphantiasis (anatomopathologie)</term>
<term>Éléphantiasis (diagnostic)</term>
</keywords>
<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Soil</term>
</keywords>
<keywords scheme="MESH" qualifier="anatomopathologie" xml:lang="fr"><term>Éléphantiasis</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Elephantiasis</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnostic" xml:lang="fr"><term>Éléphantiasis</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Elephantiasis</term>
</keywords>
<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Elephantiasis</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Diagnosis, Differential</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Rural Health</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Diagnostic différentiel</term>
<term>Femelle</term>
<term>Humains</term>
<term>Mâle</term>
<term>Santé en zone rurale</term>
<term>Sol</term>
<term>Éléphantiasis</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract">This article reviews peer-reviewed publications and book chapters on the history, epidemiology, genetics, ecology, pathogenesis, pathology and management of podoconiosis (endemic non-filarial elephantiasis). Podoconiosis is a non-infectious geochemical elephantiasis caused by exposure of bare feet to irritant alkalic clay soils. It is found in at least 10 countries in tropical Africa, Central America and northwest India, where such soils coexist with high altitude, high seasonal rainfall and low income. Podoconiosis develops in men and women working barefoot on irritant soils, with signs becoming apparent in most patients by the third decade of life. Colloid-sized silicate particles appear to enter through the skin, are taken up into macrophages in the lower limb lymphatics and cause endolymphangitis and obliteration of the lymphatic lumen. Genetic studies provide evidence for high heritability of susceptibility to podoconiosis. The economic burden is significant in affected areas dependent on subsistence farming. Podoconiosis is unique in being an entirely preventable non-communicable disease. Primary prevention entails promoting use of footwear in areas of irritant soil; early stages are reversible given good foot hygiene, but late stages result in considerable economic and social difficulties, and require extended periods of elevation and occasionally nodulectomy.</div>
</front>
</TEI>
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