Podoconiosis: non-infectious geochemical elephantiasis.
Identifieur interne : 003487 ( PubMed/Corpus ); précédent : 003486; suivant : 003488Podoconiosis: non-infectious geochemical elephantiasis.
Auteurs : Gail Davey ; Fasil Tekola ; Melanie J. NewportSource :
- Transactions of the Royal Society of Tropical Medicine and Hygiene [ 0035-9203 ] ; 2007.
English descriptors
- KwdEn :
- MESH :
- chemical : Soil.
- diagnosis : Elephantiasis.
- pathology : Elephantiasis.
- prevention & control : Elephantiasis.
- Diagnosis, Differential, Female, Humans, Male, Rural Health.
Abstract
This article reviews peer-reviewed publications and book chapters on the history, epidemiology, genetics, ecology, pathogenesis, pathology and management of podoconiosis (endemic non-filarial elephantiasis). Podoconiosis is a non-infectious geochemical elephantiasis caused by exposure of bare feet to irritant alkalic clay soils. It is found in at least 10 countries in tropical Africa, Central America and northwest India, where such soils coexist with high altitude, high seasonal rainfall and low income. Podoconiosis develops in men and women working barefoot on irritant soils, with signs becoming apparent in most patients by the third decade of life. Colloid-sized silicate particles appear to enter through the skin, are taken up into macrophages in the lower limb lymphatics and cause endolymphangitis and obliteration of the lymphatic lumen. Genetic studies provide evidence for high heritability of susceptibility to podoconiosis. The economic burden is significant in affected areas dependent on subsistence farming. Podoconiosis is unique in being an entirely preventable non-communicable disease. Primary prevention entails promoting use of footwear in areas of irritant soil; early stages are reversible given good foot hygiene, but late stages result in considerable economic and social difficulties, and require extended periods of elevation and occasionally nodulectomy.
DOI: 10.1016/j.trstmh.2007.08.013
PubMed: 17976670
Links to Exploration step
pubmed:17976670Le document en format XML
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<author><name sortKey="Davey, Gail" sort="Davey, Gail" uniqKey="Davey G" first="Gail" last="Davey">Gail Davey</name>
<affiliation><nlm:affiliation>Department of Community Health, Addis Ababa University, P.O. Box 9806, Addis Ababa, Ethiopia. nerurkar@ethionet.et</nlm:affiliation>
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<author><name sortKey="Tekola, Fasil" sort="Tekola, Fasil" uniqKey="Tekola F" first="Fasil" last="Tekola">Fasil Tekola</name>
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<author><name sortKey="Newport, Melanie J" sort="Newport, Melanie J" uniqKey="Newport M" first="Melanie J" last="Newport">Melanie J. Newport</name>
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<author><name sortKey="Newport, Melanie J" sort="Newport, Melanie J" uniqKey="Newport M" first="Melanie J" last="Newport">Melanie J. Newport</name>
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<term>Elephantiasis (diagnosis)</term>
<term>Elephantiasis (pathology)</term>
<term>Elephantiasis (prevention & control)</term>
<term>Female</term>
<term>Humans</term>
<term>Male</term>
<term>Rural Health</term>
<term>Soil</term>
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<keywords scheme="MESH" type="chemical" xml:lang="en"><term>Soil</term>
</keywords>
<keywords scheme="MESH" qualifier="diagnosis" xml:lang="en"><term>Elephantiasis</term>
</keywords>
<keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Elephantiasis</term>
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<keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>Elephantiasis</term>
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<keywords scheme="MESH" xml:lang="en"><term>Diagnosis, Differential</term>
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<front><div type="abstract" xml:lang="en">This article reviews peer-reviewed publications and book chapters on the history, epidemiology, genetics, ecology, pathogenesis, pathology and management of podoconiosis (endemic non-filarial elephantiasis). Podoconiosis is a non-infectious geochemical elephantiasis caused by exposure of bare feet to irritant alkalic clay soils. It is found in at least 10 countries in tropical Africa, Central America and northwest India, where such soils coexist with high altitude, high seasonal rainfall and low income. Podoconiosis develops in men and women working barefoot on irritant soils, with signs becoming apparent in most patients by the third decade of life. Colloid-sized silicate particles appear to enter through the skin, are taken up into macrophages in the lower limb lymphatics and cause endolymphangitis and obliteration of the lymphatic lumen. Genetic studies provide evidence for high heritability of susceptibility to podoconiosis. The economic burden is significant in affected areas dependent on subsistence farming. Podoconiosis is unique in being an entirely preventable non-communicable disease. Primary prevention entails promoting use of footwear in areas of irritant soil; early stages are reversible given good foot hygiene, but late stages result in considerable economic and social difficulties, and require extended periods of elevation and occasionally nodulectomy.</div>
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<Title>Transactions of the Royal Society of Tropical Medicine and Hygiene</Title>
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<ArticleTitle>Podoconiosis: non-infectious geochemical elephantiasis.</ArticleTitle>
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<Abstract><AbstractText>This article reviews peer-reviewed publications and book chapters on the history, epidemiology, genetics, ecology, pathogenesis, pathology and management of podoconiosis (endemic non-filarial elephantiasis). Podoconiosis is a non-infectious geochemical elephantiasis caused by exposure of bare feet to irritant alkalic clay soils. It is found in at least 10 countries in tropical Africa, Central America and northwest India, where such soils coexist with high altitude, high seasonal rainfall and low income. Podoconiosis develops in men and women working barefoot on irritant soils, with signs becoming apparent in most patients by the third decade of life. Colloid-sized silicate particles appear to enter through the skin, are taken up into macrophages in the lower limb lymphatics and cause endolymphangitis and obliteration of the lymphatic lumen. Genetic studies provide evidence for high heritability of susceptibility to podoconiosis. The economic burden is significant in affected areas dependent on subsistence farming. Podoconiosis is unique in being an entirely preventable non-communicable disease. Primary prevention entails promoting use of footwear in areas of irritant soil; early stages are reversible given good foot hygiene, but late stages result in considerable economic and social difficulties, and require extended periods of elevation and occasionally nodulectomy.</AbstractText>
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