Podoconiosis: non-infectious geochemical elephantiasis
Identifieur interne : 005F08 ( Istex/Corpus ); précédent : 005F07; suivant : 005F09Podoconiosis: non-infectious geochemical elephantiasis
Auteurs : Gail Davey ; Fasil Tekola ; Melanie J. NewportSource :
- Transactions of The Royal Society of Tropical Medicine and Hygiene [ 0035-9203 ] ; 2007-12.
English descriptors
Abstract
This article reviews peer-reviewed publications and book chapters on the history, epidemiology, genetics, ecology, pathogenesis, pathology and management of podoconiosis (endemic non-filarial elephantiasis). Podoconiosis is a non-infectious geochemical elephantiasis caused by exposure of bare feet to irritant alkalic clay soils. It is found in at least 10 countries in tropical Africa, Central America and northwest India, where such soils coexist with high altitude, high seasonal rainfall and low income. Podoconiosis develops in men and women working barefoot on irritant soils, with signs becoming apparent in most patients by the third decade of life. Colloid-sized silicate particles appear to enter through the skin, are taken up into macrophages in the lower limb lymphatics and cause endolymphangitis and obliteration of the lymphatic lumen. Genetic studies provide evidence for high heritability of susceptibility to podoconiosis. The economic burden is significant in affected areas dependent on subsistence farming. Podoconiosis is unique in being an entirely preventable non-communicable disease. Primary prevention entails promoting use of footwear in areas of irritant soil; early stages are reversible given good foot hygiene, but late stages result in considerable economic and social difficulties, and require extended periods of elevation and occasionally nodulectomy.
Url:
DOI: 10.1016/j.trstmh.2007.08.013
Links to Exploration step
ISTEX:CAE4E5E09403AA4FA965C81B33A485D1BCFA5439Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title>Podoconiosis: non-infectious geochemical elephantiasis</title><author><name sortKey="Davey, Gail" sort="Davey, Gail" uniqKey="Davey G" first="Gail" last="Davey">Gail Davey</name><affiliation><mods:affiliation>Department of Community Health, Addis Ababa University, P.O. Box 9806, Addis Ababa, Ethiopia</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: nerurkar@ethionet.et</mods:affiliation></affiliation></author><author><name sortKey="Tekola, Fasil" sort="Tekola, Fasil" uniqKey="Tekola F" first="Fasil" last="Tekola">Fasil Tekola</name><affiliation><mods:affiliation>Department of Community Health, Addis Ababa University, P.O. Box 9806, Addis Ababa, Ethiopia</mods:affiliation></affiliation></author><author><name sortKey="Newport, Melanie J" sort="Newport, Melanie J" uniqKey="Newport M" first="Melanie J." last="Newport">Melanie J. Newport</name><affiliation><mods:affiliation>Brighton and Sussex Medical School, University of Sussex, Falmer, Brighton BN1 9PS, UK</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:CAE4E5E09403AA4FA965C81B33A485D1BCFA5439</idno><date when="2007" year="2007">2007</date><idno type="doi">10.1016/j.trstmh.2007.08.013</idno><idno type="url">https://api.istex.fr/document/CAE4E5E09403AA4FA965C81B33A485D1BCFA5439/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">005F08</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">005F08</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a">Podoconiosis: non-infectious geochemical elephantiasis</title><author><name sortKey="Davey, Gail" sort="Davey, Gail" uniqKey="Davey G" first="Gail" last="Davey">Gail Davey</name><affiliation><mods:affiliation>Department of Community Health, Addis Ababa University, P.O. Box 9806, Addis Ababa, Ethiopia</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: nerurkar@ethionet.et</mods:affiliation></affiliation></author><author><name sortKey="Tekola, Fasil" sort="Tekola, Fasil" uniqKey="Tekola F" first="Fasil" last="Tekola">Fasil Tekola</name><affiliation><mods:affiliation>Department of Community Health, Addis Ababa University, P.O. Box 9806, Addis Ababa, Ethiopia</mods:affiliation></affiliation></author><author><name sortKey="Newport, Melanie J" sort="Newport, Melanie J" uniqKey="Newport M" first="Melanie J." last="Newport">Melanie J. Newport</name><affiliation><mods:affiliation>Brighton and Sussex Medical School, University of Sussex, Falmer, Brighton BN1 9PS, UK</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Transactions of The Royal Society of Tropical Medicine and Hygiene</title><title level="j" type="abbrev">Trans R Soc Trop Med Hyg</title><idno type="ISSN">0035-9203</idno><idno type="eISSN">1878-3503</idno><imprint><publisher>Royal Society of Tropical Medicine and Hygiene</publisher><date type="published" when="2007-12">2007-12</date><biblScope unit="volume">101</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="1175">1175</biblScope><biblScope unit="page" to="1180">1180</biblScope></imprint><idno type="ISSN">0035-9203</idno></series></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0035-9203</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Elephantiasis</term><term>Geochemical</term><term>Non-filarial elephantiasis</term><term>Podoconiosis</term><term>Review</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract">This article reviews peer-reviewed publications and book chapters on the history, epidemiology, genetics, ecology, pathogenesis, pathology and management of podoconiosis (endemic non-filarial elephantiasis). Podoconiosis is a non-infectious geochemical elephantiasis caused by exposure of bare feet to irritant alkalic clay soils. It is found in at least 10 countries in tropical Africa, Central America and northwest India, where such soils coexist with high altitude, high seasonal rainfall and low income. Podoconiosis develops in men and women working barefoot on irritant soils, with signs becoming apparent in most patients by the third decade of life. Colloid-sized silicate particles appear to enter through the skin, are taken up into macrophages in the lower limb lymphatics and cause endolymphangitis and obliteration of the lymphatic lumen. Genetic studies provide evidence for high heritability of susceptibility to podoconiosis. The economic burden is significant in affected areas dependent on subsistence farming. Podoconiosis is unique in being an entirely preventable non-communicable disease. Primary prevention entails promoting use of footwear in areas of irritant soil; early stages are reversible given good foot hygiene, but late stages result in considerable economic and social difficulties, and require extended periods of elevation and occasionally nodulectomy.</div></front></TEI><istex><corpusName>oup</corpusName><author><json:item><name>Gail Davey</name><affiliations><json:string>Department of Community Health, Addis Ababa University, P.O. Box 9806, Addis Ababa, Ethiopia</json:string><json:string>E-mail: nerurkar@ethionet.et</json:string></affiliations></json:item><json:item><name>Fasil Tekola</name><affiliations><json:string>Department of Community Health, Addis Ababa University, P.O. Box 9806, Addis Ababa, Ethiopia</json:string></affiliations></json:item><json:item><name>Melanie J. Newport</name><affiliations><json:string>Brighton and Sussex Medical School, University of Sussex, Falmer, Brighton BN1 9PS, UK</json:string></affiliations></json:item></author><subject><json:item><value>Podoconiosis</value></json:item><json:item><value>Elephantiasis</value></json:item><json:item><value>Geochemical</value></json:item><json:item><value>Non-filarial elephantiasis</value></json:item><json:item><value>Review</value></json:item></subject><language><json:string>unknown</json:string></language><originalGenre><json:string>review-article</json:string></originalGenre><abstract>This article reviews peer-reviewed publications and book chapters on the history, epidemiology, genetics, ecology, pathogenesis, pathology and management of podoconiosis (endemic non-filarial elephantiasis). Podoconiosis is a non-infectious geochemical elephantiasis caused by exposure of bare feet to irritant alkalic clay soils. It is found in at least 10 countries in tropical Africa, Central America and northwest India, where such soils coexist with high altitude, high seasonal rainfall and low income. Podoconiosis develops in men and women working barefoot on irritant soils, with signs becoming apparent in most patients by the third decade of life. Colloid-sized silicate particles appear to enter through the skin, are taken up into macrophages in the lower limb lymphatics and cause endolymphangitis and obliteration of the lymphatic lumen. Genetic studies provide evidence for high heritability of susceptibility to podoconiosis. The economic burden is significant in affected areas dependent on subsistence farming. Podoconiosis is unique in being an entirely preventable non-communicable disease. Primary prevention entails promoting use of footwear in areas of irritant soil; early stages are reversible given good foot hygiene, but late stages result in considerable economic and social difficulties, and require extended periods of elevation and occasionally nodulectomy.</abstract><qualityIndicators><score>7.816</score><pdfVersion>1.4</pdfVersion><pdfPageSize>595 x 794 pts</pdfPageSize><refBibsNative>true</refBibsNative><keywordCount>5</keywordCount><abstractCharCount>1389</abstractCharCount><pdfWordCount>3500</pdfWordCount><pdfCharCount>22540</pdfCharCount><pdfPageCount>6</pdfPageCount><abstractWordCount>193</abstractWordCount></qualityIndicators><title>Podoconiosis: non-infectious geochemical elephantiasis</title><genre><json:string>review-article</json:string></genre><host><title>Transactions of The Royal Society of Tropical Medicine and Hygiene</title><language><json:string>unknown</json:string></language><issn><json:string>0035-9203</json:string></issn><eissn><json:string>1878-3503</json:string></eissn><publisherId><json:string>trstmh</json:string></publisherId><volume>101</volume><issue>12</issue><pages><first>1175</first><last>1180</last></pages><genre><json:string>journal</json:string></genre></host><categories><wos><json:string>social science</json:string><json:string>public, environmental & occupational health</json:string><json:string>science</json:string><json:string>tropical medicine</json:string></wos><scienceMetrix><json:string>health sciences</json:string><json:string>clinical medicine</json:string><json:string>tropical medicine</json:string></scienceMetrix><inist><json:string>sciences appliquees, technologies et medecines</json:string><json:string>sciences biologiques et medicales</json:string><json:string>sciences medicales</json:string></inist></categories><publicationDate>2007</publicationDate><copyrightDate>2007</copyrightDate><doi><json:string>10.1016/j.trstmh.2007.08.013</json:string></doi><id>CAE4E5E09403AA4FA965C81B33A485D1BCFA5439</id><score>1</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/CAE4E5E09403AA4FA965C81B33A485D1BCFA5439/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/CAE4E5E09403AA4FA965C81B33A485D1BCFA5439/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/CAE4E5E09403AA4FA965C81B33A485D1BCFA5439/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a">Podoconiosis: non-infectious geochemical elephantiasis</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Royal Society of Tropical Medicine and Hygiene</publisher><availability><p>OUP</p></availability><date>2007</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a">Podoconiosis: non-infectious geochemical elephantiasis</title><author xml:id="author-0000" corresp="yes"><persName><forename type="first">Gail</forename><surname>Davey</surname></persName><email>nerurkar@ethionet.et</email><affiliation>Department of Community Health, Addis Ababa University, P.O. Box 9806, Addis Ababa, Ethiopia</affiliation></author><author xml:id="author-0001"><persName><forename type="first">Fasil</forename><surname>Tekola</surname></persName><affiliation>Department of Community Health, Addis Ababa University, P.O. Box 9806, Addis Ababa, Ethiopia</affiliation></author><author xml:id="author-0002"><persName><forename type="first">Melanie J.</forename><surname>Newport</surname></persName><affiliation>Brighton and Sussex Medical School, University of Sussex, Falmer, Brighton BN1 9PS, UK</affiliation></author><idno type="istex">CAE4E5E09403AA4FA965C81B33A485D1BCFA5439</idno><idno type="DOI">10.1016/j.trstmh.2007.08.013</idno></analytic><monogr><title level="j">Transactions of The Royal Society of Tropical Medicine and Hygiene</title><title level="j" type="abbrev">Trans R Soc Trop Med Hyg</title><idno type="pISSN">0035-9203</idno><idno type="eISSN">1878-3503</idno><idno type="PublisherID">trstmh</idno><idno type="PublisherID-hwp">trstmh</idno><imprint><publisher>Royal Society of Tropical Medicine and Hygiene</publisher><date type="published" when="2007-12"></date><biblScope unit="volume">101</biblScope><biblScope unit="issue">12</biblScope><biblScope unit="page" from="1175">1175</biblScope><biblScope unit="page" to="1180">1180</biblScope></imprint></monogr></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2007</date></creation><abstract><p>This article reviews peer-reviewed publications and book chapters on the history, epidemiology, genetics, ecology, pathogenesis, pathology and management of podoconiosis (endemic non-filarial elephantiasis). Podoconiosis is a non-infectious geochemical elephantiasis caused by exposure of bare feet to irritant alkalic clay soils. It is found in at least 10 countries in tropical Africa, Central America and northwest India, where such soils coexist with high altitude, high seasonal rainfall and low income. Podoconiosis develops in men and women working barefoot on irritant soils, with signs becoming apparent in most patients by the third decade of life. Colloid-sized silicate particles appear to enter through the skin, are taken up into macrophages in the lower limb lymphatics and cause endolymphangitis and obliteration of the lymphatic lumen. Genetic studies provide evidence for high heritability of susceptibility to podoconiosis. The economic burden is significant in affected areas dependent on subsistence farming. Podoconiosis is unique in being an entirely preventable non-communicable disease. Primary prevention entails promoting use of footwear in areas of irritant soil; early stages are reversible given good foot hygiene, but late stages result in considerable economic and social difficulties, and require extended periods of elevation and occasionally nodulectomy.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>Keywords</head><item><term>Podoconiosis</term></item><item><term>Elephantiasis</term></item><item><term>Geochemical</term></item><item><term>Non-filarial elephantiasis</term></item><item><term>Review</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2007-12">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/CAE4E5E09403AA4FA965C81B33A485D1BCFA5439/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="corpus oup, element #text not found" wicri:toSee="no header"><istex:xmlDeclaration>version="1.0"</istex:xmlDeclaration><istex:docType PUBLIC="-//NLM//DTD Journal Publishing DTD v2.3 20070202//EN" URI="journalpublishing.dtd" name="istex:docType"></istex:docType><istex:document><article article-type="review-article">
<front>
<journal-meta>
<journal-id journal-id-type="hwp">trstmh</journal-id>
<journal-id journal-id-type="publisher-id">trstmh</journal-id>
<journal-title>Transactions of The Royal Society of Tropical Medicine and Hygiene</journal-title>
<abbrev-journal-title>Trans R Soc Trop Med Hyg</abbrev-journal-title>
<issn pub-type="ppub">0035-9203</issn>
<issn pub-type="epub">1878-3503</issn>
<publisher>
<publisher-name>Royal Society of Tropical Medicine and Hygiene</publisher-name>
</publisher>
</journal-meta>
<article-meta>
<article-id pub-id-type="doi">10.1016/j.trstmh.2007.08.013</article-id>
<article-categories>
<subj-group subj-group-type="heading">
<subject>Reviews</subject>
</subj-group>
</article-categories>
<title-group>
<article-title>Podoconiosis: non-infectious geochemical elephantiasis</article-title>
</title-group>
<contrib-group>
<contrib contrib-type="author" corresp="yes">
<name><surname>Davey</surname><given-names>Gail</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref><xref ref-type="corresp" rid="cor1"><sup>⁎</sup></xref>
</contrib>
<contrib contrib-type="author">
<name><surname>Tekola</surname><given-names>Fasil</given-names></name><xref ref-type="aff" rid="aff1"><sup>a</sup></xref>
</contrib>
<contrib contrib-type="author">
<name><surname>Newport</surname><given-names>Melanie J.</given-names></name><xref ref-type="aff" rid="aff2"><sup>b</sup></xref>
</contrib>
<aff id="aff1">
<label>a</label>Department of Community Health, Addis Ababa University, P.O. Box 9806, Addis Ababa, Ethiopia</aff>
<aff id="aff2">
<label>b</label>Brighton and Sussex Medical School, University of Sussex, Falmer, Brighton BN1 9PS, UK</aff>
</contrib-group>
<author-notes>
<corresp id="cor1">
<label>⁎</label>Corresponding author. Present address: P.O. Box 26905/1000, Addis Ababa, Ethiopia. Tel.: +251 911 388835; fax: +251 116 627876. <italic>E-mail address:</italic> <email>nerurkar@ethionet.et</email> (G. Davey).</corresp>
</author-notes>
<pub-date pub-type="ppub">
<month>12</month>
<year>2007</year>
</pub-date>
<volume>101</volume>
<issue>12</issue>
<fpage>1175</fpage>
<lpage>1180</lpage>
<history>
<date date-type="received">
<day>15</day>
<month>5</month>
<year>2007</year>
</date>
<date date-type="rev-recd">
<day>29</day>
<month>8</month>
<year>2007</year>
</date>
<date date-type="accepted">
<day>30</day>
<month>8</month>
<year>2007</year>
</date>
</history>
<permissions>
<copyright-year>2007</copyright-year>
<copyright-holder>Royal Society of Tropical Medicine and Hygiene</copyright-holder>
</permissions>
<abstract>
<title>Summary</title>
<p>This article reviews peer-reviewed publications and book chapters on the history, epidemiology, genetics, ecology, pathogenesis, pathology and management of podoconiosis (endemic non-filarial elephantiasis). Podoconiosis is a non-infectious geochemical elephantiasis caused by exposure of bare feet to irritant alkalic clay soils. It is found in at least 10 countries in tropical Africa, Central America and northwest India, where such soils coexist with high altitude, high seasonal rainfall and low income. Podoconiosis develops in men and women working barefoot on irritant soils, with signs becoming apparent in most patients by the third decade of life. Colloid-sized silicate particles appear to enter through the skin, are taken up into macrophages in the lower limb lymphatics and cause endolymphangitis and obliteration of the lymphatic lumen. Genetic studies provide evidence for high heritability of susceptibility to podoconiosis. The economic burden is significant in affected areas dependent on subsistence farming. Podoconiosis is unique in being an entirely preventable non-communicable disease. Primary prevention entails promoting use of footwear in areas of irritant soil; early stages are reversible given good foot hygiene, but late stages result in considerable economic and social difficulties, and require extended periods of elevation and occasionally nodulectomy.</p>
</abstract>
<kwd-group xml:lang="en">
<title>Keywords</title>
<kwd>Podoconiosis</kwd>
<kwd>Elephantiasis</kwd>
<kwd>Geochemical</kwd>
<kwd>Non-filarial elephantiasis</kwd>
<kwd>Review</kwd>
</kwd-group>
</article-meta>
</front>
<body>
<sec>
<label>1</label>
<title>Introduction</title>
<p>Podoconiosis (endemic non-filarial elephantiasis) has been recognized as a specific disease entity for over 1000 years and is widespread in tropical Africa, Central America and north India, yet it remains a neglected and under-researched condition. Manual and electronic literature review identified 19 peer-reviewed research articles with podoconiosis as their main topic published between 1970 and 1990, and only 10 since then.</p>
</sec>
<sec>
<label>2</label>
<title>History</title>
<p>From the time of the Roman Empire, travellers recorded anecdotes about people with progressive swelling of the feet. A more detailed reference to ‘swollen legs’ appears in the Tibetan translations of a fourth century revelation originally recorded in Sanskrit as the second book of rGyud-bzhi (the ‘four tantras’). However, it was not until <italic>c</italic>.905 that the Persian physician Rhazes first distinguished elephantiasis ‘of the Greeks’ (lepromatous leprosy) from that ‘of the Arabs’ (most probably non-filarial elephantiasis) (<xref ref-type="bibr" rid="bib27">Price, 1984a</xref>).</p>
<p>In the 1770s, the adventurer James Bruce gave a graphic description of the elephantiasis he saw in Gondar, northern Ethiopia:<disp-quote>
<p>‘The chief seat of this disease is from the bending of the knee downwards to the ankle; the leg is swelled to a great degree, becoming one size from bottom to top, and gathered into circular wrinkles…from between these circular divisions a great quantity of lymph constantly oozes. It should seem that the black colour of the skin, the thickness of the leg, its shapeless form and the rough tubercules or excrescences, very like those seen upon the elephant, gave the name to this disease…’</p></disp-quote></p>
<p>Bruce obtained permission from the emperor, Ras Mikhail, to treat a sufferer, using a range of regimes and medications, but beyond assuaging the patient's thirst with a constant supply of whey, no treatment (including hemlock, mercury and tar-water) appeared effective (<xref ref-type="bibr" rid="bib18">Pankhurst, 1990</xref>).</p>
<p>Through the eighteenth and nineteenth centuries, the pathogenesis of elephantiasis was gradually elucidated through Hendy's study of the lymphatic system in affected people. Wucherer (in Brazil), Lewis (in India), Manson and Bancroft all recognized the role of filarial parasites in elephantiasis, and for a time it was concluded that all elephantiasis was filarial. Towards the end of the nineteenth century, the discrepancy between distribution of elephantiasis and distribution of filaria in North Africa, Central America and Europe prompted revision of this theory. For a time, streptococci were considered to be causative agents, but detailed description of patients in Guatemala (and persistently negative tests for filaria and streptococci) led Robles to infer that the elephantiasis he was seeing was an endemic condition closely associated with walking barefoot (<xref ref-type="bibr" rid="bib27">Price, 1984a</xref>).</p>
<p>Progress in recognizing the international distribution of non-filarial elephantiasis came as Cohen suggested the use of the term ‘idiopathic lymphoedema’ in place of the local terms ‘verrucosis lymphatica’ in Kenya and ‘mossy foot’ in Ethiopia (<xref ref-type="bibr" rid="bib2">Cohen, 1960</xref>). The work of Oomen in the 1960s and Price in the 1970s was notable for distinguishing and concentrating on non-filarial elephantiasis. Price extended Oomen's epidemiological studies (<xref ref-type="bibr" rid="bib20">Price, 1973</xref>, <xref ref-type="bibr" rid="bib21">1974a</xref>), and described the aetiology (<xref ref-type="bibr" rid="bib22">Price, 1974b</xref>), pathology (<xref ref-type="bibr" rid="bib25">Price, 1977</xref>; <xref ref-type="bibr" rid="bib32">Price and Henderson, 1978</xref>), and natural history (<xref ref-type="bibr" rid="bib26">Price, 1983</xref>) of non-filarial elephantiasis in Ethiopia, establishing the term podoconiosis (from the Greek for foot: <italic>podos</italic>, and dust: <italic>konos</italic>) (<xref ref-type="bibr" rid="bib29">Price, 1988</xref>), which has gained widespread acceptance.</p>
</sec>
<sec>
<label>3</label>
<title>Geographical distribution</title>
<p>Podoconiosis is found in highland areas of tropical Africa, Central America and northwest India. Areas of high prevalence have been documented in Uganda (<xref ref-type="bibr" rid="bib16">Onapa et al., 2001</xref>), Tanzania (<xref ref-type="bibr" rid="bib6">de Lalla et al., 1988</xref>), Kenya (<xref ref-type="bibr" rid="bib4">Crivelli, 1986</xref>), Rwanda, Burundi, Sudan and Ethiopia (<xref ref-type="bibr" rid="bib31">Price and Bailey, 1984</xref>), and in Equatorial Guinea (<xref ref-type="bibr" rid="bib3">Corachan et al., 1988</xref>), Cameroon, the islands of Bioko, Sao Tome & Principe (<xref ref-type="bibr" rid="bib33">Ruiz et al., 1994</xref>) and the Cape Verde islands, that is, approximately, between latitudes 15 °N and 15 °S.</p>
<p>The condition has been reported in the Central American highlands in Mexico and Guatemala south to Ecuador and Brazil in South America (<xref ref-type="bibr" rid="bib30">Price, 1990</xref>; <xref ref-type="bibr" rid="bib34">Tada and Marsden, 1993</xref>). Further east, on the north coast of South America in Suriname and French Guiana, the distinction between filarial and non-filarial elephantiasis has not been confirmed. Although filarial elephantiasis predominates in India, podoconiosis has been reported from northwest India, Sri Lanka and Indonesia. In the past, podoconiosis was common in North Africa (Algeria, Tunisia, Morocco and the Canary Islands) and Europe (France, Ireland and Scotland), but is longer found in these areas (<xref ref-type="bibr" rid="bib30">Price, 1990</xref>), since use of footwear has become standard.</p>
<p>Prevalence estimates have been made exclusively in Ethiopia, where podoconiosis is present over approximately one-fifth of the land surface of Ethiopia. Early estimations of prevalence using counts of attendees at fifty-six markets ranged from 0.42 to 3.73% (<xref ref-type="bibr" rid="bib17">Oomen, 1969</xref>), and further investigation in Wollamo zone, southern Ethiopia demonstrated prevalence of 5.38% across five markets. In the village of Ocholo, located at 2000 m altitude in the mountains west of Lake Abaya, southern Ethiopia, elephantiasis was present in 5.1% of long-term residents (<xref ref-type="bibr" rid="bib15">Mengistu et al., 1987</xref>), while in two resettlement schemes in Ilubabor, western Ethiopia, 9.1% of long-term residents were affected, and 5.2% of people resettled some 7–8 years previously (<xref ref-type="bibr" rid="bib14">Kloos et al., 1992</xref>). More recent population-based surveys in northwest (<xref ref-type="bibr" rid="bib1">Birrie et al., 1997</xref>) and southern Ethiopia (<xref ref-type="bibr" rid="bib7">Desta et al., 2003</xref>), have documented prevalence of 6% and 5.4%, respectively.</p>
</sec>
<sec>
<label>4</label>
<title>Age, gender and occupation</title>
<p>Early reports based on clinic attendees cannot be relied upon to derive an accurate sex ratio. Price found a male:female ratio of 1:1.4 in market studies, which he attributed to greater use of footwear by men (<xref ref-type="bibr" rid="bib22">Price, 1974b</xref>). Genene <xref ref-type="bibr" rid="bib15">Mengistu et al. (1987)</xref> documented a male:female ratio of 1:4.2 in a survey in Ocholo, but many men were absent from the community at the time. By contrast, <xref ref-type="bibr" rid="bib14">Kloos et al. (1992)</xref> noted higher prevalence among men in three of four resettlement communities in Keffa Region. In a single village in Pawe, Birrie et al. (1992) found a male:female ratio of 1:1.4 among sufferers. The most recent community-based study recorded a gender ratio among podoconiosis sufferers (1:0.98, <xref ref-type="fig" rid="tbl1">Table 1</xref>
<fig id="tbl1">
<label>Table 1</label>
<caption>
<p>Age-sex distribution among 33 678 residents of Wolaitta Zone, 2001</p>
</caption>
<graphic mimetype="image" xlink:href="101-12-1175-tbl001.tif"></graphic>
</fig>) that was not significantly different from the zonal gender ratio (1:1.02) (<xref ref-type="bibr" rid="bib7">Desta et al., 2003</xref>).</p>
<p>All of the major community-based studies have shown onset in the first or second decade and a progressive increase in podoconiosis prevalence up to the sixth decade. Development of podoconiosis is closely associated with living and working barefoot on irritant soils. Farmers are at high risk, but the risk extends to any occupation with prolonged contact with the soil, and the condition has been noted among goldmine workers and weavers who sit at a ground level loom.</p>
</sec>
<sec>
<label>5</label>
<title>Genetics</title>
<p>Among many families, exposure to irritant soil is more or less uniform, yet not all family members will develop podoconiosis during their lifetime. Price performed segregation analyses on 80 families with more than one affected child, having adjusted appropriately for increased likelihood of a family with more than one affected individual being included. He calculated the proportion of siblings affected as approximately 0.2, with 95% confidence limits including 0.25, suggesting an autosomal recessive trait (<xref ref-type="bibr" rid="bib19">Price, 1972</xref>). More recently, 59 multi-generational families were studied, and sibling recurrence risk calculated to be 5.07, and heritability 0.629. Segregation analysis showed the most parsimonious model to be that of an autosomal co-dominant major gene (<xref ref-type="bibr" rid="bib5">Davey et al., 2007</xref>).</p>
</sec>
<sec>
<label>6</label>
<title>Geology and climate</title>
<p>An association between podoconiosis and exposure to the local soil was suspected by Robles at the end of the nineteenth century. However, it was not until Price superimposed maps of disease occurrence onto geological surveys that persuasive evidence of a link with red clays, rich in alkali metals like sodium and potassium and associated with volcanic activity, was provided (<xref ref-type="bibr" rid="bib24">Price, 1976</xref>; <xref ref-type="bibr" rid="bib31">Price and Bailey, 1984</xref>). The climatic factors necessary for producing irritant clays include high altitude (over 1000 m above sea level) and seasonal rainfall (over 1000 mm annually). These conditions contribute to the steady disintegration of lava and the reconstitution of the mineral components into silicate clays, colloid-sized particles of which have been demonstrated in the lower limb lymph node macrophages of those living barefoot on these clays (<xref ref-type="bibr" rid="bib32">Price and Henderson, 1978</xref>). More recent comparison of soil from an endemic area with that from outside the area revealed high levels of beryllium and zirconium (both known to induce granulomata) (<xref ref-type="bibr" rid="bib11">Frommel et al., 1993</xref>), but the role of these elements is not yet established.</p>
</sec>
<sec>
<label>7</label>
<title>Population movement</title>
<p>Studies among populations forcibly resettled during the Ethiopian military regime (1974–1991) give useful insights into the period of exposure to irritant soils necessary to provoke disease. People resettled from north Wollo and Tigray (where podoconiosis is rare) to Illubabor in 1984/5 were surveyed in 1990, and 5% found to have podoconiosis (<xref ref-type="bibr" rid="bib14">Kloos et al., 1992</xref>). Likewise, of those people resettled from east Gojjam to the Tana Beles Project area around Pawe in 1984, almost all podoconiosis sufferers in 1996 reported development of the condition after moving to the area (<xref ref-type="bibr" rid="bib1">Birrie et al., 1997</xref>).</p>
</sec>
<sec>
<label>8</label>
<title>Economic consequences</title>
<p>A comparative cross-sectional study was performed in 2005 to calculate the economic burden in a zone endemic for podoconiosis. Total productivity loss for a patient amounted to 45% of total working days per year, and in a zone of 1.5 million people, the total overall annual cost of podoconiosis was calculated to exceed US$ 16 million per year (<xref ref-type="bibr" rid="bib35">Tekola et al., 2006</xref>).</p>
</sec>
<sec>
<label>9</label>
<title>Social stigma and access to health care</title>
<p>Social stigma against people with podoconiosis is rife, patients being excluded from school, denied participation in local meetings, churches and mosques, and barred from marriage with unaffected individuals (<xref ref-type="bibr" rid="bib13">GebreHanna, 2005</xref>). <xref ref-type="bibr" rid="bib21">Price (1974a)</xref> reports one podoconiosis sufferer as having remarked that ‘it would be better to have leprosy’, since stigma surrounding leprosy has diminished as a consequence of effective medicine and health care services. The belief that there is no effective medical treatment may act as a barrier to accessing health care. Recent evidence from the Mossy Foot Prevention and Treatment Association, a local non-government organization managing 30 000 patients in southern Ethiopia, suggests that sufferers attempting to access non-specialist health services encounter lack of expertise and prejudicial attitudes among health workers (<xref ref-type="bibr" rid="bib7">Desta et al., 2003</xref>).</p>
</sec>
<sec>
<label>10</label>
<title>Pathogenesis</title>
<p>The pathogenesis of podoconiosis is not yet fully elucidated. At present, most evidence suggests an important role for mineral particles on a background of genetic susceptibility, but the possible role of other cofactors (for example chronic infection or micronutrient deficiencies) has not been explored. Colloid-sized particles of elements common in irritant clays (aluminium, silicon, magnesium and iron) are absorbed through the foot and have been demonstrated in the lower limb lymph node macrophages of those living barefoot on the clays (<xref ref-type="bibr" rid="bib32">Price and Henderson, 1978</xref>). Electron microscopy shows local macrophage phagosomes to contain particles of stacked kaolinite (Al<sub>2</sub>Si<sub>2</sub>O<sub>5</sub>(OH)<sub>4</sub>), while light microscopy shows subendothelial oedema and subsequent collagenization of afferent lymphatics reducing and finally obliterating the lumen (<xref ref-type="bibr" rid="bib25">Price, 1977</xref>). Experiments have shown that silica suspension injected into rabbit lymphatics can provoke similar intense macrophage proliferation followed by lymphatic fibrosis and blockage (<xref ref-type="bibr" rid="bib12">Fyfe and Price, 1985</xref>).</p>
</sec>
<sec>
<label>11</label>
<title>Pathology</title>
<p>The pathology and natural history are well described in a range of articles (<xref ref-type="bibr" rid="bib2">Cohen, 1960</xref>; <xref ref-type="bibr" rid="bib26">Price, 1983</xref>, <xref ref-type="bibr" rid="bib28">1984b</xref>). Podoconiosis is characterized by a prodromal phase before elephantiasis sets in. Early symptoms commonly include itching of the skin of the forefoot and a burning sensation in the foot and lower leg. Early changes that may be observed are splaying of the forefoot, plantar oedema with lymph ooze, increased skin markings, hyperkeratosis with the formation of moss-like papillomata, and ‘block’ (rigid) toes. Later, the swelling may be one of two types: soft and fluid (‘water-bag’ type, <xref ref-type="fig" rid="fig1">Figure 1</xref>
<fig id="fig1" position="float">
<label>Figure 1</label>
<caption>
<p>Soft ‘water-bag’ swelling in a 20-year-old man. Photo: Ewenat GebreHanna, with permission.</p>
</caption>
<graphic mimetype="image" xlink:href="101-12-1175-fig001.tif"></graphic>
</fig>); or hard and fibrotic (‘leathery’ type, <xref ref-type="fig" rid="fig2">Figure 2</xref>
<fig id="fig2" position="float">
<label>Figure 2</label>
<caption>
<p>Nodules, moss and shiny ‘band’ compression by sandal. Photo: Gail Davey, with permission.</p>
</caption>
<graphic mimetype="image" xlink:href="101-12-1175-fig002.tif"></graphic>
</fig>), often associated with multiple hard skin nodules (<xref ref-type="bibr" rid="bib30">Price, 1990</xref>). Very long-standing disease is associated with fusion of the interdigital spaces and ankylosis of the interphalangeal or ankle joints (<xref ref-type="fig" rid="fig3">Figure 3</xref>
<fig id="fig3" position="float">
<label>Figure 3</label>
<caption>
<p>Moss, nodules and ankylosis of the ankle joint in 50-year-old man. Photo: Gail Davey, with permission.</p>
</caption>
<graphic mimetype="image" xlink:href="101-12-1175-fig003.tif"></graphic>
</fig>). Acute episodes occur in which the patients is pyrexial and the limb warm and painful. These episodes appear to be related to progression to the hard, fibrotic leg.</p>
</sec>
<sec>
<label>12</label>
<title>Differential diagnosis</title>
<p>The two conditions podoconiosis must most often be distinguished from are filarial and leprotic lymphoedema. Clinical features of podoconiosis that help distinguish it from filarial elephantiasis include the foot being the site of first symptoms (rather than elsewhere in the leg) and bilateral but asymmetric swelling usually confined to the lower leg (compared to the predominantly unilateral swelling extending above the knee in filariasis). Groin involvement in podoconiosis is extremely rare. A recent study using both midnight thick film examination and Binax™ antigen cards has confirmed that in a podoconiosis-endemic area, community workers' diagnoses are highly predictive of podoconiosis (<xref ref-type="bibr" rid="bib8">Desta et al., 2007</xref>). Podoconiosis may be distinguished from leprosy lymphoedema by the preservation of sensation in the toes and forefoot, the lack of trophic ulcers, thickened nerves or hand involvement.</p>
</sec>
<sec>
<label>13</label>
<title>Prevention and management</title>
<p>Evidence suggests that primary prevention should consist of avoidance of prolonged contact between the skin and irritant soils. This may be achieved by use of robust footwear or covering of floor surfaces in areas of irritant soil. The Mossy Foot Prevention and Treatment Association trains treated patients to make low-cost durable leather boots and shoes for their communities in an attempt at primary prevention. In Kenya, sandals are made from old car tyres with a similar aim. However, footwear remains an unaffordable luxury for residents of most affected areas in the tropics.</p>
<p>Secondary prevention (prevention of the progression of early symptoms and signs to overt elephantiasis) takes the form of training in foot hygiene (washing daily with soap and water, using antiseptics and emollients), and use of socks and shoes. Compression bandaging is effective in reducing the size of the soft type of swelling. Progression can be completely averted if these measures are strictly adhered to, but compliance must be life-long. Relocation from an area of irritant soil (<xref ref-type="bibr" rid="bib26">Price, 1983</xref>) or adoption of a non-agricultural occupation are also effective, but may not be feasible for the patient.</p>
<p>Tertiary prevention (the management of those with advanced elephantiasis) encompasses secondary prevention measures, elevation and compression of the affected leg, and, in selected cases, removal of prominent nodules. For elevation to be successful, at least 18 hours with the legs at or above the level of the heart are needed each day. Where electricity is available, intermittent compression machines may reduce swelling rapidly, but twice-daily application of elastic bandages is also effective (<xref ref-type="bibr" rid="bib23">Price, 1975</xref>). The aim of elevation and compression is to reduce the swelling of the leg so that tall compression footwear can be worn, or nodulectomy undertaken. Previously, Charles' operation (removal of skin, subcutaneous tissue and deep fascia to lay the muscles and tendons bare, followed by grafting of healthy skin), or a variant, was used (<xref ref-type="bibr" rid="bib2">Cohen, 1960</xref>; <xref ref-type="bibr" rid="bib30">Price, 1990</xref>), but long-term results are disappointing. Follow-up of patients suggests that those unable to scrupulously avoid contact with soil experience recurrent swelling which is more painful than the original disease because of scarring. Social rehabilitation is vital, and includes training treated patients in skills that enable them to generate income without contact with irritant soil. Successful training in shoemaking, bicycle repair, hairdressing and beauty care, electronics and carpentry has been given to several hundred treated patients by the Mossy Foot Association in southern Ethiopia.</p>
</sec>
<sec>
<label>14</label>
<title>Future directions</title>
<p>There are still many unresolved questions surrounding the pathogenesis of podoconiosis, in particular the pathways through which inorganic particles provoke inflammation and obliteration of the lymphatic lumen, and the roles of cofactors such as micronutrient deficiencies or chronic infections in these processes. Currently, a study investigating the role of oxidative stress in podoconiosis is underway, as is a linkage analysis using affected sibling pairs.</p>
<p>In terms of patient care, a clinical staging system, adapted from that developed for management of filarial lymphoedema (<xref ref-type="bibr" rid="bib9">Dreyer et al., 2002</xref>), is being validated and tested for inter-observer agreement and test-retest repeatability. It is anticipated that this will enable clinicians to assess medical and surgical treatment, and researchers to document the effects of public health preventive interventions. Quality of life in new and treated patients is being assessed using the Cardiff Dermatological Life Quality Index (<xref ref-type="bibr" rid="bib10">Findlay and Khan, 1994</xref>).</p>
</sec>
<sec>
<title>Funding</title>
<p>GD and FT are funded by the Wellcome Trust on project grant AL/079791. The funding body had no part in the planning or writing of the paper.</p>
</sec>
<sec>
<title>Conflicts of interest</title>
<p>GD and FT receive salaries to do research on podoconiosis.</p>
</sec>
<sec>
<title>Ethical approval</title>
<p>None required.</p>
</sec>
</body>
<back>
<ack>
<title>Acknowledgements</title>
<p>We are very grateful for the collection of early articles by EW Price made available to us by Prof. Eldryd Parry.</p>
</ack>
<ref-list>
<title>References</title>
<ref id="bib1">
<label>Birrie et al., 1997</label>
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name><surname>Birrie</surname><given-names>H.</given-names></name>
<name><surname>Balcha</surname><given-names>F.</given-names></name>
<name><surname>Jemaneh</surname><given-names>L.</given-names></name>
</person-group>
<article-title>Elephantiasis in Pawe settlement area: podoconiosis or bancroftian filariasis?</article-title>
<source>Ethiop. Med. J.</source>
<year>1997</year>
<volume>35</volume>
<fpage>245</fpage>
<lpage>250</lpage>
</nlm-citation>
</ref>
<ref id="bib2">
<label>Cohen, 1960</label>
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name><surname>Cohen</surname><given-names>L.B.</given-names></name>
</person-group>
<article-title>Idiopathic lymphoedema of Ethiopia and Kenya</article-title>
<source>East. Afr. Med. J.</source>
<year>1960</year>
<volume>37</volume>
<fpage>53</fpage>
<lpage>74</lpage>
</nlm-citation>
</ref>
<ref id="bib3">
<label>Corachan et al., 1988</label>
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name><surname>Corachan</surname><given-names>M.</given-names></name>
<name><surname>Tura</surname><given-names>J.M.</given-names></name>
<name><surname>Campo</surname><given-names>E.</given-names></name>
<name><surname>Soley</surname><given-names>M.</given-names></name>
<name><surname>Traveria</surname><given-names>A.</given-names></name>
</person-group>
<article-title>Podoconiosis in Equatorial Guinea. Report of two cases from different geological environments</article-title>
<source>Trop. Geogr. Med.</source>
<year>1988</year>
<volume>40</volume>
<fpage>359</fpage>
<lpage>364</lpage>
</nlm-citation>
</ref>
<ref id="bib4">
<label>Crivelli, 1986</label>
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name><surname>Crivelli</surname><given-names>P.</given-names></name>
</person-group>
<article-title>Non-filarial elephantiasis in Nyambene range: a geochemical disease</article-title>
<source>East. Afr. Med. J.</source>
<year>1986</year>
<volume>63</volume>
<fpage>191</fpage>
<lpage>194</lpage>
</nlm-citation>
</ref>
<ref id="bib5">
<label>Davey et al., 2007</label>
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name><surname>Davey</surname><given-names>G.</given-names></name>
<name><surname>GebreHanna</surname><given-names>E.</given-names></name>
<name><surname>Adeyemo</surname><given-names>A.</given-names></name>
<name><surname>Rotimi</surname><given-names>C.</given-names></name>
<name><surname>Newport</surname><given-names>M.</given-names></name>
<name><surname>Desta</surname><given-names>K.</given-names></name>
</person-group>
<article-title>Podoconiosis: a tropical model for gene-environment interactions?</article-title>
<source>Trans. R. Soc. Trop. Med. Hyg.</source>
<year>2007</year>
<volume>101</volume>
<fpage>91</fpage>
<lpage>96</lpage>
</nlm-citation>
</ref>
<ref id="bib6">
<label>de Lalla et al., 1988</label>
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name><surname>de Lalla</surname><given-names>F.</given-names></name>
<name><surname>Zanoni</surname><given-names>P.</given-names></name>
<name><surname>Lunetta</surname><given-names>Q.</given-names></name>
<name><surname>Moltrasio</surname><given-names>G.</given-names></name>
</person-group>
<article-title>Endemic non-filarial elephantiasis in Iringa District, Tanzania: a study of 30 patients</article-title>
<source>Trans. R. Soc. Trop. Med. Hyg.</source>
<year>1988</year>
<volume>82</volume>
<fpage>895</fpage>
<lpage>897</lpage>
</nlm-citation>
</ref>
<ref id="bib7">
<label>Desta et al., 2003</label>
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name><surname>Desta</surname><given-names>K.</given-names></name>
<name><surname>Ashine</surname><given-names>M.</given-names></name>
<name><surname>Davey</surname><given-names>G.</given-names></name>
</person-group>
<article-title>Prevalence of podoconiosis (endemic non-filarial elephantiasis) in Wolaitta, Southern Ethiopia</article-title>
<source>Trop. Doct.</source>
<year>2003</year>
<volume>32</volume>
<fpage>217</fpage>
<lpage>220</lpage>
</nlm-citation>
</ref>
<ref id="bib8">
<label>Desta et al., 2007</label>
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name><surname>Desta</surname><given-names>K.</given-names></name>
<name><surname>Ashine</surname><given-names>M.</given-names></name>
<name><surname>Davey</surname><given-names>G.</given-names></name>
</person-group>
<article-title>Predictive value of clinical assessment of patients with podoconiosis in an endemic community setting</article-title>
<source>Trans. R. Soc. Trop. Med. Hyg.</source>
<year>2007</year>
<volume>101</volume>
<fpage>621</fpage>
<lpage>623</lpage>
</nlm-citation>
</ref>
<ref id="bib9">
<label>Dreyer et al., 2002</label>
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name><surname>Dreyer</surname><given-names>G.</given-names></name>
<name><surname>Addiss</surname><given-names>D.</given-names></name>
<name><surname>Dreyer</surname><given-names>P.</given-names></name>
<name><surname>Norões</surname><given-names>J.</given-names></name>
</person-group>
<article-title>Basic Lymphedema Management</article-title>
<year>2002</year><edition>first ed.</edition>
</nlm-citation>
</ref>
<ref id="bib10">
<label>Findlay and Khan, 1994</label>
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name><surname>Findlay</surname><given-names>A.Y.</given-names></name>
<name><surname>Khan</surname><given-names>G.K.</given-names></name>
</person-group>
<article-title>Dermatology Life Quality Index (DLQI)—a simple practical measure for routine clinical use</article-title>
<source>Clin. Exp. Dermatol.</source>
<year>1994</year>
<volume>19</volume>
<fpage>210</fpage>
<lpage>216</lpage>
</nlm-citation>
</ref>
<ref id="bib11">
<label>Frommel et al., 1993</label>
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name><surname>Frommel</surname><given-names>D.</given-names></name>
<name><surname>Ayranci</surname><given-names>B.</given-names></name>
<name><surname>Pfeifer</surname><given-names>H.R.</given-names></name>
<name><surname>Sanchez</surname><given-names>A.</given-names></name>
<name><surname>Frommel</surname><given-names>A.</given-names></name>
<name><surname>Mengistu</surname><given-names>G.</given-names></name>
</person-group>
<article-title>Podoconiosis in the Ethiopian Rift Valley. Role of beryllium and zirconium</article-title>
<source>Trop. Geogr. Med.</source>
<year>1993</year>
<volume>45</volume>
<fpage>165</fpage>
<lpage>167</lpage>
</nlm-citation>
</ref>
<ref id="bib12">
<label>Fyfe and Price, 1985</label>
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name><surname>Fyfe</surname><given-names>N.C.M.</given-names></name>
<name><surname>Price</surname><given-names>E.W.</given-names></name>
</person-group>
<article-title>The effects of silica on lymph nodes and vessels—a possible mechanism in the pathogenesis of non-filarial endemic elephantiasis</article-title>
<source>Trans. R. Soc. Trop. Med. Hyg.</source>
<year>1985</year>
<volume>79</volume>
<fpage>645</fpage>
<lpage>651</lpage>
</nlm-citation>
</ref>
<ref id="bib13">
<label>GebreHanna, 2005</label>
<nlm-citation citation-type="other">
<comment>GebreHanna, E., 2005. The social burden of podoconiosis and familial occurrence in its development. MPH Thesis, Addis Ababa University, Ethiopia.</comment>
</nlm-citation>
</ref>
<ref id="bib14">
<label>Kloos et al., 1992</label>
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name><surname>Kloos</surname><given-names>H.</given-names></name>
<name><surname>Bedri Kello</surname><given-names>A.</given-names></name>
<name><surname>Addus</surname><given-names>A.</given-names></name>
</person-group>
<article-title>Podoconiosis (endemic non-filarial elephantiasis) in two resettlement schemes in western Ethiopia</article-title>
<source>Trop. Doct.</source>
<year>1992</year>
<volume>22</volume>
<fpage>109</fpage>
<lpage>112</lpage>
</nlm-citation>
</ref>
<ref id="bib15">
<label>Mengistu et al., 1987</label>
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name><surname>Mengistu</surname><given-names>G.</given-names></name>
<name><surname>Humber</surname><given-names>D.P.</given-names></name>
<name><surname>Ersumo</surname><given-names>M.</given-names></name>
<name><surname>Mamo</surname><given-names>T.</given-names></name>
</person-group>
<article-title>High prevalence of elephantiasis in Ocholo, south-west Ethiopia</article-title>
<source>Ethiop. Med. J.</source>
<year>1987</year>
<volume>25</volume>
<fpage>203</fpage>
<lpage>207</lpage>
</nlm-citation>
</ref>
<ref id="bib16">
<label>Onapa et al., 2001</label>
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name><surname>Onapa</surname><given-names>A.W.</given-names></name>
<name><surname>Simonsen</surname><given-names>P.E.</given-names></name>
<name><surname>Pedersen</surname><given-names>E.M.</given-names></name>
</person-group>
<article-title>Non-filarial elephantiasis in the Mt Elgon area (Kapchorwa District) of Uganda</article-title>
<source>Acta Trop.</source>
<year>2001</year>
<volume>78</volume>
<fpage>171</fpage>
<lpage>176</lpage>
</nlm-citation>
</ref>
<ref id="bib17">
<label>Oomen, 1969</label>
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name><surname>Oomen</surname><given-names>A.P.</given-names></name>
</person-group>
<article-title>Studies on elephantiasis of the legs in Ethiopia</article-title>
<source>Trop. Geogr. Med.</source>
<year>1969</year>
<volume>21</volume>
<fpage>236</fpage>
<lpage>253</lpage>
</nlm-citation>
</ref>
<ref id="bib18">
<label>Pankhurst, 1990</label>
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name><surname>Pankhurst</surname><given-names>R.</given-names></name>
</person-group>
<article-title>An Introduction to the Medical History of Ethiopia</article-title>
<year>1990</year><edition>first ed.</edition>
</nlm-citation>
</ref>
<ref id="bib19">
<label>Price, 1972</label>
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name><surname>Price</surname><given-names>E.W.</given-names></name>
</person-group>
<article-title>A possible genetic factor in non-filarial elephantiasis of the lower legs</article-title>
<source>Ethiop. Med. J.</source>
<year>1972</year>
<volume>10</volume>
<fpage>87</fpage>
<lpage>93</lpage>
</nlm-citation>
</ref>
<ref id="bib20">
<label>Price, 1973</label>
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name><surname>Price</surname><given-names>E.W.</given-names></name>
</person-group>
<article-title>Non-filarial elephantiasis of the lower legs in Ethiopia</article-title>
<source>Trop. Geogr. Med.</source>
<year>1973</year>
<volume>25</volume>
<fpage>23</fpage>
<lpage>27</lpage>
</nlm-citation>
</ref>
<ref id="bib21">
<label>Price, 1974a</label>
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name><surname>Price</surname><given-names>E.W.</given-names></name>
</person-group>
<article-title>Endemic elephantiasis of the lower legs in Ethiopia, an epidemiological survey</article-title>
<source>Ethiop. Med. J.</source>
<year>1974</year>
<volume>12</volume>
<fpage>77</fpage>
<lpage>90</lpage>
</nlm-citation>
</ref>
<ref id="bib22">
<label>Price, 1974b</label>
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name><surname>Price</surname><given-names>E.W.</given-names></name>
</person-group>
<article-title>The relationship between endemic elephantiasis of the lower legs and the local soils and climate. A study in Wollamo District, Southern Ethiopia</article-title>
<source>Trop. Geogr. Med.</source>
<year>1974</year>
<volume>26</volume>
<fpage>225</fpage>
<lpage>230</lpage>
</nlm-citation>
</ref>
<ref id="bib23">
<label>Price, 1975</label>
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name><surname>Price</surname><given-names>E.W.</given-names></name>
</person-group>
<article-title>The management of endemic (non-filarial) elephantiasis of the lower legs</article-title>
<source>Trop. Doct.</source>
<year>1975</year>
<volume>5</volume>
<fpage>70</fpage>
<lpage>75</lpage>
</nlm-citation>
</ref>
<ref id="bib24">
<label>Price, 1976</label>
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name><surname>Price</surname><given-names>E.W.</given-names></name>
</person-group>
<article-title>The association of endemic elephantiasis of the lower legs in East Africa with soil derived from volcanic rocks</article-title>
<source>Trans. R. Soc. Trop. Med. Hyg.</source>
<year>1976</year>
<volume>70</volume>
<fpage>288</fpage>
<lpage>295</lpage>
</nlm-citation>
</ref>
<ref id="bib25">
<label>Price, 1977</label>
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name><surname>Price</surname><given-names>E.W.</given-names></name>
</person-group>
<article-title>The site of lymphatic blockage in endemic (non-filarial) elephantiasis of the lower legs</article-title>
<source>J. Trop. Med. Hyg.</source>
<year>1977</year>
<volume>80</volume>
<fpage>230</fpage>
<lpage>237</lpage>
</nlm-citation>
</ref>
<ref id="bib26">
<label>Price, 1983</label>
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name><surname>Price</surname><given-names>E.W.</given-names></name>
</person-group>
<article-title>Endemic elephantiasis: early signs and symptoms, and control</article-title>
<source>Ethiop. Med. J.</source>
<year>1983</year>
<volume>21</volume>
<fpage>243</fpage>
<lpage>253</lpage>
</nlm-citation>
</ref>
<ref id="bib27">
<label>Price, 1984a</label>
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name><surname>Price</surname><given-names>E.W.</given-names></name>
</person-group>
<article-title>The elephantiasis story</article-title>
<source>Trop. Dis. Bull.</source>
<year>1984</year>
<volume>81</volume>
<fpage>R1</fpage>
<lpage>R12</lpage>
</nlm-citation>
</ref>
<ref id="bib28">
<label>Price, 1984b</label>
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name><surname>Price</surname><given-names>E.W.</given-names></name>
</person-group>
<article-title>Pre-elephantiasic stage of endemic nonfilarial elephantiasis of lower legs: ‘podoconiosis’</article-title>
<source>Trop. Doct.</source>
<year>1984</year>
<volume>14</volume>
<fpage>115</fpage>
<lpage>119</lpage>
</nlm-citation>
</ref>
<ref id="bib29">
<label>Price, 1988</label>
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name><surname>Price</surname><given-names>E.W.</given-names></name>
</person-group>
<article-title>Non-filarial elephantiasis - confirmed as a geochemical disease and renamed podoconiosis</article-title>
<source>Ethiop. Med. J.</source>
<year>1988</year>
<volume>26</volume>
<fpage>151</fpage>
<lpage>153</lpage>
</nlm-citation>
</ref>
<ref id="bib30">
<label>Price, 1990</label>
<nlm-citation citation-type="book">
<person-group person-group-type="author">
<name><surname>Price</surname><given-names>E.W.</given-names></name>
</person-group>
<article-title>Podoconiosis: non-filarial elephantiasis</article-title>
<year>1990</year>
</nlm-citation>
</ref>
<ref id="bib31">
<label>Price and Bailey, 1984</label>
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name><surname>Price</surname><given-names>E.W.</given-names></name>
<name><surname>Bailey</surname><given-names>D.</given-names></name>
</person-group>
<article-title>Environmental factors in the etiology of endemic elephantiasis of the lower legs in tropical Africa</article-title>
<source>Trop. Geogr. Med.</source>
<year>1984</year>
<volume>36</volume>
<fpage>1</fpage>
<lpage>5</lpage>
</nlm-citation>
</ref>
<ref id="bib32">
<label>Price and Henderson, 1978</label>
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name><surname>Price</surname><given-names>E.W.</given-names></name>
<name><surname>Henderson</surname><given-names>W.J.</given-names></name>
</person-group>
<article-title>The elemental content of lymphatic tissues in barefooted people in Ethiopia, with reference to endemic elephantiasis of the lower legs</article-title>
<source>Trans. R. Soc. Trop. Med. Hyg.</source>
<year>1978</year>
<volume>72</volume>
<fpage>132</fpage>
<lpage>136</lpage>
</nlm-citation>
</ref>
<ref id="bib33">
<label>Ruiz et al., 1994</label>
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name><surname>Ruiz</surname><given-names>L.</given-names></name>
<name><surname>Campo</surname><given-names>E.</given-names></name>
<name><surname>Corachan</surname><given-names>M.</given-names></name>
</person-group>
<article-title>Elephantiasis in Sao Tome and Principe</article-title>
<source>Acta Trop.</source>
<year>1994</year>
<volume>57</volume>
<fpage>29</fpage>
<lpage>34</lpage>
</nlm-citation>
</ref>
<ref id="bib34">
<label>Tada and Marsden, 1993</label>
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name><surname>Tada</surname><given-names>M.S.</given-names></name>
<name><surname>Marsden</surname><given-names>P.D.</given-names></name>
</person-group>
<article-title>Probable podoconiosis in Brasilia</article-title>
<source>Rev. Soc. Bras. Med. Trop.</source>
<year>1993</year>
<volume>26</volume>
<fpage>255</fpage>
</nlm-citation>
</ref>
<ref id="bib35">
<label>Tekola et al., 2006</label>
<nlm-citation citation-type="journal">
<person-group person-group-type="author">
<name><surname>Tekola</surname><given-names>F.</given-names></name>
<name><surname>HaileMariam</surname><given-names>D.</given-names></name>
<name><surname>Davey</surname><given-names>G.</given-names></name>
</person-group>
<article-title>Economic costs of endemic non-filarial elephantiasis in Wolaita Zone, Ethiopia</article-title>
<source>Trop. Med. Int. Health</source>
<year>2006</year>
<volume>11</volume>
<fpage>1136</fpage>
<lpage>1144</lpage>
</nlm-citation>
</ref>
</ref-list>
</back>
</article></istex:document></istex:metadataXml><mods version="3.6"><titleInfo><title>Podoconiosis: non-infectious geochemical elephantiasis</title></titleInfo><titleInfo type="alternative" contentType="CDATA"><title>Podoconiosis: non-infectious geochemical elephantiasis</title></titleInfo><name type="personal" displayLabel="corresp"><namePart type="given">Gail</namePart><namePart type="family">Davey</namePart><affiliation>Department of Community Health, Addis Ababa University, P.O. Box 9806, Addis Ababa, Ethiopia</affiliation><affiliation>E-mail: nerurkar@ethionet.et</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Fasil</namePart><namePart type="family">Tekola</namePart><affiliation>Department of Community Health, Addis Ababa University, P.O. Box 9806, Addis Ababa, Ethiopia</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">Melanie J.</namePart><namePart type="family">Newport</namePart><affiliation>Brighton and Sussex Medical School, University of Sussex, Falmer, Brighton BN1 9PS, UK</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="review-article" displayLabel="review-article"></genre><originInfo><publisher>Royal Society of Tropical Medicine and Hygiene</publisher><dateIssued encoding="w3cdtf">2007-12</dateIssued><copyrightDate encoding="w3cdtf">2007</copyrightDate></originInfo><physicalDescription><internetMediaType>text/html</internetMediaType></physicalDescription><abstract>This article reviews peer-reviewed publications and book chapters on the history, epidemiology, genetics, ecology, pathogenesis, pathology and management of podoconiosis (endemic non-filarial elephantiasis). Podoconiosis is a non-infectious geochemical elephantiasis caused by exposure of bare feet to irritant alkalic clay soils. It is found in at least 10 countries in tropical Africa, Central America and northwest India, where such soils coexist with high altitude, high seasonal rainfall and low income. Podoconiosis develops in men and women working barefoot on irritant soils, with signs becoming apparent in most patients by the third decade of life. Colloid-sized silicate particles appear to enter through the skin, are taken up into macrophages in the lower limb lymphatics and cause endolymphangitis and obliteration of the lymphatic lumen. Genetic studies provide evidence for high heritability of susceptibility to podoconiosis. The economic burden is significant in affected areas dependent on subsistence farming. Podoconiosis is unique in being an entirely preventable non-communicable disease. Primary prevention entails promoting use of footwear in areas of irritant soil; early stages are reversible given good foot hygiene, but late stages result in considerable economic and social difficulties, and require extended periods of elevation and occasionally nodulectomy.</abstract><subject lang="en"><genre>Keywords</genre><topic>Podoconiosis</topic><topic>Elephantiasis</topic><topic>Geochemical</topic><topic>Non-filarial elephantiasis</topic><topic>Review</topic></subject><relatedItem type="host"><titleInfo><title>Transactions of The Royal Society of Tropical Medicine and Hygiene</title></titleInfo><titleInfo type="abbreviated"><title>Trans R Soc Trop Med Hyg</title></titleInfo><genre type="journal">journal</genre><identifier type="ISSN">0035-9203</identifier><identifier type="eISSN">1878-3503</identifier><identifier type="PublisherID">trstmh</identifier><identifier type="PublisherID-hwp">trstmh</identifier><part><date>2007</date><detail type="volume"><caption>vol.</caption><number>101</number></detail><detail type="issue"><caption>no.</caption><number>12</number></detail><extent unit="pages"><start>1175</start><end>1180</end></extent></part></relatedItem><identifier type="istex">CAE4E5E09403AA4FA965C81B33A485D1BCFA5439</identifier><identifier type="DOI">10.1016/j.trstmh.2007.08.013</identifier><recordInfo><recordContentSource>OUP</recordContentSource><recordOrigin>Royal Society of Tropical Medicine and Hygiene</recordOrigin></recordInfo></mods></metadata><covers><json:item><extension>tiff</extension><original>true</original><mimetype>image/tiff</mimetype><uri>https://api.istex.fr/document/CAE4E5E09403AA4FA965C81B33A485D1BCFA5439/covers/tiff</uri></json:item></covers><annexes><json:item><extension>jpeg</extension><original>true</original><mimetype>image/jpeg</mimetype><uri>https://api.istex.fr/document/CAE4E5E09403AA4FA965C81B33A485D1BCFA5439/annexes/jpeg</uri></json:item><json:item><extension>gif</extension><original>true</original><mimetype>image/gif</mimetype><uri>https://api.istex.fr/document/CAE4E5E09403AA4FA965C81B33A485D1BCFA5439/annexes/gif</uri></json:item></annexes><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Sante/explor/LymphedemaV1/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 005F08 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 005F08 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Sante
|area= LymphedemaV1
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:CAE4E5E09403AA4FA965C81B33A485D1BCFA5439
|texte= Podoconiosis: non-infectious geochemical elephantiasis
}}
| This area was generated with Dilib version V0.6.31. |  |