H2N2V1, Main, Curation, bibRecord, 001F22

A common neutralizing epitope conserved between the hemagglutinins of influenza A virus H1 and H2 strains

Identifieur interne : 001F22 ( Main/Curation ); précédent : 001F21; suivant : 001F23

A common neutralizing epitope conserved between the hemagglutinins of influenza A virus H1 and H2 strains

Auteurs : Y. Okuno [Japon] ; Y. Isegawa ; F. Sasao ; S. Ueda

Source :

Journal of virology [ 0022-538X ] ; 1993.

RBID : Pascal:93-0479202

Descripteurs français

KwdFr :
- Animaux, Anticorps antiviraux (immunologie), Anticorps monoclonaux (immunologie), Antigènes viraux (génétique), Antigènes viraux (immunologie), Cellules cultivées, Conformation des protéines, Données de séquences moléculaires, Fusion cellulaire, Glycoprotéine hémagglutinine du virus influenza, Hémagglutinines virales (génétique), Hémagglutinines virales (immunologie), Modèles moléculaires, Orthomyxoviridae (génétique), Orthomyxoviridae (immunologie), Souris, Souris de lignée BALB C, Spécificité d'espèce, Spécificité des anticorps, Séquence conservée, Séquence d'acides aminés, Séquence nucléotidique, Tests de neutralisation, Épitopes.
MESH :
- génétique : Antigènes viraux, Hémagglutinines virales, Orthomyxoviridae.
- immunologie : Anticorps antiviraux, Anticorps monoclonaux, Antigènes viraux, Hémagglutinines virales, Orthomyxoviridae.
Pascal (Inist)
- Animaux, Cellules cultivées, Conformation des protéines, Données de séquences moléculaires, Fusion cellulaire, Glycoprotéine hémagglutinine du virus influenza, Influenzavirus A, Hémagglutinine, Glycoprotéine, Déterminant antigénique, Anticorps monoclonal, Hybridome, Modèles moléculaires, Neutralisation, Fusion cellulaire, Cellule infectée, Etude comparative, Souche, Souris, Souris de lignée BALB C, Spécificité d'espèce, Spécificité des anticorps, Séquence aminoacide, Séquence conservée, Séquence d'acides aminés, Séquence nucléotidique, Tests de neutralisation, Épitopes.

English descriptors

KwdEn :
- Amino Acid Sequence, Aminoacid sequence, Animals, Antibodies, Monoclonal (immunology), Antibodies, Viral (immunology), Antibody Specificity, Antigenic determinant, Antigens, Viral (genetics), Antigens, Viral (immunology), Base Sequence, Cell Fusion, Cell fusion, Cells, Cultured, Comparative study, Conserved Sequence, Epitopes, Glycoproteins, Hemagglutinin, Hemagglutinin Glycoproteins, Influenza Virus, Hemagglutinins, Viral (genetics), Hemagglutinins, Viral (immunology), Hybridoma, Infected cell, Influenzavirus A, Mice, Mice, Inbred BALB C, Models, Molecular, Molecular Sequence Data, Monoclonal antibody, Neutralization, Neutralization Tests, Orthomyxoviridae (genetics), Orthomyxoviridae (immunology), Protein Conformation, Species Specificity, Strain.
MESH :
- chemical , genetics : Antigens, Viral, Hemagglutinins, Viral.
- chemical , immunology : Antibodies, Monoclonal, Antibodies, Viral, Antigens, Viral, Hemagglutinins, Viral.
- genetics : Orthomyxoviridae.
- immunology : Orthomyxoviridae.
- Amino Acid Sequence, Animals, Antibody Specificity, Base Sequence, Cell Fusion, Cells, Cultured, Conserved Sequence, Epitopes, Hemagglutinin Glycoproteins, Influenza Virus, Mice, Mice, Inbred BALB C, Models, Molecular, Molecular Sequence Data, Neutralization Tests, Protein Conformation, Species Specificity.

Abstract

When mice were immunized with the A/Okuda/57 (H2N2) strain of influenza virus, a unique monoclonal antibody designated C179 was obtained. Although C179 was confirmed to recognize the hemagglutinin (HA) glycoprotein by immunoprecipitation assays, it did not show hemagglutination inhibition activity to any of the strains of the three subtypes of influenza A virus. However, it neutralized all of the H1 and H2 strains but not the H3 strains. Moreover, it inhibited polykaryon formation induced by the H1 and H2 strains but not by the H3 strains. Two antigenic variants against C179 were obtained, and nucleotide sequence analysis revealed that amino acid sequences, from 318 to 322 of HA, and from 47 to 58 of HA₂, conserved among H1 and H2 strains were responsible for the recognition of C179

Url:

http://www.ncbi.nlm.nih.gov/pmc/articles/PMC237575

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Pascal:93-0479202

Le document en format XML

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<front><div type="abstract" xml:lang="en">When mice were immunized with the A/Okuda/57 (H2N2) strain of influenza virus, a unique monoclonal antibody designated C179 was obtained. Although C179 was confirmed to recognize the hemagglutinin (HA) glycoprotein by immunoprecipitation assays, it did not show hemagglutination inhibition activity to any of the strains of the three subtypes of influenza A virus. However, it neutralized all of the H1 and H2 strains but not the H3 strains. Moreover, it inhibited polykaryon formation induced by the H1 and H2 strains but not by the H3 strains. Two antigenic variants against C179 were obtained, and nucleotide sequence analysis revealed that amino acid sequences, from 318 to 322 of HA, and from 47 to 58 of HA<sub>2</sub>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">A common neutralizing epitope conserved between the hemagglutinins of influenza A virus H1 and H2 strains.</title>
<author><name sortKey="Okuno, Y" sort="Okuno, Y" uniqKey="Okuno Y" first="Y" last="Okuno">Y. Okuno</name>
</author>
<author><name sortKey="Isegawa, Y" sort="Isegawa, Y" uniqKey="Isegawa Y" first="Y" last="Isegawa">Y. Isegawa</name>
</author>
<author><name sortKey="Sasao, F" sort="Sasao, F" uniqKey="Sasao F" first="F" last="Sasao">F. Sasao</name>
</author>
<author><name sortKey="Ueda, S" sort="Ueda, S" uniqKey="Ueda S" first="S" last="Ueda">S. Ueda</name>
</author>
</analytic>
<series><title level="j">Journal of Virology</title>
<idno type="ISSN">0022-538X</idno>
<idno type="eISSN">1098-5514</idno>
<imprint><date when="1993">1993</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Animals</term>
<term>Antibodies, Monoclonal (immunology)</term>
<term>Antibodies, Viral (immunology)</term>
<term>Antibody Specificity</term>
<term>Antigens, Viral (genetics)</term>
<term>Antigens, Viral (immunology)</term>
<term>Base Sequence</term>
<term>Cell Fusion</term>
<term>Cells, Cultured</term>
<term>Conserved Sequence</term>
<term>Epitopes</term>
<term>Hemagglutinin Glycoproteins, Influenza Virus</term>
<term>Hemagglutinins, Viral (genetics)</term>
<term>Hemagglutinins, Viral (immunology)</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Models, Molecular</term>
<term>Molecular Sequence Data</term>
<term>Neutralization Tests</term>
<term>Orthomyxoviridae (genetics)</term>
<term>Orthomyxoviridae (immunology)</term>
<term>Protein Conformation</term>
<term>Species Specificity</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Animaux</term>
<term>Anticorps antiviraux (immunologie)</term>
<term>Anticorps monoclonaux (immunologie)</term>
<term>Antigènes viraux (génétique)</term>
<term>Antigènes viraux (immunologie)</term>
<term>Cellules cultivées</term>
<term>Conformation des protéines</term>
<term>Données de séquences moléculaires</term>
<term>Fusion cellulaire</term>
<term>Glycoprotéine hémagglutinine du virus influenza</term>
<term>Hémagglutinines virales (génétique)</term>
<term>Hémagglutinines virales (immunologie)</term>
<term>Modèles moléculaires</term>
<term>Orthomyxoviridae (génétique)</term>
<term>Orthomyxoviridae (immunologie)</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
<term>Spécificité d'espèce</term>
<term>Spécificité des anticorps</term>
<term>Séquence conservée</term>
<term>Séquence d'acides aminés</term>
<term>Séquence nucléotidique</term>
<term>Tests de neutralisation</term>
<term>Épitopes</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Antigens, Viral</term>
<term>Hemagglutinins, Viral</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="immunology" xml:lang="en"><term>Antibodies, Monoclonal</term>
<term>Antibodies, Viral</term>
<term>Antigens, Viral</term>
<term>Hemagglutinins, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Orthomyxoviridae</term>
</keywords>
<keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Antigènes viraux</term>
<term>Hémagglutinines virales</term>
<term>Orthomyxoviridae</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Anticorps antiviraux</term>
<term>Anticorps monoclonaux</term>
<term>Antigènes viraux</term>
<term>Hémagglutinines virales</term>
<term>Orthomyxoviridae</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Orthomyxoviridae</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Amino Acid Sequence</term>
<term>Animals</term>
<term>Antibody Specificity</term>
<term>Base Sequence</term>
<term>Cell Fusion</term>
<term>Cells, Cultured</term>
<term>Conserved Sequence</term>
<term>Epitopes</term>
<term>Hemagglutinin Glycoproteins, Influenza Virus</term>
<term>Mice</term>
<term>Mice, Inbred BALB C</term>
<term>Models, Molecular</term>
<term>Molecular Sequence Data</term>
<term>Neutralization Tests</term>
<term>Protein Conformation</term>
<term>Species Specificity</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Animaux</term>
<term>Cellules cultivées</term>
<term>Conformation des protéines</term>
<term>Données de séquences moléculaires</term>
<term>Fusion cellulaire</term>
<term>Glycoprotéine hémagglutinine du virus influenza</term>
<term>Modèles moléculaires</term>
<term>Souris</term>
<term>Souris de lignée BALB C</term>
<term>Spécificité d'espèce</term>
<term>Spécificité des anticorps</term>
<term>Séquence conservée</term>
<term>Séquence d'acides aminés</term>
<term>Séquence nucléotidique</term>
<term>Tests de neutralisation</term>
<term>Épitopes</term>
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<front><div type="abstract" xml:lang="en"><p>When mice were immunized with the A/Okuda/57 (H2N2) strain of influenza virus, a unique monoclonal antibody designated C179 was obtained. Although C179 was confirmed to recognize the hemagglutinin (HA) glycoprotein by immunoprecipitation assays, it did not show hemagglutination inhibition activity to any of the strains of the three subtypes of influenza A virus. However, it neutralized all of the H1 and H2 strains but not the H3 strains. Moreover, it inhibited polykaryon formation induced by the H1 and H2 strains but not by the H3 strains. Two antigenic variants against C179 were obtained, and nucleotide sequence analysis revealed that amino acid sequences, from 318 to 322 of HA1 and from 47 to 58 of HA2, conserved among H1 and H2 strains were responsible for the recognition of C179. Since the two sites were located close to each other at the middle of the stem region of the HA molecule, C179 seemed to recognize these sites conformationally. These data indicated that binding of C179 to the stem region of HA inhibits the fusion activity of HA and thus results in virus neutralization and inhibition of cell-cell fusion. This is the first report which describes the presence of conserved antigenic sites on HA not only in a specific subtype but also in two subtypes of influenza A virus.</p>
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A common neutralizing epitope conserved between the hemagglutinins of influenza A virus H1 and H2 strains

A common neutralizing epitope conserved between the hemagglutinins of influenza A virus H1 and H2 strains

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