A common neutralizing epitope conserved between the hemagglutinins of influenza A virus H1 and H2 strains
Identifieur interne : 000103 ( PascalFrancis/Checkpoint ); précédent : 000102; suivant : 000104A common neutralizing epitope conserved between the hemagglutinins of influenza A virus H1 and H2 strains
Auteurs : Y. Okuno [Japon] ; Y. Isegawa ; F. Sasao ; S. UedaSource :
- Journal of virology [ 0022-538X ] ; 1993.
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Abstract
When mice were immunized with the A/Okuda/57 (H2N2) strain of influenza virus, a unique monoclonal antibody designated C179 was obtained. Although C179 was confirmed to recognize the hemagglutinin (HA) glycoprotein by immunoprecipitation assays, it did not show hemagglutination inhibition activity to any of the strains of the three subtypes of influenza A virus. However, it neutralized all of the H1 and H2 strains but not the H3 strains. Moreover, it inhibited polykaryon formation induced by the H1 and H2 strains but not by the H3 strains. Two antigenic variants against C179 were obtained, and nucleotide sequence analysis revealed that amino acid sequences, from 318 to 322 of HA, and from 47 to 58 of HA2, conserved among H1 and H2 strains were responsible for the recognition of C179
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Ueda</name></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">93-0479202</idno><date when="1993">1993</date><idno type="stanalyst">PASCAL 93-0479202 INIST</idno><idno type="RBID">Pascal:93-0479202</idno><idno type="wicri:Area/PascalFrancis/Corpus">000101</idno><idno type="wicri:Area/PascalFrancis/Curation">000113</idno><idno type="wicri:Area/PascalFrancis/Checkpoint">000103</idno><idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000103</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">A common neutralizing epitope conserved between the hemagglutinins of influenza A virus H1 and H2 strains</title><author><name sortKey="Okuno, Y" sort="Okuno, Y" uniqKey="Okuno Y" first="Y." last="Okuno">Y. Okuno</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Osaka univ., res. inst. microbial diseases, dep. preventive medicine</s1><s2>Suita, Osaka 565</s2><s3>JPN</s3></inist:fA14><country>Japon</country><wicri:noRegion>Suita, Osaka 565</wicri:noRegion></affiliation></author><author><name sortKey="Isegawa, Y" sort="Isegawa, Y" uniqKey="Isegawa Y" first="Y." last="Isegawa">Y. Isegawa</name></author><author><name sortKey="Sasao, F" sort="Sasao, F" uniqKey="Sasao F" first="F." last="Sasao">F. Sasao</name></author><author><name sortKey="Ueda, S" sort="Ueda, S" uniqKey="Ueda S" first="S." last="Ueda">S. Ueda</name></author></analytic><series><title level="j" type="main">Journal of virology</title><title level="j" type="abbreviated">J. virol.</title><idno type="ISSN">0022-538X</idno><imprint><date when="1993">1993</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Journal of virology</title><title level="j" type="abbreviated">J. virol.</title><idno type="ISSN">0022-538X</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Aminoacid sequence</term><term>Antigenic determinant</term><term>Cell fusion</term><term>Comparative study</term><term>Glycoproteins</term><term>Hemagglutinin</term><term>Hybridoma</term><term>Infected cell</term><term>Influenzavirus A</term><term>Monoclonal antibody</term><term>Neutralization</term><term>Strain</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Influenzavirus A</term><term>Hémagglutinine</term><term>Glycoprotéine</term><term>Déterminant antigénique</term><term>Anticorps monoclonal</term><term>Hybridome</term><term>Neutralisation</term><term>Fusion cellulaire</term><term>Cellule infectée</term><term>Etude comparative</term><term>Souche</term><term>Séquence aminoacide</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">When mice were immunized with the A/Okuda/57 (H2N2) strain of influenza virus, a unique monoclonal antibody designated C179 was obtained. Although C179 was confirmed to recognize the hemagglutinin (HA) glycoprotein by immunoprecipitation assays, it did not show hemagglutination inhibition activity to any of the strains of the three subtypes of influenza A virus. However, it neutralized all of the H1 and H2 strains but not the H3 strains. Moreover, it inhibited polykaryon formation induced by the H1 and H2 strains but not by the H3 strains. Two antigenic variants against C179 were obtained, and nucleotide sequence analysis revealed that amino acid sequences, from 318 to 322 of HA, and from 47 to 58 of HA<sub>2</sub>, conserved among H1 and H2 strains were responsible for the recognition of C179</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0022-538X</s0></fA01><fA03 i2="1"><s0>J. virol.</s0></fA03><fA05><s2>67</s2></fA05><fA06><s2>5</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>A common neutralizing epitope conserved between the hemagglutinins of influenza A virus H1 and H2 strains</s1></fA08><fA11 i1="01" i2="1"><s1>OKUNO (Y.)</s1></fA11><fA11 i1="02" i2="1"><s1>ISEGAWA (Y.)</s1></fA11><fA11 i1="03" i2="1"><s1>SASAO (F.)</s1></fA11><fA11 i1="04" i2="1"><s1>UEDA (S.)</s1></fA11><fA14 i1="01"><s1>Osaka univ., res. inst. microbial diseases, dep. preventive medicine</s1><s2>Suita, Osaka 565</s2><s3>JPN</s3></fA14><fA20><s1>2552-2558</s1></fA20><fA21><s1>1993</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>13592</s2><s5>354000036324610160</s5></fA43><fA44><s0>0000</s0></fA44><fA45><s0>50 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>93-0479202</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i2="1"><s0>Journal of virology</s0></fA64><fA66 i1="01"><s0>USA</s0></fA66><fC01 i1="01" l="ENG"><s0>When mice were immunized with the A/Okuda/57 (H2N2) strain of influenza virus, a unique monoclonal antibody designated C179 was obtained. 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Isegawa</name><name sortKey="Sasao, F" sort="Sasao, F" uniqKey="Sasao F" first="F." last="Sasao">F. Sasao</name><name sortKey="Ueda, S" sort="Ueda, S" uniqKey="Ueda S" first="S." last="Ueda">S. Ueda</name></noCountry><country name="Japon"><noRegion><name sortKey="Okuno, Y" sort="Okuno, Y" uniqKey="Okuno Y" first="Y." last="Okuno">Y. Okuno</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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