H2N2V1, PascalFrancis, Curation, bibRecord, 000113

A common neutralizing epitope conserved between the hemagglutinins of influenza A virus H1 and H2 strains

Identifieur interne : 000113 ( PascalFrancis/Curation ); précédent : 000112; suivant : 000114

A common neutralizing epitope conserved between the hemagglutinins of influenza A virus H1 and H2 strains

Auteurs : Y. Okuno [Japon] ; Y. Isegawa ; F. Sasao ; S. Ueda

Source :

Journal of virology [ 0022-538X ] ; 1993.

RBID : Pascal:93-0479202

Descripteurs français

Pascal (Inist)
- Influenzavirus A, Hémagglutinine, Glycoprotéine, Déterminant antigénique, Anticorps monoclonal, Hybridome, Neutralisation, Fusion cellulaire, Cellule infectée, Etude comparative, Souche, Séquence aminoacide.

English descriptors

KwdEn :
- Aminoacid sequence, Antigenic determinant, Cell fusion, Comparative study, Glycoproteins, Hemagglutinin, Hybridoma, Infected cell, Influenzavirus A, Monoclonal antibody, Neutralization, Strain.

Abstract

When mice were immunized with the A/Okuda/57 (H2N2) strain of influenza virus, a unique monoclonal antibody designated C179 was obtained. Although C179 was confirmed to recognize the hemagglutinin (HA) glycoprotein by immunoprecipitation assays, it did not show hemagglutination inhibition activity to any of the strains of the three subtypes of influenza A virus. However, it neutralized all of the H1 and H2 strains but not the H3 strains. Moreover, it inhibited polykaryon formation induced by the H1 and H2 strains but not by the H3 strains. Two antigenic variants against C179 were obtained, and nucleotide sequence analysis revealed that amino acid sequences, from 318 to 322 of HA, and from 47 to 58 of HA₂, conserved among H1 and H2 strains were responsible for the recognition of C179

A01	`01`	`1`		`@0 0022-538X`
A03		`1`		`@0 J. virol.`
A05				`@2 67`
A06				`@2 5`
A08	`01`	`1`	`ENG`	`@1 A common neutralizing epitope conserved between the hemagglutinins of influenza A virus H1 and H2 strains`
A11	`01`	`1`		`@1 OKUNO (Y.)`
A11	`02`	`1`		`@1 ISEGAWA (Y.)`
A11	`03`	`1`		`@1 SASAO (F.)`
A11	`04`	`1`		`@1 UEDA (S.)`
A14	`01`			`@1 Osaka univ., res. inst. microbial diseases, dep. preventive medicine @2 Suita, Osaka 565 @3 JPN`
A20				`@1 2552-2558`
A21				`@1 1993`
A23	`01`			`@0 ENG`
A43	`01`			`@1 INIST @2 13592 @5 354000036324610160`
A44				`@0 0000`
A45				`@0 50 ref.`
A47	`01`	`1`		`@0 93-0479202`
A60				`@1 P`
A61				`@0 A`
A64		`1`		`@0 Journal of virology`
A66	`01`			`@0 USA`
C01	`01`		`ENG`	@0 When mice were immunized with the A/Okuda/57 (H2N2) strain of influenza virus, a unique monoclonal antibody designated C179 was obtained. Although C179 was confirmed to recognize the hemagglutinin (HA) glycoprotein by immunoprecipitation assays, it did not show hemagglutination inhibition activity to any of the strains of the three subtypes of influenza A virus. However, it neutralized all of the H1 and H2 strains but not the H3 strains. Moreover, it inhibited polykaryon formation induced by the H1 and H2 strains but not by the H3 strains. Two antigenic variants against C179 were obtained, and nucleotide sequence analysis revealed that amino acid sequences, from 318 to 322 of HA, and from 47 to 58 of HA₂, conserved among H1 and H2 strains were responsible for the recognition of C179
C02	`01`	`X`		`@0 002A06B02A`
C03	`01`	`X`	`FRE`	`@0 Influenzavirus A @2 NW`
C03	`01`	`X`	`ENG`	`@0 Influenzavirus A @2 NW`
C03	`01`	`X`	`SPA`	`@0 Influenzavirus A @2 NW`
C03	`02`	`X`	`FRE`	`@0 Hémagglutinine`
C03	`02`	`X`	`ENG`	`@0 Hemagglutinin`
C03	`02`	`X`	`SPA`	`@0 Hemoaglutinina`
C03	`03`	`X`	`FRE`	`@0 Glycoprotéine`
C03	`03`	`X`	`ENG`	`@0 Glycoproteins`
C03	`03`	`X`	`SPA`	`@0 Glicoproteina`
C03	`04`	`X`	`FRE`	`@0 Déterminant antigénique`
C03	`04`	`X`	`ENG`	`@0 Antigenic determinant`
C03	`04`	`X`	`SPA`	`@0 Determinante antigénico`
C03	`05`	`X`	`FRE`	`@0 Anticorps monoclonal`
C03	`05`	`X`	`ENG`	`@0 Monoclonal antibody`
C03	`05`	`X`	`SPA`	`@0 Anticuerpo monoclonal`
C03	`06`	`X`	`FRE`	`@0 Hybridome`
C03	`06`	`X`	`ENG`	`@0 Hybridoma`
C03	`06`	`X`	`SPA`	`@0 Hibridoma`
C03	`07`	`X`	`FRE`	`@0 Neutralisation`
C03	`07`	`X`	`ENG`	`@0 Neutralization`
C03	`07`	`X`	`GER`	`@0 Neutralisation`
C03	`07`	`X`	`SPA`	`@0 Neutralización`
C03	`08`	`X`	`FRE`	`@0 Fusion cellulaire`
C03	`08`	`X`	`ENG`	`@0 Cell fusion`
C03	`08`	`X`	`SPA`	`@0 Fusión celular`
C03	`09`	`X`	`FRE`	`@0 Cellule infectée`
C03	`09`	`X`	`ENG`	`@0 Infected cell`
C03	`09`	`X`	`SPA`	`@0 Célula infectada`
C03	`10`	`X`	`FRE`	`@0 Etude comparative`
C03	`10`	`X`	`ENG`	`@0 Comparative study`
C03	`10`	`X`	`GER`	`@0 Vergleich`
C03	`10`	`X`	`SPA`	`@0 Estudio comparativo`
C03	`11`	`X`	`FRE`	`@0 Souche`
C03	`11`	`X`	`ENG`	`@0 Strain`
C03	`11`	`X`	`SPA`	`@0 Cepa`
C03	`12`	`X`	`FRE`	`@0 Séquence aminoacide`
C03	`12`	`X`	`ENG`	`@0 Aminoacid sequence`
C03	`12`	`X`	`SPA`	`@0 Secuencia aminoácido`
C07	`01`	`X`	`FRE`	`@0 Influenzavirus @2 NW`
C07	`01`	`X`	`ENG`	`@0 Influenzavirus @2 NW`
C07	`01`	`X`	`SPA`	`@0 Influenzavirus @2 NW`
C07	`02`	`X`	`FRE`	`@0 Orthomyxoviridae @2 NW`
C07	`02`	`X`	`ENG`	`@0 Orthomyxoviridae @2 NW`
C07	`02`	`X`	`SPA`	`@0 Orthomyxoviridae @2 NW`
C07	`03`	`X`	`FRE`	`@0 Virus @2 NW`
C07	`03`	`X`	`ENG`	`@0 Virus @2 NW`
C07	`03`	`X`	`SPA`	`@0 Virus @2 NW`
N21				`@1 248`

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Le document en format XML

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<author><name sortKey="Okuno, Y" sort="Okuno, Y" uniqKey="Okuno Y" first="Y." last="Okuno">Y. Okuno</name>
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<s2>Suita, Osaka 565</s2>
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<country>Japon</country>
</affiliation>
</author>
<author><name sortKey="Isegawa, Y" sort="Isegawa, Y" uniqKey="Isegawa Y" first="Y." last="Isegawa">Y. Isegawa</name>
</author>
<author><name sortKey="Sasao, F" sort="Sasao, F" uniqKey="Sasao F" first="F." last="Sasao">F. Sasao</name>
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<author><name sortKey="Ueda, S" sort="Ueda, S" uniqKey="Ueda S" first="S." last="Ueda">S. Ueda</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">A common neutralizing epitope conserved between the hemagglutinins of influenza A virus H1 and H2 strains</title>
<author><name sortKey="Okuno, Y" sort="Okuno, Y" uniqKey="Okuno Y" first="Y." last="Okuno">Y. Okuno</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>Osaka univ., res. inst. microbial diseases, dep. preventive medicine</s1>
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<series><title level="j" type="main">Journal of virology</title>
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<front><div type="abstract" xml:lang="en">When mice were immunized with the A/Okuda/57 (H2N2) strain of influenza virus, a unique monoclonal antibody designated C179 was obtained. Although C179 was confirmed to recognize the hemagglutinin (HA) glycoprotein by immunoprecipitation assays, it did not show hemagglutination inhibition activity to any of the strains of the three subtypes of influenza A virus. However, it neutralized all of the H1 and H2 strains but not the H3 strains. Moreover, it inhibited polykaryon formation induced by the H1 and H2 strains but not by the H3 strains. Two antigenic variants against C179 were obtained, and nucleotide sequence analysis revealed that amino acid sequences, from 318 to 322 of HA, and from 47 to 58 of HA<sub>2</sub>
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A common neutralizing epitope conserved between the hemagglutinins of influenza A virus H1 and H2 strains

A common neutralizing epitope conserved between the hemagglutinins of influenza A virus H1 and H2 strains

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Descripteurs français

English descriptors

Abstract

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