Immuno-epidemiologic Correlates of Pandemic H1N1 Surveillance Observations: Higher Antibody and Lower Cell-Mediated Immune Responses with Advanced Age
Identifieur interne : 000D63 ( Main/Curation ); précédent : 000D62; suivant : 000D64Immuno-epidemiologic Correlates of Pandemic H1N1 Surveillance Observations: Higher Antibody and Lower Cell-Mediated Immune Responses with Advanced Age
Auteurs : Danuta M. Skowronski [Canada] ; Travis S. Hottes [Canada] ; Janet E. Mcelhaney [Canada] ; Naveed Z. Janjua [Canada] ; Suzana Sabaiduc [Canada] ; Tracy Chan [Canada] ; Beth Gentleman [Canada] ; Dale Purych [Canada] ; Jennifer Gardy [Canada] ; David M. Patrick [Canada] ; Robert C. Brunham [Canada] ; Gaston De Serres [Canada] ; Martin Petric [Canada]Source :
- The Journal of infectious diseases [ 0022-1899 ] ; 2011.
Descripteurs français
- KwdFr :
- Adolescent, Adulte, Adulte d'âge moyen, Anticorps antiviraux (sang), Enfant, Enfant d'âge préscolaire, Facteurs de l'âge, Femelle, Grippe humaine (immunologie), Grippe humaine (virologie), Grippe humaine (épidémiologie), Humains, Jeune adulte, Lymphocytes (immunologie), Mâle, Nourrisson, Nouveau-né, Pandémies, Sous-type H1N1 du virus de la grippe A (immunologie), Sous-type H2N2 du virus de la grippe A (immunologie), Sous-type H3N2 du virus de la grippe A (immunologie), Sujet âgé, Sujet âgé de 80 ans ou plus, Tests d'inhibition de l'hémagglutination, Tests de neutralisation.
- MESH :
- immunologie : Grippe humaine, Lymphocytes, Sous-type H1N1 du virus de la grippe A, Sous-type H2N2 du virus de la grippe A, Sous-type H3N2 du virus de la grippe A.
- sang : Anticorps antiviraux.
- virologie : Grippe humaine.
- épidémiologie : Grippe humaine.
- Pascal (Inist)
- Adolescent, Adulte, Adulte d'âge moyen, Anticorps, Enfant, Enfant d'âge préscolaire, Facteurs de l'âge, Femelle, Humains, Jeune adulte, Mâle, Nourrisson, Nouveau-né, Pandémies, Réponse immune, Age, Infection, Sujet âgé, Sujet âgé de 80 ans ou plus, Tests d'inhibition de l'hémagglutination, Tests de neutralisation, Virus grippal A(H1N1).
English descriptors
- KwdEn :
- Adolescent, Adult, Age, Age Factors, Aged, Aged, 80 and over, Antibodies, Viral (blood), Antibody, Child, Child, Preschool, Female, Hemagglutination Inhibition Tests, Humans, Immune response, Infant, Infant, Newborn, Infection, Influenza A Virus, H1N1 Subtype (immunology), Influenza A Virus, H2N2 Subtype (immunology), Influenza A Virus, H3N2 Subtype (immunology), Influenza, Human (epidemiology), Influenza, Human (immunology), Influenza, Human (virology), Influenzavirus A(H1N1), Lymphocytes (immunology), Male, Middle Aged, Neutralization Tests, Pandemics, Young Adult.
- MESH :
- chemical , blood : Antibodies, Viral.
- epidemiology : Influenza, Human.
- immunology : Influenza A Virus, H1N1 Subtype, Influenza A Virus, H2N2 Subtype, Influenza A Virus, H3N2 Subtype, Influenza, Human, Lymphocytes.
- virology : Influenza, Human.
- Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Child, Child, Preschool, Female, Hemagglutination Inhibition Tests, Humans, Infant, Infant, Newborn, Male, Middle Aged, Neutralization Tests, Pandemics, Young Adult.
Abstract
Background. Pandemic H1N1 (pH1N1) surveillance data showed lower attack rates but higher risk of severe outcomes with advanced age. We explored immuno-epidemiologic correlates of surveillance findings including humoral and cell-mediated immunity (CMI). Methods. In an age-based design, ∼100 banked/residual sera per 10-year age stratum were assessed by hemagglutination inhibition (HI) and microneutralization (MN) assays for preexisting antibody to pH1N1 and recent seasonal H1N1 and H3N2 strains. In a separate birth cohort design defined by childhood influenza A/subtype priming (1919-1929: H1N1; 1945-1949: H1N1; 1958-1960: H2N2; 1969-1970: H3N2; 1978-1989: H3N2/H1N1), whole blood was collected from up to 50 volunteers per birth cohort. The ratio of Th1(IFN-γ):Th2(IL-10) cytokine responses was evaluated in vitro. Results. Antibody to seasonal viruses was highest in school-age children. Cross-reactive HI/MN antibody to pH1N1 was low among participants <70 years of age (yoa; 6%/4% ≥ 40), but seroprevalence increased at 70-79 yoa (27%/6%), increased even more at 80-89 yoa (65%/47%), and was highest at ≥90 yoa (88%/76%). CMI to pH1N1 was evident in all 5 birth cohorts but was lower compared with seasonal strains. There was little differentiation by subtype priming, but the Th1:Th2 ratio for all viruses dropped significantly in the 2 oldest cohorts. Conclusions. Preexisting antibody may have protected the very old from pH1N1 infection, while diminished CMI may have contributed to greater severity once infected. In the young, cross-reactive pH1N1 antibody was mostly absent, while more intact CMI may have protected against severe outcomes.
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Pascal:11-0131918Le document en format XML
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<author><name sortKey="Purych, Dale" sort="Purych, Dale" uniqKey="Purych D" first="Dale" last="Purych">Dale Purych</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>BC Biomedical Laboratories Ltd</s1>
<s2>Surrey, British Columbia</s2>
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<wicri:noRegion>BC Biomedical Laboratories Ltd</wicri:noRegion>
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<author><name sortKey="Gardy, Jennifer" sort="Gardy, Jennifer" uniqKey="Gardy J" first="Jennifer" last="Gardy">Jennifer Gardy</name>
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<wicri:noRegion>British Columbia Centre for Disease Control, University of British Columbia</wicri:noRegion>
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<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Microbiology and Immunology, University of British Columbia</s1>
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<wicri:noRegion>Department of Microbiology and Immunology, University of British Columbia</wicri:noRegion>
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<author><name sortKey="Patrick, David M" sort="Patrick, David M" uniqKey="Patrick D" first="David M." last="Patrick">David M. Patrick</name>
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<author><name sortKey="Brunham, Robert C" sort="Brunham, Robert C" uniqKey="Brunham R" first="Robert C." last="Brunham">Robert C. Brunham</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>British Columbia Centre for Disease Control, University of British Columbia</s1>
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<country>Canada</country>
<wicri:noRegion>Department of Medicine, University of British Columbia</wicri:noRegion>
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</author>
<author><name sortKey="De Serres, Gaston" sort="De Serres, Gaston" uniqKey="De Serres G" first="Gaston" last="De Serres">Gaston De Serres</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Institut national de santé publique du Québec, Université Laval</s1>
<s2>Québec</s2>
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<sZ>12 aut.</sZ>
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<country>Canada</country>
<wicri:noRegion>Québec</wicri:noRegion>
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<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department of Social and Preventive Medicine, Université Laval</s1>
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<s3>CAN</s3>
<sZ>12 aut.</sZ>
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<country>Canada</country>
<wicri:noRegion>Québec</wicri:noRegion>
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<author><name sortKey="Petric, Martin" sort="Petric, Martin" uniqKey="Petric M" first="Martin" last="Petric">Martin Petric</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>British Columbia Centre for Disease Control, University of British Columbia</s1>
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<country>Canada</country>
<wicri:noRegion>British Columbia Centre for Disease Control, University of British Columbia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Pathology and Laboratory Medicine, University of British Columbia</s1>
<s3>CAN</s3>
<sZ>13 aut.</sZ>
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<country>Canada</country>
<wicri:noRegion>Department of Pathology and Laboratory Medicine, University of British Columbia</wicri:noRegion>
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<series><title level="j" type="main">The Journal of infectious diseases</title>
<title level="j" type="abbreviated">J. infect. dis.</title>
<idno type="ISSN">0022-1899</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">The Journal of infectious diseases</title>
<title level="j" type="abbreviated">J. infect. dis.</title>
<idno type="ISSN">0022-1899</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Age</term>
<term>Age Factors</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Antibodies, Viral (blood)</term>
<term>Antibody</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Female</term>
<term>Hemagglutination Inhibition Tests</term>
<term>Humans</term>
<term>Immune response</term>
<term>Infant</term>
<term>Infant, Newborn</term>
<term>Infection</term>
<term>Influenza A Virus, H1N1 Subtype (immunology)</term>
<term>Influenza A Virus, H2N2 Subtype (immunology)</term>
<term>Influenza A Virus, H3N2 Subtype (immunology)</term>
<term>Influenza, Human (epidemiology)</term>
<term>Influenza, Human (immunology)</term>
<term>Influenza, Human (virology)</term>
<term>Influenzavirus A(H1N1)</term>
<term>Lymphocytes (immunology)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neutralization Tests</term>
<term>Pandemics</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Anticorps antiviraux (sang)</term>
<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Facteurs de l'âge</term>
<term>Femelle</term>
<term>Grippe humaine (immunologie)</term>
<term>Grippe humaine (virologie)</term>
<term>Grippe humaine (épidémiologie)</term>
<term>Humains</term>
<term>Jeune adulte</term>
<term>Lymphocytes (immunologie)</term>
<term>Mâle</term>
<term>Nourrisson</term>
<term>Nouveau-né</term>
<term>Pandémies</term>
<term>Sous-type H1N1 du virus de la grippe A (immunologie)</term>
<term>Sous-type H2N2 du virus de la grippe A (immunologie)</term>
<term>Sous-type H3N2 du virus de la grippe A (immunologie)</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Tests d'inhibition de l'hémagglutination</term>
<term>Tests de neutralisation</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Grippe humaine</term>
<term>Lymphocytes</term>
<term>Sous-type H1N1 du virus de la grippe A</term>
<term>Sous-type H2N2 du virus de la grippe A</term>
<term>Sous-type H3N2 du virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term>
<term>Influenza A Virus, H2N2 Subtype</term>
<term>Influenza A Virus, H3N2 Subtype</term>
<term>Influenza, Human</term>
<term>Lymphocytes</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe humaine</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Grippe humaine</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Age Factors</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Female</term>
<term>Hemagglutination Inhibition Tests</term>
<term>Humans</term>
<term>Infant</term>
<term>Infant, Newborn</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neutralization Tests</term>
<term>Pandemics</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Anticorps</term>
<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Facteurs de l'âge</term>
<term>Femelle</term>
<term>Humains</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Nourrisson</term>
<term>Nouveau-né</term>
<term>Pandémies</term>
<term>Réponse immune</term>
<term>Age</term>
<term>Infection</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Tests d'inhibition de l'hémagglutination</term>
<term>Tests de neutralisation</term>
<term>Virus grippal A(H1N1)</term>
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<front><div type="abstract" xml:lang="en">Background. Pandemic H1N1 (pH1N1) surveillance data showed lower attack rates but higher risk of severe outcomes with advanced age. We explored immuno-epidemiologic correlates of surveillance findings including humoral and cell-mediated immunity (CMI). Methods. In an age-based design, ∼100 banked/residual sera per 10-year age stratum were assessed by hemagglutination inhibition (HI) and microneutralization (MN) assays for preexisting antibody to pH1N1 and recent seasonal H1N1 and H3N2 strains. In a separate birth cohort design defined by childhood influenza A/subtype priming (1919-1929: H1N1; 1945-1949: H1N1; 1958-1960: H2N2; 1969-1970: H3N2; 1978-1989: H3N2/H1N1), whole blood was collected from up to 50 volunteers per birth cohort. The ratio of Th1(IFN-γ):Th2(IL-10) cytokine responses was evaluated in vitro. Results. Antibody to seasonal viruses was highest in school-age children. Cross-reactive HI/MN antibody to pH1N1 was low among participants <70 years of age (yoa; 6%/4% ≥ 40), but seroprevalence increased at 70-79 yoa (27%/6%), increased even more at 80-89 yoa (65%/47%), and was highest at ≥90 yoa (88%/76%). CMI to pH1N1 was evident in all 5 birth cohorts but was lower compared with seasonal strains. There was little differentiation by subtype priming, but the Th1:Th2 ratio for all viruses dropped significantly in the 2 oldest cohorts. Conclusions. Preexisting antibody may have protected the very old from pH1N1 infection, while diminished CMI may have contributed to greater severity once infected. In the young, cross-reactive pH1N1 antibody was mostly absent, while more intact CMI may have protected against severe outcomes.</div>
</front>
</TEI>
<double idat="0022-1899:2011:Skowronski D:immuno:epidemiologic:correlates"><INIST><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Immuno-epidemiologic Correlates of Pandemic H1N1 Surveillance Observations: Higher Antibody and Lower Cell-Mediated Immune Responses with Advanced Age</title>
<author><name sortKey="Skowronski, Danuta M" sort="Skowronski, Danuta M" uniqKey="Skowronski D" first="Danuta M." last="Skowronski">Danuta M. Skowronski</name>
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</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>School of Population and Public Health, University of British Columbia</s1>
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<country>Canada</country>
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</affiliation>
</author>
<author><name sortKey="Hottes, Travis S" sort="Hottes, Travis S" uniqKey="Hottes T" first="Travis S." last="Hottes">Travis S. Hottes</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>British Columbia Centre for Disease Control, University of British Columbia</s1>
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</affiliation>
</author>
<author><name sortKey="Mcelhaney, Janet E" sort="Mcelhaney, Janet E" uniqKey="Mcelhaney J" first="Janet E." last="Mcelhaney">Janet E. Mcelhaney</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Medicine, University of British Columbia</s1>
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<country>Canada</country>
<wicri:noRegion>Department of Medicine, University of British Columbia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Vancouver Coastal Health Research Institute</s1>
<s2>Vancouver</s2>
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<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Vancouver Coastal Health Research Institute</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Janjua, Naveed Z" sort="Janjua, Naveed Z" uniqKey="Janjua N" first="Naveed Z." last="Janjua">Naveed Z. Janjua</name>
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<author><name sortKey="Sabaiduc, Suzana" sort="Sabaiduc, Suzana" uniqKey="Sabaiduc S" first="Suzana" last="Sabaiduc">Suzana Sabaiduc</name>
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</affiliation>
</author>
<author><name sortKey="Chan, Tracy" sort="Chan, Tracy" uniqKey="Chan T" first="Tracy" last="Chan">Tracy Chan</name>
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<author><name sortKey="De Serres, Gaston" sort="De Serres, Gaston" uniqKey="De Serres G" first="Gaston" last="De Serres">Gaston De Serres</name>
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<sZ>12 aut.</sZ>
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<country>Canada</country>
<wicri:noRegion>Québec</wicri:noRegion>
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<author><name sortKey="Petric, Martin" sort="Petric, Martin" uniqKey="Petric M" first="Martin" last="Petric">Martin Petric</name>
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<sZ>13 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Department of Pathology and Laboratory Medicine, University of British Columbia</wicri:noRegion>
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</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">11-0131918</idno>
<date when="2011">2011</date>
<idno type="stanalyst">PASCAL 11-0131918 INIST</idno>
<idno type="RBID">Pascal:11-0131918</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000015</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000059</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000013</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000013</idno>
<idno type="wicri:doubleKey">0022-1899:2011:Skowronski D:immuno:epidemiologic:correlates</idno>
<idno type="wicri:Area/Main/Merge">000D68</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Immuno-epidemiologic Correlates of Pandemic H1N1 Surveillance Observations: Higher Antibody and Lower Cell-Mediated Immune Responses with Advanced Age</title>
<author><name sortKey="Skowronski, Danuta M" sort="Skowronski, Danuta M" uniqKey="Skowronski D" first="Danuta M." last="Skowronski">Danuta M. Skowronski</name>
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</affiliation>
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<country>Canada</country>
<wicri:noRegion>School of Population and Public Health, University of British Columbia</wicri:noRegion>
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</author>
<author><name sortKey="Hottes, Travis S" sort="Hottes, Travis S" uniqKey="Hottes T" first="Travis S." last="Hottes">Travis S. Hottes</name>
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</affiliation>
</author>
<author><name sortKey="Mcelhaney, Janet E" sort="Mcelhaney, Janet E" uniqKey="Mcelhaney J" first="Janet E." last="Mcelhaney">Janet E. Mcelhaney</name>
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<country>Canada</country>
<wicri:noRegion>Department of Medicine, University of British Columbia</wicri:noRegion>
</affiliation>
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<sZ>3 aut.</sZ>
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</inist:fA14>
<country>Canada</country>
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</affiliation>
</author>
<author><name sortKey="Janjua, Naveed Z" sort="Janjua, Naveed Z" uniqKey="Janjua N" first="Naveed Z." last="Janjua">Naveed Z. Janjua</name>
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<author><name sortKey="Sabaiduc, Suzana" sort="Sabaiduc, Suzana" uniqKey="Sabaiduc S" first="Suzana" last="Sabaiduc">Suzana Sabaiduc</name>
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</author>
<author><name sortKey="Chan, Tracy" sort="Chan, Tracy" uniqKey="Chan T" first="Tracy" last="Chan">Tracy Chan</name>
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</affiliation>
</author>
<author><name sortKey="Gentleman, Beth" sort="Gentleman, Beth" uniqKey="Gentleman B" first="Beth" last="Gentleman">Beth Gentleman</name>
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<sZ>11 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Department of Medicine, University of British Columbia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Vancouver Coastal Health Research Institute</s1>
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<sZ>3 aut.</sZ>
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</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Vancouver Coastal Health Research Institute</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Purych, Dale" sort="Purych, Dale" uniqKey="Purych D" first="Dale" last="Purych">Dale Purych</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>BC Biomedical Laboratories Ltd</s1>
<s2>Surrey, British Columbia</s2>
<s3>CAN</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>BC Biomedical Laboratories Ltd</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gardy, Jennifer" sort="Gardy, Jennifer" uniqKey="Gardy J" first="Jennifer" last="Gardy">Jennifer Gardy</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>British Columbia Centre for Disease Control, University of British Columbia</s1>
<s3>CAN</s3>
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<sZ>13 aut.</sZ>
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<country>Canada</country>
<wicri:noRegion>British Columbia Centre for Disease Control, University of British Columbia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Microbiology and Immunology, University of British Columbia</s1>
<s3>CAN</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Department of Microbiology and Immunology, University of British Columbia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Patrick, David M" sort="Patrick, David M" uniqKey="Patrick D" first="David M." last="Patrick">David M. Patrick</name>
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<country>Canada</country>
<wicri:noRegion>British Columbia Centre for Disease Control, University of British Columbia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>School of Population and Public Health, University of British Columbia</s1>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>School of Population and Public Health, University of British Columbia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Brunham, Robert C" sort="Brunham, Robert C" uniqKey="Brunham R" first="Robert C." last="Brunham">Robert C. Brunham</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>British Columbia Centre for Disease Control, University of British Columbia</s1>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
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<country>Canada</country>
<wicri:noRegion>British Columbia Centre for Disease Control, University of British Columbia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Medicine, University of British Columbia</s1>
<s3>CAN</s3>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Department of Medicine, University of British Columbia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="De Serres, Gaston" sort="De Serres, Gaston" uniqKey="De Serres G" first="Gaston" last="De Serres">Gaston De Serres</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Institut national de santé publique du Québec, Université Laval</s1>
<s2>Québec</s2>
<s3>CAN</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Québec</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department of Social and Preventive Medicine, Université Laval</s1>
<s2>Québec</s2>
<s3>CAN</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Québec</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Petric, Martin" sort="Petric, Martin" uniqKey="Petric M" first="Martin" last="Petric">Martin Petric</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>British Columbia Centre for Disease Control, University of British Columbia</s1>
<s3>CAN</s3>
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</inist:fA14>
<country>Canada</country>
<wicri:noRegion>British Columbia Centre for Disease Control, University of British Columbia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Pathology and Laboratory Medicine, University of British Columbia</s1>
<s3>CAN</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Department of Pathology and Laboratory Medicine, University of British Columbia</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">The Journal of infectious diseases</title>
<title level="j" type="abbreviated">J. infect. dis.</title>
<idno type="ISSN">0022-1899</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">The Journal of infectious diseases</title>
<title level="j" type="abbreviated">J. infect. dis.</title>
<idno type="ISSN">0022-1899</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age</term>
<term>Antibody</term>
<term>Immune response</term>
<term>Infection</term>
<term>Influenzavirus A(H1N1)</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Anticorps</term>
<term>Réponse immune</term>
<term>Age</term>
<term>Infection</term>
<term>Virus grippal A(H1N1)</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Background. Pandemic H1N1 (pH1N1) surveillance data showed lower attack rates but higher risk of severe outcomes with advanced age. We explored immuno-epidemiologic correlates of surveillance findings including humoral and cell-mediated immunity (CMI). Methods. In an age-based design, ∼100 banked/residual sera per 10-year age stratum were assessed by hemagglutination inhibition (HI) and microneutralization (MN) assays for preexisting antibody to pH1N1 and recent seasonal H1N1 and H3N2 strains. In a separate birth cohort design defined by childhood influenza A/subtype priming (1919-1929: H1N1; 1945-1949: H1N1; 1958-1960: H2N2; 1969-1970: H3N2; 1978-1989: H3N2/H1N1), whole blood was collected from up to 50 volunteers per birth cohort. The ratio of Th1(IFN-γ):Th2(IL-10) cytokine responses was evaluated in vitro. Results. Antibody to seasonal viruses was highest in school-age children. Cross-reactive HI/MN antibody to pH1N1 was low among participants <70 years of age (yoa; 6%/4% ≥ 40), but seroprevalence increased at 70-79 yoa (27%/6%), increased even more at 80-89 yoa (65%/47%), and was highest at ≥90 yoa (88%/76%). CMI to pH1N1 was evident in all 5 birth cohorts but was lower compared with seasonal strains. There was little differentiation by subtype priming, but the Th1:Th2 ratio for all viruses dropped significantly in the 2 oldest cohorts. Conclusions. Preexisting antibody may have protected the very old from pH1N1 infection, while diminished CMI may have contributed to greater severity once infected. In the young, cross-reactive pH1N1 antibody was mostly absent, while more intact CMI may have protected against severe outcomes.</div>
</front>
</TEI>
</INIST>
<PMC><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Immuno-epidemiologic Correlates of Pandemic H1N1 Surveillance Observations: Higher Antibody and Lower Cell-Mediated Immune Responses with Advanced Age</title>
<author><name sortKey="Skowronski, Danuta M" sort="Skowronski, Danuta M" uniqKey="Skowronski D" first="Danuta M." last="Skowronski">Danuta M. Skowronski</name>
<affiliation><nlm:aff id="aff1">British Columbia Centre for Disease Control</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">School of Population and Public Health</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hottes, Travis S" sort="Hottes, Travis S" uniqKey="Hottes T" first="Travis S." last="Hottes">Travis S. Hottes</name>
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</affiliation>
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</affiliation>
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</affiliation>
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</affiliation>
</author>
<author><name sortKey="Sabaiduc, Suzana" sort="Sabaiduc, Suzana" uniqKey="Sabaiduc S" first="Suzana" last="Sabaiduc">Suzana Sabaiduc</name>
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</affiliation>
</author>
<author><name sortKey="Chan, Tracy" sort="Chan, Tracy" uniqKey="Chan T" first="Tracy" last="Chan">Tracy Chan</name>
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</affiliation>
</author>
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</affiliation>
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<country xml:lang="fr">Canada</country>
<wicri:regionArea>Vancouver Coastal Health Research Institute, Vancouver</wicri:regionArea>
<wicri:noRegion>Vancouver</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Purych, Dale" sort="Purych, Dale" uniqKey="Purych D" first="Dale" last="Purych">Dale Purych</name>
<affiliation><nlm:aff id="aff7">BC Biomedical Laboratories Ltd, Surrey, British Columbia</nlm:aff>
<wicri:noCountry code="subfield">British Columbia</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Gardy, Jennifer" sort="Gardy, Jennifer" uniqKey="Gardy J" first="Jennifer" last="Gardy">Jennifer Gardy</name>
<affiliation><nlm:aff id="aff1">British Columbia Centre for Disease Control</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff4">Department of Microbiology and Immunology</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Patrick, David M" sort="Patrick, David M" uniqKey="Patrick D" first="David M." last="Patrick">David M. Patrick</name>
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</affiliation>
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</affiliation>
</author>
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</affiliation>
<affiliation><nlm:aff id="aff3">Department of Medicine</nlm:aff>
</affiliation>
</author>
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<affiliation><nlm:aff id="aff8">Institut national de santé publique du Québec</nlm:aff>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff9">Department of Social and Preventive Medicine, Université Laval, Québec, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Social and Preventive Medicine, Université Laval, Québec</wicri:regionArea>
<wicri:noRegion>Québec</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Petric, Martin" sort="Petric, Martin" uniqKey="Petric M" first="Martin" last="Petric">Martin Petric</name>
<affiliation><nlm:aff id="aff1">British Columbia Centre for Disease Control</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff5">Department of Pathology and Laboratory Medicine, University of British Columbia</nlm:aff>
<wicri:noCountry code="subfield">University of British Columbia</wicri:noCountry>
</affiliation>
</author>
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<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Immuno-epidemiologic Correlates of Pandemic H1N1 Surveillance Observations: Higher Antibody and Lower Cell-Mediated Immune Responses with Advanced Age</title>
<author><name sortKey="Skowronski, Danuta M" sort="Skowronski, Danuta M" uniqKey="Skowronski D" first="Danuta M." last="Skowronski">Danuta M. Skowronski</name>
<affiliation><nlm:aff id="aff1">British Columbia Centre for Disease Control</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">School of Population and Public Health</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Hottes, Travis S" sort="Hottes, Travis S" uniqKey="Hottes T" first="Travis S." last="Hottes">Travis S. Hottes</name>
<affiliation><nlm:aff id="aff1">British Columbia Centre for Disease Control</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Mcelhaney, Janet E" sort="Mcelhaney, Janet E" uniqKey="Mcelhaney J" first="Janet E." last="Mcelhaney">Janet E. Mcelhaney</name>
<affiliation><nlm:aff id="aff3">Department of Medicine</nlm:aff>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff6">Vancouver Coastal Health Research Institute, Vancouver, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Vancouver Coastal Health Research Institute, Vancouver</wicri:regionArea>
<wicri:noRegion>Vancouver</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Janjua, Naveed Z" sort="Janjua, Naveed Z" uniqKey="Janjua N" first="Naveed Z." last="Janjua">Naveed Z. Janjua</name>
<affiliation><nlm:aff id="aff1">British Columbia Centre for Disease Control</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">School of Population and Public Health</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Sabaiduc, Suzana" sort="Sabaiduc, Suzana" uniqKey="Sabaiduc S" first="Suzana" last="Sabaiduc">Suzana Sabaiduc</name>
<affiliation><nlm:aff id="aff1">British Columbia Centre for Disease Control</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Chan, Tracy" sort="Chan, Tracy" uniqKey="Chan T" first="Tracy" last="Chan">Tracy Chan</name>
<affiliation><nlm:aff id="aff1">British Columbia Centre for Disease Control</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Gentleman, Beth" sort="Gentleman, Beth" uniqKey="Gentleman B" first="Beth" last="Gentleman">Beth Gentleman</name>
<affiliation><nlm:aff id="aff3">Department of Medicine</nlm:aff>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff6">Vancouver Coastal Health Research Institute, Vancouver, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Vancouver Coastal Health Research Institute, Vancouver</wicri:regionArea>
<wicri:noRegion>Vancouver</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Purych, Dale" sort="Purych, Dale" uniqKey="Purych D" first="Dale" last="Purych">Dale Purych</name>
<affiliation><nlm:aff id="aff7">BC Biomedical Laboratories Ltd, Surrey, British Columbia</nlm:aff>
<wicri:noCountry code="subfield">British Columbia</wicri:noCountry>
</affiliation>
</author>
<author><name sortKey="Gardy, Jennifer" sort="Gardy, Jennifer" uniqKey="Gardy J" first="Jennifer" last="Gardy">Jennifer Gardy</name>
<affiliation><nlm:aff id="aff1">British Columbia Centre for Disease Control</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff4">Department of Microbiology and Immunology</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Patrick, David M" sort="Patrick, David M" uniqKey="Patrick D" first="David M." last="Patrick">David M. Patrick</name>
<affiliation><nlm:aff id="aff1">British Columbia Centre for Disease Control</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff2">School of Population and Public Health</nlm:aff>
</affiliation>
</author>
<author><name sortKey="Brunham, Robert C" sort="Brunham, Robert C" uniqKey="Brunham R" first="Robert C." last="Brunham">Robert C. Brunham</name>
<affiliation><nlm:aff id="aff1">British Columbia Centre for Disease Control</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff3">Department of Medicine</nlm:aff>
</affiliation>
</author>
<author><name sortKey="De Serres, Gaston" sort="De Serres, Gaston" uniqKey="De Serres G" first="Gaston" last="De Serres">Gaston De Serres</name>
<affiliation><nlm:aff id="aff8">Institut national de santé publique du Québec</nlm:aff>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff9">Department of Social and Preventive Medicine, Université Laval, Québec, Canada</nlm:aff>
<country xml:lang="fr">Canada</country>
<wicri:regionArea>Department of Social and Preventive Medicine, Université Laval, Québec</wicri:regionArea>
<wicri:noRegion>Québec</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Petric, Martin" sort="Petric, Martin" uniqKey="Petric M" first="Martin" last="Petric">Martin Petric</name>
<affiliation><nlm:aff id="aff1">British Columbia Centre for Disease Control</nlm:aff>
</affiliation>
<affiliation><nlm:aff id="aff5">Department of Pathology and Laboratory Medicine, University of British Columbia</nlm:aff>
<wicri:noCountry code="subfield">University of British Columbia</wicri:noCountry>
</affiliation>
</author>
</analytic>
<series><title level="j">The Journal of Infectious Diseases</title>
<idno type="ISSN">0022-1899</idno>
<idno type="eISSN">1537-6613</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Age Factors</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Antibodies, Viral (blood)</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Female</term>
<term>Hemagglutination Inhibition Tests</term>
<term>Humans</term>
<term>Infant</term>
<term>Infant, Newborn</term>
<term>Influenza A Virus, H1N1 Subtype (immunology)</term>
<term>Influenza A Virus, H2N2 Subtype (immunology)</term>
<term>Influenza A Virus, H3N2 Subtype (immunology)</term>
<term>Influenza, Human (epidemiology)</term>
<term>Influenza, Human (immunology)</term>
<term>Influenza, Human (virology)</term>
<term>Lymphocytes (immunology)</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neutralization Tests</term>
<term>Pandemics</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="KwdFr" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Anticorps antiviraux (sang)</term>
<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Facteurs de l'âge</term>
<term>Femelle</term>
<term>Grippe humaine (immunologie)</term>
<term>Grippe humaine (virologie)</term>
<term>Grippe humaine (épidémiologie)</term>
<term>Humains</term>
<term>Jeune adulte</term>
<term>Lymphocytes (immunologie)</term>
<term>Mâle</term>
<term>Nourrisson</term>
<term>Nouveau-né</term>
<term>Pandémies</term>
<term>Sous-type H1N1 du virus de la grippe A (immunologie)</term>
<term>Sous-type H2N2 du virus de la grippe A (immunologie)</term>
<term>Sous-type H3N2 du virus de la grippe A (immunologie)</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Tests d'inhibition de l'hémagglutination</term>
<term>Tests de neutralisation</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Antibodies, Viral</term>
</keywords>
<keywords scheme="MESH" qualifier="epidemiology" xml:lang="en"><term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="immunologie" xml:lang="fr"><term>Grippe humaine</term>
<term>Lymphocytes</term>
<term>Sous-type H1N1 du virus de la grippe A</term>
<term>Sous-type H2N2 du virus de la grippe A</term>
<term>Sous-type H3N2 du virus de la grippe A</term>
</keywords>
<keywords scheme="MESH" qualifier="immunology" xml:lang="en"><term>Influenza A Virus, H1N1 Subtype</term>
<term>Influenza A Virus, H2N2 Subtype</term>
<term>Influenza A Virus, H3N2 Subtype</term>
<term>Influenza, Human</term>
<term>Lymphocytes</term>
</keywords>
<keywords scheme="MESH" qualifier="sang" xml:lang="fr"><term>Anticorps antiviraux</term>
</keywords>
<keywords scheme="MESH" qualifier="virologie" xml:lang="fr"><term>Grippe humaine</term>
</keywords>
<keywords scheme="MESH" qualifier="virology" xml:lang="en"><term>Influenza, Human</term>
</keywords>
<keywords scheme="MESH" qualifier="épidémiologie" xml:lang="fr"><term>Grippe humaine</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Adolescent</term>
<term>Adult</term>
<term>Age Factors</term>
<term>Aged</term>
<term>Aged, 80 and over</term>
<term>Child</term>
<term>Child, Preschool</term>
<term>Female</term>
<term>Hemagglutination Inhibition Tests</term>
<term>Humans</term>
<term>Infant</term>
<term>Infant, Newborn</term>
<term>Male</term>
<term>Middle Aged</term>
<term>Neutralization Tests</term>
<term>Pandemics</term>
<term>Young Adult</term>
</keywords>
<keywords scheme="MESH" xml:lang="fr"><term>Adolescent</term>
<term>Adulte</term>
<term>Adulte d'âge moyen</term>
<term>Enfant</term>
<term>Enfant d'âge préscolaire</term>
<term>Facteurs de l'âge</term>
<term>Femelle</term>
<term>Humains</term>
<term>Jeune adulte</term>
<term>Mâle</term>
<term>Nourrisson</term>
<term>Nouveau-né</term>
<term>Pandémies</term>
<term>Sujet âgé</term>
<term>Sujet âgé de 80 ans ou plus</term>
<term>Tests d'inhibition de l'hémagglutination</term>
<term>Tests de neutralisation</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p><bold><italic>Background.</italic>
</bold>
Pandemic H1N1 (pH1N1) surveillance data showed lower attack rates but higher risk of severe outcomes with advanced age. We explored immuno-epidemiologic correlates of surveillance findings including humoral and cell-mediated immunity (CMI).</p>
<p><bold><italic>Methods.</italic>
</bold>
In an age-based design, ∼100 banked/residual sera per 10-year age stratum were assessed by hemagglutination inhibition (HI) and microneutralization (MN) assays for preexisting antibody to pH1N1 and recent seasonal H1N1 and H3N2 strains. In a separate birth cohort design defined by childhood influenza A/subtype priming (1919–1929: H1N1; 1945–1949: H1N1; 1958–1960: H2N2; 1969–1970: H3N2; 1978–1989: H3N2/H1N1), whole blood was collected from up to 50 volunteers per birth cohort. The ratio of Th1(IFN-γ):Th2(IL-10) cytokine responses was evaluated in vitro.</p>
<p><bold><italic>Results.</italic>
</bold>
Antibody to seasonal viruses was highest in school-age children. Cross-reactive HI/MN antibody to pH1N1 was low among participants <70 years of age (yoa; 6%/4% ≥ 40), but seroprevalence increased at 70–79 yoa (27%/6%), increased even more at 80–89 yoa (65%/47%), and was highest at ≥90 yoa (88%/76%). CMI to pH1N1 was evident in all 5 birth cohorts but was lower compared with seasonal strains. There was little differentiation by subtype priming, but the Th1:Th2 ratio for all viruses dropped significantly in the 2 oldest cohorts.</p>
<p><bold><italic>Conclusions.</italic>
</bold>
Preexisting antibody may have protected the very old from pH1N1 infection, while diminished CMI may have contributed to greater severity once infected. In the young, cross-reactive pH1N1 antibody was mostly absent, while more intact CMI may have protected against severe outcomes.</p>
</div>
</front>
</TEI>
</PMC>
</double>
</record>
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