Immuno-epidemiologic Correlates of Pandemic H1N1 Surveillance Observations: Higher Antibody and Lower Cell-Mediated Immune Responses with Advanced Age
Identifieur interne : 000D68 ( Main/Merge ); précédent : 000D67; suivant : 000D69Immuno-epidemiologic Correlates of Pandemic H1N1 Surveillance Observations: Higher Antibody and Lower Cell-Mediated Immune Responses with Advanced Age
Auteurs : Danuta M. Skowronski [Canada] ; Travis S. Hottes [Canada] ; Janet E. Mcelhaney [Canada] ; Naveed Z. Janjua [Canada] ; Suzana Sabaiduc [Canada] ; Tracy Chan [Canada] ; Beth Gentleman [Canada] ; Dale Purych [Canada] ; Jennifer Gardy [Canada] ; David M. Patrick [Canada] ; Robert C. Brunham [Canada] ; Gaston De Serres [Canada] ; Martin Petric [Canada]Source :
- The Journal of infectious diseases [ 0022-1899 ] ; 2011.
Descripteurs français
- Pascal (Inist)
English descriptors
- KwdEn :
Abstract
Background. Pandemic H1N1 (pH1N1) surveillance data showed lower attack rates but higher risk of severe outcomes with advanced age. We explored immuno-epidemiologic correlates of surveillance findings including humoral and cell-mediated immunity (CMI). Methods. In an age-based design, ∼100 banked/residual sera per 10-year age stratum were assessed by hemagglutination inhibition (HI) and microneutralization (MN) assays for preexisting antibody to pH1N1 and recent seasonal H1N1 and H3N2 strains. In a separate birth cohort design defined by childhood influenza A/subtype priming (1919-1929: H1N1; 1945-1949: H1N1; 1958-1960: H2N2; 1969-1970: H3N2; 1978-1989: H3N2/H1N1), whole blood was collected from up to 50 volunteers per birth cohort. The ratio of Th1(IFN-γ):Th2(IL-10) cytokine responses was evaluated in vitro. Results. Antibody to seasonal viruses was highest in school-age children. Cross-reactive HI/MN antibody to pH1N1 was low among participants <70 years of age (yoa; 6%/4% ≥ 40), but seroprevalence increased at 70-79 yoa (27%/6%), increased even more at 80-89 yoa (65%/47%), and was highest at ≥90 yoa (88%/76%). CMI to pH1N1 was evident in all 5 birth cohorts but was lower compared with seasonal strains. There was little differentiation by subtype priming, but the Th1:Th2 ratio for all viruses dropped significantly in the 2 oldest cohorts. Conclusions. Preexisting antibody may have protected the very old from pH1N1 infection, while diminished CMI may have contributed to greater severity once infected. In the young, cross-reactive pH1N1 antibody was mostly absent, while more intact CMI may have protected against severe outcomes.
Links toward previous steps (curation, corpus...)
- to stream PascalFrancis, to step Corpus: 000015
- to stream PascalFrancis, to step Curation: 000059
- to stream PascalFrancis, to step Checkpoint: 000013
Links to Exploration step
Pascal:11-0131918Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Immuno-epidemiologic Correlates of Pandemic H1N1 Surveillance Observations: Higher Antibody and Lower Cell-Mediated Immune Responses with Advanced Age</title>
<author><name sortKey="Skowronski, Danuta M" sort="Skowronski, Danuta M" uniqKey="Skowronski D" first="Danuta M." last="Skowronski">Danuta M. Skowronski</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>British Columbia Centre for Disease Control, University of British Columbia</s1>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>British Columbia Centre for Disease Control, University of British Columbia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>School of Population and Public Health, University of British Columbia</s1>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>School of Population and Public Health, University of British Columbia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hottes, Travis S" sort="Hottes, Travis S" uniqKey="Hottes T" first="Travis S." last="Hottes">Travis S. Hottes</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>British Columbia Centre for Disease Control, University of British Columbia</s1>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>British Columbia Centre for Disease Control, University of British Columbia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mcelhaney, Janet E" sort="Mcelhaney, Janet E" uniqKey="Mcelhaney J" first="Janet E." last="Mcelhaney">Janet E. Mcelhaney</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Medicine, University of British Columbia</s1>
<s3>CAN</s3>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Department of Medicine, University of British Columbia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Vancouver Coastal Health Research Institute</s1>
<s2>Vancouver</s2>
<s3>CAN</s3>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Vancouver Coastal Health Research Institute</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Janjua, Naveed Z" sort="Janjua, Naveed Z" uniqKey="Janjua N" first="Naveed Z." last="Janjua">Naveed Z. Janjua</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>British Columbia Centre for Disease Control, University of British Columbia</s1>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>British Columbia Centre for Disease Control, University of British Columbia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>School of Population and Public Health, University of British Columbia</s1>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>School of Population and Public Health, University of British Columbia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sabaiduc, Suzana" sort="Sabaiduc, Suzana" uniqKey="Sabaiduc S" first="Suzana" last="Sabaiduc">Suzana Sabaiduc</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>British Columbia Centre for Disease Control, University of British Columbia</s1>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>British Columbia Centre for Disease Control, University of British Columbia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chan, Tracy" sort="Chan, Tracy" uniqKey="Chan T" first="Tracy" last="Chan">Tracy Chan</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>British Columbia Centre for Disease Control, University of British Columbia</s1>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>British Columbia Centre for Disease Control, University of British Columbia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gentleman, Beth" sort="Gentleman, Beth" uniqKey="Gentleman B" first="Beth" last="Gentleman">Beth Gentleman</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Medicine, University of British Columbia</s1>
<s3>CAN</s3>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Department of Medicine, University of British Columbia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Vancouver Coastal Health Research Institute</s1>
<s2>Vancouver</s2>
<s3>CAN</s3>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Vancouver Coastal Health Research Institute</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Purych, Dale" sort="Purych, Dale" uniqKey="Purych D" first="Dale" last="Purych">Dale Purych</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>BC Biomedical Laboratories Ltd</s1>
<s2>Surrey, British Columbia</s2>
<s3>CAN</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>BC Biomedical Laboratories Ltd</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gardy, Jennifer" sort="Gardy, Jennifer" uniqKey="Gardy J" first="Jennifer" last="Gardy">Jennifer Gardy</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>British Columbia Centre for Disease Control, University of British Columbia</s1>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>British Columbia Centre for Disease Control, University of British Columbia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Microbiology and Immunology, University of British Columbia</s1>
<s3>CAN</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Department of Microbiology and Immunology, University of British Columbia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Patrick, David M" sort="Patrick, David M" uniqKey="Patrick D" first="David M." last="Patrick">David M. Patrick</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>British Columbia Centre for Disease Control, University of British Columbia</s1>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>British Columbia Centre for Disease Control, University of British Columbia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>School of Population and Public Health, University of British Columbia</s1>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>School of Population and Public Health, University of British Columbia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Brunham, Robert C" sort="Brunham, Robert C" uniqKey="Brunham R" first="Robert C." last="Brunham">Robert C. Brunham</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>British Columbia Centre for Disease Control, University of British Columbia</s1>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>British Columbia Centre for Disease Control, University of British Columbia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Medicine, University of British Columbia</s1>
<s3>CAN</s3>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Department of Medicine, University of British Columbia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="De Serres, Gaston" sort="De Serres, Gaston" uniqKey="De Serres G" first="Gaston" last="De Serres">Gaston De Serres</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Institut national de santé publique du Québec, Université Laval</s1>
<s2>Québec</s2>
<s3>CAN</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Québec</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department of Social and Preventive Medicine, Université Laval</s1>
<s2>Québec</s2>
<s3>CAN</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Québec</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Petric, Martin" sort="Petric, Martin" uniqKey="Petric M" first="Martin" last="Petric">Martin Petric</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>British Columbia Centre for Disease Control, University of British Columbia</s1>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>British Columbia Centre for Disease Control, University of British Columbia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Pathology and Laboratory Medicine, University of British Columbia</s1>
<s3>CAN</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Department of Pathology and Laboratory Medicine, University of British Columbia</wicri:noRegion>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">INIST</idno>
<idno type="inist">11-0131918</idno>
<date when="2011">2011</date>
<idno type="stanalyst">PASCAL 11-0131918 INIST</idno>
<idno type="RBID">Pascal:11-0131918</idno>
<idno type="wicri:Area/PascalFrancis/Corpus">000015</idno>
<idno type="wicri:Area/PascalFrancis/Curation">000059</idno>
<idno type="wicri:Area/PascalFrancis/Checkpoint">000013</idno>
<idno type="wicri:explorRef" wicri:stream="PascalFrancis" wicri:step="Checkpoint">000013</idno>
<idno type="wicri:doubleKey">0022-1899:2011:Skowronski D:immuno:epidemiologic:correlates</idno>
<idno type="wicri:Area/Main/Merge">000D68</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Immuno-epidemiologic Correlates of Pandemic H1N1 Surveillance Observations: Higher Antibody and Lower Cell-Mediated Immune Responses with Advanced Age</title>
<author><name sortKey="Skowronski, Danuta M" sort="Skowronski, Danuta M" uniqKey="Skowronski D" first="Danuta M." last="Skowronski">Danuta M. Skowronski</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>British Columbia Centre for Disease Control, University of British Columbia</s1>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>British Columbia Centre for Disease Control, University of British Columbia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>School of Population and Public Health, University of British Columbia</s1>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>School of Population and Public Health, University of British Columbia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Hottes, Travis S" sort="Hottes, Travis S" uniqKey="Hottes T" first="Travis S." last="Hottes">Travis S. Hottes</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>British Columbia Centre for Disease Control, University of British Columbia</s1>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>British Columbia Centre for Disease Control, University of British Columbia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Mcelhaney, Janet E" sort="Mcelhaney, Janet E" uniqKey="Mcelhaney J" first="Janet E." last="Mcelhaney">Janet E. Mcelhaney</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Medicine, University of British Columbia</s1>
<s3>CAN</s3>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Department of Medicine, University of British Columbia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Vancouver Coastal Health Research Institute</s1>
<s2>Vancouver</s2>
<s3>CAN</s3>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Vancouver Coastal Health Research Institute</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Janjua, Naveed Z" sort="Janjua, Naveed Z" uniqKey="Janjua N" first="Naveed Z." last="Janjua">Naveed Z. Janjua</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>British Columbia Centre for Disease Control, University of British Columbia</s1>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>British Columbia Centre for Disease Control, University of British Columbia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>School of Population and Public Health, University of British Columbia</s1>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>School of Population and Public Health, University of British Columbia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Sabaiduc, Suzana" sort="Sabaiduc, Suzana" uniqKey="Sabaiduc S" first="Suzana" last="Sabaiduc">Suzana Sabaiduc</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>British Columbia Centre for Disease Control, University of British Columbia</s1>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>British Columbia Centre for Disease Control, University of British Columbia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Chan, Tracy" sort="Chan, Tracy" uniqKey="Chan T" first="Tracy" last="Chan">Tracy Chan</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>British Columbia Centre for Disease Control, University of British Columbia</s1>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>British Columbia Centre for Disease Control, University of British Columbia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gentleman, Beth" sort="Gentleman, Beth" uniqKey="Gentleman B" first="Beth" last="Gentleman">Beth Gentleman</name>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Medicine, University of British Columbia</s1>
<s3>CAN</s3>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Department of Medicine, University of British Columbia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Vancouver Coastal Health Research Institute</s1>
<s2>Vancouver</s2>
<s3>CAN</s3>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Vancouver Coastal Health Research Institute</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Purych, Dale" sort="Purych, Dale" uniqKey="Purych D" first="Dale" last="Purych">Dale Purych</name>
<affiliation wicri:level="1"><inist:fA14 i1="07"><s1>BC Biomedical Laboratories Ltd</s1>
<s2>Surrey, British Columbia</s2>
<s3>CAN</s3>
<sZ>8 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>BC Biomedical Laboratories Ltd</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Gardy, Jennifer" sort="Gardy, Jennifer" uniqKey="Gardy J" first="Jennifer" last="Gardy">Jennifer Gardy</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>British Columbia Centre for Disease Control, University of British Columbia</s1>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>British Columbia Centre for Disease Control, University of British Columbia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Microbiology and Immunology, University of British Columbia</s1>
<s3>CAN</s3>
<sZ>9 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Department of Microbiology and Immunology, University of British Columbia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Patrick, David M" sort="Patrick, David M" uniqKey="Patrick D" first="David M." last="Patrick">David M. Patrick</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>British Columbia Centre for Disease Control, University of British Columbia</s1>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>British Columbia Centre for Disease Control, University of British Columbia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="02"><s1>School of Population and Public Health, University of British Columbia</s1>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>10 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>School of Population and Public Health, University of British Columbia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Brunham, Robert C" sort="Brunham, Robert C" uniqKey="Brunham R" first="Robert C." last="Brunham">Robert C. Brunham</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>British Columbia Centre for Disease Control, University of British Columbia</s1>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>British Columbia Centre for Disease Control, University of British Columbia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Medicine, University of British Columbia</s1>
<s3>CAN</s3>
<sZ>3 aut.</sZ>
<sZ>7 aut.</sZ>
<sZ>11 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Department of Medicine, University of British Columbia</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="De Serres, Gaston" sort="De Serres, Gaston" uniqKey="De Serres G" first="Gaston" last="De Serres">Gaston De Serres</name>
<affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Institut national de santé publique du Québec, Université Laval</s1>
<s2>Québec</s2>
<s3>CAN</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Québec</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department of Social and Preventive Medicine, Université Laval</s1>
<s2>Québec</s2>
<s3>CAN</s3>
<sZ>12 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Québec</wicri:noRegion>
</affiliation>
</author>
<author><name sortKey="Petric, Martin" sort="Petric, Martin" uniqKey="Petric M" first="Martin" last="Petric">Martin Petric</name>
<affiliation wicri:level="1"><inist:fA14 i1="01"><s1>British Columbia Centre for Disease Control, University of British Columbia</s1>
<s3>CAN</s3>
<sZ>1 aut.</sZ>
<sZ>2 aut.</sZ>
<sZ>4 aut.</sZ>
<sZ>5 aut.</sZ>
<sZ>6 aut.</sZ>
<sZ>9 aut.</sZ>
<sZ>10 aut.</sZ>
<sZ>11 aut.</sZ>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>British Columbia Centre for Disease Control, University of British Columbia</wicri:noRegion>
</affiliation>
<affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Pathology and Laboratory Medicine, University of British Columbia</s1>
<s3>CAN</s3>
<sZ>13 aut.</sZ>
</inist:fA14>
<country>Canada</country>
<wicri:noRegion>Department of Pathology and Laboratory Medicine, University of British Columbia</wicri:noRegion>
</affiliation>
</author>
</analytic>
<series><title level="j" type="main">The Journal of infectious diseases</title>
<title level="j" type="abbreviated">J. infect. dis.</title>
<idno type="ISSN">0022-1899</idno>
<imprint><date when="2011">2011</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
<seriesStmt><title level="j" type="main">The Journal of infectious diseases</title>
<title level="j" type="abbreviated">J. infect. dis.</title>
<idno type="ISSN">0022-1899</idno>
</seriesStmt>
</fileDesc>
<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age</term>
<term>Antibody</term>
<term>Immune response</term>
<term>Infection</term>
<term>Influenzavirus A(H1N1)</term>
</keywords>
<keywords scheme="Pascal" xml:lang="fr"><term>Anticorps</term>
<term>Réponse immune</term>
<term>Age</term>
<term>Infection</term>
<term>Virus grippal A(H1N1)</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">Background. Pandemic H1N1 (pH1N1) surveillance data showed lower attack rates but higher risk of severe outcomes with advanced age. We explored immuno-epidemiologic correlates of surveillance findings including humoral and cell-mediated immunity (CMI). Methods. In an age-based design, ∼100 banked/residual sera per 10-year age stratum were assessed by hemagglutination inhibition (HI) and microneutralization (MN) assays for preexisting antibody to pH1N1 and recent seasonal H1N1 and H3N2 strains. In a separate birth cohort design defined by childhood influenza A/subtype priming (1919-1929: H1N1; 1945-1949: H1N1; 1958-1960: H2N2; 1969-1970: H3N2; 1978-1989: H3N2/H1N1), whole blood was collected from up to 50 volunteers per birth cohort. The ratio of Th1(IFN-γ):Th2(IL-10) cytokine responses was evaluated in vitro. Results. Antibody to seasonal viruses was highest in school-age children. Cross-reactive HI/MN antibody to pH1N1 was low among participants <70 years of age (yoa; 6%/4% ≥ 40), but seroprevalence increased at 70-79 yoa (27%/6%), increased even more at 80-89 yoa (65%/47%), and was highest at ≥90 yoa (88%/76%). CMI to pH1N1 was evident in all 5 birth cohorts but was lower compared with seasonal strains. There was little differentiation by subtype priming, but the Th1:Th2 ratio for all viruses dropped significantly in the 2 oldest cohorts. Conclusions. Preexisting antibody may have protected the very old from pH1N1 infection, while diminished CMI may have contributed to greater severity once infected. In the young, cross-reactive pH1N1 antibody was mostly absent, while more intact CMI may have protected against severe outcomes.</div>
</front>
</TEI>
<affiliations><list><country><li>Canada</li>
</country>
</list>
<tree><country name="Canada"><noRegion><name sortKey="Skowronski, Danuta M" sort="Skowronski, Danuta M" uniqKey="Skowronski D" first="Danuta M." last="Skowronski">Danuta M. Skowronski</name>
</noRegion>
<name sortKey="Brunham, Robert C" sort="Brunham, Robert C" uniqKey="Brunham R" first="Robert C." last="Brunham">Robert C. Brunham</name>
<name sortKey="Brunham, Robert C" sort="Brunham, Robert C" uniqKey="Brunham R" first="Robert C." last="Brunham">Robert C. Brunham</name>
<name sortKey="Chan, Tracy" sort="Chan, Tracy" uniqKey="Chan T" first="Tracy" last="Chan">Tracy Chan</name>
<name sortKey="De Serres, Gaston" sort="De Serres, Gaston" uniqKey="De Serres G" first="Gaston" last="De Serres">Gaston De Serres</name>
<name sortKey="De Serres, Gaston" sort="De Serres, Gaston" uniqKey="De Serres G" first="Gaston" last="De Serres">Gaston De Serres</name>
<name sortKey="Gardy, Jennifer" sort="Gardy, Jennifer" uniqKey="Gardy J" first="Jennifer" last="Gardy">Jennifer Gardy</name>
<name sortKey="Gardy, Jennifer" sort="Gardy, Jennifer" uniqKey="Gardy J" first="Jennifer" last="Gardy">Jennifer Gardy</name>
<name sortKey="Gentleman, Beth" sort="Gentleman, Beth" uniqKey="Gentleman B" first="Beth" last="Gentleman">Beth Gentleman</name>
<name sortKey="Gentleman, Beth" sort="Gentleman, Beth" uniqKey="Gentleman B" first="Beth" last="Gentleman">Beth Gentleman</name>
<name sortKey="Hottes, Travis S" sort="Hottes, Travis S" uniqKey="Hottes T" first="Travis S." last="Hottes">Travis S. Hottes</name>
<name sortKey="Janjua, Naveed Z" sort="Janjua, Naveed Z" uniqKey="Janjua N" first="Naveed Z." last="Janjua">Naveed Z. Janjua</name>
<name sortKey="Janjua, Naveed Z" sort="Janjua, Naveed Z" uniqKey="Janjua N" first="Naveed Z." last="Janjua">Naveed Z. Janjua</name>
<name sortKey="Mcelhaney, Janet E" sort="Mcelhaney, Janet E" uniqKey="Mcelhaney J" first="Janet E." last="Mcelhaney">Janet E. Mcelhaney</name>
<name sortKey="Mcelhaney, Janet E" sort="Mcelhaney, Janet E" uniqKey="Mcelhaney J" first="Janet E." last="Mcelhaney">Janet E. Mcelhaney</name>
<name sortKey="Patrick, David M" sort="Patrick, David M" uniqKey="Patrick D" first="David M." last="Patrick">David M. Patrick</name>
<name sortKey="Patrick, David M" sort="Patrick, David M" uniqKey="Patrick D" first="David M." last="Patrick">David M. Patrick</name>
<name sortKey="Petric, Martin" sort="Petric, Martin" uniqKey="Petric M" first="Martin" last="Petric">Martin Petric</name>
<name sortKey="Petric, Martin" sort="Petric, Martin" uniqKey="Petric M" first="Martin" last="Petric">Martin Petric</name>
<name sortKey="Purych, Dale" sort="Purych, Dale" uniqKey="Purych D" first="Dale" last="Purych">Dale Purych</name>
<name sortKey="Sabaiduc, Suzana" sort="Sabaiduc, Suzana" uniqKey="Sabaiduc S" first="Suzana" last="Sabaiduc">Suzana Sabaiduc</name>
<name sortKey="Skowronski, Danuta M" sort="Skowronski, Danuta M" uniqKey="Skowronski D" first="Danuta M." last="Skowronski">Danuta M. Skowronski</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/H2N2V1/Data/Main/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000D68 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Merge/biblio.hfd -nk 000D68 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= H2N2V1 |flux= Main |étape= Merge |type= RBID |clé= Pascal:11-0131918 |texte= Immuno-epidemiologic Correlates of Pandemic H1N1 Surveillance Observations: Higher Antibody and Lower Cell-Mediated Immune Responses with Advanced Age }}
This area was generated with Dilib version V0.6.33. |