Immuno-epidemiologic correlates of pandemic H1N1 surveillance observations: higher antibody and lower cell-mediated immune responses with advanced age.
Identifieur interne : 000179 ( PubMed/Corpus ); précédent : 000178; suivant : 000180Immuno-epidemiologic correlates of pandemic H1N1 surveillance observations: higher antibody and lower cell-mediated immune responses with advanced age.
Auteurs : Danuta M. Skowronski ; Travis S. Hottes ; Janet E. Mcelhaney ; Naveed Z. Janjua ; Suzana Sabaiduc ; Tracy Chan ; Beth Gentleman ; Dale Purych ; Jennifer Gardy ; David M. Patrick ; Robert C. Brunham ; Gaston De Serres ; Martin PetricSource :
- The Journal of infectious diseases [ 1537-6613 ] ; 2011.
English descriptors
- KwdEn :
- Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Antibodies, Viral (blood), Child, Child, Preschool, Female, Hemagglutination Inhibition Tests, Humans, Infant, Infant, Newborn, Influenza A Virus, H1N1 Subtype (immunology), Influenza A Virus, H2N2 Subtype (immunology), Influenza A Virus, H3N2 Subtype (immunology), Influenza, Human (epidemiology), Influenza, Human (immunology), Influenza, Human (virology), Lymphocytes (immunology), Male, Middle Aged, Neutralization Tests, Pandemics, Young Adult.
- MESH :
- chemical , blood : Antibodies, Viral.
- epidemiology : Influenza, Human.
- immunology : Influenza A Virus, H1N1 Subtype, Influenza A Virus, H2N2 Subtype, Influenza A Virus, H3N2 Subtype, Influenza, Human, Lymphocytes.
- virology : Influenza, Human.
- Adolescent, Adult, Age Factors, Aged, Aged, 80 and over, Child, Child, Preschool, Female, Hemagglutination Inhibition Tests, Humans, Infant, Infant, Newborn, Male, Middle Aged, Neutralization Tests, Pandemics, Young Adult.
Abstract
Pandemic H1N1 (pH1N1) surveillance data showed lower attack rates but higher risk of severe outcomes with advanced age. We explored immuno-epidemiologic correlates of surveillance findings including humoral and cell-mediated immunity (CMI).
DOI: 10.1093/infdis/jiq039
PubMed: 21288814
Links to Exploration step
pubmed:21288814Le document en format XML
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<term>Influenza, Human (virology)</term>
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<term>Neutralization Tests</term>
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<front><div type="abstract" xml:lang="en">Pandemic H1N1 (pH1N1) surveillance data showed lower attack rates but higher risk of severe outcomes with advanced age. We explored immuno-epidemiologic correlates of surveillance findings including humoral and cell-mediated immunity (CMI).</div>
</front>
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<pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">21288814</PMID>
<DateCompleted><Year>2011</Year>
<Month>03</Month>
<Day>14</Day>
</DateCompleted>
<DateRevised><Year>2018</Year>
<Month>11</Month>
<Day>13</Day>
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<JournalIssue CitedMedium="Internet"><Volume>203</Volume>
<Issue>2</Issue>
<PubDate><Year>2011</Year>
<Month>Jan</Month>
<Day>15</Day>
</PubDate>
</JournalIssue>
<Title>The Journal of infectious diseases</Title>
<ISOAbbreviation>J. Infect. Dis.</ISOAbbreviation>
</Journal>
<ArticleTitle>Immuno-epidemiologic correlates of pandemic H1N1 surveillance observations: higher antibody and lower cell-mediated immune responses with advanced age.</ArticleTitle>
<Pagination><MedlinePgn>158-67</MedlinePgn>
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<Abstract><AbstractText Label="BACKGROUND" NlmCategory="BACKGROUND">Pandemic H1N1 (pH1N1) surveillance data showed lower attack rates but higher risk of severe outcomes with advanced age. We explored immuno-epidemiologic correlates of surveillance findings including humoral and cell-mediated immunity (CMI).</AbstractText>
<AbstractText Label="METHODS" NlmCategory="METHODS">In an age-based design, ∼100 banked/residual sera per 10-year age stratum were assessed by hemagglutination inhibition (HI) and microneutralization (MN) assays for preexisting antibody to pH1N1 and recent seasonal H1N1 and H3N2 strains. In a separate birth cohort design defined by childhood influenza A/subtype priming (1919-1929: H1N1; 1945-1949: H1N1; 1958-1960: H2N2; 1969-1970: H3N2; 1978-1989: H3N2/H1N1), whole blood was collected from up to 50 volunteers per birth cohort. The ratio of Th1(IFN-γ):Th2(IL-10) cytokine responses was evaluated in vitro.</AbstractText>
<AbstractText Label="RESULTS" NlmCategory="RESULTS">Antibody to seasonal viruses was highest in school-age children. Cross-reactive HI/MN antibody to pH1N1 was low among participants <70 years of age (yoa; 6%/4% ≥ 40), but seroprevalence increased at 70-79 yoa (27%/6%), increased even more at 80-89 yoa (65%/47%), and was highest at ≥90 yoa (88%/76%). CMI to pH1N1 was evident in all 5 birth cohorts but was lower compared with seasonal strains. There was little differentiation by subtype priming, but the Th1:Th2 ratio for all viruses dropped significantly in the 2 oldest cohorts.</AbstractText>
<AbstractText Label="CONCLUSIONS" NlmCategory="CONCLUSIONS">Preexisting antibody may have protected the very old from pH1N1 infection, while diminished CMI may have contributed to greater severity once infected. In the young, cross-reactive pH1N1 antibody was mostly absent, while more intact CMI may have protected against severe outcomes.</AbstractText>
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<ForeName>Danuta M</ForeName>
<Initials>DM</Initials>
<AffiliationInfo><Affiliation>British Columbia Centre for Disease Control, Vancouver, BC, V5Z 4R4, Canada. danuta.skowronski@bccdc.ca</Affiliation>
</AffiliationInfo>
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<Author ValidYN="Y"><LastName>McElhaney</LastName>
<ForeName>Janet E</ForeName>
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<Author ValidYN="Y"><LastName>Janjua</LastName>
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<Author ValidYN="Y"><LastName>Sabaiduc</LastName>
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