Immuno-epidemiologic Correlates of Pandemic H1N1 Surveillance Observations: Higher Antibody and Lower Cell-Mediated Immune Responses with Advanced Age
Identifieur interne : 000059 ( PascalFrancis/Curation ); précédent : 000058; suivant : 000060Immuno-epidemiologic Correlates of Pandemic H1N1 Surveillance Observations: Higher Antibody and Lower Cell-Mediated Immune Responses with Advanced Age
Auteurs : Danuta M. Skowronski [Canada] ; Travis S. Hottes [Canada] ; Janet E. Mcelhaney [Canada] ; Naveed Z. Janjua [Canada] ; Suzana Sabaiduc [Canada] ; Tracy Chan [Canada] ; Beth Gentleman [Canada] ; Dale Purych [Canada] ; Jennifer Gardy [Canada] ; David M. Patrick [Canada] ; Robert C. Brunham [Canada] ; Gaston De Serres [Canada] ; Martin Petric [Canada]Source :
- The Journal of infectious diseases [ 0022-1899 ] ; 2011.
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Abstract
Background. Pandemic H1N1 (pH1N1) surveillance data showed lower attack rates but higher risk of severe outcomes with advanced age. We explored immuno-epidemiologic correlates of surveillance findings including humoral and cell-mediated immunity (CMI). Methods. In an age-based design, ∼100 banked/residual sera per 10-year age stratum were assessed by hemagglutination inhibition (HI) and microneutralization (MN) assays for preexisting antibody to pH1N1 and recent seasonal H1N1 and H3N2 strains. In a separate birth cohort design defined by childhood influenza A/subtype priming (1919-1929: H1N1; 1945-1949: H1N1; 1958-1960: H2N2; 1969-1970: H3N2; 1978-1989: H3N2/H1N1), whole blood was collected from up to 50 volunteers per birth cohort. The ratio of Th1(IFN-γ):Th2(IL-10) cytokine responses was evaluated in vitro. Results. Antibody to seasonal viruses was highest in school-age children. Cross-reactive HI/MN antibody to pH1N1 was low among participants <70 years of age (yoa; 6%/4% ≥ 40), but seroprevalence increased at 70-79 yoa (27%/6%), increased even more at 80-89 yoa (65%/47%), and was highest at ≥90 yoa (88%/76%). CMI to pH1N1 was evident in all 5 birth cohorts but was lower compared with seasonal strains. There was little differentiation by subtype priming, but the Th1:Th2 ratio for all viruses dropped significantly in the 2 oldest cohorts. Conclusions. Preexisting antibody may have protected the very old from pH1N1 infection, while diminished CMI may have contributed to greater severity once infected. In the young, cross-reactive pH1N1 antibody was mostly absent, while more intact CMI may have protected against severe outcomes.
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en" level="a">Immuno-epidemiologic Correlates of Pandemic H1N1 Surveillance Observations: Higher Antibody and Lower Cell-Mediated Immune Responses with Advanced Age</title><author><name sortKey="Skowronski, Danuta M" sort="Skowronski, Danuta M" uniqKey="Skowronski D" first="Danuta M." last="Skowronski">Danuta M. Skowronski</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>British Columbia Centre for Disease Control, University of British Columbia</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Canada</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>School of Population and Public Health, University of British Columbia</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country></affiliation></author><author><name sortKey="Hottes, Travis S" sort="Hottes, Travis S" uniqKey="Hottes T" first="Travis S." last="Hottes">Travis S. Hottes</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>British Columbia Centre for Disease Control, University of British Columbia</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Canada</country></affiliation></author><author><name sortKey="Mcelhaney, Janet E" sort="Mcelhaney, Janet E" uniqKey="Mcelhaney J" first="Janet E." last="Mcelhaney">Janet E. Mcelhaney</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Medicine, University of British Columbia</s1><s3>CAN</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Canada</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Vancouver Coastal Health Research Institute</s1><s2>Vancouver</s2><s3>CAN</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Canada</country></affiliation></author><author><name sortKey="Janjua, Naveed Z" sort="Janjua, Naveed Z" uniqKey="Janjua N" first="Naveed Z." last="Janjua">Naveed Z. Janjua</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>British Columbia Centre for Disease Control, University of British Columbia</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Canada</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>School of Population and Public Health, University of British Columbia</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country></affiliation></author><author><name sortKey="Sabaiduc, Suzana" sort="Sabaiduc, Suzana" uniqKey="Sabaiduc S" first="Suzana" last="Sabaiduc">Suzana Sabaiduc</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>British Columbia Centre for Disease Control, University of British Columbia</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Canada</country></affiliation></author><author><name sortKey="Chan, Tracy" sort="Chan, Tracy" uniqKey="Chan T" first="Tracy" last="Chan">Tracy Chan</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>British Columbia Centre for Disease Control, University of British Columbia</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Canada</country></affiliation></author><author><name sortKey="Gentleman, Beth" sort="Gentleman, Beth" uniqKey="Gentleman B" first="Beth" last="Gentleman">Beth Gentleman</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Medicine, University of British Columbia</s1><s3>CAN</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Canada</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Vancouver Coastal Health Research Institute</s1><s2>Vancouver</s2><s3>CAN</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Canada</country></affiliation></author><author><name sortKey="Purych, Dale" sort="Purych, Dale" uniqKey="Purych D" first="Dale" last="Purych">Dale Purych</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>BC Biomedical Laboratories Ltd</s1><s2>Surrey, British Columbia</s2><s3>CAN</s3><sZ>8 aut.</sZ></inist:fA14><country>Canada</country></affiliation></author><author><name sortKey="Gardy, Jennifer" sort="Gardy, Jennifer" uniqKey="Gardy J" first="Jennifer" last="Gardy">Jennifer Gardy</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>British Columbia Centre for Disease Control, University of British Columbia</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Canada</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Microbiology and Immunology, University of British Columbia</s1><s3>CAN</s3><sZ>9 aut.</sZ></inist:fA14><country>Canada</country></affiliation></author><author><name sortKey="Patrick, David M" sort="Patrick, David M" uniqKey="Patrick D" first="David M." last="Patrick">David M. Patrick</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>British Columbia Centre for Disease Control, University of British Columbia</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Canada</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>School of Population and Public Health, University of British Columbia</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country></affiliation></author><author><name sortKey="Brunham, Robert C" sort="Brunham, Robert C" uniqKey="Brunham R" first="Robert C." last="Brunham">Robert C. Brunham</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>British Columbia Centre for Disease Control, University of British Columbia</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Canada</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Medicine, University of British Columbia</s1><s3>CAN</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Canada</country></affiliation></author><author><name sortKey="De Serres, Gaston" sort="De Serres, Gaston" uniqKey="De Serres G" first="Gaston" last="De Serres">Gaston De Serres</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Institut national de santé publique du Québec, Université Laval</s1><s2>Québec</s2><s3>CAN</s3><sZ>12 aut.</sZ></inist:fA14><country>Canada</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department of Social and Preventive Medicine, Université Laval</s1><s2>Québec</s2><s3>CAN</s3><sZ>12 aut.</sZ></inist:fA14><country>Canada</country></affiliation></author><author><name sortKey="Petric, Martin" sort="Petric, Martin" uniqKey="Petric M" first="Martin" last="Petric">Martin Petric</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>British Columbia Centre for Disease Control, University of British Columbia</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Canada</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Pathology and Laboratory Medicine, University of British Columbia</s1><s3>CAN</s3><sZ>13 aut.</sZ></inist:fA14><country>Canada</country></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">INIST</idno><idno type="inist">11-0131918</idno><date when="2011">2011</date><idno type="stanalyst">PASCAL 11-0131918 INIST</idno><idno type="RBID">Pascal:11-0131918</idno><idno type="wicri:Area/PascalFrancis/Corpus">000015</idno><idno type="wicri:Area/PascalFrancis/Curation">000059</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a">Immuno-epidemiologic Correlates of Pandemic H1N1 Surveillance Observations: Higher Antibody and Lower Cell-Mediated Immune Responses with Advanced Age</title><author><name sortKey="Skowronski, Danuta M" sort="Skowronski, Danuta M" uniqKey="Skowronski D" first="Danuta M." last="Skowronski">Danuta M. Skowronski</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>British Columbia Centre for Disease Control, University of British Columbia</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Canada</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>School of Population and Public Health, University of British Columbia</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country></affiliation></author><author><name sortKey="Hottes, Travis S" sort="Hottes, Travis S" uniqKey="Hottes T" first="Travis S." last="Hottes">Travis S. Hottes</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>British Columbia Centre for Disease Control, University of British Columbia</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Canada</country></affiliation></author><author><name sortKey="Mcelhaney, Janet E" sort="Mcelhaney, Janet E" uniqKey="Mcelhaney J" first="Janet E." last="Mcelhaney">Janet E. Mcelhaney</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Medicine, University of British Columbia</s1><s3>CAN</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Canada</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Vancouver Coastal Health Research Institute</s1><s2>Vancouver</s2><s3>CAN</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Canada</country></affiliation></author><author><name sortKey="Janjua, Naveed Z" sort="Janjua, Naveed Z" uniqKey="Janjua N" first="Naveed Z." last="Janjua">Naveed Z. Janjua</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>British Columbia Centre for Disease Control, University of British Columbia</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Canada</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>School of Population and Public Health, University of British Columbia</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country></affiliation></author><author><name sortKey="Sabaiduc, Suzana" sort="Sabaiduc, Suzana" uniqKey="Sabaiduc S" first="Suzana" last="Sabaiduc">Suzana Sabaiduc</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>British Columbia Centre for Disease Control, University of British Columbia</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Canada</country></affiliation></author><author><name sortKey="Chan, Tracy" sort="Chan, Tracy" uniqKey="Chan T" first="Tracy" last="Chan">Tracy Chan</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>British Columbia Centre for Disease Control, University of British Columbia</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Canada</country></affiliation></author><author><name sortKey="Gentleman, Beth" sort="Gentleman, Beth" uniqKey="Gentleman B" first="Beth" last="Gentleman">Beth Gentleman</name><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Medicine, University of British Columbia</s1><s3>CAN</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Canada</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="06"><s1>Vancouver Coastal Health Research Institute</s1><s2>Vancouver</s2><s3>CAN</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ></inist:fA14><country>Canada</country></affiliation></author><author><name sortKey="Purych, Dale" sort="Purych, Dale" uniqKey="Purych D" first="Dale" last="Purych">Dale Purych</name><affiliation wicri:level="1"><inist:fA14 i1="07"><s1>BC Biomedical Laboratories Ltd</s1><s2>Surrey, British Columbia</s2><s3>CAN</s3><sZ>8 aut.</sZ></inist:fA14><country>Canada</country></affiliation></author><author><name sortKey="Gardy, Jennifer" sort="Gardy, Jennifer" uniqKey="Gardy J" first="Jennifer" last="Gardy">Jennifer Gardy</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>British Columbia Centre for Disease Control, University of British Columbia</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Canada</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="04"><s1>Department of Microbiology and Immunology, University of British Columbia</s1><s3>CAN</s3><sZ>9 aut.</sZ></inist:fA14><country>Canada</country></affiliation></author><author><name sortKey="Patrick, David M" sort="Patrick, David M" uniqKey="Patrick D" first="David M." last="Patrick">David M. Patrick</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>British Columbia Centre for Disease Control, University of British Columbia</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Canada</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="02"><s1>School of Population and Public Health, University of British Columbia</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>Canada</country></affiliation></author><author><name sortKey="Brunham, Robert C" sort="Brunham, Robert C" uniqKey="Brunham R" first="Robert C." last="Brunham">Robert C. Brunham</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>British Columbia Centre for Disease Control, University of British Columbia</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Canada</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="03"><s1>Department of Medicine, University of British Columbia</s1><s3>CAN</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>11 aut.</sZ></inist:fA14><country>Canada</country></affiliation></author><author><name sortKey="De Serres, Gaston" sort="De Serres, Gaston" uniqKey="De Serres G" first="Gaston" last="De Serres">Gaston De Serres</name><affiliation wicri:level="1"><inist:fA14 i1="08"><s1>Institut national de santé publique du Québec, Université Laval</s1><s2>Québec</s2><s3>CAN</s3><sZ>12 aut.</sZ></inist:fA14><country>Canada</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="09"><s1>Department of Social and Preventive Medicine, Université Laval</s1><s2>Québec</s2><s3>CAN</s3><sZ>12 aut.</sZ></inist:fA14><country>Canada</country></affiliation></author><author><name sortKey="Petric, Martin" sort="Petric, Martin" uniqKey="Petric M" first="Martin" last="Petric">Martin Petric</name><affiliation wicri:level="1"><inist:fA14 i1="01"><s1>British Columbia Centre for Disease Control, University of British Columbia</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ></inist:fA14><country>Canada</country></affiliation><affiliation wicri:level="1"><inist:fA14 i1="05"><s1>Department of Pathology and Laboratory Medicine, University of British Columbia</s1><s3>CAN</s3><sZ>13 aut.</sZ></inist:fA14><country>Canada</country></affiliation></author></analytic><series><title level="j" type="main">The Journal of infectious diseases</title><title level="j" type="abbreviated">J. infect. dis.</title><idno type="ISSN">0022-1899</idno><imprint><date when="2011">2011</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">The Journal of infectious diseases</title><title level="j" type="abbreviated">J. infect. dis.</title><idno type="ISSN">0022-1899</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Age</term><term>Antibody</term><term>Immune response</term><term>Infection</term><term>Influenzavirus A(H1N1)</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Anticorps</term><term>Réponse immune</term><term>Age</term><term>Infection</term><term>Virus grippal A(H1N1)</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Background. Pandemic H1N1 (pH1N1) surveillance data showed lower attack rates but higher risk of severe outcomes with advanced age. We explored immuno-epidemiologic correlates of surveillance findings including humoral and cell-mediated immunity (CMI). Methods. In an age-based design, ∼100 banked/residual sera per 10-year age stratum were assessed by hemagglutination inhibition (HI) and microneutralization (MN) assays for preexisting antibody to pH1N1 and recent seasonal H1N1 and H3N2 strains. In a separate birth cohort design defined by childhood influenza A/subtype priming (1919-1929: H1N1; 1945-1949: H1N1; 1958-1960: H2N2; 1969-1970: H3N2; 1978-1989: H3N2/H1N1), whole blood was collected from up to 50 volunteers per birth cohort. The ratio of Th1(IFN-γ):Th2(IL-10) cytokine responses was evaluated in vitro. Results. Antibody to seasonal viruses was highest in school-age children. Cross-reactive HI/MN antibody to pH1N1 was low among participants <70 years of age (yoa; 6%/4% ≥ 40), but seroprevalence increased at 70-79 yoa (27%/6%), increased even more at 80-89 yoa (65%/47%), and was highest at ≥90 yoa (88%/76%). CMI to pH1N1 was evident in all 5 birth cohorts but was lower compared with seasonal strains. There was little differentiation by subtype priming, but the Th1:Th2 ratio for all viruses dropped significantly in the 2 oldest cohorts. Conclusions. Preexisting antibody may have protected the very old from pH1N1 infection, while diminished CMI may have contributed to greater severity once infected. In the young, cross-reactive pH1N1 antibody was mostly absent, while more intact CMI may have protected against severe outcomes.</div></front></TEI><inist><standard h6="B"><pA><fA01 i1="01" i2="1"><s0>0022-1899</s0></fA01><fA02 i1="01"><s0>JIDIAQ</s0></fA02><fA03 i2="1"><s0>J. infect. dis.</s0></fA03><fA05><s2>203</s2></fA05><fA06><s2>2</s2></fA06><fA08 i1="01" i2="1" l="ENG"><s1>Immuno-epidemiologic Correlates of Pandemic H1N1 Surveillance Observations: Higher Antibody and Lower Cell-Mediated Immune Responses with Advanced Age</s1></fA08><fA11 i1="01" i2="1"><s1>SKOWRONSKI (Danuta M.)</s1></fA11><fA11 i1="02" i2="1"><s1>HOTTES (Travis S.)</s1></fA11><fA11 i1="03" i2="1"><s1>MCELHANEY (Janet E.)</s1></fA11><fA11 i1="04" i2="1"><s1>JANJUA (Naveed Z.)</s1></fA11><fA11 i1="05" i2="1"><s1>SABAIDUC (Suzana)</s1></fA11><fA11 i1="06" i2="1"><s1>CHAN (Tracy)</s1></fA11><fA11 i1="07" i2="1"><s1>GENTLEMAN (Beth)</s1></fA11><fA11 i1="08" i2="1"><s1>PURYCH (Dale)</s1></fA11><fA11 i1="09" i2="1"><s1>GARDY (Jennifer)</s1></fA11><fA11 i1="10" i2="1"><s1>PATRICK (David M.)</s1></fA11><fA11 i1="11" i2="1"><s1>BRUNHAM (Robert C.)</s1></fA11><fA11 i1="12" i2="1"><s1>DE SERRES (Gaston)</s1></fA11><fA11 i1="13" i2="1"><s1>PETRIC (Martin)</s1></fA11><fA14 i1="01"><s1>British Columbia Centre for Disease Control, University of British Columbia</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>4 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>9 aut.</sZ><sZ>10 aut.</sZ><sZ>11 aut.</sZ><sZ>13 aut.</sZ></fA14><fA14 i1="02"><s1>School of Population and Public Health, University of British Columbia</s1><s3>CAN</s3><sZ>1 aut.</sZ><sZ>4 aut.</sZ><sZ>10 aut.</sZ></fA14><fA14 i1="03"><s1>Department of Medicine, University of British Columbia</s1><s3>CAN</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ><sZ>11 aut.</sZ></fA14><fA14 i1="04"><s1>Department of Microbiology and Immunology, University of British Columbia</s1><s3>CAN</s3><sZ>9 aut.</sZ></fA14><fA14 i1="05"><s1>Department of Pathology and Laboratory Medicine, University of British Columbia</s1><s3>CAN</s3><sZ>13 aut.</sZ></fA14><fA14 i1="06"><s1>Vancouver Coastal Health Research Institute</s1><s2>Vancouver</s2><s3>CAN</s3><sZ>3 aut.</sZ><sZ>7 aut.</sZ></fA14><fA14 i1="07"><s1>BC Biomedical Laboratories Ltd</s1><s2>Surrey, British Columbia</s2><s3>CAN</s3><sZ>8 aut.</sZ></fA14><fA14 i1="08"><s1>Institut national de santé publique du Québec, Université Laval</s1><s2>Québec</s2><s3>CAN</s3><sZ>12 aut.</sZ></fA14><fA14 i1="09"><s1>Department of Social and Preventive Medicine, Université Laval</s1><s2>Québec</s2><s3>CAN</s3><sZ>12 aut.</sZ></fA14><fA20><s1>158-167</s1></fA20><fA21><s1>2011</s1></fA21><fA23 i1="01"><s0>ENG</s0></fA23><fA43 i1="01"><s1>INIST</s1><s2>2052</s2><s5>354000194614000050</s5></fA43><fA44><s0>0000</s0><s1>© 2011 INIST-CNRS. All rights reserved.</s1></fA44><fA45><s0>41 ref.</s0></fA45><fA47 i1="01" i2="1"><s0>11-0131918</s0></fA47><fA60><s1>P</s1></fA60><fA61><s0>A</s0></fA61><fA64 i1="01" i2="1"><s0>The Journal of infectious diseases</s0></fA64><fA66 i1="01"><s0>GBR</s0></fA66><fC01 i1="01" l="ENG"><s0>Background. Pandemic H1N1 (pH1N1) surveillance data showed lower attack rates but higher risk of severe outcomes with advanced age. We explored immuno-epidemiologic correlates of surveillance findings including humoral and cell-mediated immunity (CMI). Methods. In an age-based design, ∼100 banked/residual sera per 10-year age stratum were assessed by hemagglutination inhibition (HI) and microneutralization (MN) assays for preexisting antibody to pH1N1 and recent seasonal H1N1 and H3N2 strains. In a separate birth cohort design defined by childhood influenza A/subtype priming (1919-1929: H1N1; 1945-1949: H1N1; 1958-1960: H2N2; 1969-1970: H3N2; 1978-1989: H3N2/H1N1), whole blood was collected from up to 50 volunteers per birth cohort. The ratio of Th1(IFN-γ):Th2(IL-10) cytokine responses was evaluated in vitro. Results. Antibody to seasonal viruses was highest in school-age children. Cross-reactive HI/MN antibody to pH1N1 was low among participants <70 years of age (yoa; 6%/4% ≥ 40), but seroprevalence increased at 70-79 yoa (27%/6%), increased even more at 80-89 yoa (65%/47%), and was highest at ≥90 yoa (88%/76%). CMI to pH1N1 was evident in all 5 birth cohorts but was lower compared with seasonal strains. There was little differentiation by subtype priming, but the Th1:Th2 ratio for all viruses dropped significantly in the 2 oldest cohorts. Conclusions. Preexisting antibody may have protected the very old from pH1N1 infection, while diminished CMI may have contributed to greater severity once infected. In the young, cross-reactive pH1N1 antibody was mostly absent, while more intact CMI may have protected against severe outcomes.</s0></fC01><fC02 i1="01" i2="X"><s0>002A05</s0></fC02><fC02 i1="02" i2="X"><s0>002B05</s0></fC02><fC03 i1="01" i2="X" l="FRE"><s0>Anticorps</s0><s5>05</s5></fC03><fC03 i1="01" i2="X" l="ENG"><s0>Antibody</s0><s5>05</s5></fC03><fC03 i1="01" i2="X" l="SPA"><s0>Anticuerpo</s0><s5>05</s5></fC03><fC03 i1="02" i2="X" l="FRE"><s0>Réponse immune</s0><s5>06</s5></fC03><fC03 i1="02" i2="X" l="ENG"><s0>Immune response</s0><s5>06</s5></fC03><fC03 i1="02" i2="X" l="SPA"><s0>Respuesta inmune</s0><s5>06</s5></fC03><fC03 i1="03" i2="X" l="FRE"><s0>Age</s0><s5>07</s5></fC03><fC03 i1="03" i2="X" l="ENG"><s0>Age</s0><s5>07</s5></fC03><fC03 i1="03" i2="X" l="SPA"><s0>Edad</s0><s5>07</s5></fC03><fC03 i1="04" i2="X" l="FRE"><s0>Infection</s0><s5>08</s5></fC03><fC03 i1="04" i2="X" l="ENG"><s0>Infection</s0><s5>08</s5></fC03><fC03 i1="04" i2="X" l="SPA"><s0>Infección</s0><s5>08</s5></fC03><fC03 i1="05" i2="X" l="FRE"><s0>Virus grippal A(H1N1)</s0><s4>CD</s4><s5>96</s5></fC03><fC03 i1="05" i2="X" l="ENG"><s0>Influenzavirus A(H1N1)</s0><s4>CD</s4><s5>96</s5></fC03><fN21><s1>087</s1></fN21><fN44 i1="01"><s1>OTO</s1></fN44><fN82><s1>OTO</s1></fN82></pA></standard></inist></record>Pour manipuler ce document sous Unix (Dilib)
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