ChloroquineV1, Main, Merge, bibRecord, 001631

A new xanthone from the bark extract of Rheedia acuminata and antiplasmodial activity of its major compounds.

Identifieur interne : 001631 ( Main/Merge ); précédent : 001630; suivant : 001632

A new xanthone from the bark extract of Rheedia acuminata and antiplasmodial activity of its major compounds.

Auteurs : Guillaume Marti [France] ; Véronique Eparvier ; Marc Litaudon ; Philippe Grellier ; Françoise Guéritte

Source :

Molecules (Basel, Switzerland) [ 1420-3049 ] ; 2010.

RBID : pubmed:20948498

Descripteurs français

KwdFr :
- Animaux, Antipaludiques (), Antipaludiques (pharmacologie), Clusiaceae (), Extraits de plantes (), Extraits de plantes (pharmacologie), Humains, Plasmodium falciparum (), Structure moléculaire, Xanthones (), Xanthones (pharmacologie), Écorce ().
MESH :
- pharmacologie : Antipaludiques, Extraits de plantes, Xanthones.
- Animaux, Antipaludiques, Clusiaceae, Extraits de plantes, Humains, Plasmodium falciparum, Structure moléculaire, Xanthones, Écorce.

English descriptors

KwdEn :
- Animals, Antimalarials (chemistry), Antimalarials (pharmacology), Clusiaceae (chemistry), Humans, Molecular Structure, Plant Bark (chemistry), Plant Extracts (chemistry), Plant Extracts (pharmacology), Plasmodium falciparum (drug effects), Xanthones (chemistry), Xanthones (pharmacology).
MESH :
- chemical , chemistry : Antimalarials, Plant Extracts, Xanthones.
- chemical , pharmacology : Antimalarials, Plant Extracts, Xanthones.
- chemistry : Clusiaceae, Plant Bark.
- drug effects : Plasmodium falciparum.
- Animals, Humans, Molecular Structure.
mix :
- Clusiaceae, Rheedia acuminata, antiplasmodial activity, cytotoxicity, xanthones.

Abstract

Bioassay-guided fractionation of the ethyl acetate bark extract of Rheedia acuminata led to the isolation of the new compound 1,5,6-trihydroxy-3-methoxy-7-geranyl-xanthone, together with four known compounds. These compounds were tested in vitro for their antiplasmodial activity on a chloroquine-resistant strain of Plasmodium falciparum (FcB1) and for their cytotoxicity against the human diploid embryonic lung cell line MRC-5.

Url:

DOI: 10.3390/molecules15107106
PubMed: 20948498

Links to Exploration step

pubmed:20948498

Le document en format XML

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<author><name sortKey="Grellier, Philippe" sort="Grellier, Philippe" uniqKey="Grellier P" first="Philippe" last="Grellier">Philippe Grellier</name>
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<author><name sortKey="Gueritte, Francoise" sort="Gueritte, Francoise" uniqKey="Gueritte F" first="Francoise" last="Guéritte">Francoise Guéritte</name>
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<idno type="DOI">10.3390/molecules15107106</idno>
<series><title level="j">Molecules</title>
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<term>Rheedia acuminata</term>
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<front><div type="abstract" xml:lang="en">              <p>Bioassay-guided fractionation of the ethyl acetate bark extract of Rheedia acuminata led to the isolation of the new compound 1,5,6-trihydroxy-3-methoxy-7-geranyl-xanthone (1), together with four known compounds 2-5. These compounds were tested in vitro for their antiplasmodial activity on a chloroquine-resistant strain of Plasmodium falciparum (FcB1) and for their cytotoxicity against the human diploid embryonic lung cell line MRC-5.</p>
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A new xanthone from the bark extract of Rheedia acuminata and antiplasmodial activity of its major compounds.

A new xanthone from the bark extract of Rheedia acuminata and antiplasmodial activity of its major compounds.

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