ChloroquineV1, Ncbi, Merge, bibRecord, 000142

A new xanthone from the bark extract of Rheedia acuminata and antiplasmodial activity of its major compounds.

Identifieur interne : 000142 ( Ncbi/Merge ); précédent : 000141; suivant : 000143

A new xanthone from the bark extract of Rheedia acuminata and antiplasmodial activity of its major compounds.

Auteurs : Guillaume Marti [France] ; Véronique Eparvier ; Marc Litaudon ; Philippe Grellier ; Françoise Guéritte

Source :

Molecules (Basel, Switzerland) [ 1420-3049 ] ; 2010.

RBID : pubmed:20948498

Descripteurs français

KwdFr :
- Animaux, Antipaludiques (), Antipaludiques (pharmacologie), Clusiaceae (), Extraits de plantes (), Extraits de plantes (pharmacologie), Humains, Plasmodium falciparum (), Structure moléculaire, Xanthones (), Xanthones (pharmacologie), Écorce ().
MESH :
- pharmacologie : Antipaludiques, Extraits de plantes, Xanthones.
- Animaux, Antipaludiques, Clusiaceae, Extraits de plantes, Humains, Plasmodium falciparum, Structure moléculaire, Xanthones, Écorce.

English descriptors

KwdEn :
- Animals, Antimalarials (chemistry), Antimalarials (pharmacology), Clusiaceae (chemistry), Humans, Molecular Structure, Plant Bark (chemistry), Plant Extracts (chemistry), Plant Extracts (pharmacology), Plasmodium falciparum (drug effects), Xanthones (chemistry), Xanthones (pharmacology).
MESH :
- chemical , chemistry : Antimalarials, Plant Extracts, Xanthones.
- chemical , pharmacology : Antimalarials, Plant Extracts, Xanthones.
- chemistry : Clusiaceae, Plant Bark.
- drug effects : Plasmodium falciparum.
- Animals, Humans, Molecular Structure.

Abstract

Bioassay-guided fractionation of the ethyl acetate bark extract of Rheedia acuminata led to the isolation of the new compound 1,5,6-trihydroxy-3-methoxy-7-geranyl-xanthone, together with four known compounds. These compounds were tested in vitro for their antiplasmodial activity on a chloroquine-resistant strain of Plasmodium falciparum (FcB1) and for their cytotoxicity against the human diploid embryonic lung cell line MRC-5.

DOI: 10.3390/molecules15107106
PubMed: 20948498

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pubmed:20948498

Le document en format XML

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<front><div type="abstract" xml:lang="en">Bioassay-guided fractionation of the ethyl acetate bark extract of Rheedia acuminata led to the isolation of the new compound 1,5,6-trihydroxy-3-methoxy-7-geranyl-xanthone, together with four known compounds. These compounds were tested in vitro for their antiplasmodial activity on a chloroquine-resistant strain of Plasmodium falciparum (FcB1) and for their cytotoxicity against the human diploid embryonic lung cell line MRC-5.</div>
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A new xanthone from the bark extract of Rheedia acuminata and antiplasmodial activity of its major compounds.

A new xanthone from the bark extract of Rheedia acuminata and antiplasmodial activity of its major compounds.

Source :

Descripteurs français

English descriptors

Abstract

Links toward previous steps (curation, corpus...)

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

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Pour générer des pages wiki