ChloroquineV1, Hal, Corpus, bibRecord, 000006

A new xanthone from the bark extract of Rheedia acuminata and antiplasmodial activity of its major compounds.

Identifieur interne : 000006 ( Hal/Corpus ); précédent : 000005; suivant : 000007

A new xanthone from the bark extract of Rheedia acuminata and antiplasmodial activity of its major compounds.

Auteurs : Guillaume Marti ; Véronique Eparvier ; Marc Litaudon ; Philippe Grellier ; Françoise Guéritte

Source :

Molecules [ 1420-3049 ] ; 2010.

RBID : Hal:hal-00530117

Abstract

Bioassay-guided fractionation of the ethyl acetate bark extract of Rheedia acuminata led to the isolation of the new compound 1,5,6-trihydroxy-3-methoxy-7-geranyl-xanthone, together with four known compounds. These compounds were tested in vitro for their antiplasmodial activity on a chloroquine-resistant strain of Plasmodium falciparum (FcB1) and for their cytotoxicity against the human diploid embryonic lung cell line MRC-5.

Url:

https://hal.archives-ouvertes.fr/hal-00530117

DOI: 10.3390/molecules15107106

Links to Exploration step

Hal:hal-00530117

Le document en format XML

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<front><div type="abstract" xml:lang="en">              <p>Bioassay-guided fractionation of the ethyl acetate bark extract of Rheedia acuminata led to the isolation of the new compound 1,5,6-trihydroxy-3-methoxy-7-geranyl-xanthone, together with four known compounds. These compounds were tested in vitro for their antiplasmodial activity on a chloroquine-resistant strain of Plasmodium falciparum (FcB1) and for their cytotoxicity against the human diploid embryonic lung cell line MRC-5.</p>
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A new xanthone from the bark extract of Rheedia acuminata and antiplasmodial activity of its major compounds.

A new xanthone from the bark extract of Rheedia acuminata and antiplasmodial activity of its major compounds.

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