Targeting the Gut Microbiota to Treat Cachexia
Identifieur interne : 000380 ( Main/Merge ); précédent : 000379; suivant : 000381Targeting the Gut Microbiota to Treat Cachexia
Auteurs : Laurence Genton [Suisse] ; Julie Mareschal [Suisse] ; Yannick Charretier [Suisse] ; Vladimir Lazarevic [Suisse] ; Laure B. Bindels [Belgique] ; Jacques Schrenzel [Suisse]Source :
- Frontiers in Cellular and Infection Microbiology [ 2235-2988 ] ; 2019.
Abstract
Cachexia occurs in many chronic diseases and is associated with increased morbidity and mortality. It is treated by nutritional support but often with limited effectiveness, leading to the search of other therapeutic strategies. The modulation of gut microbiota, whether through pro-, pre-, syn- or antibiotics or fecal transplantation, is attracting ever-growing interest in the field of obesity, but could also be an interesting and innovative alternative for treating cachexia. This article reviews the evidence linking the features of malnutrition, as defined by the Global Leadership Initiative on Malnutrition [low body mass index (BMI), unintentional body weight loss, low muscle mass, low appetite, and systemic inflammation] and the gut microbiota in human adults with cachexia-associated diseases, and shows the limitations of the present research in that field with suggestions for future directions.
Url:
DOI: 10.3389/fcimb.2019.00305
PubMed: 31572686
PubMed Central: 6751326
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PMC:6751326Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Targeting the Gut Microbiota to Treat Cachexia</title><author><name sortKey="Genton, Laurence" sort="Genton, Laurence" uniqKey="Genton L" first="Laurence" last="Genton">Laurence Genton</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Clinical Nutrition, Geneva University Hospitals and University of Geneva</institution>,<addr-line>Geneva</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mareschal, Julie" sort="Mareschal, Julie" uniqKey="Mareschal J" first="Julie" last="Mareschal">Julie Mareschal</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Clinical Nutrition, Geneva University Hospitals and University of Geneva</institution>,<addr-line>Geneva</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Charretier, Yannick" sort="Charretier, Yannick" uniqKey="Charretier Y" first="Yannick" last="Charretier">Yannick Charretier</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Genomic Research Laboratory, Service of Infectious Diseases, Geneva University Hospitals and University of Geneva</institution>,<addr-line>Geneva</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lazarevic, Vladimir" sort="Lazarevic, Vladimir" uniqKey="Lazarevic V" first="Vladimir" last="Lazarevic">Vladimir Lazarevic</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Genomic Research Laboratory, Service of Infectious Diseases, Geneva University Hospitals and University of Geneva</institution>,<addr-line>Geneva</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bindels, Laure B" sort="Bindels, Laure B" uniqKey="Bindels L" first="Laure B." last="Bindels">Laure B. 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Bindels</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Université Catholique de Louvain</institution>,<addr-line>Brussels</addr-line>,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Schrenzel, Jacques" sort="Schrenzel, Jacques" uniqKey="Schrenzel J" first="Jacques" last="Schrenzel">Jacques Schrenzel</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Genomic Research Laboratory, Service of Infectious Diseases, Geneva University Hospitals and University of Geneva</institution>,<addr-line>Geneva</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Frontiers in Cellular and Infection Microbiology</title><idno type="eISSN">2235-2988</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Cachexia occurs in many chronic diseases and is associated with increased morbidity and mortality. It is treated by nutritional support but often with limited effectiveness, leading to the search of other therapeutic strategies. The modulation of gut microbiota, whether through pro-, pre-, syn- or antibiotics or fecal transplantation, is attracting ever-growing interest in the field of obesity, but could also be an interesting and innovative alternative for treating cachexia. This article reviews the evidence linking the features of malnutrition, as defined by the Global Leadership Initiative on Malnutrition [low body mass index (BMI), unintentional body weight loss, low muscle mass, low appetite, and systemic inflammation] and the gut microbiota in human adults with cachexia-associated diseases, and shows the limitations of the present research in that field with suggestions for future directions.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ahluwalia, V" uniqKey="Ahluwalia V">V. 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