Targeting the Gut Microbiota to Treat Cachexia
Identifieur interne : 000958 ( Pmc/Curation ); précédent : 000957; suivant : 000959Targeting the Gut Microbiota to Treat Cachexia
Auteurs : Laurence Genton [Suisse] ; Julie Mareschal [Suisse] ; Yannick Charretier [Suisse] ; Vladimir Lazarevic [Suisse] ; Laure B. Bindels [Belgique] ; Jacques Schrenzel [Suisse]Source :
- Frontiers in Cellular and Infection Microbiology [ 2235-2988 ] ; 2019.
Abstract
Cachexia occurs in many chronic diseases and is associated with increased morbidity and mortality. It is treated by nutritional support but often with limited effectiveness, leading to the search of other therapeutic strategies. The modulation of gut microbiota, whether through pro-, pre-, syn- or antibiotics or fecal transplantation, is attracting ever-growing interest in the field of obesity, but could also be an interesting and innovative alternative for treating cachexia. This article reviews the evidence linking the features of malnutrition, as defined by the Global Leadership Initiative on Malnutrition [low body mass index (BMI), unintentional body weight loss, low muscle mass, low appetite, and systemic inflammation] and the gut microbiota in human adults with cachexia-associated diseases, and shows the limitations of the present research in that field with suggestions for future directions.
Url:
DOI: 10.3389/fcimb.2019.00305
PubMed: 31572686
PubMed Central: 6751326
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<front><div type="abstract" xml:lang="en"><p>Cachexia occurs in many chronic diseases and is associated with increased morbidity and mortality. It is treated by nutritional support but often with limited effectiveness, leading to the search of other therapeutic strategies. The modulation of gut microbiota, whether through pro-, pre-, syn- or antibiotics or fecal transplantation, is attracting ever-growing interest in the field of obesity, but could also be an interesting and innovative alternative for treating cachexia. This article reviews the evidence linking the features of malnutrition, as defined by the Global Leadership Initiative on Malnutrition [low body mass index (BMI), unintentional body weight loss, low muscle mass, low appetite, and systemic inflammation] and the gut microbiota in human adults with cachexia-associated diseases, and shows the limitations of the present research in that field with suggestions for future directions.</p>
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<pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Front Cell Infect Microbiol</journal-id>
<journal-id journal-id-type="iso-abbrev">Front Cell Infect Microbiol</journal-id>
<journal-id journal-id-type="publisher-id">Front. Cell. Infect. Microbiol.</journal-id>
<journal-title-group><journal-title>Frontiers in Cellular and Infection Microbiology</journal-title>
</journal-title-group>
<issn pub-type="epub">2235-2988</issn>
<publisher><publisher-name>Frontiers Media S.A.</publisher-name>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">31572686</article-id>
<article-id pub-id-type="pmc">6751326</article-id>
<article-id pub-id-type="doi">10.3389/fcimb.2019.00305</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Cellular and Infection Microbiology</subject>
<subj-group><subject>Mini Review</subject>
</subj-group>
</subj-group>
</article-categories>
<title-group><article-title>Targeting the Gut Microbiota to Treat Cachexia</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Genton</surname>
<given-names>Laurence</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
<xref ref-type="corresp" rid="c001"><sup>*</sup>
</xref>
<uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/111130/overview"></uri>
</contrib>
<contrib contrib-type="author"><name><surname>Mareschal</surname>
<given-names>Julie</given-names>
</name>
<xref ref-type="aff" rid="aff1"><sup>1</sup>
</xref>
</contrib>
<contrib contrib-type="author"><name><surname>Charretier</surname>
<given-names>Yannick</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
<uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/191427/overview"></uri>
</contrib>
<contrib contrib-type="author"><name><surname>Lazarevic</surname>
<given-names>Vladimir</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
<uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/30638/overview"></uri>
</contrib>
<contrib contrib-type="author"><name><surname>Bindels</surname>
<given-names>Laure B.</given-names>
</name>
<xref ref-type="aff" rid="aff3"><sup>3</sup>
</xref>
<uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/219485/overview"></uri>
</contrib>
<contrib contrib-type="author"><name><surname>Schrenzel</surname>
<given-names>Jacques</given-names>
</name>
<xref ref-type="aff" rid="aff2"><sup>2</sup>
</xref>
<uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/35883/overview"></uri>
</contrib>
</contrib-group>
<aff id="aff1"><sup>1</sup>
<institution>Clinical Nutrition, Geneva University Hospitals and University of Geneva</institution>
,<addr-line>Geneva</addr-line>
,<country>Switzerland</country>
</aff>
<aff id="aff2"><sup>2</sup>
<institution>Genomic Research Laboratory, Service of Infectious Diseases, Geneva University Hospitals and University of Geneva</institution>
,<addr-line>Geneva</addr-line>
,<country>Switzerland</country>
</aff>
<aff id="aff3"><sup>3</sup>
<institution>Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Université Catholique de Louvain</institution>
,<addr-line>Brussels</addr-line>
,<country>Belgium</country>
</aff>
<author-notes><fn fn-type="edited-by"><p>Edited by: Benoit Guery, Lausanne University Hospital (CHUV), Switzerland</p>
</fn>
<fn fn-type="edited-by"><p>Reviewed by: David R. Brown, University of Minnesota Twin Cities, United States; Irving Coy Allen, Virginia Tech, United States</p>
</fn>
<corresp id="c001">*Correspondence: Laurence Genton <email>laurence.genton@hcuge.ch</email>
</corresp>
<fn fn-type="other" id="fn001"><p>This article was submitted to Microbiome in Health and Disease, a section of the journal Frontiers in Cellular and Infection Microbiology</p>
</fn>
</author-notes>
<pub-date pub-type="epub"><day>12</day>
<month>9</month>
<year>2019</year>
</pub-date>
<pub-date pub-type="collection"><year>2019</year>
</pub-date>
<volume>9</volume>
<elocation-id>305</elocation-id>
<history><date date-type="received"><day>06</day>
<month>6</month>
<year>2019</year>
</date>
<date date-type="accepted"><day>09</day>
<month>8</month>
<year>2019</year>
</date>
</history>
<permissions><copyright-statement>Copyright © 2019 Genton, Mareschal, Charretier, Lazarevic, Bindels and Schrenzel.</copyright-statement>
<copyright-year>2019</copyright-year>
<copyright-holder>Genton, Mareschal, Charretier, Lazarevic, Bindels and Schrenzel</copyright-holder>
<license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</license-p>
</license>
</permissions>
<abstract><p>Cachexia occurs in many chronic diseases and is associated with increased morbidity and mortality. It is treated by nutritional support but often with limited effectiveness, leading to the search of other therapeutic strategies. The modulation of gut microbiota, whether through pro-, pre-, syn- or antibiotics or fecal transplantation, is attracting ever-growing interest in the field of obesity, but could also be an interesting and innovative alternative for treating cachexia. This article reviews the evidence linking the features of malnutrition, as defined by the Global Leadership Initiative on Malnutrition [low body mass index (BMI), unintentional body weight loss, low muscle mass, low appetite, and systemic inflammation] and the gut microbiota in human adults with cachexia-associated diseases, and shows the limitations of the present research in that field with suggestions for future directions.</p>
</abstract>
<kwd-group><kwd>gut</kwd>
<kwd>gut microbiota</kwd>
<kwd>metabolism</kwd>
<kwd>cachexia</kwd>
<kwd>metagenomic</kwd>
</kwd-group>
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