Targeting the Gut Microbiota to Treat Cachexia
Identifieur interne : 000342 ( Pmc/Checkpoint ); précédent : 000341; suivant : 000343Targeting the Gut Microbiota to Treat Cachexia
Auteurs : Laurence Genton [Suisse] ; Julie Mareschal [Suisse] ; Yannick Charretier [Suisse] ; Vladimir Lazarevic [Suisse] ; Laure B. Bindels [Belgique] ; Jacques Schrenzel [Suisse]Source :
- Frontiers in Cellular and Infection Microbiology [ 2235-2988 ] ; 2019.
Abstract
Cachexia occurs in many chronic diseases and is associated with increased morbidity and mortality. It is treated by nutritional support but often with limited effectiveness, leading to the search of other therapeutic strategies. The modulation of gut microbiota, whether through pro-, pre-, syn- or antibiotics or fecal transplantation, is attracting ever-growing interest in the field of obesity, but could also be an interesting and innovative alternative for treating cachexia. This article reviews the evidence linking the features of malnutrition, as defined by the Global Leadership Initiative on Malnutrition [low body mass index (BMI), unintentional body weight loss, low muscle mass, low appetite, and systemic inflammation] and the gut microbiota in human adults with cachexia-associated diseases, and shows the limitations of the present research in that field with suggestions for future directions.
Url:
DOI: 10.3389/fcimb.2019.00305
PubMed: 31572686
PubMed Central: 6751326
Affiliations:
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<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Targeting the Gut Microbiota to Treat Cachexia</title><author><name sortKey="Genton, Laurence" sort="Genton, Laurence" uniqKey="Genton L" first="Laurence" last="Genton">Laurence Genton</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Clinical Nutrition, Geneva University Hospitals and University of Geneva</institution>,<addr-line>Geneva</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mareschal, Julie" sort="Mareschal, Julie" uniqKey="Mareschal J" first="Julie" last="Mareschal">Julie Mareschal</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Clinical Nutrition, Geneva University Hospitals and University of Geneva</institution>,<addr-line>Geneva</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Charretier, Yannick" sort="Charretier, Yannick" uniqKey="Charretier Y" first="Yannick" last="Charretier">Yannick Charretier</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Genomic Research Laboratory, Service of Infectious Diseases, Geneva University Hospitals and University of Geneva</institution>,<addr-line>Geneva</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lazarevic, Vladimir" sort="Lazarevic, Vladimir" uniqKey="Lazarevic V" first="Vladimir" last="Lazarevic">Vladimir Lazarevic</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Genomic Research Laboratory, Service of Infectious Diseases, Geneva University Hospitals and University of Geneva</institution>,<addr-line>Geneva</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bindels, Laure B" sort="Bindels, Laure B" uniqKey="Bindels L" first="Laure B." last="Bindels">Laure B. Bindels</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Université Catholique de Louvain</institution>,<addr-line>Brussels</addr-line>,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Schrenzel, Jacques" sort="Schrenzel, Jacques" uniqKey="Schrenzel J" first="Jacques" last="Schrenzel">Jacques Schrenzel</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Genomic Research Laboratory, Service of Infectious Diseases, Geneva University Hospitals and University of Geneva</institution>,<addr-line>Geneva</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31572686</idno><idno type="pmc">6751326</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751326</idno><idno type="RBID">PMC:6751326</idno><idno type="doi">10.3389/fcimb.2019.00305</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000958</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000958</idno><idno type="wicri:Area/Pmc/Curation">000958</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000958</idno><idno type="wicri:Area/Pmc/Checkpoint">000342</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000342</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Targeting the Gut Microbiota to Treat Cachexia</title><author><name sortKey="Genton, Laurence" sort="Genton, Laurence" uniqKey="Genton L" first="Laurence" last="Genton">Laurence Genton</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Clinical Nutrition, Geneva University Hospitals and University of Geneva</institution>,<addr-line>Geneva</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Mareschal, Julie" sort="Mareschal, Julie" uniqKey="Mareschal J" first="Julie" last="Mareschal">Julie Mareschal</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Clinical Nutrition, Geneva University Hospitals and University of Geneva</institution>,<addr-line>Geneva</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Charretier, Yannick" sort="Charretier, Yannick" uniqKey="Charretier Y" first="Yannick" last="Charretier">Yannick Charretier</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Genomic Research Laboratory, Service of Infectious Diseases, Geneva University Hospitals and University of Geneva</institution>,<addr-line>Geneva</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Lazarevic, Vladimir" sort="Lazarevic, Vladimir" uniqKey="Lazarevic V" first="Vladimir" last="Lazarevic">Vladimir Lazarevic</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Genomic Research Laboratory, Service of Infectious Diseases, Geneva University Hospitals and University of Geneva</institution>,<addr-line>Geneva</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Bindels, Laure B" sort="Bindels, Laure B" uniqKey="Bindels L" first="Laure B." last="Bindels">Laure B. Bindels</name><affiliation wicri:level="1"><nlm:aff id="aff3"><institution>Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Université Catholique de Louvain</institution>,<addr-line>Brussels</addr-line>,<country>Belgium</country></nlm:aff><country xml:lang="fr">Belgique</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Schrenzel, Jacques" sort="Schrenzel, Jacques" uniqKey="Schrenzel J" first="Jacques" last="Schrenzel">Jacques Schrenzel</name><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Genomic Research Laboratory, Service of Infectious Diseases, Geneva University Hospitals and University of Geneva</institution>,<addr-line>Geneva</addr-line>,<country>Switzerland</country></nlm:aff><country xml:lang="fr">Suisse</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Frontiers in Cellular and Infection Microbiology</title><idno type="eISSN">2235-2988</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Cachexia occurs in many chronic diseases and is associated with increased morbidity and mortality. It is treated by nutritional support but often with limited effectiveness, leading to the search of other therapeutic strategies. The modulation of gut microbiota, whether through pro-, pre-, syn- or antibiotics or fecal transplantation, is attracting ever-growing interest in the field of obesity, but could also be an interesting and innovative alternative for treating cachexia. This article reviews the evidence linking the features of malnutrition, as defined by the Global Leadership Initiative on Malnutrition [low body mass index (BMI), unintentional body weight loss, low muscle mass, low appetite, and systemic inflammation] and the gut microbiota in human adults with cachexia-associated diseases, and shows the limitations of the present research in that field with suggestions for future directions.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ahluwalia, V" uniqKey="Ahluwalia V">V. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Front Cell Infect Microbiol</journal-id><journal-id journal-id-type="iso-abbrev">Front Cell Infect Microbiol</journal-id><journal-id journal-id-type="publisher-id">Front. Cell. Infect. Microbiol.</journal-id><journal-title-group><journal-title>Frontiers in Cellular and Infection Microbiology</journal-title></journal-title-group><issn pub-type="epub">2235-2988</issn><publisher><publisher-name>Frontiers Media S.A.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">31572686</article-id><article-id pub-id-type="pmc">6751326</article-id><article-id pub-id-type="doi">10.3389/fcimb.2019.00305</article-id><article-categories><subj-group subj-group-type="heading"><subject>Cellular and Infection Microbiology</subject><subj-group><subject>Mini Review</subject></subj-group></subj-group></article-categories><title-group><article-title>Targeting the Gut Microbiota to Treat Cachexia</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Genton</surname><given-names>Laurence</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="corresp" rid="c001"><sup>*</sup></xref><uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/111130/overview"></uri></contrib><contrib contrib-type="author"><name><surname>Mareschal</surname><given-names>Julie</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Charretier</surname><given-names>Yannick</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/191427/overview"></uri></contrib><contrib contrib-type="author"><name><surname>Lazarevic</surname><given-names>Vladimir</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/30638/overview"></uri></contrib><contrib contrib-type="author"><name><surname>Bindels</surname><given-names>Laure B.</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref><uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/219485/overview"></uri></contrib><contrib contrib-type="author"><name><surname>Schrenzel</surname><given-names>Jacques</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/35883/overview"></uri></contrib></contrib-group><aff id="aff1"><sup>1</sup><institution>Clinical Nutrition, Geneva University Hospitals and University of Geneva</institution>,<addr-line>Geneva</addr-line>,<country>Switzerland</country></aff><aff id="aff2"><sup>2</sup><institution>Genomic Research Laboratory, Service of Infectious Diseases, Geneva University Hospitals and University of Geneva</institution>,<addr-line>Geneva</addr-line>,<country>Switzerland</country></aff><aff id="aff3"><sup>3</sup><institution>Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Université Catholique de Louvain</institution>,<addr-line>Brussels</addr-line>,<country>Belgium</country></aff><author-notes><fn fn-type="edited-by"><p>Edited by: Benoit Guery, Lausanne University Hospital (CHUV), Switzerland</p></fn><fn fn-type="edited-by"><p>Reviewed by: David R. Brown, University of Minnesota Twin Cities, United States; Irving Coy Allen, Virginia Tech, United States</p></fn><corresp id="c001">*Correspondence: Laurence Genton <email>laurence.genton@hcuge.ch</email></corresp><fn fn-type="other" id="fn001"><p>This article was submitted to Microbiome in Health and Disease, a section of the journal Frontiers in Cellular and Infection Microbiology</p></fn></author-notes><pub-date pub-type="epub"><day>12</day><month>9</month><year>2019</year></pub-date><pub-date pub-type="collection"><year>2019</year></pub-date><volume>9</volume><elocation-id>305</elocation-id><history><date date-type="received"><day>06</day><month>6</month><year>2019</year></date><date date-type="accepted"><day>09</day><month>8</month><year>2019</year></date></history><permissions><copyright-statement>Copyright © 2019 Genton, Mareschal, Charretier, Lazarevic, Bindels and Schrenzel.</copyright-statement><copyright-year>2019</copyright-year><copyright-holder>Genton, Mareschal, Charretier, Lazarevic, Bindels and Schrenzel</copyright-holder><license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</license-p></license></permissions><abstract><p>Cachexia occurs in many chronic diseases and is associated with increased morbidity and mortality. It is treated by nutritional support but often with limited effectiveness, leading to the search of other therapeutic strategies. The modulation of gut microbiota, whether through pro-, pre-, syn- or antibiotics or fecal transplantation, is attracting ever-growing interest in the field of obesity, but could also be an interesting and innovative alternative for treating cachexia. This article reviews the evidence linking the features of malnutrition, as defined by the Global Leadership Initiative on Malnutrition [low body mass index (BMI), unintentional body weight loss, low muscle mass, low appetite, and systemic inflammation] and the gut microbiota in human adults with cachexia-associated diseases, and shows the limitations of the present research in that field with suggestions for future directions.</p></abstract><kwd-group><kwd>gut</kwd><kwd>gut microbiota</kwd><kwd>metabolism</kwd><kwd>cachexia</kwd><kwd>metagenomic</kwd></kwd-group><counts><fig-count count="1"></fig-count><table-count count="1"></table-count><equation-count count="0"></equation-count><ref-count count="61"></ref-count><page-count count="8"></page-count><word-count count="6227"></word-count></counts></article-meta></front></pmc><affiliations><list><country><li>Belgique</li><li>Suisse</li></country></list><tree><country name="Suisse"><noRegion><name sortKey="Genton, Laurence" sort="Genton, Laurence" uniqKey="Genton L" first="Laurence" last="Genton">Laurence Genton</name></noRegion><name sortKey="Charretier, Yannick" sort="Charretier, Yannick" uniqKey="Charretier Y" first="Yannick" last="Charretier">Yannick Charretier</name><name sortKey="Lazarevic, Vladimir" sort="Lazarevic, Vladimir" uniqKey="Lazarevic V" first="Vladimir" last="Lazarevic">Vladimir Lazarevic</name><name sortKey="Mareschal, Julie" sort="Mareschal, Julie" uniqKey="Mareschal J" first="Julie" last="Mareschal">Julie Mareschal</name><name sortKey="Schrenzel, Jacques" sort="Schrenzel, Jacques" uniqKey="Schrenzel J" first="Jacques" last="Schrenzel">Jacques Schrenzel</name></country><country name="Belgique"><noRegion><name sortKey="Bindels, Laure B" sort="Bindels, Laure B" uniqKey="Bindels L" first="Laure B." last="Bindels">Laure B. Bindels</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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