Targeting the Gut Microbiota to Treat Cachexia
Identifieur interne : 000958 ( Pmc/Corpus ); précédent : 000957; suivant : 000959Targeting the Gut Microbiota to Treat Cachexia
Auteurs : Laurence Genton ; Julie Mareschal ; Yannick Charretier ; Vladimir Lazarevic ; Laure B. Bindels ; Jacques SchrenzelSource :
- Frontiers in Cellular and Infection Microbiology [ 2235-2988 ] ; 2019.
Abstract
Cachexia occurs in many chronic diseases and is associated with increased morbidity and mortality. It is treated by nutritional support but often with limited effectiveness, leading to the search of other therapeutic strategies. The modulation of gut microbiota, whether through pro-, pre-, syn- or antibiotics or fecal transplantation, is attracting ever-growing interest in the field of obesity, but could also be an interesting and innovative alternative for treating cachexia. This article reviews the evidence linking the features of malnutrition, as defined by the Global Leadership Initiative on Malnutrition [low body mass index (BMI), unintentional body weight loss, low muscle mass, low appetite, and systemic inflammation] and the gut microbiota in human adults with cachexia-associated diseases, and shows the limitations of the present research in that field with suggestions for future directions.
Url:
DOI: 10.3389/fcimb.2019.00305
PubMed: 31572686
PubMed Central: 6751326
Links to Exploration step
PMC:6751326Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Targeting the Gut Microbiota to Treat Cachexia</title><author><name sortKey="Genton, Laurence" sort="Genton, Laurence" uniqKey="Genton L" first="Laurence" last="Genton">Laurence Genton</name><affiliation><nlm:aff id="aff1"><institution>Clinical Nutrition, Geneva University Hospitals and University of Geneva</institution>,<addr-line>Geneva</addr-line>,<country>Switzerland</country></nlm:aff></affiliation></author><author><name sortKey="Mareschal, Julie" sort="Mareschal, Julie" uniqKey="Mareschal J" first="Julie" last="Mareschal">Julie Mareschal</name><affiliation><nlm:aff id="aff1"><institution>Clinical Nutrition, Geneva University Hospitals and University of Geneva</institution>,<addr-line>Geneva</addr-line>,<country>Switzerland</country></nlm:aff></affiliation></author><author><name sortKey="Charretier, Yannick" sort="Charretier, Yannick" uniqKey="Charretier Y" first="Yannick" last="Charretier">Yannick Charretier</name><affiliation><nlm:aff id="aff2"><institution>Genomic Research Laboratory, Service of Infectious Diseases, Geneva University Hospitals and University of Geneva</institution>,<addr-line>Geneva</addr-line>,<country>Switzerland</country></nlm:aff></affiliation></author><author><name sortKey="Lazarevic, Vladimir" sort="Lazarevic, Vladimir" uniqKey="Lazarevic V" first="Vladimir" last="Lazarevic">Vladimir Lazarevic</name><affiliation><nlm:aff id="aff2"><institution>Genomic Research Laboratory, Service of Infectious Diseases, Geneva University Hospitals and University of Geneva</institution>,<addr-line>Geneva</addr-line>,<country>Switzerland</country></nlm:aff></affiliation></author><author><name sortKey="Bindels, Laure B" sort="Bindels, Laure B" uniqKey="Bindels L" first="Laure B." last="Bindels">Laure B. Bindels</name><affiliation><nlm:aff id="aff3"><institution>Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Université Catholique de Louvain</institution>,<addr-line>Brussels</addr-line>,<country>Belgium</country></nlm:aff></affiliation></author><author><name sortKey="Schrenzel, Jacques" sort="Schrenzel, Jacques" uniqKey="Schrenzel J" first="Jacques" last="Schrenzel">Jacques Schrenzel</name><affiliation><nlm:aff id="aff2"><institution>Genomic Research Laboratory, Service of Infectious Diseases, Geneva University Hospitals and University of Geneva</institution>,<addr-line>Geneva</addr-line>,<country>Switzerland</country></nlm:aff></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">PMC</idno><idno type="pmid">31572686</idno><idno type="pmc">6751326</idno><idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6751326</idno><idno type="RBID">PMC:6751326</idno><idno type="doi">10.3389/fcimb.2019.00305</idno><date when="2019">2019</date><idno type="wicri:Area/Pmc/Corpus">000958</idno><idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000958</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Targeting the Gut Microbiota to Treat Cachexia</title><author><name sortKey="Genton, Laurence" sort="Genton, Laurence" uniqKey="Genton L" first="Laurence" last="Genton">Laurence Genton</name><affiliation><nlm:aff id="aff1"><institution>Clinical Nutrition, Geneva University Hospitals and University of Geneva</institution>,<addr-line>Geneva</addr-line>,<country>Switzerland</country></nlm:aff></affiliation></author><author><name sortKey="Mareschal, Julie" sort="Mareschal, Julie" uniqKey="Mareschal J" first="Julie" last="Mareschal">Julie Mareschal</name><affiliation><nlm:aff id="aff1"><institution>Clinical Nutrition, Geneva University Hospitals and University of Geneva</institution>,<addr-line>Geneva</addr-line>,<country>Switzerland</country></nlm:aff></affiliation></author><author><name sortKey="Charretier, Yannick" sort="Charretier, Yannick" uniqKey="Charretier Y" first="Yannick" last="Charretier">Yannick Charretier</name><affiliation><nlm:aff id="aff2"><institution>Genomic Research Laboratory, Service of Infectious Diseases, Geneva University Hospitals and University of Geneva</institution>,<addr-line>Geneva</addr-line>,<country>Switzerland</country></nlm:aff></affiliation></author><author><name sortKey="Lazarevic, Vladimir" sort="Lazarevic, Vladimir" uniqKey="Lazarevic V" first="Vladimir" last="Lazarevic">Vladimir Lazarevic</name><affiliation><nlm:aff id="aff2"><institution>Genomic Research Laboratory, Service of Infectious Diseases, Geneva University Hospitals and University of Geneva</institution>,<addr-line>Geneva</addr-line>,<country>Switzerland</country></nlm:aff></affiliation></author><author><name sortKey="Bindels, Laure B" sort="Bindels, Laure B" uniqKey="Bindels L" first="Laure B." last="Bindels">Laure B. Bindels</name><affiliation><nlm:aff id="aff3"><institution>Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Université Catholique de Louvain</institution>,<addr-line>Brussels</addr-line>,<country>Belgium</country></nlm:aff></affiliation></author><author><name sortKey="Schrenzel, Jacques" sort="Schrenzel, Jacques" uniqKey="Schrenzel J" first="Jacques" last="Schrenzel">Jacques Schrenzel</name><affiliation><nlm:aff id="aff2"><institution>Genomic Research Laboratory, Service of Infectious Diseases, Geneva University Hospitals and University of Geneva</institution>,<addr-line>Geneva</addr-line>,<country>Switzerland</country></nlm:aff></affiliation></author></analytic><series><title level="j">Frontiers in Cellular and Infection Microbiology</title><idno type="eISSN">2235-2988</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Cachexia occurs in many chronic diseases and is associated with increased morbidity and mortality. It is treated by nutritional support but often with limited effectiveness, leading to the search of other therapeutic strategies. The modulation of gut microbiota, whether through pro-, pre-, syn- or antibiotics or fecal transplantation, is attracting ever-growing interest in the field of obesity, but could also be an interesting and innovative alternative for treating cachexia. This article reviews the evidence linking the features of malnutrition, as defined by the Global Leadership Initiative on Malnutrition [low body mass index (BMI), unintentional body weight loss, low muscle mass, low appetite, and systemic inflammation] and the gut microbiota in human adults with cachexia-associated diseases, and shows the limitations of the present research in that field with suggestions for future directions.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ahluwalia, V" uniqKey="Ahluwalia V">V. Ahluwalia</name></author><author><name sortKey="Betrapally, N S" uniqKey="Betrapally N">N. S. Betrapally</name></author><author><name sortKey="Hylemon, P B" uniqKey="Hylemon P">P. B. Hylemon</name></author><author><name sortKey="White, M B" uniqKey="White M">M. B. White</name></author><author><name sortKey="Gillevet, P M" uniqKey="Gillevet P">P. M. Gillevet</name></author><author><name sortKey="Unser, A B" uniqKey="Unser A">A. B. Unser</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Alang, N" uniqKey="Alang N">N. Alang</name></author><author><name sortKey="Kelly, C R" uniqKey="Kelly C">C. R. Kelly</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Allen, J M" uniqKey="Allen J">J. M. Allen</name></author><author><name sortKey="Mailing, L J" uniqKey="Mailing L">L. J. Mailing</name></author><author><name sortKey="Cohrs, J" uniqKey="Cohrs J">J. Cohrs</name></author><author><name sortKey="Salmonson, C" uniqKey="Salmonson C">C. Salmonson</name></author><author><name sortKey="Fryer, J D" uniqKey="Fryer J">J. D. Fryer</name></author><author><name sortKey="Nehra, V" uniqKey="Nehra V">V. Nehra</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Angelakis, E" uniqKey="Angelakis E">E. Angelakis</name></author><author><name sortKey="Million, M" uniqKey="Million M">M. Million</name></author><author><name sortKey="Kankoe, S" uniqKey="Kankoe S">S. Kankoe</name></author><author><name sortKey="Lagier, J C" uniqKey="Lagier J">J. C. Lagier</name></author><author><name sortKey="Armougom, F" uniqKey="Armougom F">F. Armougom</name></author><author><name sortKey="Giorgi, R" uniqKey="Giorgi R">R. Giorgi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Aquilani, R" uniqKey="Aquilani R">R. Aquilani</name></author><author><name sortKey="Opasich, C" uniqKey="Opasich C">C. Opasich</name></author><author><name sortKey="Gualco, A" uniqKey="Gualco A">A. Gualco</name></author><author><name sortKey="Verri, M" uniqKey="Verri M">M. Verri</name></author><author><name sortKey="Testa, A" uniqKey="Testa A">A. Testa</name></author><author><name sortKey="Pasini, E" uniqKey="Pasini E">E. Pasini</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Argiles, J M" uniqKey="Argiles J">J. M. Argilés</name></author><author><name sortKey="Lopez Soriano, F J" uniqKey="Lopez Soriano F">F. J. Lopez-Soriano</name></author><author><name sortKey="Toledo, M" uniqKey="Toledo M">M. Toledo</name></author><author><name sortKey="Betancourd, A" uniqKey="Betancourd A">A. Betancourd</name></author><author><name sortKey="Serpe, R" uniqKey="Serpe R">R. Serpe</name></author><author><name sortKey="Busquets, S" uniqKey="Busquets S">S. Busquets</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Armougom, F" uniqKey="Armougom F">F. Armougom</name></author><author><name sortKey="Henry, M" uniqKey="Henry M">M. Henry</name></author><author><name sortKey="Vialettes, B" uniqKey="Vialettes B">B. Vialettes</name></author><author><name sortKey="Raccah, D" uniqKey="Raccah D">D. Raccah</name></author><author><name sortKey="Raoult, D" uniqKey="Raoult D">D. Raoult</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Baldwin, C" uniqKey="Baldwin C">C. Baldwin</name></author><author><name sortKey="Spiro, A" uniqKey="Spiro A">A. Spiro</name></author><author><name sortKey="Ahern, R" uniqKey="Ahern R">R. Ahern</name></author><author><name sortKey="Emery, P W" uniqKey="Emery P">P. W. Emery</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barret, M" uniqKey="Barret M">M. Barret</name></author><author><name sortKey="Malka, D" uniqKey="Malka D">D. Malka</name></author><author><name sortKey="Aparicio, T" uniqKey="Aparicio T">T. Aparicio</name></author><author><name sortKey="Dalban, C" uniqKey="Dalban C">C. Dalban</name></author><author><name sortKey="Locher, C" uniqKey="Locher C">C. Locher</name></author><author><name sortKey="Sabate, J M" uniqKey="Sabate J">J. M. Sabate</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Barton, W" uniqKey="Barton W">W. Barton</name></author><author><name sortKey="Penney, N C" uniqKey="Penney N">N. C. Penney</name></author><author><name sortKey="Cronin, O" uniqKey="Cronin O">O. Cronin</name></author><author><name sortKey="Garcia Perez, I" uniqKey="Garcia Perez I">I. Garcia-Perez</name></author><author><name sortKey="Molloy, M G" uniqKey="Molloy M">M. G. Molloy</name></author><author><name sortKey="Holmes, E" uniqKey="Holmes E">E. Holmes</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bindels, L B" uniqKey="Bindels L">L. B. Bindels</name></author><author><name sortKey="Delzenne, N M" uniqKey="Delzenne N">N. M. Delzenne</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Borgo, F" uniqKey="Borgo F">F. Borgo</name></author><author><name sortKey="Riva, A" uniqKey="Riva A">A. Riva</name></author><author><name sortKey="Benetti, A" uniqKey="Benetti A">A. Benetti</name></author><author><name sortKey="Casiraghi, M C" uniqKey="Casiraghi M">M. C. Casiraghi</name></author><author><name sortKey="Bertelli, S" uniqKey="Bertelli S">S. Bertelli</name></author><author><name sortKey="Garbossa, S" uniqKey="Garbossa S">S. Garbossa</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Bozetti, F" uniqKey="Bozetti F">F. Bozetti</name></author><author><name sortKey="Mariani, L" uniqKey="Mariani L">L. Mariani</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Buigues, C" uniqKey="Buigues C">C. Buigues</name></author><author><name sortKey="Fernandez Garrido, J" uniqKey="Fernandez Garrido J">J. Fernández-Garrido</name></author><author><name sortKey="Pruimboom, L" uniqKey="Pruimboom L">L. Pruimboom</name></author><author><name sortKey="Hoogland, A J" uniqKey="Hoogland A">A. J. Hoogland</name></author><author><name sortKey="Navarro Martinez, R" uniqKey="Navarro Martinez R">R. Navarro-Martínez</name></author><author><name sortKey="Martinez Martinez, M" uniqKey="Martinez Martinez M">M. Martínez-Martínez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Canfora, E E" uniqKey="Canfora E">E. E. Canfora</name></author><author><name sortKey="Jocken, J W" uniqKey="Jocken J">J. W. Jocken</name></author><author><name sortKey="Blaak, E E" uniqKey="Blaak E">E. E. Blaak</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cani, P D" uniqKey="Cani P">P. D. Cani</name></author><author><name sortKey="Lecourt, E" uniqKey="Lecourt E">E. Lecourt</name></author><author><name sortKey="Dewulf, E M" uniqKey="Dewulf E">E. M. Dewulf</name></author><author><name sortKey="Sohet, F M" uniqKey="Sohet F">F. M. Sohet</name></author><author><name sortKey="Pachikian, B D" uniqKey="Pachikian B">B. D. Pachikian</name></author><author><name sortKey="Naslain, D" uniqKey="Naslain D">D. Naslain</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cederholm, T" uniqKey="Cederholm T">T. Cederholm</name></author><author><name sortKey="Bosaeus, I" uniqKey="Bosaeus I">I. Bosaeus</name></author><author><name sortKey="Barazzoni, R" uniqKey="Barazzoni R">R. Barazzoni</name></author><author><name sortKey="Bauer, J" uniqKey="Bauer J">J. Bauer</name></author><author><name sortKey="Van Gossum, A" uniqKey="Van Gossum A">A. Van Gossum</name></author><author><name sortKey="Klek, S" uniqKey="Klek S">S. Klek</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cederholm, T" uniqKey="Cederholm T">T. Cederholm</name></author><author><name sortKey="Jensen, G L" uniqKey="Jensen G">G. L. Jensen</name></author><author><name sortKey="Correia, M" uniqKey="Correia M">M. Correia</name></author><author><name sortKey="Gonzalez, M C" uniqKey="Gonzalez M">M. C. Gonzalez</name></author><author><name sortKey="Fukushima, R" uniqKey="Fukushima R">R. Fukushima</name></author><author><name sortKey="Higashiguchi, T" uniqKey="Higashiguchi T">T. Higashiguchi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Chambers, E S" uniqKey="Chambers E">E. S. Chambers</name></author><author><name sortKey="Viardot, A" uniqKey="Viardot A">A. Viardot</name></author><author><name sortKey="Psichas, A" uniqKey="Psichas A">A. Psichas</name></author><author><name sortKey="Morrison, D J" uniqKey="Morrison D">D. J. Morrison</name></author><author><name sortKey="Murphy, K G" uniqKey="Murphy K">K. G. Murphy</name></author><author><name sortKey="Zac Varghese, S E" uniqKey="Zac Varghese S">S. E. Zac-Varghese</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Clarke, S F" uniqKey="Clarke S">S. F. Clarke</name></author><author><name sortKey="Murphy, E F" uniqKey="Murphy E">E. F. Murphy</name></author><author><name sortKey="O Sullivan, O" uniqKey="O Sullivan O">O. O'Sullivan</name></author><author><name sortKey="Lucey, A J" uniqKey="Lucey A">A. J. Lucey</name></author><author><name sortKey="Humphreys, M" uniqKey="Humphreys M">M. Humphreys</name></author><author><name sortKey="Hogan, A" uniqKey="Hogan A">A. Hogan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Cui, B" uniqKey="Cui B">B. Cui</name></author><author><name sortKey="Feng, Q" uniqKey="Feng Q">Q. Feng</name></author><author><name sortKey="Wang, H" uniqKey="Wang H">H. Wang</name></author><author><name sortKey="Wang, M" uniqKey="Wang M">M. Wang</name></author><author><name sortKey="Peng, Z" uniqKey="Peng Z">Z. Peng</name></author><author><name sortKey="Li, P" uniqKey="Li P">P. Li</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="De Vadder, F" uniqKey="De Vadder F">F. De Vadder</name></author><author><name sortKey="Kovatcheva Datchary, P" uniqKey="Kovatcheva Datchary P">P. Kovatcheva-Datchary</name></author><author><name sortKey="Goncalves, D" uniqKey="Goncalves D">D. Goncalves</name></author><author><name sortKey="Vinera, J" uniqKey="Vinera J">J. Vinera</name></author><author><name sortKey="Zitoun, C" uniqKey="Zitoun C">C. Zitoun</name></author><author><name sortKey="Duchampt, A" uniqKey="Duchampt A">A. Duchampt</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Deutz, N E" uniqKey="Deutz N">N. E. Deutz</name></author><author><name sortKey="Bauer, J M" uniqKey="Bauer J">J. M. Bauer</name></author><author><name sortKey="Barazzoni, R" uniqKey="Barazzoni R">R. Barazzoni</name></author><author><name sortKey="Biolo, G" uniqKey="Biolo G">G. Biolo</name></author><author><name sortKey="Boirie, Y" uniqKey="Boirie Y">Y. Boirie</name></author><author><name sortKey="Bosy Westphal, A" uniqKey="Bosy Westphal A">A. Bosy-Westphal</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ehlermann, P" uniqKey="Ehlermann P">P. Ehlermann</name></author><author><name sortKey="Dosch, A O" uniqKey="Dosch A">A. O. Dösch</name></author><author><name sortKey="Katus, H A" uniqKey="Katus H">H. A. Katus</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Evans, W J" uniqKey="Evans W">W. J. Evans</name></author><author><name sortKey="Morley, J E" uniqKey="Morley J">J. E. Morley</name></author><author><name sortKey="Argiles, J" uniqKey="Argiles J">J. Argilés</name></author><author><name sortKey="Bales, C" uniqKey="Bales C">C. Bales</name></author><author><name sortKey="Baracos, V" uniqKey="Baracos V">V. Baracos</name></author><author><name sortKey="Guttridge, D" uniqKey="Guttridge D">D. Guttridge</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fearon, K" uniqKey="Fearon K">K. Fearon</name></author><author><name sortKey="Strasser, F" uniqKey="Strasser F">F. Strasser</name></author><author><name sortKey="Anker, S D" uniqKey="Anker S">S. D. Anker</name></author><author><name sortKey="Bosaeus, I" uniqKey="Bosaeus I">I. Bosaeus</name></author><author><name sortKey="Bruera, E" uniqKey="Bruera E">E. Bruera</name></author><author><name sortKey="Fainsinger, R L" uniqKey="Fainsinger R">R. L. Fainsinger</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Fearon, K C" uniqKey="Fearon K">K. C. Fearon</name></author><author><name sortKey="Voss, A C" uniqKey="Voss A">A. C. Voss</name></author><author><name sortKey="Hustead, D S" uniqKey="Hustead D">D. S. Hustead</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Ferreira, I M" uniqKey="Ferreira I">I. M. Ferreira</name></author><author><name sortKey="Brooks, D" uniqKey="Brooks D">D. Brooks</name></author><author><name sortKey="White, J" uniqKey="White J">J. White</name></author><author><name sortKey="Goldstein, R" uniqKey="Goldstein R">R. Goldstein</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Genton, L" uniqKey="Genton L">L. Genton</name></author><author><name sortKey="Cani, P D" uniqKey="Cani P">P. D. Cani</name></author><author><name sortKey="Schrenzel, J" uniqKey="Schrenzel J">J. Schrenzel</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Guo, Y" uniqKey="Guo Y">Y. Guo</name></author><author><name sortKey="Huang, Z P" uniqKey="Huang Z">Z. P. Huang</name></author><author><name sortKey="Liu, C Q" uniqKey="Liu C">C. Q. Liu</name></author><author><name sortKey="Qi, L" uniqKey="Qi L">L. Qi</name></author><author><name sortKey="Sheng, Y" uniqKey="Sheng Y">Y. Sheng</name></author><author><name sortKey="Zou, D J" uniqKey="Zou D">D. J. Zou</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Haran, J P" uniqKey="Haran J">J. P. Haran</name></author><author><name sortKey="Bucci, V" uniqKey="Bucci V">V. Bucci</name></author><author><name sortKey="Dutta, P" uniqKey="Dutta P">P. Dutta</name></author><author><name sortKey="Ward, D" uniqKey="Ward D">D. Ward</name></author><author><name sortKey="Mccormick, B" uniqKey="Mccormick B">B. McCormick</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="He, Y" uniqKey="He Y">Y. He</name></author><author><name sortKey="Wu, W" uniqKey="Wu W">W. Wu</name></author><author><name sortKey="Zheng, H M" uniqKey="Zheng H">H. M. Zheng</name></author><author><name sortKey="Li, P" uniqKey="Li P">P. Li</name></author><author><name sortKey="Mcdonald, D" uniqKey="Mcdonald D">D. McDonald</name></author><author><name sortKey="Sheng, H F" uniqKey="Sheng H">H. F. Sheng</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Jensen, G L" uniqKey="Jensen G">G. L. Jensen</name></author><author><name sortKey="Cederholm, T" uniqKey="Cederholm T">T. Cederholm</name></author><author><name sortKey="Correia, M I T D" uniqKey="Correia M">M. I. T. D. Correia</name></author><author><name sortKey="Gonzalez, M C" uniqKey="Gonzalez M">M. C. Gonzalez</name></author><author><name sortKey="Fukushima, R" uniqKey="Fukushima R">R. Fukushima</name></author><author><name sortKey="Higashiguchi, T" uniqKey="Higashiguchi T">T. Higashiguchi</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kanbay, M" uniqKey="Kanbay M">M. Kanbay</name></author><author><name sortKey="Onal, E M" uniqKey="Onal E">E. M. Onal</name></author><author><name sortKey="Afsar, B" uniqKey="Afsar B">B. Afsar</name></author><author><name sortKey="Dagel, T" uniqKey="Dagel T">T. Dagel</name></author><author><name sortKey="Yerlikaya, A" uniqKey="Yerlikaya A">A. Yerlikaya</name></author><author><name sortKey="Covic, A" uniqKey="Covic A">A. Covic</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Kleiman, S C" uniqKey="Kleiman S">S. C. Kleiman</name></author><author><name sortKey="Watson, H J" uniqKey="Watson H">H. J. Watson</name></author><author><name sortKey="Bulik Sullivan, E C" uniqKey="Bulik Sullivan E">E. C. Bulik-Sullivan</name></author><author><name sortKey="Huh, E Y" uniqKey="Huh E">E. Y. Huh</name></author><author><name sortKey="Tarantino, L M" uniqKey="Tarantino L">L. M. Tarantino</name></author><author><name sortKey="Bulik, C M" uniqKey="Bulik C">C. M. Bulik</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Klosterbuer, A S" uniqKey="Klosterbuer A">A. S. Klosterbuer</name></author><author><name sortKey="Thomas, W" uniqKey="Thomas W">W. Thomas</name></author><author><name sortKey="Slavin, J L" uniqKey="Slavin J">J. L. Slavin</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Konishi, M" uniqKey="Konishi M">M. Konishi</name></author><author><name sortKey="Ishida, J" uniqKey="Ishida J">J. Ishida</name></author><author><name sortKey="Von Haehling, S" uniqKey="Von Haehling S">S. von Haehling</name></author><author><name sortKey="Anker, S D" uniqKey="Anker S">S. D. Anker</name></author><author><name sortKey="Springer, J" uniqKey="Springer J">J. Springer</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Lin, R" uniqKey="Lin R">R. Lin</name></author><author><name sortKey="Liu, W" uniqKey="Liu W">W. Liu</name></author><author><name sortKey="Piao, M" uniqKey="Piao M">M. Piao</name></author><author><name sortKey="Zhu, H" uniqKey="Zhu H">H. Zhu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Mack, I" uniqKey="Mack I">I. Mack</name></author><author><name sortKey="Cuntz, U" uniqKey="Cuntz U">U. Cuntz</name></author><author><name sortKey="Gramer, C" uniqKey="Gramer C">C. Gramer</name></author><author><name sortKey="Niedermaier, S" uniqKey="Niedermaier S">S. Niedermaier</name></author><author><name sortKey="Pohl, C" uniqKey="Pohl C">C. Pohl</name></author><author><name sortKey="Schwiertz, A" uniqKey="Schwiertz A">A. Schwiertz</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Malavaki, C J" uniqKey="Malavaki C">C. J. Malavaki</name></author><author><name sortKey="Sakkas, G K" uniqKey="Sakkas G">G. K. Sakkas</name></author><author><name sortKey="Mitrou, G I" uniqKey="Mitrou G">G. I. Mitrou</name></author><author><name sortKey="Kalyva, A" uniqKey="Kalyva A">A. Kalyva</name></author><author><name sortKey="Stefanidis, I" uniqKey="Stefanidis I">I. Stefanidis</name></author><author><name sortKey="Myburgh, K H" uniqKey="Myburgh K">K. H. Myburgh</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Martin, L" uniqKey="Martin L">L. Martin</name></author><author><name sortKey="Baracos, V E" uniqKey="Baracos V">V. E. Baracos</name></author><author><name sortKey="Jagoe, R T" uniqKey="Jagoe R">R. T. Jagoe</name></author><author><name sortKey="Chasen, M" uniqKey="Chasen M">M. Chasen</name></author><author><name sortKey="Senesse, P" uniqKey="Senesse P">P. Senesse</name></author><author><name sortKey="Antoun, S" uniqKey="Antoun S">S. Antoun</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morita, C" uniqKey="Morita C">C. Morita</name></author><author><name sortKey="Tsuji, H" uniqKey="Tsuji H">H. Tsuji</name></author><author><name sortKey="Hata, T" uniqKey="Hata T">T. Hata</name></author><author><name sortKey="Gondo, M" uniqKey="Gondo M">M. Gondo</name></author><author><name sortKey="Takakura, S" uniqKey="Takakura S">S. Takakura</name></author><author><name sortKey="Kawai, K" uniqKey="Kawai K">K. Kawai</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Morrison, D J" uniqKey="Morrison D">D. J. Morrison</name></author><author><name sortKey="Preston, T" uniqKey="Preston T">T. Preston</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Muscaritoli, M" uniqKey="Muscaritoli M">M. Muscaritoli</name></author><author><name sortKey="Anker, S D" uniqKey="Anker S">S. D. Anker</name></author><author><name sortKey="Argiles, J" uniqKey="Argiles J">J. Argilés</name></author><author><name sortKey="Aversa, Z" uniqKey="Aversa Z">Z. Aversa</name></author><author><name sortKey="Bauer, J M" uniqKey="Bauer J">J. M. Bauer</name></author><author><name sortKey="Biolo, G" uniqKey="Biolo G">G. Biolo</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nagatomo, Y" uniqKey="Nagatomo Y">Y. Nagatomo</name></author><author><name sortKey="Tang, W H" uniqKey="Tang W">W. H. Tang</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Nagpal, R" uniqKey="Nagpal R">R. Nagpal</name></author><author><name sortKey="Kumar, M" uniqKey="Kumar M">M. Kumar</name></author><author><name sortKey="Yadav, A K" uniqKey="Yadav A">A. K. Yadav</name></author><author><name sortKey="Hemalatha, R" uniqKey="Hemalatha R">R. Hemalatha</name></author><author><name sortKey="Yadav, H" uniqKey="Yadav H">H. Yadav</name></author><author><name sortKey="Marotta, F" uniqKey="Marotta F">F. Marotta</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Perez Santiago, J" uniqKey="Perez Santiago J">J. Pérez-Santiago</name></author><author><name sortKey="Gianella, S" uniqKey="Gianella S">S. Gianella</name></author><author><name sortKey="Massanella, M" uniqKey="Massanella M">M. Massanella</name></author><author><name sortKey="Spina, C A" uniqKey="Spina C">C. A. Spina</name></author><author><name sortKey="Karris, M Y" uniqKey="Karris M">M. Y. Karris</name></author><author><name sortKey="Var, S R" uniqKey="Var S">S. R. Var</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Pfleiderer, A" uniqKey="Pfleiderer A">A. Pfleiderer</name></author><author><name sortKey="Lagier, J C" uniqKey="Lagier J">J. C. Lagier</name></author><author><name sortKey="Armougom, F" uniqKey="Armougom F">F. Armougom</name></author><author><name sortKey="Robert, C" uniqKey="Robert C">C. Robert</name></author><author><name sortKey="Vialettes, B" uniqKey="Vialettes B">B. Vialettes</name></author><author><name sortKey="Raoult, D" uniqKey="Raoult D">D. Raoult</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Reimer, R A" uniqKey="Reimer R">R. A. Reimer</name></author><author><name sortKey="Willis, H J" uniqKey="Willis H">H. J. Willis</name></author><author><name sortKey="Tunnicliffe, J M" uniqKey="Tunnicliffe J">J. M. Tunnicliffe</name></author><author><name sortKey="Park, H" uniqKey="Park H">H. Park</name></author><author><name sortKey="Madsen, K L" uniqKey="Madsen K">K. L. Madsen</name></author><author><name sortKey="Soto Vaca, A" uniqKey="Soto Vaca A">A. Soto-Vaca</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sakamoto, M" uniqKey="Sakamoto M">M. Sakamoto</name></author><author><name sortKey="Mikasa, K" uniqKey="Mikasa K">K. Mikasa</name></author><author><name sortKey="Majima, T" uniqKey="Majima T">T. Majima</name></author><author><name sortKey="Hamada, K" uniqKey="Hamada K">K. Hamada</name></author><author><name sortKey="Konishi, M" uniqKey="Konishi M">M. Konishi</name></author><author><name sortKey="Maeda, K" uniqKey="Maeda K">K. Maeda</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Seganfredo, F B" uniqKey="Seganfredo F">F. B. Seganfredo</name></author><author><name sortKey="Blume, C A" uniqKey="Blume C">C. A. Blume</name></author><author><name sortKey="Moehlecke, M" uniqKey="Moehlecke M">M. Moehlecke</name></author><author><name sortKey="Giongo, A" uniqKey="Giongo A">A. Giongo</name></author><author><name sortKey="Casagrande, D S" uniqKey="Casagrande D">D. S. Casagrande</name></author><author><name sortKey="Spolidoro, J V N" uniqKey="Spolidoro J">J. V. N. Spolidoro</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Serrano Villar, S" uniqKey="Serrano Villar S">S. Serrano-Villar</name></author><author><name sortKey="Vazquez Castellanos, J F" uniqKey="Vazquez Castellanos J">J. F. Vázquez-Castellanos</name></author><author><name sortKey="Vallejo, A" uniqKey="Vallejo A">A. Vallejo</name></author><author><name sortKey="Latorre, A" uniqKey="Latorre A">A. Latorre</name></author><author><name sortKey="Sainz, T" uniqKey="Sainz T">T. Sainz</name></author><author><name sortKey="Ferrando Martinez, S" uniqKey="Ferrando Martinez S">S. Ferrando-Martínez</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Sorensen, J" uniqKey="Sorensen J">J. Sorensen</name></author><author><name sortKey="Kondrup, J" uniqKey="Kondrup J">J. Kondrup</name></author><author><name sortKey="Prokopowicz, J" uniqKey="Prokopowicz J">J. Prokopowicz</name></author><author><name sortKey="Schiesser, M" uniqKey="Schiesser M">M. Schiesser</name></author><author><name sortKey="Kr Henbuhl, L" uniqKey="Kr Henbuhl L">L. Krähenbühl</name></author><author><name sortKey="Meier, R" uniqKey="Meier R">R. Meier</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Takayama, K" uniqKey="Takayama K">K. Takayama</name></author><author><name sortKey="Katakami, N" uniqKey="Katakami N">N. Katakami</name></author><author><name sortKey="Yokoyama, T" uniqKey="Yokoyama T">T. Yokoyama</name></author><author><name sortKey="Atagi, S" uniqKey="Atagi S">S. Atagi</name></author><author><name sortKey="Yoshimori, K" uniqKey="Yoshimori K">K. Yoshimori</name></author><author><name sortKey="Kagamu, H" uniqKey="Kagamu H">H. Kagamu</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Tanaka, K" uniqKey="Tanaka K">K. Tanaka</name></author><author><name sortKey="Yano, M" uniqKey="Yano M">M. Yano</name></author><author><name sortKey="Motoori, M" uniqKey="Motoori M">M. Motoori</name></author><author><name sortKey="Kishi, K" uniqKey="Kishi K">K. Kishi</name></author><author><name sortKey="Miyashiro, I" uniqKey="Miyashiro I">I. Miyashiro</name></author><author><name sortKey="Ohue, M" uniqKey="Ohue M">M. Ohue</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Temel, J S" uniqKey="Temel J">J. S. Temel</name></author><author><name sortKey="Abernethy, A P" uniqKey="Abernethy A">A. P. Abernethy</name></author><author><name sortKey="Currow, D C" uniqKey="Currow D">D. C. Currow</name></author><author><name sortKey="Friend, J" uniqKey="Friend J">J. Friend</name></author><author><name sortKey="Duus, E M" uniqKey="Duus E">E. M. Duus</name></author><author><name sortKey="Yan, Y" uniqKey="Yan Y">Y. Yan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Thuny, F" uniqKey="Thuny F">F. Thuny</name></author><author><name sortKey="Richet, H" uniqKey="Richet H">H. Richet</name></author><author><name sortKey="Casalta, J P" uniqKey="Casalta J">J. P. Casalta</name></author><author><name sortKey="Angelakis, E" uniqKey="Angelakis E">E. Angelakis</name></author><author><name sortKey="Habib, G" uniqKey="Habib G">G. Habib</name></author><author><name sortKey="Raoult, D" uniqKey="Raoult D">D. Raoult</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Vaghef Mehrabany, E" uniqKey="Vaghef Mehrabany E">E. Vaghef-Mehrabany</name></author><author><name sortKey="Alipour, B" uniqKey="Alipour B">B. Alipour</name></author><author><name sortKey="Homayouni Rad, A" uniqKey="Homayouni Rad A">A. Homayouni-Rad</name></author><author><name sortKey="Sharif, S K" uniqKey="Sharif S">S. K. Sharif</name></author><author><name sortKey="Asghari Jafarabadi, M" uniqKey="Asghari Jafarabadi M">M. Asghari-Jafarabadi</name></author><author><name sortKey="Zavvari, S" uniqKey="Zavvari S">S. Zavvari</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Van De Wouw, M" uniqKey="Van De Wouw M">M. van de Wouw</name></author><author><name sortKey="Schellekens, H" uniqKey="Schellekens H">H. Schellekens</name></author><author><name sortKey="Dinan, T G" uniqKey="Dinan T">T. G. Dinan</name></author><author><name sortKey="Cryan, J F" uniqKey="Cryan J">J. F. Cryan</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Von Haehling, S" uniqKey="Von Haehling S">S. von Haehling</name></author><author><name sortKey="Anker, M S" uniqKey="Anker M">M. S. Anker</name></author><author><name sortKey="Anker, S D" uniqKey="Anker S">S. D. Anker</name></author></analytic></biblStruct><biblStruct><analytic><author><name sortKey="Zhao, L" uniqKey="Zhao L">L. Zhao</name></author><author><name sortKey="Zhang, F" uniqKey="Zhang F">F. Zhang</name></author><author><name sortKey="Ding, X" uniqKey="Ding X">X. Ding</name></author><author><name sortKey="Wu, G" uniqKey="Wu G">G. Wu</name></author><author><name sortKey="Lam, Y Y" uniqKey="Lam Y">Y. Y. Lam</name></author><author><name sortKey="Wang, X" uniqKey="Wang X">X. Wang</name></author></analytic></biblStruct></listBibl></div1></back></TEI><pmc article-type="review-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">Front Cell Infect Microbiol</journal-id><journal-id journal-id-type="iso-abbrev">Front Cell Infect Microbiol</journal-id><journal-id journal-id-type="publisher-id">Front. Cell. Infect. Microbiol.</journal-id><journal-title-group><journal-title>Frontiers in Cellular and Infection Microbiology</journal-title></journal-title-group><issn pub-type="epub">2235-2988</issn><publisher><publisher-name>Frontiers Media S.A.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">31572686</article-id><article-id pub-id-type="pmc">6751326</article-id><article-id pub-id-type="doi">10.3389/fcimb.2019.00305</article-id><article-categories><subj-group subj-group-type="heading"><subject>Cellular and Infection Microbiology</subject><subj-group><subject>Mini Review</subject></subj-group></subj-group></article-categories><title-group><article-title>Targeting the Gut Microbiota to Treat Cachexia</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>Genton</surname><given-names>Laurence</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="corresp" rid="c001"><sup>*</sup></xref><uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/111130/overview"></uri></contrib><contrib contrib-type="author"><name><surname>Mareschal</surname><given-names>Julie</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Charretier</surname><given-names>Yannick</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/191427/overview"></uri></contrib><contrib contrib-type="author"><name><surname>Lazarevic</surname><given-names>Vladimir</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/30638/overview"></uri></contrib><contrib contrib-type="author"><name><surname>Bindels</surname><given-names>Laure B.</given-names></name><xref ref-type="aff" rid="aff3"><sup>3</sup></xref><uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/219485/overview"></uri></contrib><contrib contrib-type="author"><name><surname>Schrenzel</surname><given-names>Jacques</given-names></name><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/35883/overview"></uri></contrib></contrib-group><aff id="aff1"><sup>1</sup><institution>Clinical Nutrition, Geneva University Hospitals and University of Geneva</institution>,<addr-line>Geneva</addr-line>,<country>Switzerland</country></aff><aff id="aff2"><sup>2</sup><institution>Genomic Research Laboratory, Service of Infectious Diseases, Geneva University Hospitals and University of Geneva</institution>,<addr-line>Geneva</addr-line>,<country>Switzerland</country></aff><aff id="aff3"><sup>3</sup><institution>Metabolism and Nutrition Research Group, Louvain Drug Research Institute, Université Catholique de Louvain</institution>,<addr-line>Brussels</addr-line>,<country>Belgium</country></aff><author-notes><fn fn-type="edited-by"><p>Edited by: Benoit Guery, Lausanne University Hospital (CHUV), Switzerland</p></fn><fn fn-type="edited-by"><p>Reviewed by: David R. Brown, University of Minnesota Twin Cities, United States; Irving Coy Allen, Virginia Tech, United States</p></fn><corresp id="c001">*Correspondence: Laurence Genton <email>laurence.genton@hcuge.ch</email></corresp><fn fn-type="other" id="fn001"><p>This article was submitted to Microbiome in Health and Disease, a section of the journal Frontiers in Cellular and Infection Microbiology</p></fn></author-notes><pub-date pub-type="epub"><day>12</day><month>9</month><year>2019</year></pub-date><pub-date pub-type="collection"><year>2019</year></pub-date><volume>9</volume><elocation-id>305</elocation-id><history><date date-type="received"><day>06</day><month>6</month><year>2019</year></date><date date-type="accepted"><day>09</day><month>8</month><year>2019</year></date></history><permissions><copyright-statement>Copyright © 2019 Genton, Mareschal, Charretier, Lazarevic, Bindels and Schrenzel.</copyright-statement><copyright-year>2019</copyright-year><copyright-holder>Genton, Mareschal, Charretier, Lazarevic, Bindels and Schrenzel</copyright-holder><license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</license-p></license></permissions><abstract><p>Cachexia occurs in many chronic diseases and is associated with increased morbidity and mortality. It is treated by nutritional support but often with limited effectiveness, leading to the search of other therapeutic strategies. The modulation of gut microbiota, whether through pro-, pre-, syn- or antibiotics or fecal transplantation, is attracting ever-growing interest in the field of obesity, but could also be an interesting and innovative alternative for treating cachexia. This article reviews the evidence linking the features of malnutrition, as defined by the Global Leadership Initiative on Malnutrition [low body mass index (BMI), unintentional body weight loss, low muscle mass, low appetite, and systemic inflammation] and the gut microbiota in human adults with cachexia-associated diseases, and shows the limitations of the present research in that field with suggestions for future directions.</p></abstract><kwd-group><kwd>gut</kwd><kwd>gut microbiota</kwd><kwd>metabolism</kwd><kwd>cachexia</kwd><kwd>metagenomic</kwd></kwd-group><counts><fig-count count="1"></fig-count><table-count count="1"></table-count><equation-count count="0"></equation-count><ref-count count="61"></ref-count><page-count count="8"></page-count><word-count count="6227"></word-count></counts></article-meta></front><body><sec sec-type="intro" id="s1"><title>Introduction</title><p>Cachexia is “a multifactorial syndrome characterized by a progressive loss of body weight and skeletal muscle mass” (Evans et al., <xref rid="B24" ref-type="bibr">2008</xref>). Although this term is mostly used in the context of cancer, cachexia can also be found in other chronic diseases as for instance chronic obstructive pulmonary disease, chronic heart, kidney, or liver failure, AIDS and rheumatoid arthritis (Muscaritoli et al., <xref rid="B42" ref-type="bibr">2010</xref>). Its prevalence is estimated between 10 and 50% depending on the underlying disease (von Haehling et al., <xref rid="B58" ref-type="bibr">2016</xref>). Clinical consequences of cachexia are impaired physical function, fatigue, low quality of life, longer length of hospital stay, and increased mortality (Sorensen et al., <xref rid="B51" ref-type="bibr">2008</xref>), and in case of cancer, increased risk of chemotherapy toxicity with subsequent dose reductions and treatment delays (Barret et al., <xref rid="B8" ref-type="bibr">2011</xref>).</p><p>Several expert consensuses and observational studies have provided clinical definitions for cachexia, mostly in the context of cancer (<xref rid="T1" ref-type="table">Table 1</xref>). In 2015, a consensus of the European Society of Clinical Nutrition and Metabolism defined cachexia as disease-related malnutrition which differentiates it from starvation, sarcopenia and frailty (Cederholm et al., <xref rid="B16" ref-type="bibr">2015</xref>). More recently, the Global Leadership Initiative on Malnutrition (GLIM), which involves experts of several nutritional societies from all over the world, recommended to diagnose malnutrition with at least one phenotypic criterion [low body mass index (BMI), unintentional weight loss, or decreased muscle mass] and one etiologic criterion (reduced food intake or assimilation, disease burden or inflammatory state) (Cederholm et al., <xref rid="B17" ref-type="bibr">2018</xref>; Jensen et al., <xref rid="B32" ref-type="bibr">2019</xref>). Although some features of cachexia may differ from other types of malnutrition (for instance the inherent inclusion of disease burden in cachexia), the authors recommend using these clinical diagnostic criteria whatever the type of malnutrition, as the priority is to determine whether a patient needs nutritional support.</p><table-wrap id="T1" position="float"><label>Table 1</label><caption><p>Definitions of cachexia.</p></caption><table frame="hsides" rules="groups"><thead><tr><th valign="top" align="left" rowspan="1" colspan="1"><bold>References</bold></th><th valign="top" align="left" rowspan="1" colspan="1"><bold>Criteria for cachexia</bold></th><th valign="top" align="left" rowspan="1" colspan="1"><bold>Criteria basis</bold></th></tr></thead><tbody><tr><td valign="top" align="left" rowspan="1" colspan="1">Fearon et al., <xref rid="B26" ref-type="bibr">2006</xref></td><td valign="top" align="left" rowspan="1" colspan="1">Cachexia in pancreas cancer:
<list list-type="bullet"><list-item><p>Unintentional weight loss ≥10% in the last 6 months and</p></list-item><list-item><p>Decreased energy intake ≤1,500 kcal and</p></list-item><list-item><p>Systemic inflammation (CRP ≥ 10 mg/l)</p></list-item></list></td><td valign="top" align="left" rowspan="1" colspan="1">Single center study comparing weight loss vs. weight loss + decreased energy intake + systemic inflammation on body composition, functional status and survival</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Evans et al., <xref rid="B24" ref-type="bibr">2008</xref></td><td valign="top" align="left" rowspan="1" colspan="1">Cachexia:
<list list-type="bullet"><list-item><p>Unintentional weight loss ≥ 5% in the last 12 months and 3 of the following critera:</p></list-item><list-item><p>Reduced muscle strength</p></list-item><list-item><p>Reduced fat-free mass index</p></list-item><list-item><p>Fatigue</p></list-item><list-item><p>Biological abnormalities: increased inflammatory markers, anemia, hypoalbuminemia</p></list-item></list></td><td valign="top" align="left" rowspan="1" colspan="1">Expert consensus</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Bozetti and Mariani, <xref rid="B12" ref-type="bibr">2009</xref></td><td valign="top" align="left" rowspan="1" colspan="1">Cachexia in cancer:
<list list-type="bullet"><list-item><p>Unintentional weight loss ≥10% in the last 6 months and</p></list-item><list-item><p>Anorexia or</p></list-item><list-item><p>Fatigue or</p></list-item><list-item><p>Early satiation</p></list-item></list></td><td valign="top" align="left" rowspan="1" colspan="1">Single center study evaluating the trend of clinical nutritional and oncologic variables between 4 classes of severity of cachexia, based on combinations of unintentional weight loss + anorexia, fatigue or early satiation</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Muscaritoli et al., <xref rid="B42" ref-type="bibr">2010</xref></td><td valign="top" align="left" rowspan="1" colspan="1">Pre-cachexia:
<list list-type="bullet"><list-item><p>Unintentional weight loss ≤ 5% in the last 6 months and</p></list-item><list-item><p>Underlying chronic disease and</p></list-item><list-item><p>Chronic or systemic inflammatory response and</p></list-item><list-item><p>Anorexia or anorexia-related symptoms</p></list-item></list></td><td valign="top" align="left" rowspan="1" colspan="1">Expert consensus</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Fearon et al., <xref rid="B25" ref-type="bibr">2011</xref></td><td valign="top" align="left" rowspan="1" colspan="1">Pre-cachexia in cancer:
<list list-type="bullet"><list-item><p>Unintentional weight loss ≤ 5% in the last 6 months and</p></list-item><list-item><p>Anorexia</p></list-item></list>Cachexia in cancer:
<list list-type="bullet"><list-item><p>Weight loss > 5% in the last 6 months or</p></list-item><list-item><p>Body mass index <20 and weight loss >2% or</p></list-item><list-item><p>Sarcopenia and weight loss >2%</p></list-item><list-item><p>Often reduced food intake/systemic inflammation Refractory cachexia in cancer:</p></list-item><list-item><p>No answer to treatment and</p></list-item><list-item><p>Low performance score and</p></list-item><list-item><p><3 months survival</p></list-item></list></td><td valign="top" align="left" rowspan="1" colspan="1">Expert consensus</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Argilés et al., <xref rid="B5a" ref-type="bibr">2011</xref></td><td valign="top" align="left" rowspan="1" colspan="1">Cachexia score (CASCO) in cancer:
<list list-type="bullet"><list-item><p>Unintentional weight loss and lean body mass loss (40%)</p></list-item><list-item><p>Anorexia (15%)</p></list-item><list-item><p>Inflammatory, immunological and metabolic disturbances (20%)</p></list-item><list-item><p>Physical performance (15%)</p></list-item><list-item><p>Quality of life (10%)</p></list-item></list></td><td valign="top" align="left" rowspan="1" colspan="1">Expert consensus, score not yet validated</td></tr><tr><td valign="top" align="left" rowspan="1" colspan="1">Martin et al., <xref rid="B39" ref-type="bibr">2015</xref></td><td valign="top" align="left" rowspan="1" colspan="1">Five stages of cancer cachexia according to:
<list list-type="bullet"><list-item><p>Unintentional weight loss</p></list-item><list-item><p>Body mass index</p></list-item></list></td><td valign="top" align="left" rowspan="1" colspan="1">Multicenter cohort study evaluating the impact of body mass index and weight loss on survival</td></tr></tbody></table></table-wrap><p>Presently, cachexia is treated by nutritional support, but with limited effectiveness (Aquilani et al., <xref rid="B5" ref-type="bibr">2008</xref>; Baldwin et al., <xref rid="B7" ref-type="bibr">2012</xref>; Ferreira et al., <xref rid="B27" ref-type="bibr">2012</xref>; Konishi et al., <xref rid="B36" ref-type="bibr">2016</xref>). This implies the need of a multimodal approach including not only nutritional support or orexigenic agents, but also anti-catabolic and anti-inflammatory treatments. A promising therapeutic target for cachexia may lie in the gut microbiota that interacts with the other components of the gut barrier, namely the gut epithelium, the gut-associated lymphoid tissue (GALT) and the enteric nervous system.</p><p>This article reviews the evidence linking the features of malnutrition as defined by the GLIM and the gut microbiota in human adults with cachexia-associated diseases, and shows the limitations of the present research in that field with suggestions for future directions. Although microbiota in humans is generally measured in the feces, we will refer to it as gut microbiota.</p></sec><sec id="s2"><title>Low BMI and Gut Microbiota</title><p>The link between overweight/obesity and gut microbiota is attracting ever-growing interest, but the association between a BMI below the normal range (<18.5 kg/m<sup>2</sup>) and gut microbiota in cachexia-associated diseases has not been formally evaluated.</p><p>A few studies investigated the gut microbiota by 16S rRNA gene profiling in patients with anorexia nervosa, a condition of low BMI due to starvation, i.e., negative energy balance. Their microbial alpha-diversity was low (Kleiman et al., <xref rid="B34" ref-type="bibr">2015</xref>) or normal (Mack et al., <xref rid="B37" ref-type="bibr">2016</xref>; Borgo et al., <xref rid="B11" ref-type="bibr">2017</xref>). Compared to lean healthy controls, alterations at the phyla level are controversial, especially regarding Bacteroidetes and Firmicutes (Armougom et al., <xref rid="B6" ref-type="bibr">2009</xref>; Mack et al., <xref rid="B37" ref-type="bibr">2016</xref>; Borgo et al., <xref rid="B11" ref-type="bibr">2017</xref>). At the family level, patients with anorexia nervosa display a lower abundance of <italic>Enterobacteriaceae</italic> (Borgo et al., <xref rid="B11" ref-type="bibr">2017</xref>) and <italic>Lactobacillus</italic> (Mack et al., <xref rid="B37" ref-type="bibr">2016</xref>). Studies reported a reduction in the genera <italic>Ruminococcus, Clostridium, Roseburia</italic> (Borgo et al., <xref rid="B11" ref-type="bibr">2017</xref>), <italic>Anaerostipes, Faecalibacterium</italic>, and in unspecified genera of the order <italic>Coriobacteriales</italic> (Kleiman et al., <xref rid="B34" ref-type="bibr">2015</xref>), and of the species <italic>Clostridium coccoides, Clostridium leptum</italic>, and <italic>Bacteroides fragilis</italic>. Some of these bacteria are producing short-chain fatty acids, which are key signaling molecules for the regulation of appetite, lipid and glucose metabolism as well as immune functions (Morrison and Preston, <xref rid="B41" ref-type="bibr">2016</xref>). A lower fecal concentration of propionate, acetate (Morita et al., <xref rid="B40" ref-type="bibr">2015</xref>) and butyrate (Borgo et al., <xref rid="B11" ref-type="bibr">2017</xref>) was described. Finally, several studies found higher levels of the archaeon <italic>Methanobrevibacter smithii</italic> in these patients (Armougom et al., <xref rid="B6" ref-type="bibr">2009</xref>; Mack et al., <xref rid="B37" ref-type="bibr">2016</xref>; Borgo et al., <xref rid="B11" ref-type="bibr">2017</xref>).</p><p>Two trials followed the patients with anorexia nervosa after a refeeding protocol leading to an increase of BMI by 2.3 ± 1.2/kg/m<sup>2</sup> (Mack et al., <xref rid="B37" ref-type="bibr">2016</xref>), and 1.2 kg/m<sup>2</sup> (Kleiman et al., <xref rid="B34" ref-type="bibr">2015</xref>). Gut microbiota composition of these patients did not normalize with weight gain, although their microbial diversity and richness was increased.</p><p>These studies show the large inter-individual variability of gut microbiota composition in patients with anorexia nervosa and the inconsistencies between some studies. Such inconsistencies could be attributed either to the low number of patients included in these studies or to regional variation in gut microbiota being larger than the anorexia microbial signature itself (He et al., <xref rid="B31" ref-type="bibr">2018</xref>). If the gut microbiota is to play a role in body weight regulation, these results suggests that either taxonomic discrimination needs to be performed more in depth or that the bacterial function and metabolites are more important than the microbiota composition for BMI regulation. For instance, stool culture could identify 11 new bacterial species in a young anorectic patient with a BMI of 10.4 kg/m<sup>2</sup> compared to 16S rRNA, which demonstrates the room for improvement in the technology for taxonomic discrimination (Pfleiderer et al., <xref rid="B46" ref-type="bibr">2013</xref>). Whether the condition of anorexia nervosa can be compared to cachexia is unclear as it does not take into account other parameters of cachexia, as for instance systemic inflammation.</p></sec><sec id="s3"><title>Body Weight Loss and Gut Microbiota</title><p>Body weight loss is a dynamic condition requiring a longitudinal follow-up. To our knowledge, no study has concentrated on the link between unintentional weight loss and gut microbiota.</p><p>A recent systematic review including 10 studies focused on surgery-induced voluntary weight loss in humans (Guo et al., <xref rid="B29" ref-type="bibr">2018</xref>). Bariatric surgery had a controversial impact on the richness and diversity of gut microbiota. It led to a decrease in the abundance of Firmicutes, <italic>Clostridiales, Clostridiaceae, Blautia</italic>, and <italic>Dorea</italic> but to an increase in Bacteroidetes, Fusobacteria, Proteobacteria, and Verrucomicrobia. Shotgun metagenomic sequencing highlighted the up-regulation of nitrogen and fatty acid metabolism, and, after Roux-en-Y gastric bypass, the stimulation of the phosphotransferase system, involved in bacterial sugar uptake, and of the sulfur relay system and the purine metabolism. When considering weight loss induced by hypocaloric diets, another systemic review found no consistent effects on microbial alpha-diversity, abundance or phylum composition (Seganfredo et al., <xref rid="B49" ref-type="bibr">2017</xref>). However, this intervention induced a decrease in <italic>Bifidobacterium</italic> spp, <italic>Clostridium</italic> cluster XIVa species, <italic>Roseburia</italic> spp, and <italic>Eubacterium rectale</italic>. Both reviews showed a correlation between changes in specific bacterial taxa and metabolic issues, like improvements in lipid profile, glucose homeostasis, and inflammatory markers. However, unintentional weight loss can likely not be compared to these situations as the pathogenesis is different.</p><p>Some papers report an unintentional weight gain after fecal microbiota transplantation (FMT) in patients with chronic diseases. A case-report showed a weight gain of 17 kg in 6 months after FMT for recurrent <italic>Clostridium difficile</italic> colitis, in a heart-transplant patient weighing 37.9 kg at baseline (Ehlermann et al., <xref rid="B23" ref-type="bibr">2014</xref>). Another case-report demonstrated a weight gain of 18 kg within 3 years after FMT for recurrent <italic>C. difficile</italic> colitis (Alang and Kelly, <xref rid="B2" ref-type="bibr">2015</xref>). Finally, in 22 patients with Crohn's disease, an FMT led to a mean weight gain of 3 kg in 6 months (Cui et al., <xref rid="B20" ref-type="bibr">2015</xref>). These findings suggest that components of the FMT, as for instance gut microbiota, could also be involved in unintentional weight loss.</p><p>Similarly, some antibiotics seem to be involved in weight gain (Angelakis et al., <xref rid="B4" ref-type="bibr">2014</xref>). It was speculated that the unintentional BMI increase (2.3 ± 0.9kg/m<sup>2</sup> in 1 year) induced by vancomycin/gentamicin therapy in infective endocarditis patients could be due to the gut colonization of <italic>Lactobacillus</italic> spp. These microorganisms, used as growth promoter in animals, are intrinsically resistant to vancomycin and were over-represented in the feces of obese patients (Thuny et al., <xref rid="B55" ref-type="bibr">2010</xref>). Claritromycin was also associated with weight gain (4 kg in 3 months) in patients with non-small cell lung cancer, leading the authors to suggest that this antibiotic may limit the progression of cachexia (Sakamoto et al., <xref rid="B48" ref-type="bibr">2001</xref>). In any case, whether antibiotics should be used against weight loss is very questionable in view of the thread of antibiotic resistance.</p></sec><sec id="s4"><title>Low Muscle Mass and Gut Microbiota</title><p>The association between low muscle mass and gut microbiota has been suggested in a few studies comparing older vs. younger people, and sedentary vs. physically active people.</p><p>Older people are known to be at risk for malnutrition, especially of sarcopenia which is defined as a low muscle mass and function. In 23 nursing home residents ≥65 years, malnutrition was associated with a lower abundance of butyrate-producing organisms (<italic>Roseburia intestinalis</italic> and <italic>Subdoligranulum</italic>) and higher loads of dysbiotic bacteria such as <italic>Enterococcus feacalis</italic> and <italic>Citrobacter freundii</italic>, as compared to a good nutritional state (Haran et al., <xref rid="B30" ref-type="bibr">2018</xref>). Shotgun metagenomic sequencing highlighted a lower abundance of genes involved in vitamin B production and in the metabolism of essential amino acids, purine and pyrimidine, in older vs. younger residents, and an increased biosynthesis of the bacterial wall components peptidoglycan and lipopolysaccharides in those who were malnourished. Buigues et al. randomized 60 apparently healthy volunteers ≥65 years to a daily oral prebiotic composed of inulin and fructooligosaccharides or a maltodextrin placebo for 13 weeks. The group that received the prebiotics improved their self-reported chronic fatigue and measured handgrip strength (Buigues et al., <xref rid="B13" ref-type="bibr">2016</xref>). No analysis of gut microbiota was performed. None of these studies determined muscle mass and thus the link remains speculative in older people.</p><p>Gut microbiota differences were also found between athletes and sedentary subjects. Clarke et al. compared the gut microbiota of 40 male rugby players (BMI 28.8 ± 3.8 kg/m<sup>2</sup>), with that of age-matched healthy controls having either a normal (22.7 ± 1.8 kg/m<sup>2</sup>) or high BMI (31.2 ± 3.0 kg/m<sup>2</sup>) (Clarke et al., <xref rid="B19" ref-type="bibr">2014</xref>). Compared to the high BMI controls, the rugby players had a higher lean body mass and an increased proportion of the mucin-degrading species <italic>Akkermansia muciniphila</italic>. The relative protein intake of the rugby players was higher and positively correlated with microbiota diversity. The authors extended their analysis by applying metagenomic shotgun sequencing (Barton et al., <xref rid="B9" ref-type="bibr">2018</xref>). They found an increase in the pathways related to amino acids and antibiotic biosynthesis and carbohydrate degradation in athletes and reported higher levels of fecal short-chain fatty acids. Interestingly, Allen et al. randomized 32 lean and obese sedentary persons to a 6-week endurance training, thrice weekly, followed by a 6-week sedentary period (Allen et al., <xref rid="B3" ref-type="bibr">2018</xref>). Exercise significantly increased lean body mass, cardio-respiratory fitness and decreased fat mass but body composition of all participants returned to baseline values after the 6 weeks of sedentary lifestyle. Butyrate-producing taxa increased with exercise in lean participants and correlated with increases in lean mass and reduction of fat mass. Thus, physical exercise modulates gut microbiota although most of these studies are observational and cross-sectional. Knowing that resistance exercise is a recognized treatment to counteract loss of muscle mass and function (Deutz et al., <xref rid="B22" ref-type="bibr">2014</xref>), these studies suggest a potential link between gut microbiota and muscle.</p></sec><sec id="s5"><title>Low Appetite and Gut Microbiota</title><p>Appetite is regulated at the level of the arcuate nucleus of the hypothalamus, more precisely in the anorexigenic pro-opiomelanocortin-expressing neurons and the orexigenic agouti-related peptide and neuropeptide-expressing neurons. The hypothalamus receives inputs from the enteric nervous system via the vagus nerve, and from appetite mediators via the peripheral circulation or the vagus nerve (van de Wouw et al., <xref rid="B57" ref-type="bibr">2017</xref>). A low appetite, as in cachexia, could thus result from an altered interaction between the gut microbiota and the enteric nervous system or appetite mediators originating in the gut.</p><p>Vagotomized subjects were shown to have a decreased appetite and hunger and an increased sensation of satiety and fullness. However, no human study showed the role of gut microbiota on the vagus nerve signaling. Gut microbiota derived-short-chain fatty acids can stimulate the free-fatty acid receptor 3 (FFA3), expressed on portal nerves, and thus trigger the vagus nerve in animal studies (De Vadder et al., <xref rid="B21" ref-type="bibr">2014</xref>).</p><p>Human studies start to concentrate on the link between gut microbiota and appetite mediators or appetite sensation. The anorexigenic neuropeptide PYY, the glucagon-like peptide-1 (GLP-1), both secreted by the enteroendocrine cells of the ileum and colon, and the cholecystokinin, secreted by the duodenum, could theoretically be easy targets for the gut microbiota or its metabolites. If gut microbiota modulates appetite via intestinal appetite mediators, high levels of PYY and GLP-1 and dysbiosis would be expected in cachexia, but this relationship has not yet been explored. In overweight or normal-weight subjects, several studies evaluated the impact of prebiotics, known to modulate the gut microbiota, on plasma PYY and GLP-1, although with controversial effects (Cani et al., <xref rid="B15" ref-type="bibr">2009</xref>; Klosterbuer et al., <xref rid="B35" ref-type="bibr">2012</xref>; Chambers et al., <xref rid="B18" ref-type="bibr">2015</xref>). Reimer et al. showed an increase abundance of <italic>Bifidobacterium</italic> and a lower appetite in overweight adults assigned to inulin-type fructans intake for 12 weeks, as compared to whey protein or nothing (Reimer et al., <xref rid="B47" ref-type="bibr">2017</xref>). Recently, a randomized open-label trial exposed patients with type 2 diabetes mellitus to a high-fiber diet or a conventional educational and dietetic program over 3 months (Zhao et al., <xref rid="B59" ref-type="bibr">2018</xref>). The high-fiber diet led to a higher weight loss, higher plasma levels of post-prandial GLP1 and fasting PYY, and an increase in fecal butyric acid. These results suggest that dietary fibers may regulate the level of appetite mediators through short-chain fatty acids production.</p><p>Interestingly, among the orexigenic mediators, the ghrelin-receptor agonist anamorelin, given at 100 mg once a day for 12 weeks was shown to increase lean body mass in two studies including cachectic patients with non-small lung patients (Takayama et al., <xref rid="B52" ref-type="bibr">2016</xref>; Temel et al., <xref rid="B54" ref-type="bibr">2016</xref>). Whether gut microbiota composition or function inhibits ghrelin secretion from the stomach or pancreas in cachectic patients is unknown.</p></sec><sec id="s6"><title>Systemic Inflammation and Gut Microbiota</title><p>The GALT is the largest immune organ. The complex association of the gut microbiota with systemic inflammation in the context of obesity and high-fat diet is beyond the scope of this paper (Nagpal et al., <xref rid="B44" ref-type="bibr">2016</xref>).</p><p>An association between systemic inflammation and gut dysbiosis has been shown in cachexia-associated diseases as chronic kidney disease (Kanbay et al., <xref rid="B33" ref-type="bibr">2018</xref>), hepatic liver cirrhosis (Ahluwalia et al., <xref rid="B1" ref-type="bibr">2016</xref>), and heart failure (Nagatomo and Tang, <xref rid="B43" ref-type="bibr">2015</xref>). If gut microbiota was to be a causal factor of the systemic inflammation found in cachexia-associated diseases, it would imply that pro-inflammatory bacterial components or metabolites translocate across the gut barrier and would induce a pro-inflammatory systemic response via the GALT. In line with this hypothesis, an increased intestinal permeability has been shown in several cachexia-associated diseases, which could facilitate the crossing of pro-inflammatory molecules through the paracellular pathway (Genton et al., <xref rid="B28" ref-type="bibr">2015</xref>). Furthermore, several randomized controlled trials modulating gut microbiota through pre- pro-, syn-, or antibiotics and demonstrating gut microbiota modifications, also report changes in immune and inflammatory parameters in oncologic surgery (Tanaka et al., <xref rid="B53" ref-type="bibr">2012</xref>), HIV (Pérez-Santiago et al., <xref rid="B45" ref-type="bibr">2013</xref>; Serrano-Villar et al., <xref rid="B50" ref-type="bibr">2017</xref>) and rheumatoid arthritis (Vaghef-Mehrabany et al., <xref rid="B56" ref-type="bibr">2014</xref>). However, no study was performed specifically in cachectic patients.</p></sec><sec id="s7"><title>Potential Mechanisms Linking Gut Microbiota and Cachexia</title><p>A simplified scheme summarizes the hypothetical links between chronic diseases and cachexia (<xref ref-type="fig" rid="F1">Figure 1</xref>). As highlighted in the previous paragraphs, one of the hallmarks of disease-related malnutrition is low muscle mass. However, in clinical routine, no method for measuring muscle mass is generally available and it is easier to rely on medical history (body weight loss, anorexia), body weight, and inflammatory plasma markers.</p><fig id="F1" position="float"><label>Figure 1</label><caption><p>The figure summarizes hypothetical links between chronic diseases and cachexia, based on the opinion of the authors. Chronic diseases lead to changes in gut microbiota composition and function, which in turn affect the components of the gut barrier. The combined modifications of the gut epithelium, the gut-associated lymphoid tissue and the enteric nervous system could result in cachexia.</p></caption><graphic xlink:href="fcimb-09-00305-g0001"></graphic></fig><p>Bindels and Delzenne previously reviewed the potential links between gut microbiota and muscle mass, based on animal studies (Bindels and Delzenne, <xref rid="B10" ref-type="bibr">2013</xref>). Briefly, gut microbiota could lead to low muscle mass through several mechanisms: (1) decreased amino acid bioavailability for the host, because the amino acids are used by the gut microbiota (Lin et al., <xref rid="B5b" ref-type="bibr">2017</xref>); (2) stimulation of the Toll-like receptors/NF-kB pathway by pathogen-associated molecular patterns (PAMPs) in muscle cells. Indeed, circulating peptidoglycan of Gram-positive bacteria, lipopolysaccharides, flagellin or bacterial nucleic acids are recognized by the Toll-like receptors in muscle cells, and may activate the NF-kB pathway, which leads to muscle loss (Malavaki et al., <xref rid="B38" ref-type="bibr">2015</xref>); (3) stimulation of pro-inflammatory cytokines secretion resulting from increased gut permeability, described in cachectic diseases, and subsequent translocation of PAMPs from the gut lumen into the GALT, and finally (4) through the production of microbiota-derived metabolites. For instance, bile acids can activate, in the skeletal muscle, the intracellular thyroid hormone leading to an elevation of energy expenditure and the nuclear farnesoid X receptor which hinders fat deposition in the muscle. Furthermore, dietary fibers, converted to short-chain fatty acids by gut microbiota, are involved in body weight control, through increased energy expenditure, appetite control and improved metabolic function of adipose tissue and skeletal muscle in overweight persons (Canfora et al., <xref rid="B14" ref-type="bibr">2015</xref>). By analogy, we could speculate a low amount of short-chain fatty acid production in cachectic patients but this has not been demonstrated.</p></sec><sec id="s8"><title>Limitations and Perspectives for Human Studies Targeting Gut Microbiota in Cachexia</title><p>The afore-mentioned human studies suggest that the fecal material containing the gut microbiota may be involved in energy metabolism and the development of cachexia. However, many issues need to be addressed before using gut microbiota modulation as an evidence-based treatment for cachexia in clinical routine.</p><p>Most published studies focused on obesity and not on cachexia. With the increased aging of the population and the increased prevalence of chronic diseases and risk of cachexia, attention should focus also on cachexia, which can be viewed as the opposite metabolic state when based on BMI. As mentioned in the introduction, there is presently no consensus on the definition of cachexia (<xref rid="T1" ref-type="table">Table 1</xref>). All definitions agree on the components of low BMI and weight loss, although the cut-offs are variable, and some include also low muscle mass and function, anorexia, and systemic inflammation. However, a single definition of cachexia, whatever chronic disease, accepted by all concerned medical specialties, would standardize the patients qualified as cachectic, allow evaluating outcomes with less biases related to the study population and allow to understand if the alterations of gut microbiota and barrier are similar in all diseases associated with cachexia.</p><p>Another issue is the lack of a standardized approach to collect, store, process and analyze the feces for bacterial composition and function, which leads to difficult comparisons of results. Standardization of the methodology is essential for future personalized nutrition based on the analysis of the gut microbiota composition and function. Furthermore, most human studies use fecal bacteria as a surrogate marker of gut bacteria. This procedure opens the question whether fecal bacteria reflect the bacterial composition in the lumen of the small bowel, where nutrient digestion and absorption occurs. Also, does the luminal bacterial content which is eliminated in the feces differ from bacteria trapped in the mucus layer of the gut? An insight in the role of bacteria according to its location would require the development of new methods allowing an easy and safe access to the whole small bowel, while presently endoscopy can provide samples only of the proximal small bowel and the colon. Reassuringly, as FMT studies were sufficient to induce weight gain in the recipient, we can hypothesize that in the future we will be able to identify fecal components impacting on the host's health without requiring invasive methods.</p><p>Beside the location of the bacteria, and whatever the BMI, it is unclear whether the composition of the gut microbiota, its function, its interactions with other microorganisms, or microbial or host metabolites found in the fecal material are associated with gut barrier alterations and subsequent alterations in energy metabolism. It is likely that other gut components than bacteria, as viruses, protozoans and fungi also play an important role in gut microbial homeostasis and the resulting metabolic health of the host, but unraveling these interactions in cachexia has not yet started. Thus, combined approaches using metagenomics, metabolomics, measurement, or surrogate markers of the gut barrier permeability may provide a better understanding of these associations and subsequently open hypotheses for interventional studies.</p><p>Finally, this short review on cachexia components and gut microbiota shows that most knowledge is based on associations and not on causality. Very few longitudinal human studies, whether observational or interventional, have been published. The interpretation of these associations is thus difficult and evidence-based treatments not possible.</p></sec><sec sec-type="conclusions" id="s9"><title>Conclusion</title><p>Gut microbiota is an interesting target to potentially treat and prevent cachexia. However, there is presently insufficient evidence that gut microbiota modulation could improve its components and thus clinical outcome in humans.</p></sec><sec id="s10"><title>Author Contributions</title><p>LG, JM, and YC wrote the manuscript. LB, VL, and JS revised the manuscript.</p><sec><title>Conflict of Interest Statement</title><p>The authors declare that the research was conducted in the absence of any commercial or financial relationships that could be construed as a potential conflict of interest.</p></sec></sec></body><back><ref-list><title>References</title><ref id="B1"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ahluwalia</surname><given-names>V.</given-names></name><name><surname>Betrapally</surname><given-names>N. S.</given-names></name><name><surname>Hylemon</surname><given-names>P. B.</given-names></name><name><surname>White</surname><given-names>M. B.</given-names></name><name><surname>Gillevet</surname><given-names>P. M.</given-names></name><name><surname>Unser</surname><given-names>A. B.</given-names></name><etal></etal></person-group>. (<year>2016</year>). <article-title>Impaired gut-liver-brain axis in patients with cirrhosis</article-title>. <source>Sci. Rep</source>. <volume>6</volume>:<fpage>26800</fpage>. <pub-id pub-id-type="doi">10.1038/srep26800</pub-id><pub-id pub-id-type="pmid">27225869</pub-id></mixed-citation></ref><ref id="B2"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Alang</surname><given-names>N.</given-names></name><name><surname>Kelly</surname><given-names>C. R.</given-names></name></person-group> (<year>2015</year>). <article-title>Weight gain after fecal microbiota transplantation</article-title>. <source>Open Forum Infect. Dis</source>. <volume>2</volume>:<fpage>ofv004</fpage>. <pub-id pub-id-type="doi">10.1093/ofid/ofv004</pub-id><pub-id pub-id-type="pmid">26034755</pub-id></mixed-citation></ref><ref id="B3"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Allen</surname><given-names>J. M.</given-names></name><name><surname>Mailing</surname><given-names>L. J.</given-names></name><name><surname>Cohrs</surname><given-names>J.</given-names></name><name><surname>Salmonson</surname><given-names>C.</given-names></name><name><surname>Fryer</surname><given-names>J. D.</given-names></name><name><surname>Nehra</surname><given-names>V.</given-names></name><etal></etal></person-group>. (<year>2018</year>). <article-title>Exercise training-induced modification of the gut microbiota persists after microbiota colonization and attenuates the response to chemically-induced colitis in gnotobiotic mice</article-title>. <source>Gut Microbes</source><volume>9</volume>, <fpage>115</fpage>–<lpage>130</lpage>. <pub-id pub-id-type="doi">10.1080/19490976.2017.1372077</pub-id><pub-id pub-id-type="pmid">28862530</pub-id></mixed-citation></ref><ref id="B4"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Angelakis</surname><given-names>E.</given-names></name><name><surname>Million</surname><given-names>M.</given-names></name><name><surname>Kankoe</surname><given-names>S.</given-names></name><name><surname>Lagier</surname><given-names>J. C.</given-names></name><name><surname>Armougom</surname><given-names>F.</given-names></name><name><surname>Giorgi</surname><given-names>R.</given-names></name><etal></etal></person-group>. (<year>2014</year>). <article-title>Abnormal weight gain and gut microbiota modifications are side effects of long-term doxycycline and hydroxychloroquine treatment</article-title>. <source>Antimicrob. Agents Chemother.</source><volume>58</volume>, <fpage>3342</fpage>–<lpage>3347</lpage>. <pub-id pub-id-type="doi">10.1128/AAC.02437-14</pub-id><pub-id pub-id-type="pmid">24687497</pub-id></mixed-citation></ref><ref id="B5"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Aquilani</surname><given-names>R.</given-names></name><name><surname>Opasich</surname><given-names>C.</given-names></name><name><surname>Gualco</surname><given-names>A.</given-names></name><name><surname>Verri</surname><given-names>M.</given-names></name><name><surname>Testa</surname><given-names>A.</given-names></name><name><surname>Pasini</surname><given-names>E.</given-names></name><etal></etal></person-group> (<year>2008</year>). <article-title>Adequate energy-protein intake is not enough to improve nutritional and metabolic status in muscle-depleted patients with chronic heart failure</article-title>. <source>Eur. J. Heart Fail</source>. <volume>10</volume>, <fpage>1127</fpage>–<lpage>1135</lpage>. <pub-id pub-id-type="doi">10.1016/j.ejheart.2008.09.002</pub-id><pub-id pub-id-type="pmid">18835539</pub-id></mixed-citation></ref><ref id="B5a"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Argilés</surname><given-names>J. M.</given-names></name><name><surname>Lopez-Soriano</surname><given-names>F. J.</given-names></name><name><surname>Toledo</surname><given-names>M.</given-names></name><name><surname>Betancourd</surname><given-names>A.</given-names></name><name><surname>Serpe</surname><given-names>R.</given-names></name><name><surname>Busquets</surname><given-names>S.</given-names></name></person-group> (<year>2011</year>). <article-title>The cachexia score (CASCO): a new tool for staging cachectic cancer patients</article-title>. <source>J. Cachexia Sarcopenia Muscle</source><volume>2</volume>, <fpage>87</fpage>–<lpage>93</lpage>. <pub-id pub-id-type="doi">10.1007/s13539-011-0027-5</pub-id><pub-id pub-id-type="pmid">21766054</pub-id></mixed-citation></ref><ref id="B6"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Armougom</surname><given-names>F.</given-names></name><name><surname>Henry</surname><given-names>M.</given-names></name><name><surname>Vialettes</surname><given-names>B.</given-names></name><name><surname>Raccah</surname><given-names>D.</given-names></name><name><surname>Raoult</surname><given-names>D.</given-names></name></person-group> (<year>2009</year>). <article-title>Monitoring bacterial community of human gut microbiota reveals an increase in Lactobacillus in obese patients and Methanogens in anorexic patients</article-title>. <source>PLoS ONE</source><volume>4</volume>:<fpage>e7125</fpage>. <pub-id pub-id-type="doi">10.1371/journal.pone.0007125</pub-id><pub-id pub-id-type="pmid">19774074</pub-id></mixed-citation></ref><ref id="B7"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Baldwin</surname><given-names>C.</given-names></name><name><surname>Spiro</surname><given-names>A.</given-names></name><name><surname>Ahern</surname><given-names>R.</given-names></name><name><surname>Emery</surname><given-names>P. W.</given-names></name></person-group> (<year>2012</year>). <article-title>Oral nutritional interventions in malnourished patients with cancer: a systematic review and meta-analysis</article-title>. <source>J. Natl. Cancer Inst.</source><volume>104</volume>, <fpage>371</fpage>–<lpage>385</lpage>. <pub-id pub-id-type="doi">10.1093/jnci/djr556</pub-id><pub-id pub-id-type="pmid">22345712</pub-id></mixed-citation></ref><ref id="B8"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Barret</surname><given-names>M.</given-names></name><name><surname>Malka</surname><given-names>D.</given-names></name><name><surname>Aparicio</surname><given-names>T.</given-names></name><name><surname>Dalban</surname><given-names>C.</given-names></name><name><surname>Locher</surname><given-names>C.</given-names></name><name><surname>Sabate</surname><given-names>J. M.</given-names></name><etal></etal></person-group>. (<year>2011</year>). <article-title>Nutritional status affects treatment tolerability and survival in metastatic colorectal cancer patients: results of an AGEO prospective multicenter study</article-title>. <source>Oncology</source><volume>81</volume>, <fpage>395</fpage>–<lpage>402</lpage>. <pub-id pub-id-type="doi">10.1159/000335478</pub-id><pub-id pub-id-type="pmid">22269999</pub-id></mixed-citation></ref><ref id="B9"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Barton</surname><given-names>W.</given-names></name><name><surname>Penney</surname><given-names>N. C.</given-names></name><name><surname>Cronin</surname><given-names>O.</given-names></name><name><surname>Garcia-Perez</surname><given-names>I.</given-names></name><name><surname>Molloy</surname><given-names>M. G.</given-names></name><name><surname>Holmes</surname><given-names>E.</given-names></name><etal></etal></person-group>. (<year>2018</year>). <article-title>The microbiome of professional athletes differs from that of more sedentary subjects in composition and particularly at the functional metabolic level</article-title>. <source>Gut</source><volume>67</volume>, <fpage>625</fpage>–<lpage>633</lpage>. <pub-id pub-id-type="doi">10.1136/gutjnl-2016-313627</pub-id><pub-id pub-id-type="pmid">28360096</pub-id></mixed-citation></ref><ref id="B10"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bindels</surname><given-names>L. B.</given-names></name><name><surname>Delzenne</surname><given-names>N. M.</given-names></name></person-group> (<year>2013</year>). <article-title>Muscle wasting: the gut microbiota as a new therapeutic target?</article-title><source>Int. J. Biochem. Cell Biol.</source><volume>45</volume>, <fpage>2186</fpage>–<lpage>2190</lpage>. <pub-id pub-id-type="doi">10.1016/j.biocel.2013.06.021</pub-id><pub-id pub-id-type="pmid">23831839</pub-id></mixed-citation></ref><ref id="B11"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Borgo</surname><given-names>F.</given-names></name><name><surname>Riva</surname><given-names>A.</given-names></name><name><surname>Benetti</surname><given-names>A.</given-names></name><name><surname>Casiraghi</surname><given-names>M. C.</given-names></name><name><surname>Bertelli</surname><given-names>S.</given-names></name><name><surname>Garbossa</surname><given-names>S.</given-names></name><etal></etal></person-group>. (<year>2017</year>). <article-title>Microbiota in anorexia nervosa: the triangle between bacterial species, metabolites and psychological tests</article-title>. <source>PLoS ONE</source><volume>12</volume>:<fpage>e0179739</fpage>. <pub-id pub-id-type="doi">10.1371/journal.pone.0179739</pub-id><pub-id pub-id-type="pmid">28636668</pub-id></mixed-citation></ref><ref id="B12"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Bozetti</surname><given-names>F.</given-names></name><name><surname>Mariani</surname><given-names>L.</given-names></name></person-group> (<year>2009</year>). <article-title>Defining and classifying cancer cachexia: a proposal by the SCRINIO working group</article-title>. <source>J. Parenter Enter Nutr.</source><volume>33</volume>, <fpage>361</fpage>–<lpage>367</lpage>. <pub-id pub-id-type="doi">10.1177/0148607108325076</pub-id></mixed-citation></ref><ref id="B13"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Buigues</surname><given-names>C.</given-names></name><name><surname>Fernández-Garrido</surname><given-names>J.</given-names></name><name><surname>Pruimboom</surname><given-names>L.</given-names></name><name><surname>Hoogland</surname><given-names>A. J.</given-names></name><name><surname>Navarro-Martínez</surname><given-names>R.</given-names></name><name><surname>Martínez-Martínez</surname><given-names>M.</given-names></name><etal></etal></person-group>. (<year>2016</year>). <article-title>Effect of a prebiotic formulation on frailty syndrome: a randomized, double-blind clinical trial</article-title>. <source>Int. J. Mol. Sci.</source><volume>17</volume>:<fpage>E932</fpage>. <pub-id pub-id-type="doi">10.3390/ijms17060932</pub-id><pub-id pub-id-type="pmid">27314331</pub-id></mixed-citation></ref><ref id="B14"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Canfora</surname><given-names>E. E.</given-names></name><name><surname>Jocken</surname><given-names>J. W.</given-names></name><name><surname>Blaak</surname><given-names>E. E.</given-names></name></person-group> (<year>2015</year>). <article-title>Short-chain fatty acids in control of body weight and insulin sensitivity</article-title>. <source>Nat. Rev. Endocrinol.</source><volume>11</volume>, <fpage>557</fpage>–<lpage>591</lpage>. <pub-id pub-id-type="doi">10.1038/nrendo.2015.128</pub-id><pub-id pub-id-type="pmid">26260141</pub-id></mixed-citation></ref><ref id="B15"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Cani</surname><given-names>P. D.</given-names></name><name><surname>Lecourt</surname><given-names>E.</given-names></name><name><surname>Dewulf</surname><given-names>E. M.</given-names></name><name><surname>Sohet</surname><given-names>F. M.</given-names></name><name><surname>Pachikian</surname><given-names>B. D.</given-names></name><name><surname>Naslain</surname><given-names>D.</given-names></name><etal></etal></person-group>. (<year>2009</year>). <article-title>Gut microbiota fermentation of prebiotics increases satietogenic and incretin gut peptide production with consequences for appetite sensation and glucose response after a meal</article-title>. <source>Am. J. Clin. Nutr</source>. <volume>90</volume>, <fpage>1236</fpage>–<lpage>1243</lpage>. <pub-id pub-id-type="doi">10.3945/ajcn.2009.28095</pub-id><pub-id pub-id-type="pmid">19776140</pub-id></mixed-citation></ref><ref id="B16"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Cederholm</surname><given-names>T.</given-names></name><name><surname>Bosaeus</surname><given-names>I.</given-names></name><name><surname>Barazzoni</surname><given-names>R.</given-names></name><name><surname>Bauer</surname><given-names>J.</given-names></name><name><surname>Van Gossum</surname><given-names>A.</given-names></name><name><surname>Klek</surname><given-names>S.</given-names></name><etal></etal></person-group>. (<year>2015</year>). <article-title>Diagnostic criteria for malnutrition - an ESPEN Consensus Statement</article-title>. <source>Clin. Nutr</source>. <volume>34</volume>, <fpage>335</fpage>–<lpage>340</lpage>. <pub-id pub-id-type="doi">10.1016/j.clnu.2015.03.001</pub-id><pub-id pub-id-type="pmid">25799486</pub-id></mixed-citation></ref><ref id="B17"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Cederholm</surname><given-names>T.</given-names></name><name><surname>Jensen</surname><given-names>G. L.</given-names></name><name><surname>Correia</surname><given-names>M.</given-names></name><name><surname>Gonzalez</surname><given-names>M. C.</given-names></name><name><surname>Fukushima</surname><given-names>R.</given-names></name><name><surname>Higashiguchi</surname><given-names>T.</given-names></name><etal></etal></person-group> (<year>2018</year>). <article-title>GLIM criteria for the diagnosis of malnutrition - A consensus report from the global clinical nutrition community</article-title>. <source>Clin. Nutr</source>. <volume>38</volume>, <fpage>1</fpage>–<lpage>9</lpage>. <pub-id pub-id-type="doi">10.1016/j.clnu.2018.08.002</pub-id><pub-id pub-id-type="pmid">30181091</pub-id></mixed-citation></ref><ref id="B18"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Chambers</surname><given-names>E. S.</given-names></name><name><surname>Viardot</surname><given-names>A.</given-names></name><name><surname>Psichas</surname><given-names>A.</given-names></name><name><surname>Morrison</surname><given-names>D. J.</given-names></name><name><surname>Murphy</surname><given-names>K. G.</given-names></name><name><surname>Zac-Varghese</surname><given-names>S. E.</given-names></name><etal></etal></person-group>. (<year>2015</year>). <article-title>Effects of targeted delivery of propionate to the human colon on appetite regulation, body weight maintenance and adiposity in overweight adults</article-title>. <source>Gut</source><volume>64</volume>, <fpage>1744</fpage>–<lpage>1754</lpage>. <pub-id pub-id-type="doi">10.1136/gutjnl-2014-307913</pub-id><pub-id pub-id-type="pmid">25500202</pub-id></mixed-citation></ref><ref id="B19"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Clarke</surname><given-names>S. F.</given-names></name><name><surname>Murphy</surname><given-names>E. F.</given-names></name><name><surname>O'Sullivan</surname><given-names>O.</given-names></name><name><surname>Lucey</surname><given-names>A. J.</given-names></name><name><surname>Humphreys</surname><given-names>M.</given-names></name><name><surname>Hogan</surname><given-names>A.</given-names></name><etal></etal></person-group>. (<year>2014</year>). <article-title>Exercise and associated dietary extremes impact on gut microbial diversity</article-title>. <source>Gut</source><volume>63</volume>, <fpage>1913</fpage>–<lpage>1920</lpage>. <pub-id pub-id-type="doi">10.1136/gutjnl-2013-306541</pub-id><pub-id pub-id-type="pmid">25021423</pub-id></mixed-citation></ref><ref id="B20"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Cui</surname><given-names>B.</given-names></name><name><surname>Feng</surname><given-names>Q.</given-names></name><name><surname>Wang</surname><given-names>H.</given-names></name><name><surname>Wang</surname><given-names>M.</given-names></name><name><surname>Peng</surname><given-names>Z.</given-names></name><name><surname>Li</surname><given-names>P.</given-names></name><etal></etal></person-group>. (<year>2015</year>). <article-title>Fecal microbiota transplantation through mid-gut for refractory Crohn's disease: safety, feasibility, and efficacy trial results</article-title>. <source>J. Gastroenterol. Hepatol.</source><volume>30</volume>, <fpage>51</fpage>–<lpage>58</lpage>. <pub-id pub-id-type="doi">10.1111/jgh.12727</pub-id><pub-id pub-id-type="pmid">25168749</pub-id></mixed-citation></ref><ref id="B21"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>De Vadder</surname><given-names>F.</given-names></name><name><surname>Kovatcheva-Datchary</surname><given-names>P.</given-names></name><name><surname>Goncalves</surname><given-names>D.</given-names></name><name><surname>Vinera</surname><given-names>J.</given-names></name><name><surname>Zitoun</surname><given-names>C.</given-names></name><name><surname>Duchampt</surname><given-names>A.</given-names></name><etal></etal></person-group>. (<year>2014</year>). <article-title>Microbiota-generated metabolites promote metabolic benefits via gut-brain neural circuits</article-title>. <source>Cell</source><volume>156</volume>, <fpage>84</fpage>–<lpage>96</lpage>. <pub-id pub-id-type="doi">10.1016/j.cell.2013.12.016</pub-id><pub-id pub-id-type="pmid">24412651</pub-id></mixed-citation></ref><ref id="B22"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Deutz</surname><given-names>N. E.</given-names></name><name><surname>Bauer</surname><given-names>J. M.</given-names></name><name><surname>Barazzoni</surname><given-names>R.</given-names></name><name><surname>Biolo</surname><given-names>G.</given-names></name><name><surname>Boirie</surname><given-names>Y.</given-names></name><name><surname>Bosy-Westphal</surname><given-names>A.</given-names></name><etal></etal></person-group>. (<year>2014</year>). <article-title>Protein intake and exercise for optimal muscle function with aging: recommendations from the ESPEN Expert Group</article-title>. <source>Clin. Nutr</source>. <volume>33</volume>, <fpage>929</fpage>–<lpage>936</lpage>. <pub-id pub-id-type="doi">10.1016/j.clnu.2014.04.007</pub-id><pub-id pub-id-type="pmid">24814383</pub-id></mixed-citation></ref><ref id="B23"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ehlermann</surname><given-names>P.</given-names></name><name><surname>Dösch</surname><given-names>A. O.</given-names></name><name><surname>Katus</surname><given-names>H. A.</given-names></name></person-group> (<year>2014</year>). <article-title>Donor fecal transfer for recurrent Clostridium difficile-associated diarrhea in heart transplantation</article-title>. <source>J. Heart Lung Transplant.</source><volume>33</volume>, <fpage>551</fpage>–<lpage>553</lpage>. <pub-id pub-id-type="doi">10.1016/j.healun.2014.02.002</pub-id><pub-id pub-id-type="pmid">24742697</pub-id></mixed-citation></ref><ref id="B24"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Evans</surname><given-names>W. J.</given-names></name><name><surname>Morley</surname><given-names>J. E.</given-names></name><name><surname>Argilés</surname><given-names>J.</given-names></name><name><surname>Bales</surname><given-names>C.</given-names></name><name><surname>Baracos</surname><given-names>V.</given-names></name><name><surname>Guttridge</surname><given-names>D.</given-names></name><etal></etal></person-group>. (<year>2008</year>). <article-title>Cachexia: a new definition</article-title>. <source>Clin. Nutr.</source><volume>27</volume>, <fpage>793</fpage>–<lpage>799</lpage>. <pub-id pub-id-type="doi">10.1016/j.clnu.2008.06.013</pub-id><pub-id pub-id-type="pmid">18718696</pub-id></mixed-citation></ref><ref id="B25"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Fearon</surname><given-names>K.</given-names></name><name><surname>Strasser</surname><given-names>F.</given-names></name><name><surname>Anker</surname><given-names>S. D.</given-names></name><name><surname>Bosaeus</surname><given-names>I.</given-names></name><name><surname>Bruera</surname><given-names>E.</given-names></name><name><surname>Fainsinger</surname><given-names>R. L.</given-names></name><etal></etal></person-group>. (<year>2011</year>). <article-title>Definition and classification of cancer cachexia: an international consensus</article-title>. <source>Lancet Oncol.</source><volume>12</volume>, <fpage>489</fpage>–<lpage>495</lpage>. <pub-id pub-id-type="doi">10.1016/S1470-2045(10)70218-7</pub-id><pub-id pub-id-type="pmid">21296615</pub-id></mixed-citation></ref><ref id="B26"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Fearon</surname><given-names>K. C.</given-names></name><name><surname>Voss</surname><given-names>A. C.</given-names></name><name><surname>Hustead</surname><given-names>D. S.</given-names></name></person-group> (<year>2006</year>). <article-title>Definition of cancer cachexia: effect of weight loss, reduced food intake, and systemic inflammation on functional status and prognosis</article-title>. <source>Am. J. Clin. Nutr.</source><volume>83</volume>, <fpage>1345</fpage>–<lpage>1350</lpage>. <pub-id pub-id-type="doi">10.1093/ajcn/83.6.1345</pub-id><pub-id pub-id-type="pmid">16762946</pub-id></mixed-citation></ref><ref id="B27"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Ferreira</surname><given-names>I. M.</given-names></name><name><surname>Brooks</surname><given-names>D.</given-names></name><name><surname>White</surname><given-names>J.</given-names></name><name><surname>Goldstein</surname><given-names>R.</given-names></name></person-group> (<year>2012</year>). <article-title>Nutritional supplementation for stable chronic obstructive pulmonary disease</article-title>. <source>Cochrane Database Syst. Rev</source>. <volume>12</volume>:<fpage>CD000998</fpage>. <pub-id pub-id-type="doi">10.1002/14651858.CD000998.pub3</pub-id><pub-id pub-id-type="pmid">23235577</pub-id></mixed-citation></ref><ref id="B28"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Genton</surname><given-names>L.</given-names></name><name><surname>Cani</surname><given-names>P. D.</given-names></name><name><surname>Schrenzel</surname><given-names>J.</given-names></name></person-group> (<year>2015</year>). <article-title>Alterations of gut barrier and gut microbiota in food restriction, food deprivation and protein-energy wasting</article-title>. <source>Clin. Nutr</source>. <volume>34</volume>, <fpage>341</fpage>–<lpage>349</lpage>. <pub-id pub-id-type="doi">10.1016/j.clnu.2014.10.003</pub-id><pub-id pub-id-type="pmid">25459400</pub-id></mixed-citation></ref><ref id="B29"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Guo</surname><given-names>Y.</given-names></name><name><surname>Huang</surname><given-names>Z. P.</given-names></name><name><surname>Liu</surname><given-names>C. Q.</given-names></name><name><surname>Qi</surname><given-names>L.</given-names></name><name><surname>Sheng</surname><given-names>Y.</given-names></name><name><surname>Zou</surname><given-names>D. J.</given-names></name></person-group> (<year>2018</year>). <article-title>Modulation of the gut microbiome: a systematic review of the effect of bariatric surgery</article-title>. <source>Eur. J. Endocrinol.</source><volume>178</volume>, <fpage>43</fpage>–<lpage>56</lpage>. <pub-id pub-id-type="doi">10.1530/EJE-17-0403</pub-id><pub-id pub-id-type="pmid">28916564</pub-id></mixed-citation></ref><ref id="B30"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Haran</surname><given-names>J. P.</given-names></name><name><surname>Bucci</surname><given-names>V.</given-names></name><name><surname>Dutta</surname><given-names>P.</given-names></name><name><surname>Ward</surname><given-names>D.</given-names></name><name><surname>McCormick</surname><given-names>B.</given-names></name></person-group> (<year>2018</year>). <article-title>The nursing home elder microbiome stability and associations with age, frailty, nutrition and physical location</article-title>. <source>J. Med. Microbiol</source>. <volume>67</volume>, <fpage>40</fpage>–<lpage>51</lpage>. <pub-id pub-id-type="doi">10.1099/jmm.0.000640</pub-id><pub-id pub-id-type="pmid">29134939</pub-id></mixed-citation></ref><ref id="B31"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>He</surname><given-names>Y.</given-names></name><name><surname>Wu</surname><given-names>W.</given-names></name><name><surname>Zheng</surname><given-names>H. M.</given-names></name><name><surname>Li</surname><given-names>P.</given-names></name><name><surname>McDonald</surname><given-names>D.</given-names></name><name><surname>Sheng</surname><given-names>H. F.</given-names></name><etal></etal></person-group> (<year>2018</year>). <article-title>Regional variation limits applications of healthy gut microbiome reference ranges and disease models</article-title>. <source>Nat. Med</source>. <volume>24</volume>, <fpage>1532</fpage>–<lpage>1535</lpage>. <pub-id pub-id-type="doi">10.1038/s41591-018-0164-x</pub-id><pub-id pub-id-type="pmid">30150716</pub-id></mixed-citation></ref><ref id="B32"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Jensen</surname><given-names>G. L.</given-names></name><name><surname>Cederholm</surname><given-names>T.</given-names></name><name><surname>Correia</surname><given-names>M. I. T. D.</given-names></name><name><surname>Gonzalez</surname><given-names>M. C.</given-names></name><name><surname>Fukushima</surname><given-names>R.</given-names></name><name><surname>Higashiguchi</surname><given-names>T.</given-names></name><etal></etal></person-group>. (<year>2019</year>). <article-title>GLIM criteria for the diagnosis of malnutrition: a consensus report from the global clinical nutrition community</article-title>. <source>JPEN J. Parenter. Enteral Nutr.</source><volume>43</volume>, <fpage>32</fpage>–<lpage>40</lpage>. <pub-id pub-id-type="doi">10.1002/jpen.1440</pub-id><pub-id pub-id-type="pmid">30175461</pub-id></mixed-citation></ref><ref id="B33"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kanbay</surname><given-names>M.</given-names></name><name><surname>Onal</surname><given-names>E. M.</given-names></name><name><surname>Afsar</surname><given-names>B.</given-names></name><name><surname>Dagel</surname><given-names>T.</given-names></name><name><surname>Yerlikaya</surname><given-names>A.</given-names></name><name><surname>Covic</surname><given-names>A.</given-names></name><etal></etal></person-group>. (<year>2018</year>). <article-title>The crosstalk of gut microbiota and chronic kidney disease: role of inflammation, proteinuria, hypertension, and diabetes mellitus</article-title>. <source>Int. Urol. Nephrol.</source><volume>50</volume>, <fpage>1453</fpage>–<lpage>1466</lpage>. <pub-id pub-id-type="doi">10.1007/s11255-018-1873-2</pub-id><pub-id pub-id-type="pmid">29728993</pub-id></mixed-citation></ref><ref id="B34"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Kleiman</surname><given-names>S. C.</given-names></name><name><surname>Watson</surname><given-names>H. J.</given-names></name><name><surname>Bulik-Sullivan</surname><given-names>E. C.</given-names></name><name><surname>Huh</surname><given-names>E. Y.</given-names></name><name><surname>Tarantino</surname><given-names>L. M.</given-names></name><name><surname>Bulik</surname><given-names>C. M.</given-names></name><etal></etal></person-group>. (<year>2015</year>). <article-title>The intestinal microbiota in acute anorexia nervosa and during renourishment: relationship to depression, anxiety, and eating disorder psychopathology</article-title>. <source>Psychosom. Med.</source><volume>77</volume>, <fpage>969</fpage>–<lpage>981</lpage>. <pub-id pub-id-type="doi">10.1097/PSY.0000000000000247</pub-id><pub-id pub-id-type="pmid">26428446</pub-id></mixed-citation></ref><ref id="B35"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Klosterbuer</surname><given-names>A. S.</given-names></name><name><surname>Thomas</surname><given-names>W.</given-names></name><name><surname>Slavin</surname><given-names>J. L.</given-names></name></person-group> (<year>2012</year>). <article-title>Resistant starch and pullulan reduce postprandial glucose, insulin, and GLP-1, but have no effect on satiety in healthy humans</article-title>. <source>J. Agric. Food Chem.</source><volume>60</volume>, <fpage>11928</fpage>–<lpage>11934</lpage>. <pub-id pub-id-type="doi">10.1021/jf303083r</pub-id><pub-id pub-id-type="pmid">23136915</pub-id></mixed-citation></ref><ref id="B36"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Konishi</surname><given-names>M.</given-names></name><name><surname>Ishida</surname><given-names>J.</given-names></name><name><surname>von Haehling</surname><given-names>S.</given-names></name><name><surname>Anker</surname><given-names>S. D.</given-names></name><name><surname>Springer</surname><given-names>J.</given-names></name></person-group> (<year>2016</year>). <article-title>Nutrition in cachexia: from bench to bedside</article-title>. <source>J. Cachexia Sarcopenia Muscle</source><volume>7</volume>, <fpage>107</fpage>–<lpage>109</lpage>. <pub-id pub-id-type="doi">10.1002/jcsm.12111</pub-id><pub-id pub-id-type="pmid">27030816</pub-id></mixed-citation></ref><ref id="B5b"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Lin</surname><given-names>R.</given-names></name><name><surname>Liu</surname><given-names>W.</given-names></name><name><surname>Piao</surname><given-names>M.</given-names></name><name><surname>Zhu</surname><given-names>H.</given-names></name></person-group> (<year>2017</year>). <article-title>A review of the relationship between the gut microbiota and amino acid metabolism</article-title>. <source>Amino Acids</source><volume>49</volume>, <fpage>2083</fpage>–<lpage>2090</lpage>. <pub-id pub-id-type="doi">10.1007/s00726-017-2493-3</pub-id><pub-id pub-id-type="pmid">28932911</pub-id></mixed-citation></ref><ref id="B37"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Mack</surname><given-names>I.</given-names></name><name><surname>Cuntz</surname><given-names>U.</given-names></name><name><surname>Gramer</surname><given-names>C.</given-names></name><name><surname>Niedermaier</surname><given-names>S.</given-names></name><name><surname>Pohl</surname><given-names>C.</given-names></name><name><surname>Schwiertz</surname><given-names>A.</given-names></name><etal></etal></person-group> (<year>2016</year>). <article-title>Weight gain in anorexia nervosa does not ameliorate the faecal microbiota, branched chain fatty acid profiles, and gastrointestinal complaints</article-title>. <source>Sci. Rep</source>. <volume>6</volume>:<fpage>26752</fpage><pub-id pub-id-type="doi">10.1038/srep26752</pub-id><pub-id pub-id-type="pmid">27229737</pub-id></mixed-citation></ref><ref id="B38"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Malavaki</surname><given-names>C. J.</given-names></name><name><surname>Sakkas</surname><given-names>G. K.</given-names></name><name><surname>Mitrou</surname><given-names>G. I.</given-names></name><name><surname>Kalyva</surname><given-names>A.</given-names></name><name><surname>Stefanidis</surname><given-names>I.</given-names></name><name><surname>Myburgh</surname><given-names>K. H.</given-names></name><etal></etal></person-group>. (<year>2015</year>). <article-title>Skeletal muscle atrophy: disease-induced mechanisms may mask disuse atrophy</article-title>. <source>J. Muscle Res. Cell Motil.</source><volume>36</volume>, <fpage>405</fpage>–<lpage>421</lpage>. <pub-id pub-id-type="doi">10.1007/s10974-015-9439-8</pub-id><pub-id pub-id-type="pmid">26728748</pub-id></mixed-citation></ref><ref id="B39"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Martin</surname><given-names>L.</given-names></name><name><surname>Baracos</surname><given-names>V. E.</given-names></name><name><surname>Jagoe</surname><given-names>R. T.</given-names></name><name><surname>Chasen</surname><given-names>M.</given-names></name><name><surname>Senesse</surname><given-names>P.</given-names></name><name><surname>Antoun</surname><given-names>S.</given-names></name><etal></etal></person-group>. (<year>2015</year>). <article-title>Diagnostic criteria for the classification of cancer-associated weight loss</article-title>. <source>J. Clin. Oncol.</source><volume>33</volume>, <fpage>90</fpage>–<lpage>99</lpage>. <pub-id pub-id-type="doi">10.1200/JCO.2014.56.1894</pub-id><pub-id pub-id-type="pmid">25422490</pub-id></mixed-citation></ref><ref id="B40"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Morita</surname><given-names>C.</given-names></name><name><surname>Tsuji</surname><given-names>H.</given-names></name><name><surname>Hata</surname><given-names>T.</given-names></name><name><surname>Gondo</surname><given-names>M.</given-names></name><name><surname>Takakura</surname><given-names>S.</given-names></name><name><surname>Kawai</surname><given-names>K.</given-names></name><etal></etal></person-group>. (<year>2015</year>). <article-title>Gut dysbiosis in patients with anorexia nervosa</article-title>. <source>PLoS ONE</source><volume>10</volume>:<fpage>e0145274</fpage>. <pub-id pub-id-type="doi">10.1371/journal.pone.0145274</pub-id><pub-id pub-id-type="pmid">26682545</pub-id></mixed-citation></ref><ref id="B41"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Morrison</surname><given-names>D. J.</given-names></name><name><surname>Preston</surname><given-names>T.</given-names></name></person-group> (<year>2016</year>). <article-title>Formation of short chain fatty acids by the gut microbiota and their impact on human metabolism</article-title>. <source>Gut Microbes</source><volume>7</volume>, <fpage>189</fpage>–<lpage>200</lpage>. <pub-id pub-id-type="doi">10.1080/19490976.2015.1134082</pub-id><pub-id pub-id-type="pmid">26963409</pub-id></mixed-citation></ref><ref id="B42"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Muscaritoli</surname><given-names>M.</given-names></name><name><surname>Anker</surname><given-names>S. D.</given-names></name><name><surname>Argilés</surname><given-names>J.</given-names></name><name><surname>Aversa</surname><given-names>Z.</given-names></name><name><surname>Bauer</surname><given-names>J. M.</given-names></name><name><surname>Biolo</surname><given-names>G.</given-names></name><etal></etal></person-group> (<year>2010</year>). <article-title>Consensus definition of sarcopenia, cachexia and pre-cachexia: joint document elaborated by Special Interest Groups (SIG) “cachexia-anorexia in chronic wasting diseases” and “nutrition in geriatrics”</article-title>. <source>Clin. Nutr</source>. <volume>29</volume>, <fpage>154</fpage>–<lpage>159</lpage>. <pub-id pub-id-type="doi">10.1016/j.clnu.2009.12.004</pub-id><pub-id pub-id-type="pmid">20060626</pub-id></mixed-citation></ref><ref id="B43"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Nagatomo</surname><given-names>Y.</given-names></name><name><surname>Tang</surname><given-names>W. H.</given-names></name></person-group> (<year>2015</year>). <article-title>Intersections between microbiome and heart failure: revisiting the gut hypothesis</article-title>. <source>J. Card. Fail.</source><volume>21</volume>, <fpage>973</fpage>–<lpage>980</lpage>. <pub-id pub-id-type="doi">10.1016/j.cardfail.2015.09.017</pub-id><pub-id pub-id-type="pmid">26435097</pub-id></mixed-citation></ref><ref id="B44"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Nagpal</surname><given-names>R.</given-names></name><name><surname>Kumar</surname><given-names>M.</given-names></name><name><surname>Yadav</surname><given-names>A. K.</given-names></name><name><surname>Hemalatha</surname><given-names>R.</given-names></name><name><surname>Yadav</surname><given-names>H.</given-names></name><name><surname>Marotta</surname><given-names>F.</given-names></name><etal></etal></person-group>. (<year>2016</year>). <article-title>Gut microbiota in health and disease: an overview focused on metabolic inflammation</article-title>. <source>Benef. Microbes</source><volume>7</volume>, <fpage>181</fpage>–<lpage>194</lpage>. <pub-id pub-id-type="doi">10.3920/bm2015.0062</pub-id><pub-id pub-id-type="pmid">26645350</pub-id></mixed-citation></ref><ref id="B45"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Pérez-Santiago</surname><given-names>J.</given-names></name><name><surname>Gianella</surname><given-names>S.</given-names></name><name><surname>Massanella</surname><given-names>M.</given-names></name><name><surname>Spina</surname><given-names>C. A.</given-names></name><name><surname>Karris</surname><given-names>M. Y.</given-names></name><name><surname>Var</surname><given-names>S. R.</given-names></name><etal></etal></person-group>. (<year>2013</year>). <article-title>Gut Lactobacillales are associated with higher CD4 and less microbial translocation during HIV infection</article-title>. <source>AIDS</source><volume>27</volume>, <fpage>1921</fpage>–<lpage>1931</lpage>. <pub-id pub-id-type="doi">10.1097/QAD.0b013e3283611816</pub-id><pub-id pub-id-type="pmid">24180001</pub-id></mixed-citation></ref><ref id="B46"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Pfleiderer</surname><given-names>A.</given-names></name><name><surname>Lagier</surname><given-names>J. C.</given-names></name><name><surname>Armougom</surname><given-names>F.</given-names></name><name><surname>Robert</surname><given-names>C.</given-names></name><name><surname>Vialettes</surname><given-names>B.</given-names></name><name><surname>Raoult</surname><given-names>D.</given-names></name></person-group> (<year>2013</year>). <article-title>Culturomics identified 11 new bacterial species from a single anorexia nervosa stool sample</article-title>. <source>Eur. J. Clin. Microbiol. Infect. Dis</source>. <volume>32</volume>, <fpage>1471</fpage>–<lpage>1481</lpage>. <pub-id pub-id-type="doi">10.1007/s10096-013-1900-2</pub-id><pub-id pub-id-type="pmid">23728738</pub-id></mixed-citation></ref><ref id="B47"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Reimer</surname><given-names>R. A.</given-names></name><name><surname>Willis</surname><given-names>H. J.</given-names></name><name><surname>Tunnicliffe</surname><given-names>J. M.</given-names></name><name><surname>Park</surname><given-names>H.</given-names></name><name><surname>Madsen</surname><given-names>K. L.</given-names></name><name><surname>Soto-Vaca</surname><given-names>A.</given-names></name></person-group> (<year>2017</year>). <article-title>Inulin-type fructans and whey protein both modulate appetite but only fructans alter gut microbiota in adults with overweight/obesity: a randomized controlled trial</article-title>. <source>Mol. Nutr. Food Res</source>. <volume>61</volume>:<fpage>1700484</fpage>. <pub-id pub-id-type="doi">10.1002/mnfr.201700484</pub-id><pub-id pub-id-type="pmid">28730743</pub-id></mixed-citation></ref><ref id="B48"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Sakamoto</surname><given-names>M.</given-names></name><name><surname>Mikasa</surname><given-names>K.</given-names></name><name><surname>Majima</surname><given-names>T.</given-names></name><name><surname>Hamada</surname><given-names>K.</given-names></name><name><surname>Konishi</surname><given-names>M.</given-names></name><name><surname>Maeda</surname><given-names>K.</given-names></name><etal></etal></person-group>. (<year>2001</year>). <article-title>Anti-cachectic effect of clarithromycin for patients with unresectable non-small cell lung cancer</article-title>. <source>Chemotherapy</source><volume>47</volume>, <fpage>444</fpage>–<lpage>451</lpage>. <pub-id pub-id-type="doi">10.1159/000048556</pub-id><pub-id pub-id-type="pmid">11786660</pub-id></mixed-citation></ref><ref id="B49"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Seganfredo</surname><given-names>F. B.</given-names></name><name><surname>Blume</surname><given-names>C. A.</given-names></name><name><surname>Moehlecke</surname><given-names>M.</given-names></name><name><surname>Giongo</surname><given-names>A.</given-names></name><name><surname>Casagrande</surname><given-names>D. S.</given-names></name><name><surname>Spolidoro</surname><given-names>J. V. N.</given-names></name><etal></etal></person-group>. (<year>2017</year>). <article-title>Weight-loss interventions and gut microbiota changes in overweight and obese patients: a systematic review</article-title>. <source>Obes. Rev</source>. <volume>18</volume>, <fpage>832</fpage>–<lpage>851</lpage>. <pub-id pub-id-type="doi">10.1111/obr.12541</pub-id><pub-id pub-id-type="pmid">28524627</pub-id></mixed-citation></ref><ref id="B50"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Serrano-Villar</surname><given-names>S.</given-names></name><name><surname>Vázquez-Castellanos</surname><given-names>J. F.</given-names></name><name><surname>Vallejo</surname><given-names>A.</given-names></name><name><surname>Latorre</surname><given-names>A.</given-names></name><name><surname>Sainz</surname><given-names>T.</given-names></name><name><surname>Ferrando-Martínez</surname><given-names>S.</given-names></name><etal></etal></person-group>. (<year>2017</year>). <article-title>The effects of prebiotics on microbial dysbiosis, butyrate production and immunity in HIV-infected subjects</article-title>. <source>Mucosal Immunol.</source><volume>10</volume>, <fpage>1279</fpage>–<lpage>1293</lpage>. <pub-id pub-id-type="doi">10.1038/mi.2016.122</pub-id><pub-id pub-id-type="pmid">28000678</pub-id></mixed-citation></ref><ref id="B51"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Sorensen</surname><given-names>J.</given-names></name><name><surname>Kondrup</surname><given-names>J.</given-names></name><name><surname>Prokopowicz</surname><given-names>J.</given-names></name><name><surname>Schiesser</surname><given-names>M.</given-names></name><name><surname>Krähenbühl</surname><given-names>L.</given-names></name><name><surname>Meier</surname><given-names>R.</given-names></name><etal></etal></person-group>. (<year>2008</year>). <article-title>EuroOOPS: an international, multicentre study to implement nutritional risk screening and evaluate clinical outcome</article-title>. <source>Clin. Nutr.</source><volume>27</volume>, <fpage>340</fpage>–<lpage>349</lpage>. <pub-id pub-id-type="doi">10.1016/j.clnu.2008.03.012</pub-id><pub-id pub-id-type="pmid">18504063</pub-id></mixed-citation></ref><ref id="B52"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Takayama</surname><given-names>K.</given-names></name><name><surname>Katakami</surname><given-names>N.</given-names></name><name><surname>Yokoyama</surname><given-names>T.</given-names></name><name><surname>Atagi</surname><given-names>S.</given-names></name><name><surname>Yoshimori</surname><given-names>K.</given-names></name><name><surname>Kagamu</surname><given-names>H.</given-names></name><etal></etal></person-group>. (<year>2016</year>). <article-title>Anamorelin (ONO-7643) in Japanese patients with non-small cell lung cancer and cachexia: results of a randomized phase 2 trial</article-title>. <source>Support. Care Cancer</source><volume>24</volume>, <fpage>3495</fpage>–<lpage>3505</lpage>. <pub-id pub-id-type="doi">10.1007/s00520-016-3144-z</pub-id><pub-id pub-id-type="pmid">27005463</pub-id></mixed-citation></ref><ref id="B53"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Tanaka</surname><given-names>K.</given-names></name><name><surname>Yano</surname><given-names>M.</given-names></name><name><surname>Motoori</surname><given-names>M.</given-names></name><name><surname>Kishi</surname><given-names>K.</given-names></name><name><surname>Miyashiro</surname><given-names>I.</given-names></name><name><surname>Ohue</surname><given-names>M.</given-names></name><etal></etal></person-group>. (<year>2012</year>). <article-title>Impact of perioperative administration of synbiotics in patients with esophageal cancer undergoing esophagectomy: a prospective randomized controlled trial</article-title>. <source>Surgery</source><volume>152</volume>, <fpage>832</fpage>–<lpage>842</lpage>. <pub-id pub-id-type="doi">10.1016/j.surg.2012.02.021</pub-id><pub-id pub-id-type="pmid">22503510</pub-id></mixed-citation></ref><ref id="B54"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Temel</surname><given-names>J. S.</given-names></name><name><surname>Abernethy</surname><given-names>A. P.</given-names></name><name><surname>Currow</surname><given-names>D. C.</given-names></name><name><surname>Friend</surname><given-names>J.</given-names></name><name><surname>Duus</surname><given-names>E. M.</given-names></name><name><surname>Yan</surname><given-names>Y.</given-names></name><etal></etal></person-group>. (<year>2016</year>). <article-title>Anamorelin in patients with non-small-cell lung cancer and cachexia (ROMANA 1 and ROMANA 2): results from two randomised, double-blind, phase 3 trials</article-title>. <source>Lancet Oncol</source>. <volume>17</volume>, <fpage>519</fpage>–<lpage>531</lpage>. <pub-id pub-id-type="doi">10.1016/S1470-2045(15)00558-6</pub-id><pub-id pub-id-type="pmid">26906526</pub-id></mixed-citation></ref><ref id="B55"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Thuny</surname><given-names>F.</given-names></name><name><surname>Richet</surname><given-names>H.</given-names></name><name><surname>Casalta</surname><given-names>J. P.</given-names></name><name><surname>Angelakis</surname><given-names>E.</given-names></name><name><surname>Habib</surname><given-names>G.</given-names></name><name><surname>Raoult</surname><given-names>D.</given-names></name></person-group> (<year>2010</year>). <article-title>Vancomycin treatment of infective endocarditis is linked with recently acquired obesity</article-title>. <source>PLoS ONE</source><volume>5</volume>:<fpage>e9074</fpage>. <pub-id pub-id-type="doi">10.1371/journal.pone.0009074</pub-id><pub-id pub-id-type="pmid">20161775</pub-id></mixed-citation></ref><ref id="B56"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Vaghef-Mehrabany</surname><given-names>E.</given-names></name><name><surname>Alipour</surname><given-names>B.</given-names></name><name><surname>Homayouni-Rad</surname><given-names>A.</given-names></name><name><surname>Sharif</surname><given-names>S. K.</given-names></name><name><surname>Asghari-Jafarabadi</surname><given-names>M.</given-names></name><name><surname>Zavvari</surname><given-names>S.</given-names></name></person-group> (<year>2014</year>). <article-title>Probiotic supplementation improves inflammatory status in patients with rheumatoid arthritis</article-title>. <source>Nutrition</source><volume>30</volume>, <fpage>430</fpage>–<lpage>435</lpage>. <pub-id pub-id-type="doi">10.1016/j.nut.2013.09.007</pub-id><pub-id pub-id-type="pmid">24355439</pub-id></mixed-citation></ref><ref id="B57"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>van de Wouw</surname><given-names>M.</given-names></name><name><surname>Schellekens</surname><given-names>H.</given-names></name><name><surname>Dinan</surname><given-names>T. G.</given-names></name><name><surname>Cryan</surname><given-names>J. F.</given-names></name></person-group> (<year>2017</year>). <article-title>Microbiota-gut-brain axis: modulator of host metabolism and appetite</article-title>. <source>J. Nutr</source>. <volume>147</volume>, <fpage>727</fpage>–<lpage>745</lpage>. <pub-id pub-id-type="doi">10.3945/jn.116.240481</pub-id><pub-id pub-id-type="pmid">28356427</pub-id></mixed-citation></ref><ref id="B58"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>von Haehling</surname><given-names>S.</given-names></name><name><surname>Anker</surname><given-names>M. S.</given-names></name><name><surname>Anker</surname><given-names>S. D.</given-names></name></person-group> (<year>2016</year>). <article-title>Prevalence and clinical impact of cachexia in chronic illness in Europe, U. S. A., and Japan: facts and numbers update 2016</article-title>. <source>J. Cachexia Sarcopenia Muscle</source><volume>7</volume>, <fpage>507</fpage>–<lpage>509</lpage>. <pub-id pub-id-type="doi">10.1002/jcsm.12167</pub-id><pub-id pub-id-type="pmid">27891294</pub-id></mixed-citation></ref><ref id="B59"><mixed-citation publication-type="journal"><person-group person-group-type="author"><name><surname>Zhao</surname><given-names>L.</given-names></name><name><surname>Zhang</surname><given-names>F.</given-names></name><name><surname>Ding</surname><given-names>X.</given-names></name><name><surname>Wu</surname><given-names>G.</given-names></name><name><surname>Lam</surname><given-names>Y. Y.</given-names></name><name><surname>Wang</surname><given-names>X.</given-names></name><etal></etal></person-group>. (<year>2018</year>). <article-title>Gut bacteria selectively promoted by dietary fibers alleviate type 2 diabetes</article-title>. <source>Science</source><volume>359</volume>, <fpage>1151</fpage>–<lpage>1156</lpage>. <pub-id pub-id-type="doi">10.1126/science.aao5774</pub-id><pub-id pub-id-type="pmid">29590046</pub-id></mixed-citation></ref></ref-list></back></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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