Theranostic Nanomedicine for Malignant Gliomas
Identifieur interne : 000329 ( Main/Exploration ); précédent : 000328; suivant : 000330Theranostic Nanomedicine for Malignant Gliomas
Auteurs : Michele D'Angelo [Italie] ; Vanessa Castelli [Italie] ; Elisabetta Benedetti [Italie] ; Andrea Antonosante [Italie] ; Mariano Catanesi [Italie] ; Reyes Dominguez-Benot [Italie] ; Giuseppina Pitari [Italie] ; Rodolfo Ippoliti [Italie] ; Annamaria Cimini [Italie, États-Unis]Source :
- Frontiers in Bioengineering and Biotechnology [ 2296-4185 ] ; 2019.
Abstract
Brain tumors mainly originate from glial cells and are classified as gliomas. Malignant gliomas represent an incurable disease; indeed, after surgery and chemotherapy, recurrence appears within a few months, and mortality has remained high in the last decades. This is mainly due to the heterogeneity of malignant gliomas, indicating that a single therapy is not effective for all patients. In this regard, the advent of theranostic nanomedicine, a combination of imaging and therapeutic agents, represents a strategic tool for the management of malignant brain tumors, allowing for the detection of therapies that are specific to the single patient and avoiding overdosing the non-responders. Here, recent theranostic nanomedicine approaches for glioma therapy are described.
Url:
DOI: 10.3389/fbioe.2019.00325
PubMed: 31799246
PubMed Central: 6868071
Affiliations:
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Le document en format XML
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<front><div type="abstract" xml:lang="en"><p>Brain tumors mainly originate from glial cells and are classified as gliomas. Malignant gliomas represent an incurable disease; indeed, after surgery and chemotherapy, recurrence appears within a few months, and mortality has remained high in the last decades. This is mainly due to the heterogeneity of malignant gliomas, indicating that a single therapy is not effective for all patients. In this regard, the advent of theranostic nanomedicine, a combination of imaging and therapeutic agents, represents a strategic tool for the management of malignant brain tumors, allowing for the detection of therapies that are specific to the single patient and avoiding overdosing the non-responders. Here, recent theranostic nanomedicine approaches for glioma therapy are described.</p>
</div>
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