Theranostic Nanomedicine for Malignant Gliomas
Identifieur interne : 000950 ( Pmc/Curation ); précédent : 000949; suivant : 000951Theranostic Nanomedicine for Malignant Gliomas
Auteurs : Michele D'Angelo [Italie] ; Vanessa Castelli [Italie] ; Elisabetta Benedetti [Italie] ; Andrea Antonosante [Italie] ; Mariano Catanesi [Italie] ; Reyes Dominguez-Benot [Italie] ; Giuseppina Pitari [Italie] ; Rodolfo Ippoliti [Italie] ; Annamaria Cimini [Italie, États-Unis]Source :
- Frontiers in Bioengineering and Biotechnology [ 2296-4185 ] ; 2019.
Abstract
Brain tumors mainly originate from glial cells and are classified as gliomas. Malignant gliomas represent an incurable disease; indeed, after surgery and chemotherapy, recurrence appears within a few months, and mortality has remained high in the last decades. This is mainly due to the heterogeneity of malignant gliomas, indicating that a single therapy is not effective for all patients. In this regard, the advent of theranostic nanomedicine, a combination of imaging and therapeutic agents, represents a strategic tool for the management of malignant brain tumors, allowing for the detection of therapies that are specific to the single patient and avoiding overdosing the non-responders. Here, recent theranostic nanomedicine approaches for glioma therapy are described.
Url:
DOI: 10.3389/fbioe.2019.00325
PubMed: 31799246
PubMed Central: 6868071
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D'Angelo</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Life, Health and Environmental Sciences, University of L'Aquila</institution>,<addr-line>L'Aquila</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Castelli, Vanessa" sort="Castelli, Vanessa" uniqKey="Castelli V" first="Vanessa" last="Castelli">Vanessa Castelli</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Life, Health and Environmental Sciences, University of L'Aquila</institution>,<addr-line>L'Aquila</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Benedetti, Elisabetta" sort="Benedetti, Elisabetta" uniqKey="Benedetti E" first="Elisabetta" last="Benedetti">Elisabetta Benedetti</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Life, Health and Environmental Sciences, University of L'Aquila</institution>,<addr-line>L'Aquila</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Antonosante, Andrea" sort="Antonosante, Andrea" uniqKey="Antonosante A" first="Andrea" last="Antonosante">Andrea Antonosante</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Life, Health and Environmental Sciences, University of L'Aquila</institution>,<addr-line>L'Aquila</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Catanesi, Mariano" sort="Catanesi, Mariano" uniqKey="Catanesi M" first="Mariano" last="Catanesi">Mariano Catanesi</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Life, Health and Environmental Sciences, University of L'Aquila</institution>,<addr-line>L'Aquila</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Dominguez Benot, Reyes" sort="Dominguez Benot, Reyes" uniqKey="Dominguez Benot R" first="Reyes" last="Dominguez-Benot">Reyes Dominguez-Benot</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Life, Health and Environmental Sciences, University of L'Aquila</institution>,<addr-line>L'Aquila</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Pitari, Giuseppina" sort="Pitari, Giuseppina" uniqKey="Pitari G" first="Giuseppina" last="Pitari">Giuseppina Pitari</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Life, Health and Environmental Sciences, University of L'Aquila</institution>,<addr-line>L'Aquila</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Ippoliti, Rodolfo" sort="Ippoliti, Rodolfo" uniqKey="Ippoliti R" first="Rodolfo" last="Ippoliti">Rodolfo Ippoliti</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Life, Health and Environmental Sciences, University of L'Aquila</institution>,<addr-line>L'Aquila</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author><author><name sortKey="Cimini, Annamaria" sort="Cimini, Annamaria" uniqKey="Cimini A" first="Annamaria" last="Cimini">Annamaria Cimini</name><affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Life, Health and Environmental Sciences, University of L'Aquila</institution>,<addr-line>L'Aquila</addr-line>,<country>Italy</country></nlm:aff><country xml:lang="fr">Italie</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation><affiliation wicri:level="1"><nlm:aff id="aff2"><institution>Department of Biology, Sbarro Institute for Cancer Research and Molecular Medicine, Temple University</institution>,<addr-line>Philadelphia, PA</addr-line>,<country>United States</country></nlm:aff><country xml:lang="fr">États-Unis</country><wicri:regionArea># see nlm:aff country strict</wicri:regionArea></affiliation></author></analytic><series><title level="j">Frontiers in Bioengineering and Biotechnology</title><idno type="eISSN">2296-4185</idno><imprint><date when="2019">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"><p>Brain tumors mainly originate from glial cells and are classified as gliomas. Malignant gliomas represent an incurable disease; indeed, after surgery and chemotherapy, recurrence appears within a few months, and mortality has remained high in the last decades. This is mainly due to the heterogeneity of malignant gliomas, indicating that a single therapy is not effective for all patients. In this regard, the advent of theranostic nanomedicine, a combination of imaging and therapeutic agents, represents a strategic tool for the management of malignant brain tumors, allowing for the detection of therapies that are specific to the single patient and avoiding overdosing the non-responders. Here, recent theranostic nanomedicine approaches for glioma therapy are described.</p></div></front><back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Agrawal, P" uniqKey="Agrawal P">P. Agrawal</name></author><author><name sortKey="Singh, R P" uniqKey="Singh R">R. P. 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<front><journal-meta><journal-id journal-id-type="nlm-ta">Front Bioeng Biotechnol</journal-id><journal-id journal-id-type="iso-abbrev">Front Bioeng Biotechnol</journal-id><journal-id journal-id-type="publisher-id">Front. Bioeng. Biotechnol.</journal-id><journal-title-group><journal-title>Frontiers in Bioengineering and Biotechnology</journal-title></journal-title-group><issn pub-type="epub">2296-4185</issn><publisher><publisher-name>Frontiers Media S.A.</publisher-name></publisher></journal-meta><article-meta><article-id pub-id-type="pmid">31799246</article-id><article-id pub-id-type="pmc">6868071</article-id><article-id pub-id-type="doi">10.3389/fbioe.2019.00325</article-id><article-categories><subj-group subj-group-type="heading"><subject>Bioengineering and Biotechnology</subject><subj-group><subject>Review</subject></subj-group></subj-group></article-categories><title-group><article-title>Theranostic Nanomedicine for Malignant Gliomas</article-title></title-group><contrib-group><contrib contrib-type="author"><name><surname>d'Angelo</surname><given-names>Michele</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Castelli</surname><given-names>Vanessa</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Benedetti</surname><given-names>Elisabetta</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/690653/overview"></uri></contrib><contrib contrib-type="author"><name><surname>Antonosante</surname><given-names>Andrea</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/784227/overview"></uri></contrib><contrib contrib-type="author"><name><surname>Catanesi</surname><given-names>Mariano</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Dominguez-Benot</surname><given-names>Reyes</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/809503/overview"></uri></contrib><contrib contrib-type="author"><name><surname>Pitari</surname><given-names>Giuseppina</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref></contrib><contrib contrib-type="author"><name><surname>Ippoliti</surname><given-names>Rodolfo</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/663572/overview"></uri></contrib><contrib contrib-type="author"><name><surname>Cimini</surname><given-names>Annamaria</given-names></name><xref ref-type="aff" rid="aff1"><sup>1</sup></xref><xref ref-type="aff" rid="aff2"><sup>2</sup></xref><xref ref-type="corresp" rid="c001"><sup>*</sup></xref><uri xlink:type="simple" xlink:href="http://loop.frontiersin.org/people/70204/overview"></uri></contrib></contrib-group><aff id="aff1"><sup>1</sup><institution>Department of Life, Health and Environmental Sciences, University of L'Aquila</institution>,<addr-line>L'Aquila</addr-line>,<country>Italy</country></aff><aff id="aff2"><sup>2</sup><institution>Department of Biology, Sbarro Institute for Cancer Research and Molecular Medicine, Temple University</institution>,<addr-line>Philadelphia, PA</addr-line>,<country>United States</country></aff><author-notes><fn fn-type="edited-by"><p>Edited by: Gianni Ciofani, Italian Institute of Technology (IIT), Italy</p></fn><fn fn-type="edited-by"><p>Reviewed by: Varpu Seija Marjomäki, University of Jyväskylä, Finland; Sílvia Pujals, Institute for Bioengineering of Catalonia (IBEC), Spain</p></fn><corresp id="c001">*Correspondence: Annamaria Cimini <email>annamaria.cimini@univaq.it</email></corresp><fn fn-type="other" id="fn001"><p>This article was submitted to Nanobiotechnology, a section of the journal Frontiers in Bioengineering and Biotechnology</p></fn></author-notes><pub-date pub-type="epub"><day>14</day><month>11</month><year>2019</year></pub-date><pub-date pub-type="collection"><year>2019</year></pub-date><volume>7</volume><elocation-id>325</elocation-id><history><date date-type="received"><day>29</day><month>7</month><year>2019</year></date><date date-type="accepted"><day>28</day><month>10</month><year>2019</year></date></history><permissions><copyright-statement>Copyright © 2019 d'Angelo, Castelli, Benedetti, Antonosante, Catanesi, Dominguez-Benot, Pitari, Ippoliti and Cimini.</copyright-statement><copyright-year>2019</copyright-year><copyright-holder>d'Angelo, Castelli, Benedetti, Antonosante, Catanesi, Dominguez-Benot, Pitari, Ippoliti and Cimini</copyright-holder><license xlink:href="http://creativecommons.org/licenses/by/4.0/"><license-p>This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.</license-p></license></permissions><abstract><p>Brain tumors mainly originate from glial cells and are classified as gliomas. Malignant gliomas represent an incurable disease; indeed, after surgery and chemotherapy, recurrence appears within a few months, and mortality has remained high in the last decades. This is mainly due to the heterogeneity of malignant gliomas, indicating that a single therapy is not effective for all patients. In this regard, the advent of theranostic nanomedicine, a combination of imaging and therapeutic agents, represents a strategic tool for the management of malignant brain tumors, allowing for the detection of therapies that are specific to the single patient and avoiding overdosing the non-responders. Here, recent theranostic nanomedicine approaches for glioma therapy are described.</p></abstract><kwd-group><kwd>theranostic nanoplatform</kwd><kwd>brain tumors</kwd><kwd>targeted therapy</kwd><kwd>drug delivery</kwd><kwd>diagnosis</kwd></kwd-group><counts><fig-count count="2"></fig-count><table-count count="3"></table-count><equation-count count="0"></equation-count><ref-count count="168"></ref-count><page-count count="14"></page-count><word-count count="11923"></word-count></counts></article-meta></front></pmc></record>Pour manipuler ce document sous Unix (Dilib)
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