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Anti-RNP positivity in primary Sjögren’s syndrome is associated with a more active disease and a more frequent muscular and pulmonary involvement

Identifieur interne : 000A80 ( Main/Exploration ); précédent : 000A79; suivant : 000A81

Anti-RNP positivity in primary Sjögren’s syndrome is associated with a more active disease and a more frequent muscular and pulmonary involvement

Auteurs : Salam Abbara [France] ; Raphaele Seror [France] ; Julien Henry [France] ; Pascale Chretien [France] ; Aude Gleizes [France] ; Salima Hacein-Bey-Abina [France] ; Xavier Mariette [France] ; Gaetane Nocturne [France]

Source :

RBID : PMC:6802987

Abstract

Objectives

To describe and compare the clinical and biological characteristics of subjects with primary Sjögren’s syndrome (pSS) with and without anti-RNP antibodies.

Methods

Patients fulfilling the American College of Rheumatology (ACR)/EULAR 2016 criteria for pSS and having anti-RNP antibodies, without other connective tissue disease diagnosed and no anti-dsDNA antibodies were retrieved from the database from our French National Reference Center. These patients were compared with all other patients with pSS with negative anti-Sm, anti-RNP and anti-dsDNA antibodies.

Results

Overall, 21 patients with pSS positive for anti-RNP antibodies and 446 negative for anti-RNP antibodies were retrieved. Anti-RNP-positive patients had a lower median age at onset of pSS symptoms (41.0 vs 50.0 years, p=0.01), a higher median EULAR Sjögren’s syndrome disease activity index at inclusion (8.0 vs 3.0, p<0.01), more frequently constitutional symptoms (14.3% vs 0.01%, p<0.01), myositis (19.0% vs 2.3%, p<0.01) and pulmonary (19.0% vs 5.7%, p=0.04) involvement. Moreover, anti-RNP-positive patients had higher median gammaglobulin levels (22.5 vs 13 g/L, p<0.01), more frequently anti-SSA antibodies (90.5% vs 67.1%, p=0.03), but less frequent lymphocytic sialadenitis with a focus score ≥1 (66.7% vs 85.5%, p=0.03). If the analysis is restricted to anti-SSA-positive patients, anti-RNP positivity is associated with the same clinicobiologic features except the pulmonary involvement.

Conclusion

Patients with pSS with anti-RNP antibodies displayed a more active systemic disease, with more frequent muscular and pulmonary involvement, and increased gammaglobulin level, compared with anti-RNP-negative patients.


Url:
DOI: 10.1136/rmdopen-2019-001033
PubMed: 31673417
PubMed Central: 6802987


Affiliations:

Links toward previous steps (curation, corpus...)

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<country>France</country>
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<country xml:lang="fr">France</country>
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<name sortKey="Hacein Bey Abina, Salima" sort="Hacein Bey Abina, Salima" uniqKey="Hacein Bey Abina S" first="Salima" last="Hacein-Bey-Abina">Salima Hacein-Bey-Abina</name>
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<institution content-type="department">Department of Immunology</institution>
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<addr-line content-type="city">Le Kremlin-Bicêtre</addr-line>
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<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<addr-line content-type="city">Paris</addr-line>
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<institution>Department of Rheumatology, AP-HP, Paris-Sud University Hospitals, Le Kremlin-Bicêtre Hospital</institution>
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<country>France</country>
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<institution>INSERM U1184, Center for Immunology of Viral Infections and Autoimmune Diseases, Paris-Sud University</institution>
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<sec>
<title>Objectives</title>
<p>To describe and compare the clinical and biological characteristics of subjects with primary Sjögren’s syndrome (pSS) with and without anti-RNP antibodies.</p>
</sec>
<sec>
<title>Methods</title>
<p>Patients fulfilling the American College of Rheumatology (ACR)/EULAR 2016 criteria for pSS and having anti-RNP antibodies, without other connective tissue disease diagnosed and no anti-dsDNA antibodies were retrieved from the database from our French National Reference Center. These patients were compared with all other patients with pSS with negative anti-Sm, anti-RNP and anti-dsDNA antibodies.</p>
</sec>
<sec>
<title>Results</title>
<p>Overall, 21 patients with pSS positive for anti-RNP antibodies and 446 negative for anti-RNP antibodies were retrieved. Anti-RNP-positive patients had a lower median age at onset of pSS symptoms (41.0 vs 50.0 years, p=0.01), a higher median EULAR Sjögren’s syndrome disease activity index at inclusion (8.0 vs 3.0, p<0.01), more frequently constitutional symptoms (14.3% vs 0.01%, p<0.01), myositis (19.0% vs 2.3%, p<0.01) and pulmonary (19.0% vs 5.7%, p=0.04) involvement. Moreover, anti-RNP-positive patients had higher median gammaglobulin levels (22.5 vs 13 g/L, p<0.01), more frequently anti-SSA antibodies (90.5% vs 67.1%, p=0.03), but less frequent lymphocytic sialadenitis with a focus score ≥1 (66.7% vs 85.5%, p=0.03). If the analysis is restricted to anti-SSA-positive patients, anti-RNP positivity is associated with the same clinicobiologic features except the pulmonary involvement.</p>
</sec>
<sec>
<title>Conclusion</title>
<p>Patients with pSS with anti-RNP antibodies displayed a more active systemic disease, with more frequent muscular and pulmonary involvement, and increased gammaglobulin level, compared with anti-RNP-negative patients.</p>
</sec>
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