Anti-RNP positivity in primary Sjögren’s syndrome is associated with a more active disease and a more frequent muscular and pulmonary involvement
Identifieur interne : 000B62 ( Ncbi/Merge ); précédent : 000B61; suivant : 000B63Anti-RNP positivity in primary Sjögren’s syndrome is associated with a more active disease and a more frequent muscular and pulmonary involvement
Auteurs : Salam Abbara [France] ; Raphaele Seror [France] ; Julien Henry [France] ; Pascale Chretien [France] ; Aude Gleizes [France] ; Salima Hacein-Bey-Abina [France] ; Xavier Mariette [France] ; Gaetane Nocturne [France]Source :
- RMD Open [ 2056-5933 ] ; 2019.
Abstract
To describe and compare the clinical and biological characteristics of subjects with primary Sjögren’s syndrome (pSS) with and without anti-RNP antibodies.
Patients fulfilling the American College of Rheumatology (ACR)/EULAR 2016 criteria for pSS and having anti-RNP antibodies, without other connective tissue disease diagnosed and no anti-dsDNA antibodies were retrieved from the database from our French National Reference Center. These patients were compared with all other patients with pSS with negative anti-Sm, anti-RNP and anti-dsDNA antibodies.
Overall, 21 patients with pSS positive for anti-RNP antibodies and 446 negative for anti-RNP antibodies were retrieved. Anti-RNP-positive patients had a lower median age at onset of pSS symptoms (41.0 vs 50.0 years, p=0.01), a higher median EULAR Sjögren’s syndrome disease activity index at inclusion (8.0 vs 3.0, p<0.01), more frequently constitutional symptoms (14.3% vs 0.01%, p<0.01), myositis (19.0% vs 2.3%, p<0.01) and pulmonary (19.0% vs 5.7%, p=0.04) involvement. Moreover, anti-RNP-positive patients had higher median gammaglobulin levels (22.5 vs 13 g/L, p<0.01), more frequently anti-SSA antibodies (90.5% vs 67.1%, p=0.03), but less frequent lymphocytic sialadenitis with a focus score ≥1 (66.7% vs 85.5%, p=0.03). If the analysis is restricted to anti-SSA-positive patients, anti-RNP positivity is associated with the same clinicobiologic features except the pulmonary involvement.
Patients with pSS with anti-RNP antibodies displayed a more active systemic disease, with more frequent muscular and pulmonary involvement, and increased gammaglobulin level, compared with anti-RNP-negative patients.
Url:
DOI: 10.1136/rmdopen-2019-001033
PubMed: 31673417
PubMed Central: 6802987
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: 000796
- to stream Pmc, to step Curation: 000796
- to stream Pmc, to step Checkpoint: 000A06
Links to Exploration step
PMC:6802987Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Anti-RNP positivity in primary Sjögren’s syndrome is associated with a more active disease and a more frequent muscular and pulmonary involvement</title>
<author><name sortKey="Abbara, Salam" sort="Abbara, Salam" uniqKey="Abbara S" first="Salam" last="Abbara">Salam Abbara</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Rheumatology, AP-HP, Paris-Sud University Hospitals, Le Kremlin-Bicêtre Hospital</institution>
,<addr-line content-type="city">Le Kremlin-Bicêtre</addr-line>
,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Seror, Raphaele" sort="Seror, Raphaele" uniqKey="Seror R" first="Raphaele" last="Seror">Raphaele Seror</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Rheumatology, AP-HP, Paris-Sud University Hospitals, Le Kremlin-Bicêtre Hospital</institution>
,<addr-line content-type="city">Le Kremlin-Bicêtre</addr-line>
,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>INSERM U1184, Center for Immunology of Viral Infections and Autoimmune Diseases, Paris-Sud University</institution>
,<addr-line content-type="city">Le Kremlin-Bicêtre</addr-line>
,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Henry, Julien" sort="Henry, Julien" uniqKey="Henry J" first="Julien" last="Henry">Julien Henry</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Rheumatology, AP-HP, Paris-Sud University Hospitals, Le Kremlin-Bicêtre Hospital</institution>
,<addr-line content-type="city">Le Kremlin-Bicêtre</addr-line>
,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chretien, Pascale" sort="Chretien, Pascale" uniqKey="Chretien P" first="Pascale" last="Chretien">Pascale Chretien</name>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution content-type="department">Department of Immunology</institution>
,<institution>Hôpital Kremlin Bicêtre, Assistance Publique–Hopitaux de Paris (AP-HP)</institution>
,<addr-line content-type="city">Le Kremlin-Bicêtre</addr-line>
,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gleizes, Aude" sort="Gleizes, Aude" uniqKey="Gleizes A" first="Aude" last="Gleizes">Aude Gleizes</name>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution content-type="department">Department of Immunology</institution>
,<institution>Hôpital Kremlin Bicêtre, Assistance Publique–Hopitaux de Paris (AP-HP)</institution>
,<addr-line content-type="city">Le Kremlin-Bicêtre</addr-line>
,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Université Paris-Sud, INSERM UMR 996, Faculty of Pharmacy, Université Paris-Saclay</institution>
,<addr-line content-type="city">Châtenay-Malabry</addr-line>
,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hacein Bey Abina, Salima" sort="Hacein Bey Abina, Salima" uniqKey="Hacein Bey Abina S" first="Salima" last="Hacein-Bey-Abina">Salima Hacein-Bey-Abina</name>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution content-type="department">Department of Immunology</institution>
,<institution>Hôpital Kremlin Bicêtre, Assistance Publique–Hopitaux de Paris (AP-HP)</institution>
,<addr-line content-type="city">Le Kremlin-Bicêtre</addr-line>
,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff5"><institution>UTCBS, CNRS UMR 8258, INSERM U1022, Faculté de Pharmacie de Paris, Université Sorbonne-Paris-Cité, Université Paris- Descartes</institution>
,<addr-line content-type="city">Paris</addr-line>
,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mariette, Xavier" sort="Mariette, Xavier" uniqKey="Mariette X" first="Xavier" last="Mariette">Xavier Mariette</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Rheumatology, AP-HP, Paris-Sud University Hospitals, Le Kremlin-Bicêtre Hospital</institution>
,<addr-line content-type="city">Le Kremlin-Bicêtre</addr-line>
,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>INSERM U1184, Center for Immunology of Viral Infections and Autoimmune Diseases, Paris-Sud University</institution>
,<addr-line content-type="city">Le Kremlin-Bicêtre</addr-line>
,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nocturne, Gaetane" sort="Nocturne, Gaetane" uniqKey="Nocturne G" first="Gaetane" last="Nocturne">Gaetane Nocturne</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Rheumatology, AP-HP, Paris-Sud University Hospitals, Le Kremlin-Bicêtre Hospital</institution>
,<addr-line content-type="city">Le Kremlin-Bicêtre</addr-line>
,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>INSERM U1184, Center for Immunology of Viral Infections and Autoimmune Diseases, Paris-Sud University</institution>
,<addr-line content-type="city">Le Kremlin-Bicêtre</addr-line>
,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">31673417</idno>
<idno type="pmc">6802987</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6802987</idno>
<idno type="RBID">PMC:6802987</idno>
<idno type="doi">10.1136/rmdopen-2019-001033</idno>
<date when="2019">2019</date>
<idno type="wicri:Area/Pmc/Corpus">000796</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Corpus" wicri:corpus="PMC">000796</idno>
<idno type="wicri:Area/Pmc/Curation">000796</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Curation">000796</idno>
<idno type="wicri:Area/Pmc/Checkpoint">000A06</idno>
<idno type="wicri:explorRef" wicri:stream="Pmc" wicri:step="Checkpoint">000A06</idno>
<idno type="wicri:Area/Ncbi/Merge">000B62</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main">Anti-RNP positivity in primary Sjögren’s syndrome is associated with a more active disease and a more frequent muscular and pulmonary involvement</title>
<author><name sortKey="Abbara, Salam" sort="Abbara, Salam" uniqKey="Abbara S" first="Salam" last="Abbara">Salam Abbara</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Rheumatology, AP-HP, Paris-Sud University Hospitals, Le Kremlin-Bicêtre Hospital</institution>
,<addr-line content-type="city">Le Kremlin-Bicêtre</addr-line>
,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Seror, Raphaele" sort="Seror, Raphaele" uniqKey="Seror R" first="Raphaele" last="Seror">Raphaele Seror</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Rheumatology, AP-HP, Paris-Sud University Hospitals, Le Kremlin-Bicêtre Hospital</institution>
,<addr-line content-type="city">Le Kremlin-Bicêtre</addr-line>
,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>INSERM U1184, Center for Immunology of Viral Infections and Autoimmune Diseases, Paris-Sud University</institution>
,<addr-line content-type="city">Le Kremlin-Bicêtre</addr-line>
,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Henry, Julien" sort="Henry, Julien" uniqKey="Henry J" first="Julien" last="Henry">Julien Henry</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Rheumatology, AP-HP, Paris-Sud University Hospitals, Le Kremlin-Bicêtre Hospital</institution>
,<addr-line content-type="city">Le Kremlin-Bicêtre</addr-line>
,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Chretien, Pascale" sort="Chretien, Pascale" uniqKey="Chretien P" first="Pascale" last="Chretien">Pascale Chretien</name>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution content-type="department">Department of Immunology</institution>
,<institution>Hôpital Kremlin Bicêtre, Assistance Publique–Hopitaux de Paris (AP-HP)</institution>
,<addr-line content-type="city">Le Kremlin-Bicêtre</addr-line>
,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Gleizes, Aude" sort="Gleizes, Aude" uniqKey="Gleizes A" first="Aude" last="Gleizes">Aude Gleizes</name>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution content-type="department">Department of Immunology</institution>
,<institution>Hôpital Kremlin Bicêtre, Assistance Publique–Hopitaux de Paris (AP-HP)</institution>
,<addr-line content-type="city">Le Kremlin-Bicêtre</addr-line>
,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff4"><institution>Université Paris-Sud, INSERM UMR 996, Faculty of Pharmacy, Université Paris-Saclay</institution>
,<addr-line content-type="city">Châtenay-Malabry</addr-line>
,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Hacein Bey Abina, Salima" sort="Hacein Bey Abina, Salima" uniqKey="Hacein Bey Abina S" first="Salima" last="Hacein-Bey-Abina">Salima Hacein-Bey-Abina</name>
<affiliation wicri:level="1"><nlm:aff id="aff3"><institution content-type="department">Department of Immunology</institution>
,<institution>Hôpital Kremlin Bicêtre, Assistance Publique–Hopitaux de Paris (AP-HP)</institution>
,<addr-line content-type="city">Le Kremlin-Bicêtre</addr-line>
,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff5"><institution>UTCBS, CNRS UMR 8258, INSERM U1022, Faculté de Pharmacie de Paris, Université Sorbonne-Paris-Cité, Université Paris- Descartes</institution>
,<addr-line content-type="city">Paris</addr-line>
,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Mariette, Xavier" sort="Mariette, Xavier" uniqKey="Mariette X" first="Xavier" last="Mariette">Xavier Mariette</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Rheumatology, AP-HP, Paris-Sud University Hospitals, Le Kremlin-Bicêtre Hospital</institution>
,<addr-line content-type="city">Le Kremlin-Bicêtre</addr-line>
,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>INSERM U1184, Center for Immunology of Viral Infections and Autoimmune Diseases, Paris-Sud University</institution>
,<addr-line content-type="city">Le Kremlin-Bicêtre</addr-line>
,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
<author><name sortKey="Nocturne, Gaetane" sort="Nocturne, Gaetane" uniqKey="Nocturne G" first="Gaetane" last="Nocturne">Gaetane Nocturne</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Rheumatology, AP-HP, Paris-Sud University Hospitals, Le Kremlin-Bicêtre Hospital</institution>
,<addr-line content-type="city">Le Kremlin-Bicêtre</addr-line>
,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>INSERM U1184, Center for Immunology of Viral Infections and Autoimmune Diseases, Paris-Sud University</institution>
,<addr-line content-type="city">Le Kremlin-Bicêtre</addr-line>
,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
</affiliation>
</author>
</analytic>
<series><title level="j">RMD Open</title>
<idno type="eISSN">2056-5933</idno>
<imprint><date when="2019">2019</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><sec><title>Objectives</title>
<p>To describe and compare the clinical and biological characteristics of subjects with primary Sjögren’s syndrome (pSS) with and without anti-RNP antibodies.</p>
</sec>
<sec><title>Methods</title>
<p>Patients fulfilling the American College of Rheumatology (ACR)/EULAR 2016 criteria for pSS and having anti-RNP antibodies, without other connective tissue disease diagnosed and no anti-dsDNA antibodies were retrieved from the database from our French National Reference Center. These patients were compared with all other patients with pSS with negative anti-Sm, anti-RNP and anti-dsDNA antibodies.</p>
</sec>
<sec><title>Results</title>
<p>Overall, 21 patients with pSS positive for anti-RNP antibodies and 446 negative for anti-RNP antibodies were retrieved. Anti-RNP-positive patients had a lower median age at onset of pSS symptoms (41.0 vs 50.0 years, p=0.01), a higher median EULAR Sjögren’s syndrome disease activity index at inclusion (8.0 vs 3.0, p<0.01), more frequently constitutional symptoms (14.3% vs 0.01%, p<0.01), myositis (19.0% vs 2.3%, p<0.01) and pulmonary (19.0% vs 5.7%, p=0.04) involvement. Moreover, anti-RNP-positive patients had higher median gammaglobulin levels (22.5 vs 13 g/L, p<0.01), more frequently anti-SSA antibodies (90.5% vs 67.1%, p=0.03), but less frequent lymphocytic sialadenitis with a focus score ≥1 (66.7% vs 85.5%, p=0.03). If the analysis is restricted to anti-SSA-positive patients, anti-RNP positivity is associated with the same clinicobiologic features except the pulmonary involvement.</p>
</sec>
<sec><title>Conclusion</title>
<p>Patients with pSS with anti-RNP antibodies displayed a more active systemic disease, with more frequent muscular and pulmonary involvement, and increased gammaglobulin level, compared with anti-RNP-negative patients.</p>
</sec>
</div>
</front>
<back><div1 type="bibliography"><listBibl><biblStruct><analytic><author><name sortKey="Ramos Casals, M" uniqKey="Ramos Casals M">M Ramos-Casals</name>
</author>
<author><name sortKey="Brito Zer N, P" uniqKey="Brito Zer N P">P Brito-Zerón</name>
</author>
<author><name sortKey="Seror, R" uniqKey="Seror R">R Seror</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Shiboski, Ch" uniqKey="Shiboski C">CH Shiboski</name>
</author>
<author><name sortKey="Shiboski, Sc" uniqKey="Shiboski S">SC Shiboski</name>
</author>
<author><name sortKey="Seror, R" uniqKey="Seror R">R Seror</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Payet, J" uniqKey="Payet J">J Payet</name>
</author>
<author><name sortKey="Belkhir, R" uniqKey="Belkhir R">R Belkhir</name>
</author>
<author><name sortKey="Gottenberg, Je" uniqKey="Gottenberg J">JE Gottenberg</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cavazzana, I" uniqKey="Cavazzana I">I Cavazzana</name>
</author>
<author><name sortKey="Ceribelli, A" uniqKey="Ceribelli A">A Ceribelli</name>
</author>
<author><name sortKey="Quinzanini, M" uniqKey="Quinzanini M">M Quinzanini</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Benito Garcia, E" uniqKey="Benito Garcia E">E Benito-Garcia</name>
</author>
<author><name sortKey="Schur, Ph" uniqKey="Schur P">PH Schur</name>
</author>
<author><name sortKey="Lahita, R" uniqKey="Lahita R">R Lahita</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sharp, Gc" uniqKey="Sharp G">GC Sharp</name>
</author>
<author><name sortKey="Irvin, Ws" uniqKey="Irvin W">WS Irvin</name>
</author>
<author><name sortKey="Tan, Em" uniqKey="Tan E">EM Tan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ter Borg, Ej" uniqKey="Ter Borg E">EJ ter Borg</name>
</author>
<author><name sortKey="Groen, H" uniqKey="Groen H">H Groen</name>
</author>
<author><name sortKey="Horst, G" uniqKey="Horst G">G Horst</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Petri, M" uniqKey="Petri M">M Petri</name>
</author>
<author><name sortKey="Orbai, A M" uniqKey="Orbai A">A-M Orbai</name>
</author>
<author><name sortKey="Alarc N, Gs" uniqKey="Alarc N G">GS Alarcón</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chisholm, Dm" uniqKey="Chisholm D">DM Chisholm</name>
</author>
<author><name sortKey="Mason, Dk" uniqKey="Mason D">DK Mason</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Alarcon Segovia, D" uniqKey="Alarcon Segovia D">D Alarcon-Segovia</name>
</author>
<author><name sortKey="Villareal, M" uniqKey="Villareal M">M Villareal</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kasukawa, R" uniqKey="Kasukawa R">R Kasukawa</name>
</author>
<author><name sortKey="Sharp, G" uniqKey="Sharp G">G Sharp</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bournia, V K" uniqKey="Bournia V">V-K Bournia</name>
</author>
<author><name sortKey="Vlachoyiannopoulos, Pg" uniqKey="Vlachoyiannopoulos P">PG Vlachoyiannopoulos</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Paradowska Gorycka, A" uniqKey="Paradowska Gorycka A">A Paradowska-Gorycka</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Karlsen, M" uniqKey="Karlsen M">M Karlsen</name>
</author>
<author><name sortKey="Jakobsen, K" uniqKey="Jakobsen K">K Jakobsen</name>
</author>
<author><name sortKey="Jonsson, R" uniqKey="Jonsson R">R Jonsson</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Goules, Av" uniqKey="Goules A">AV Goules</name>
</author>
<author><name sortKey="Kapsogeorgou, Ek" uniqKey="Kapsogeorgou E">EK Kapsogeorgou</name>
</author>
<author><name sortKey="Tzioufas, Ag" uniqKey="Tzioufas A">AG Tzioufas</name>
</author>
</analytic>
</biblStruct>
</listBibl>
</div1>
</back>
</TEI>
<pmc article-type="research-article"><pmc-dir>properties open_access</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-ta">RMD Open</journal-id>
<journal-id journal-id-type="iso-abbrev">RMD Open</journal-id>
<journal-id journal-id-type="hwp">rmdopen</journal-id>
<journal-id journal-id-type="publisher-id">rmdopen</journal-id>
<journal-title-group><journal-title>RMD Open</journal-title>
</journal-title-group>
<issn pub-type="epub">2056-5933</issn>
<publisher><publisher-name>BMJ Publishing Group</publisher-name>
<publisher-loc>BMA House, Tavistock Square, London, WC1H 9JR</publisher-loc>
</publisher>
</journal-meta>
<article-meta><article-id pub-id-type="pmid">31673417</article-id>
<article-id pub-id-type="pmc">6802987</article-id>
<article-id pub-id-type="publisher-id">rmdopen-2019-001033</article-id>
<article-id pub-id-type="doi">10.1136/rmdopen-2019-001033</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Sjögren Syndrome</subject>
</subj-group>
<subj-group subj-group-type="hwp-journal-coll"><subject>1506</subject>
</subj-group>
<series-title>Original article</series-title>
</article-categories>
<title-group><article-title>Anti-RNP positivity in primary Sjögren’s syndrome is associated with a more active disease and a more frequent muscular and pulmonary involvement</article-title>
</title-group>
<contrib-group><contrib id="author-70672167" contrib-type="author"><contrib-id contrib-id-type="orcid" authenticated="false">http://orcid.org/0000-0001-8486-433X</contrib-id>
<name><surname>Abbara</surname>
<given-names>Salam</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib id="author-41233426" contrib-type="author"><name><surname>Seror</surname>
<given-names>Raphaele</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="aff" rid="aff2">2</xref>
</contrib>
<contrib id="author-70672359" contrib-type="author"><name><surname>Henry</surname>
<given-names>Julien</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
</contrib>
<contrib id="author-70672375" contrib-type="author"><name><surname>Chretien</surname>
<given-names>Pascale</given-names>
</name>
<xref ref-type="aff" rid="aff3">3</xref>
</contrib>
<contrib id="author-60782454" contrib-type="author"><name><surname>Gleizes</surname>
<given-names>Aude</given-names>
</name>
<xref ref-type="aff" rid="aff3">3</xref>
<xref ref-type="aff" rid="aff4">4</xref>
</contrib>
<contrib id="author-60784145" contrib-type="author"><name><surname>Hacein-Bey-Abina</surname>
<given-names>Salima</given-names>
</name>
<xref ref-type="aff" rid="aff3">3</xref>
<xref ref-type="aff" rid="aff5">5</xref>
</contrib>
<contrib id="author-60784224" contrib-type="author"><name><surname>Mariette</surname>
<given-names>Xavier</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="aff" rid="aff2">2</xref>
</contrib>
<contrib id="author-70672399" contrib-type="author" corresp="yes"><name><surname>Nocturne</surname>
<given-names>Gaetane</given-names>
</name>
<xref ref-type="aff" rid="aff1">1</xref>
<xref ref-type="aff" rid="aff2">2</xref>
</contrib>
</contrib-group>
<aff id="aff1"><label>1</label>
<institution>Department of Rheumatology, AP-HP, Paris-Sud University Hospitals, Le Kremlin-Bicêtre Hospital</institution>
,<addr-line content-type="city">Le Kremlin-Bicêtre</addr-line>
,<country>France</country>
</aff>
<aff id="aff2"><label>2</label>
<institution>INSERM U1184, Center for Immunology of Viral Infections and Autoimmune Diseases, Paris-Sud University</institution>
,<addr-line content-type="city">Le Kremlin-Bicêtre</addr-line>
,<country>France</country>
</aff>
<aff id="aff3"><label>3</label>
<institution content-type="department">Department of Immunology</institution>
,<institution>Hôpital Kremlin Bicêtre, Assistance Publique–Hopitaux de Paris (AP-HP)</institution>
,<addr-line content-type="city">Le Kremlin-Bicêtre</addr-line>
,<country>France</country>
</aff>
<aff id="aff4"><label>4</label>
<institution>Université Paris-Sud, INSERM UMR 996, Faculty of Pharmacy, Université Paris-Saclay</institution>
,<addr-line content-type="city">Châtenay-Malabry</addr-line>
,<country>France</country>
</aff>
<aff id="aff5"><label>5</label>
<institution>UTCBS, CNRS UMR 8258, INSERM U1022, Faculté de Pharmacie de Paris, Université Sorbonne-Paris-Cité, Université Paris- Descartes</institution>
,<addr-line content-type="city">Paris</addr-line>
,<country>France</country>
</aff>
<author-notes><corresp><label>Correspondence to</label>
Dr Gaetane Nocturne; <email>gaetane.nocturne@aphp.fr</email>
</corresp>
<fn fn-type="other"><p>XM and GN are co-last authors.</p>
</fn>
</author-notes>
<pub-date pub-type="collection"><year>2019</year>
</pub-date>
<pub-date pub-type="epub"><day>1</day>
<month>10</month>
<year>2019</year>
</pub-date>
<volume>5</volume>
<issue>2</issue>
<elocation-id>e001033</elocation-id>
<history><date date-type="received"><day>11</day>
<month>6</month>
<year>2019</year>
</date>
<date date-type="rev-recd"><day>04</day>
<month>9</month>
<year>2019</year>
</date>
<date date-type="accepted"><day>08</day>
<month>9</month>
<year>2019</year>
</date>
</history>
<permissions><copyright-statement>© Author(s) (or their employer(s)) 2019. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.</copyright-statement>
<copyright-year>2019</copyright-year>
<license license-type="open-access"><license-p>This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: <ext-link ext-link-type="uri" xlink:href="http://creativecommons.org/licenses/by-nc/4.0/">http://creativecommons.org/licenses/by-nc/4.0/</ext-link>
.</license-p>
</license>
</permissions>
<self-uri xlink:title="pdf" xlink:href="rmdopen-2019-001033.pdf"></self-uri>
<abstract><sec><title>Objectives</title>
<p>To describe and compare the clinical and biological characteristics of subjects with primary Sjögren’s syndrome (pSS) with and without anti-RNP antibodies.</p>
</sec>
<sec><title>Methods</title>
<p>Patients fulfilling the American College of Rheumatology (ACR)/EULAR 2016 criteria for pSS and having anti-RNP antibodies, without other connective tissue disease diagnosed and no anti-dsDNA antibodies were retrieved from the database from our French National Reference Center. These patients were compared with all other patients with pSS with negative anti-Sm, anti-RNP and anti-dsDNA antibodies.</p>
</sec>
<sec><title>Results</title>
<p>Overall, 21 patients with pSS positive for anti-RNP antibodies and 446 negative for anti-RNP antibodies were retrieved. Anti-RNP-positive patients had a lower median age at onset of pSS symptoms (41.0 vs 50.0 years, p=0.01), a higher median EULAR Sjögren’s syndrome disease activity index at inclusion (8.0 vs 3.0, p<0.01), more frequently constitutional symptoms (14.3% vs 0.01%, p<0.01), myositis (19.0% vs 2.3%, p<0.01) and pulmonary (19.0% vs 5.7%, p=0.04) involvement. Moreover, anti-RNP-positive patients had higher median gammaglobulin levels (22.5 vs 13 g/L, p<0.01), more frequently anti-SSA antibodies (90.5% vs 67.1%, p=0.03), but less frequent lymphocytic sialadenitis with a focus score ≥1 (66.7% vs 85.5%, p=0.03). If the analysis is restricted to anti-SSA-positive patients, anti-RNP positivity is associated with the same clinicobiologic features except the pulmonary involvement.</p>
</sec>
<sec><title>Conclusion</title>
<p>Patients with pSS with anti-RNP antibodies displayed a more active systemic disease, with more frequent muscular and pulmonary involvement, and increased gammaglobulin level, compared with anti-RNP-negative patients.</p>
</sec>
</abstract>
<kwd-group><kwd>primary Sjögren’s Syndrome</kwd>
<kwd>antibodies</kwd>
<kwd>anti-RNP</kwd>
<kwd>myositis</kwd>
</kwd-group>
<custom-meta-group><custom-meta><meta-name>special-feature</meta-name>
<meta-value>unlocked</meta-value>
</custom-meta>
</custom-meta-group>
</article-meta>
</front>
</pmc>
<affiliations><list><country><li>France</li>
</country>
</list>
<tree><country name="France"><noRegion><name sortKey="Abbara, Salam" sort="Abbara, Salam" uniqKey="Abbara S" first="Salam" last="Abbara">Salam Abbara</name>
</noRegion>
<name sortKey="Chretien, Pascale" sort="Chretien, Pascale" uniqKey="Chretien P" first="Pascale" last="Chretien">Pascale Chretien</name>
<name sortKey="Gleizes, Aude" sort="Gleizes, Aude" uniqKey="Gleizes A" first="Aude" last="Gleizes">Aude Gleizes</name>
<name sortKey="Gleizes, Aude" sort="Gleizes, Aude" uniqKey="Gleizes A" first="Aude" last="Gleizes">Aude Gleizes</name>
<name sortKey="Hacein Bey Abina, Salima" sort="Hacein Bey Abina, Salima" uniqKey="Hacein Bey Abina S" first="Salima" last="Hacein-Bey-Abina">Salima Hacein-Bey-Abina</name>
<name sortKey="Hacein Bey Abina, Salima" sort="Hacein Bey Abina, Salima" uniqKey="Hacein Bey Abina S" first="Salima" last="Hacein-Bey-Abina">Salima Hacein-Bey-Abina</name>
<name sortKey="Henry, Julien" sort="Henry, Julien" uniqKey="Henry J" first="Julien" last="Henry">Julien Henry</name>
<name sortKey="Mariette, Xavier" sort="Mariette, Xavier" uniqKey="Mariette X" first="Xavier" last="Mariette">Xavier Mariette</name>
<name sortKey="Mariette, Xavier" sort="Mariette, Xavier" uniqKey="Mariette X" first="Xavier" last="Mariette">Xavier Mariette</name>
<name sortKey="Nocturne, Gaetane" sort="Nocturne, Gaetane" uniqKey="Nocturne G" first="Gaetane" last="Nocturne">Gaetane Nocturne</name>
<name sortKey="Nocturne, Gaetane" sort="Nocturne, Gaetane" uniqKey="Nocturne G" first="Gaetane" last="Nocturne">Gaetane Nocturne</name>
<name sortKey="Seror, Raphaele" sort="Seror, Raphaele" uniqKey="Seror R" first="Raphaele" last="Seror">Raphaele Seror</name>
<name sortKey="Seror, Raphaele" sort="Seror, Raphaele" uniqKey="Seror R" first="Raphaele" last="Seror">Raphaele Seror</name>
</country>
</tree>
</affiliations>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Ncbi/Merge
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000B62 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd -nk 000B62 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Sante |area= ChloroquineV1 |flux= Ncbi |étape= Merge |type= RBID |clé= PMC:6802987 |texte= Anti-RNP positivity in primary Sjögren’s syndrome is associated with a more active disease and a more frequent muscular and pulmonary involvement }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Merge/RBID.i -Sk "pubmed:31673417" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Merge/biblio.hfd \ | NlmPubMed2Wicri -a ChloroquineV1
![]() | This area was generated with Dilib version V0.6.33. | ![]() |