Anti-RNP positivity in primary Sjögren’s syndrome is associated with a more active disease and a more frequent muscular and pulmonary involvement
Identifieur interne : 000B62 ( Ncbi/Curation ); précédent : 000B61; suivant : 000B63Anti-RNP positivity in primary Sjögren’s syndrome is associated with a more active disease and a more frequent muscular and pulmonary involvement
Auteurs : Salam Abbara [France] ; Raphaele Seror [France] ; Julien Henry [France] ; Pascale Chretien [France] ; Aude Gleizes [France] ; Salima Hacein-Bey-Abina [France] ; Xavier Mariette [France] ; Gaetane Nocturne [France]Source :
- RMD Open [ 2056-5933 ] ; 2019.
Abstract
To describe and compare the clinical and biological characteristics of subjects with primary Sjögren’s syndrome (pSS) with and without anti-RNP antibodies.
Patients fulfilling the American College of Rheumatology (ACR)/EULAR 2016 criteria for pSS and having anti-RNP antibodies, without other connective tissue disease diagnosed and no anti-dsDNA antibodies were retrieved from the database from our French National Reference Center. These patients were compared with all other patients with pSS with negative anti-Sm, anti-RNP and anti-dsDNA antibodies.
Overall, 21 patients with pSS positive for anti-RNP antibodies and 446 negative for anti-RNP antibodies were retrieved. Anti-RNP-positive patients had a lower median age at onset of pSS symptoms (41.0 vs 50.0 years, p=0.01), a higher median EULAR Sjögren’s syndrome disease activity index at inclusion (8.0 vs 3.0, p<0.01), more frequently constitutional symptoms (14.3% vs 0.01%, p<0.01), myositis (19.0% vs 2.3%, p<0.01) and pulmonary (19.0% vs 5.7%, p=0.04) involvement. Moreover, anti-RNP-positive patients had higher median gammaglobulin levels (22.5 vs 13 g/L, p<0.01), more frequently anti-SSA antibodies (90.5% vs 67.1%, p=0.03), but less frequent lymphocytic sialadenitis with a focus score ≥1 (66.7% vs 85.5%, p=0.03). If the analysis is restricted to anti-SSA-positive patients, anti-RNP positivity is associated with the same clinicobiologic features except the pulmonary involvement.
Patients with pSS with anti-RNP antibodies displayed a more active systemic disease, with more frequent muscular and pulmonary involvement, and increased gammaglobulin level, compared with anti-RNP-negative patients.
Url:
DOI: 10.1136/rmdopen-2019-001033
PubMed: 31673417
PubMed Central: 6802987
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<author><name sortKey="Seror, Raphaele" sort="Seror, Raphaele" uniqKey="Seror R" first="Raphaele" last="Seror">Raphaele Seror</name>
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<author><name sortKey="Hacein Bey Abina, Salima" sort="Hacein Bey Abina, Salima" uniqKey="Hacein Bey Abina S" first="Salima" last="Hacein-Bey-Abina">Salima Hacein-Bey-Abina</name>
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,<addr-line content-type="city">Paris</addr-line>
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<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Mariette, Xavier" sort="Mariette, Xavier" uniqKey="Mariette X" first="Xavier" last="Mariette">Xavier Mariette</name>
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,<addr-line content-type="city">Le Kremlin-Bicêtre</addr-line>
,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<author><name sortKey="Nocturne, Gaetane" sort="Nocturne, Gaetane" uniqKey="Nocturne G" first="Gaetane" last="Nocturne">Gaetane Nocturne</name>
<affiliation wicri:level="1"><nlm:aff id="aff1"><institution>Department of Rheumatology, AP-HP, Paris-Sud University Hospitals, Le Kremlin-Bicêtre Hospital</institution>
,<addr-line content-type="city">Le Kremlin-Bicêtre</addr-line>
,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<affiliation wicri:level="1"><nlm:aff id="aff2"><institution>INSERM U1184, Center for Immunology of Viral Infections and Autoimmune Diseases, Paris-Sud University</institution>
,<addr-line content-type="city">Le Kremlin-Bicêtre</addr-line>
,<country>France</country>
</nlm:aff>
<country xml:lang="fr">France</country>
<wicri:regionArea># see nlm:aff country strict</wicri:regionArea>
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<front><div type="abstract" xml:lang="en"><sec><title>Objectives</title>
<p>To describe and compare the clinical and biological characteristics of subjects with primary Sjögren’s syndrome (pSS) with and without anti-RNP antibodies.</p>
</sec>
<sec><title>Methods</title>
<p>Patients fulfilling the American College of Rheumatology (ACR)/EULAR 2016 criteria for pSS and having anti-RNP antibodies, without other connective tissue disease diagnosed and no anti-dsDNA antibodies were retrieved from the database from our French National Reference Center. These patients were compared with all other patients with pSS with negative anti-Sm, anti-RNP and anti-dsDNA antibodies.</p>
</sec>
<sec><title>Results</title>
<p>Overall, 21 patients with pSS positive for anti-RNP antibodies and 446 negative for anti-RNP antibodies were retrieved. Anti-RNP-positive patients had a lower median age at onset of pSS symptoms (41.0 vs 50.0 years, p=0.01), a higher median EULAR Sjögren’s syndrome disease activity index at inclusion (8.0 vs 3.0, p<0.01), more frequently constitutional symptoms (14.3% vs 0.01%, p<0.01), myositis (19.0% vs 2.3%, p<0.01) and pulmonary (19.0% vs 5.7%, p=0.04) involvement. Moreover, anti-RNP-positive patients had higher median gammaglobulin levels (22.5 vs 13 g/L, p<0.01), more frequently anti-SSA antibodies (90.5% vs 67.1%, p=0.03), but less frequent lymphocytic sialadenitis with a focus score ≥1 (66.7% vs 85.5%, p=0.03). If the analysis is restricted to anti-SSA-positive patients, anti-RNP positivity is associated with the same clinicobiologic features except the pulmonary involvement.</p>
</sec>
<sec><title>Conclusion</title>
<p>Patients with pSS with anti-RNP antibodies displayed a more active systemic disease, with more frequent muscular and pulmonary involvement, and increased gammaglobulin level, compared with anti-RNP-negative patients.</p>
</sec>
</div>
</front>
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<author><name sortKey="Brito Zer N, P" uniqKey="Brito Zer N P">P Brito-Zerón</name>
</author>
<author><name sortKey="Seror, R" uniqKey="Seror R">R Seror</name>
</author>
</analytic>
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<biblStruct><analytic><author><name sortKey="Shiboski, Ch" uniqKey="Shiboski C">CH Shiboski</name>
</author>
<author><name sortKey="Shiboski, Sc" uniqKey="Shiboski S">SC Shiboski</name>
</author>
<author><name sortKey="Seror, R" uniqKey="Seror R">R Seror</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Payet, J" uniqKey="Payet J">J Payet</name>
</author>
<author><name sortKey="Belkhir, R" uniqKey="Belkhir R">R Belkhir</name>
</author>
<author><name sortKey="Gottenberg, Je" uniqKey="Gottenberg J">JE Gottenberg</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Cavazzana, I" uniqKey="Cavazzana I">I Cavazzana</name>
</author>
<author><name sortKey="Ceribelli, A" uniqKey="Ceribelli A">A Ceribelli</name>
</author>
<author><name sortKey="Quinzanini, M" uniqKey="Quinzanini M">M Quinzanini</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Benito Garcia, E" uniqKey="Benito Garcia E">E Benito-Garcia</name>
</author>
<author><name sortKey="Schur, Ph" uniqKey="Schur P">PH Schur</name>
</author>
<author><name sortKey="Lahita, R" uniqKey="Lahita R">R Lahita</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Sharp, Gc" uniqKey="Sharp G">GC Sharp</name>
</author>
<author><name sortKey="Irvin, Ws" uniqKey="Irvin W">WS Irvin</name>
</author>
<author><name sortKey="Tan, Em" uniqKey="Tan E">EM Tan</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Ter Borg, Ej" uniqKey="Ter Borg E">EJ ter Borg</name>
</author>
<author><name sortKey="Groen, H" uniqKey="Groen H">H Groen</name>
</author>
<author><name sortKey="Horst, G" uniqKey="Horst G">G Horst</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Petri, M" uniqKey="Petri M">M Petri</name>
</author>
<author><name sortKey="Orbai, A M" uniqKey="Orbai A">A-M Orbai</name>
</author>
<author><name sortKey="Alarc N, Gs" uniqKey="Alarc N G">GS Alarcón</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Chisholm, Dm" uniqKey="Chisholm D">DM Chisholm</name>
</author>
<author><name sortKey="Mason, Dk" uniqKey="Mason D">DK Mason</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Alarcon Segovia, D" uniqKey="Alarcon Segovia D">D Alarcon-Segovia</name>
</author>
<author><name sortKey="Villareal, M" uniqKey="Villareal M">M Villareal</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Kasukawa, R" uniqKey="Kasukawa R">R Kasukawa</name>
</author>
<author><name sortKey="Sharp, G" uniqKey="Sharp G">G Sharp</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Bournia, V K" uniqKey="Bournia V">V-K Bournia</name>
</author>
<author><name sortKey="Vlachoyiannopoulos, Pg" uniqKey="Vlachoyiannopoulos P">PG Vlachoyiannopoulos</name>
</author>
</analytic>
</biblStruct>
<biblStruct><analytic><author><name sortKey="Paradowska Gorycka, A" uniqKey="Paradowska Gorycka A">A Paradowska-Gorycka</name>
</author>
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