Arthritis in primary Sjögren's syndrome: Characteristics, outcome and treatment from French multicenter retrospective study
Identifieur interne : 000251 ( Main/Exploration ); précédent : 000250; suivant : 000252Arthritis in primary Sjögren's syndrome: Characteristics, outcome and treatment from French multicenter retrospective study
Auteurs : Adrien Mirouse [France] ; Raphaele Séror [France] ; Eric Vicaut [France] ; Xavier Mariette [France] ; Maxime Dougados [France] ; Anne-Laure Fauchais [France] ; Alban Deroux [France] ; Azeddine Dellal [France] ; Nathalie Costedoat-Chalumeau [France] ; Guillaume Denis [France] ; Jeremie Sellam [France] ; Jean-Benoît Arlet [France] ; Christian Lavigne [France] ; Geoffrey Urbanski [France] ; Dominique Fischer-Dumont [France] ; Abdou Diallo [France] ; Olivier Fain [France] ; Arsène Mékinian [France]Source :
- Autoimmunity Reviews [ 1568-9972 ] ; 2019.
English descriptors
Abstract
OBJECTIVE: To describe the characteristics and the outcome of primary Sjögren Syndrome (pSS) associated arthritis and to compare the efficacy of different therapeutic regimen.METHODS: We conducted a retrospective study using Club Rhumatisme and Inflammation (CRI) and French Internal Medicine Society (SNFMI) networks. All patients with a diagnosis of pSS and at least one episode of clinical and/or echographic synovitis were included. Patients with synovitis (cases) were compared to pSS patients without synovitis (controls).RESULTS: 57 patients (93% women) were included with a median age of 54 years [45-63]. Patients with synovitis had more frequently lymph node enlargement (12.3% vs. 1.8%, p = .007) and a higher ESSDAI score (8 [6-12] vs. 2 [1-4], p < .0001). There was no difference concerning CRP levels, rheumatoid factor and cyclic citrullinated peptide (CCP)-antibodies positivity. Among 57 patients with synovitis, 101 various treatment courses have been used during the follow-up of 40 [22.5-77] months. First treatment course consisted in steroids alone (3.5%), steroids in association (79%) with hydroxychloroquine (HCQ) (49%), methotrexate (MTX) (35%), rituximab (RTX) (5.3%) or other immunosuppressive drugs (7%). HCQ, MTX, and RTX were associated with a significant reduction of tender and swollen joint count, and a significant steroids-sparing effect. No difference could be shown for the joint response between these treatment regimens.CONCLUSION: pSS articular manifestations may include synovitis which could mimic rheumatoid arthritis but differ by the absence of structural damage. Even if the use of HCQ, MTX, and RTX seem to be effective for joint involvement, the best regimen remains to be determined.
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DOI: 10.1016/j.autrev.2018.06.015
Affiliations:
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Le document en format XML
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<author><name sortKey="Fischer Dumont, Dominique" sort="Fischer Dumont, Dominique" uniqKey="Fischer Dumont D" first="Dominique" last="Fischer-Dumont">Dominique Fischer-Dumont</name>
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<date type="end">2019-12-31</date>
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<country>France</country>
<placeName><settlement type="city">Paris</settlement>
<region type="region" nuts="2">Île-de-France</region>
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<orgName type="university">Université Paris 13</orgName>
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<author><name sortKey="Diallo, Abdou" sort="Diallo, Abdou" uniqKey="Diallo A" first="Abdou" last="Diallo">Abdou Diallo</name>
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<idno type="IdRef">027542084</idno>
<orgName>Université Paris Diderot - Paris 7</orgName>
<orgName type="acronym">UPD7</orgName>
<desc> <address> <addrLine>5 rue Thomas-Mann - 75205 Paris cedex 13</addrLine>
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<ref type="url">http://www.univ-paris-diderot.fr</ref>
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<country>France</country>
</affiliation>
</author>
<author><name sortKey="Fain, Olivier" sort="Fain, Olivier" uniqKey="Fain O" first="Olivier" last="Fain">Olivier Fain</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-413221" status="VALID"> <orgName>Sorbonne Université</orgName>
<orgName type="acronym">SU</orgName>
<date type="start">2018-01-01</date>
<desc> <address> <addrLine>21 rue de l’École de médecine - 75006 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.sorbonne-universite.fr/</ref>
</desc>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
<author><name sortKey="Mekinian, Arsene" sort="Mekinian, Arsene" uniqKey="Mekinian A" first="Arsène" last="Mékinian">Arsène Mékinian</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-413221" status="VALID"> <orgName>Sorbonne Université</orgName>
<orgName type="acronym">SU</orgName>
<date type="start">2018-01-01</date>
<desc> <address> <addrLine>21 rue de l’École de médecine - 75006 Paris</addrLine>
<country key="FR"></country>
</address>
<ref type="url">http://www.sorbonne-universite.fr/</ref>
</desc>
</hal:affiliation>
<country>France</country>
</affiliation>
</author>
</analytic>
<idno type="DOI">10.1016/j.autrev.2018.06.015</idno>
<series><title level="j">Autoimmunity Reviews</title>
<idno type="ISSN">1568-9972</idno>
<imprint><date type="datePub">2019</date>
</imprint>
</series>
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</sourceDesc>
</fileDesc>
<profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>DMARDS</term>
<term>Primary Sjögren's syndrome</term>
<term>Rituximab</term>
<term>Synovitis</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"> <p>OBJECTIVE: To describe the characteristics and the outcome of primary Sjögren Syndrome (pSS) associated arthritis and to compare the efficacy of different therapeutic regimen.METHODS: We conducted a retrospective study using Club Rhumatisme and Inflammation (CRI) and French Internal Medicine Society (SNFMI) networks. All patients with a diagnosis of pSS and at least one episode of clinical and/or echographic synovitis were included. Patients with synovitis (cases) were compared to pSS patients without synovitis (controls).RESULTS: 57 patients (93% women) were included with a median age of 54 years [45-63]. Patients with synovitis had more frequently lymph node enlargement (12.3% vs. 1.8%, p = .007) and a higher ESSDAI score (8 [6-12] vs. 2 [1-4], p < .0001). There was no difference concerning CRP levels, rheumatoid factor and cyclic citrullinated peptide (CCP)-antibodies positivity. Among 57 patients with synovitis, 101 various treatment courses have been used during the follow-up of 40 [22.5-77] months. First treatment course consisted in steroids alone (3.5%), steroids in association (79%) with hydroxychloroquine (HCQ) (49%), methotrexate (MTX) (35%), rituximab (RTX) (5.3%) or other immunosuppressive drugs (7%). HCQ, MTX, and RTX were associated with a significant reduction of tender and swollen joint count, and a significant steroids-sparing effect. No difference could be shown for the joint response between these treatment regimens.CONCLUSION: pSS articular manifestations may include synovitis which could mimic rheumatoid arthritis but differ by the absence of structural damage. Even if the use of HCQ, MTX, and RTX seem to be effective for joint involvement, the best regimen remains to be determined.</p>
</div>
</front>
</TEI>
<affiliations><list><country><li>France</li>
</country>
<region><li>Pays de la Loire</li>
<li>Île-de-France</li>
</region>
<settlement><li>Angers</li>
<li>Paris</li>
</settlement>
<orgName><li>Université Paris 13</li>
<li>Université d'Angers</li>
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<tree><country name="France"><noRegion><name sortKey="Mirouse, Adrien" sort="Mirouse, Adrien" uniqKey="Mirouse A" first="Adrien" last="Mirouse">Adrien Mirouse</name>
</noRegion>
<name sortKey="Arlet, Jean Benoit" sort="Arlet, Jean Benoit" uniqKey="Arlet J" first="Jean-Benoît" last="Arlet">Jean-Benoît Arlet</name>
<name sortKey="Costedoat Chalumeau, Nathalie" sort="Costedoat Chalumeau, Nathalie" uniqKey="Costedoat Chalumeau N" first="Nathalie" last="Costedoat-Chalumeau">Nathalie Costedoat-Chalumeau</name>
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<name sortKey="Deroux, Alban" sort="Deroux, Alban" uniqKey="Deroux A" first="Alban" last="Deroux">Alban Deroux</name>
<name sortKey="Diallo, Abdou" sort="Diallo, Abdou" uniqKey="Diallo A" first="Abdou" last="Diallo">Abdou Diallo</name>
<name sortKey="Dougados, Maxime" sort="Dougados, Maxime" uniqKey="Dougados M" first="Maxime" last="Dougados">Maxime Dougados</name>
<name sortKey="Fain, Olivier" sort="Fain, Olivier" uniqKey="Fain O" first="Olivier" last="Fain">Olivier Fain</name>
<name sortKey="Fauchais, Anne Laure" sort="Fauchais, Anne Laure" uniqKey="Fauchais A" first="Anne-Laure" last="Fauchais">Anne-Laure Fauchais</name>
<name sortKey="Fischer Dumont, Dominique" sort="Fischer Dumont, Dominique" uniqKey="Fischer Dumont D" first="Dominique" last="Fischer-Dumont">Dominique Fischer-Dumont</name>
<name sortKey="Lavigne, Christian" sort="Lavigne, Christian" uniqKey="Lavigne C" first="Christian" last="Lavigne">Christian Lavigne</name>
<name sortKey="Mariette, Xavier" sort="Mariette, Xavier" uniqKey="Mariette X" first="Xavier" last="Mariette">Xavier Mariette</name>
<name sortKey="Mekinian, Arsene" sort="Mekinian, Arsene" uniqKey="Mekinian A" first="Arsène" last="Mékinian">Arsène Mékinian</name>
<name sortKey="Sellam, Jeremie" sort="Sellam, Jeremie" uniqKey="Sellam J" first="Jeremie" last="Sellam">Jeremie Sellam</name>
<name sortKey="Seror, Raphaele" sort="Seror, Raphaele" uniqKey="Seror R" first="Raphaele" last="Séror">Raphaele Séror</name>
<name sortKey="Urbanski, Geoffrey" sort="Urbanski, Geoffrey" uniqKey="Urbanski G" first="Geoffrey" last="Urbanski">Geoffrey Urbanski</name>
<name sortKey="Vicaut, Eric" sort="Vicaut, Eric" uniqKey="Vicaut E" first="Eric" last="Vicaut">Eric Vicaut</name>
</country>
</tree>
</affiliations>
</record>
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