Circulating follicular helper T cells are increased in systemic sclerosis and promote plasmablast differentiation through the IL-21 pathway which can be inhibited by ruxolitinib
Identifieur interne : 000250 ( Main/Exploration ); précédent : 000249; suivant : 000251Circulating follicular helper T cells are increased in systemic sclerosis and promote plasmablast differentiation through the IL-21 pathway which can be inhibited by ruxolitinib
Auteurs : Laure Ricard [France] ; Vincent Jachiet [France] ; Florent Malard [France] ; Yishan Ye ; Nicolas Stocker ; Sébastien Rivière [France] ; Patricia Senet [France] ; Jean-Benoit Monfort [États-Unis] ; Olivier Fain [France] ; Mohamad Mohty [France] ; Béatrice Gaugler [France] ; Arsène Mékinian [France]Source :
- Annals of the Rheumatic Diseases [ 0003-4967 ] ; 2019.
Abstract
Approximately 1 to 3% of women have recurrent early miscarriages, defined as ≥3 pregnancy losses before 14 weeks of gestation. The immune deregulation and tolerance rupture could be the origin of these miscarriages in at least 30% of these women. Chronic intervillositis of unknown etiology (CIUE) is a rare placental lesion characterized by intrauterine deaths, growth restriction and high recurrence rate. In cases with recurrent obstetrical adverse events and intrauterine deaths, we previously reported the benefit of hydroxychloroquine combination to prednisone. Even few data raised the potential value of TNF antagonists in early recurrent miscarriages, these cases show its potential value in the setting of recurrent refractory chronic intervillositis and unexplained miscarriages.
Url:
DOI: 10.1136/annrheumdis-2018-214382
Affiliations:
- France, États-Unis
- Franche-Comté
- Besançon
- Université de Bourgogne Franche-Comté, Université de Franche-Comté
Links toward previous steps (curation, corpus...)
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Le document en format XML
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<country>France</country>
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<author><name sortKey="Senet, Patricia" sort="Senet, Patricia" uniqKey="Senet P" first="Patricia" last="Senet">Patricia Senet</name>
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<country>France</country>
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<author><name sortKey="Monfort, Jean Benoit" sort="Monfort, Jean Benoit" uniqKey="Monfort J" first="Jean-Benoit" last="Monfort">Jean-Benoit Monfort</name>
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<orgName type="acronym">CEE</orgName>
<desc> <address> <addrLine>Room 121 Hudson Hall, Box 90287, Durham, NC 27708-0287</addrLine>
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<orgName>Duke University [Durham]</orgName>
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<country key="US"></country>
</address>
<ref type="url">http://www.duke.edu/</ref>
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<country>États-Unis</country>
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<author><name sortKey="Fain, Olivier" sort="Fain, Olivier" uniqKey="Fain O" first="Olivier" last="Fain">Olivier Fain</name>
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<author><name sortKey="Mohty, Mohamad" sort="Mohty, Mohamad" uniqKey="Mohty M" first="Mohamad" last="Mohty">Mohamad Mohty</name>
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<author><name sortKey="Gaugler, Beatrice" sort="Gaugler, Beatrice" uniqKey="Gaugler B" first="Béatrice" last="Gaugler">Béatrice Gaugler</name>
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<orgName>Institut National de la Santé et de la Recherche Médicale</orgName>
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<desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine>
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<orgName type="acronym">UFC</orgName>
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<country>France</country>
<placeName><settlement type="city" wicri:auto="siege">Besançon</settlement>
<region type="region" nuts="2">Franche-Comté</region>
</placeName>
<orgName type="university">Université de Franche-Comté</orgName>
<orgName type="institution" wicri:auto="newGroup">Université de Bourgogne Franche-Comté</orgName>
</affiliation>
</author>
<author><name sortKey="Mekinian, Arsene" sort="Mekinian, Arsene" uniqKey="Mekinian A" first="Arsène" last="Mékinian">Arsène Mékinian</name>
<affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-413221" status="VALID"> <orgName>Sorbonne Université</orgName>
<orgName type="acronym">SU</orgName>
<date type="start">2018-01-01</date>
<desc> <address> <addrLine>21 rue de l’École de médecine - 75006 Paris</addrLine>
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</address>
<ref type="url">http://www.sorbonne-universite.fr/</ref>
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</analytic>
<idno type="DOI">10.1136/annrheumdis-2018-214382</idno>
<series><title level="j">Annals of the Rheumatic Diseases</title>
<idno type="ISSN">0003-4967</idno>
<imprint><date type="datePub">2019</date>
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<front><div type="abstract" xml:lang="en"> <p>Approximately 1 to 3% of women have recurrent early miscarriages, defined as ≥3 pregnancy losses before 14 weeks of gestation. The immune deregulation and tolerance rupture could be the origin of these miscarriages in at least 30% of these women. Chronic intervillositis of unknown etiology (CIUE) is a rare placental lesion characterized by intrauterine deaths, growth restriction and high recurrence rate. In cases with recurrent obstetrical adverse events and intrauterine deaths, we previously reported the benefit of hydroxychloroquine combination to prednisone. Even few data raised the potential value of TNF antagonists in early recurrent miscarriages, these cases show its potential value in the setting of recurrent refractory chronic intervillositis and unexplained miscarriages.</p>
</div>
</front>
</TEI>
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<li>États-Unis</li>
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</settlement>
<orgName><li>Université de Bourgogne Franche-Comté</li>
<li>Université de Franche-Comté</li>
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<name sortKey="Ye, Yishan" sort="Ye, Yishan" uniqKey="Ye Y" first="Yishan" last="Ye">Yishan Ye</name>
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<country name="France"><noRegion><name sortKey="Ricard, Laure" sort="Ricard, Laure" uniqKey="Ricard L" first="Laure" last="Ricard">Laure Ricard</name>
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<name sortKey="Gaugler, Beatrice" sort="Gaugler, Beatrice" uniqKey="Gaugler B" first="Béatrice" last="Gaugler">Béatrice Gaugler</name>
<name sortKey="Jachiet, Vincent" sort="Jachiet, Vincent" uniqKey="Jachiet V" first="Vincent" last="Jachiet">Vincent Jachiet</name>
<name sortKey="Malard, Florent" sort="Malard, Florent" uniqKey="Malard F" first="Florent" last="Malard">Florent Malard</name>
<name sortKey="Mekinian, Arsene" sort="Mekinian, Arsene" uniqKey="Mekinian A" first="Arsène" last="Mékinian">Arsène Mékinian</name>
<name sortKey="Mohty, Mohamad" sort="Mohty, Mohamad" uniqKey="Mohty M" first="Mohamad" last="Mohty">Mohamad Mohty</name>
<name sortKey="Riviere, Sebastien" sort="Riviere, Sebastien" uniqKey="Riviere S" first="Sébastien" last="Rivière">Sébastien Rivière</name>
<name sortKey="Senet, Patricia" sort="Senet, Patricia" uniqKey="Senet P" first="Patricia" last="Senet">Patricia Senet</name>
</country>
<country name="États-Unis"><noRegion><name sortKey="Monfort, Jean Benoit" sort="Monfort, Jean Benoit" uniqKey="Monfort J" first="Jean-Benoit" last="Monfort">Jean-Benoit Monfort</name>
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