Arthritis in primary Sjögren's syndrome: Characteristics, outcome and treatment from French multicenter retrospective study
Identifieur interne : 000020 ( Hal/Checkpoint ); précédent : 000019; suivant : 000021Arthritis in primary Sjögren's syndrome: Characteristics, outcome and treatment from French multicenter retrospective study
Auteurs : Adrien Mirouse [France] ; Raphaele Séror [France] ; Eric Vicaut [France] ; Xavier Mariette [France] ; Maxime Dougados [France] ; Anne-Laure Fauchais [France] ; Alban Deroux [France] ; Azeddine Dellal [France] ; Nathalie Costedoat-Chalumeau [France] ; Guillaume Denis [France] ; Jeremie Sellam [France] ; Jean-Benoît Arlet [France] ; Christian Lavigne [France] ; Geoffrey Urbanski [France] ; Dominique Fischer-Dumont [France] ; Abdou Diallo [France] ; Olivier Fain [France] ; Arsène Mékinian [France]Source :
- Autoimmunity Reviews [ 1568-9972 ] ; 2019.
English descriptors
Abstract
OBJECTIVE: To describe the characteristics and the outcome of primary Sjögren Syndrome (pSS) associated arthritis and to compare the efficacy of different therapeutic regimen.METHODS: We conducted a retrospective study using Club Rhumatisme and Inflammation (CRI) and French Internal Medicine Society (SNFMI) networks. All patients with a diagnosis of pSS and at least one episode of clinical and/or echographic synovitis were included. Patients with synovitis (cases) were compared to pSS patients without synovitis (controls).RESULTS: 57 patients (93% women) were included with a median age of 54 years [45-63]. Patients with synovitis had more frequently lymph node enlargement (12.3% vs. 1.8%, p = .007) and a higher ESSDAI score (8 [6-12] vs. 2 [1-4], p < .0001). There was no difference concerning CRP levels, rheumatoid factor and cyclic citrullinated peptide (CCP)-antibodies positivity. Among 57 patients with synovitis, 101 various treatment courses have been used during the follow-up of 40 [22.5-77] months. First treatment course consisted in steroids alone (3.5%), steroids in association (79%) with hydroxychloroquine (HCQ) (49%), methotrexate (MTX) (35%), rituximab (RTX) (5.3%) or other immunosuppressive drugs (7%). HCQ, MTX, and RTX were associated with a significant reduction of tender and swollen joint count, and a significant steroids-sparing effect. No difference could be shown for the joint response between these treatment regimens.CONCLUSION: pSS articular manifestations may include synovitis which could mimic rheumatoid arthritis but differ by the absence of structural damage. Even if the use of HCQ, MTX, and RTX seem to be effective for joint involvement, the best regimen remains to be determined.
Url:
DOI: 10.1016/j.autrev.2018.06.015
Links toward previous steps (curation, corpus...)
Links to Exploration step
Hal:hal-02171337Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en">Arthritis in primary Sjögren's syndrome: Characteristics, outcome and treatment from French multicenter retrospective study</title><author><name sortKey="Mirouse, Adrien" sort="Mirouse, Adrien" uniqKey="Mirouse A" first="Adrien" last="Mirouse">Adrien Mirouse</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-541912" status="VALID"> <idno type="RNSR">200918542V</idno> <orgName>Centre de Recherche Saint-Antoine</orgName> <orgName type="acronym">CR Saint-Antoine</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation name="U938" active="#struct-303623" type="direct"></relation> <relation active="#struct-413221" type="direct"></relation> </listRelation> <tutelles><tutelle name="U938" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle><tutelle active="#struct-413221" type="direct"><org type="institution" xml:id="struct-413221" status="VALID"> <orgName>Sorbonne Université</orgName> <orgName type="acronym">SU</orgName> <date type="start">2018-01-01</date> <desc> <address> <addrLine>21 rue de l’École de médecine - 75006 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.sorbonne-universite.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Seror, Raphaele" sort="Seror, Raphaele" uniqKey="Seror R" first="Raphaele" last="Séror">Raphaele Séror</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-18212" status="VALID"> <orgName>Service de rhumatologie</orgName> <desc> <address> <addrLine>Le Kremlin-Bicêtre</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-92966" type="direct"></relation> <relation active="#struct-300068" type="direct"></relation> <relation active="#struct-300148" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-92966" type="direct"><org type="institution" xml:id="struct-92966" status="VALID"> <orgName>Université Paris-Sud - Paris 11</orgName> <orgName type="acronym">UP11</orgName> <desc> <address> <addrLine>Bâtiment 300 - 91405 Orsay cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.u-psud.fr/</ref> </desc> </org></tutelle><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-300148" type="direct"><org type="institution" xml:id="struct-300148" status="VALID"> <orgName>Hôpital Bicêtre</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Vicaut, Eric" sort="Vicaut, Eric" uniqKey="Vicaut E" first="Eric" last="Vicaut">Eric Vicaut</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-26729" status="OLD"> <orgName>Hôpital Lariboisière</orgName> <date type="end">2019-12-31</date> <desc> <address> <addrLine>2, rue Ambroise - Paré 75475 Paris Cedex 10</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300068" type="direct"></relation> <relation active="#struct-300128" type="direct"></relation> <relation active="#struct-300301" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-300128" type="direct"><org type="institution" xml:id="struct-300128" status="VALID"> <orgName>Hôpital Lariboisière</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-300301" type="direct"><org type="institution" xml:id="struct-300301" status="VALID"> <idno type="ISNI">0000000121514068</idno> <idno type="IdRef">027542084</idno> <orgName>Université Paris Diderot - Paris 7</orgName> <orgName type="acronym">UPD7</orgName> <desc> <address> <addrLine>5 rue Thomas-Mann - 75205 Paris cedex 13</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-paris-diderot.fr</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Mariette, Xavier" sort="Mariette, Xavier" uniqKey="Mariette X" first="Xavier" last="Mariette">Xavier Mariette</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-312432" status="VALID"> <orgName>AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre)</orgName> <desc> <address> <addrLine>78 Rue du Général Leclerc 94270 Le Kremlin-Bicêtre</addrLine> <country key="FR"></country> </address> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Dougados, Maxime" sort="Dougados, Maxime" uniqKey="Dougados M" first="Maxime" last="Dougados">Maxime Dougados</name><affiliation wicri:level="1"><hal:affiliation type="department" xml:id="struct-18258" status="VALID"> <orgName>Service de rhumatologie [CHU Cochin]</orgName> <desc> <address> <addrLine>27 rue du Faubourg Saint-Jacques 75014 Paris</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300123" type="direct"></relation> <relation active="#struct-300068" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300123" type="direct"><org type="institution" xml:id="struct-300123" status="VALID"> <orgName>CHU Cochin [AP-HP]</orgName> <desc> <address> <addrLine>27 Rue du Faubourg Saint-Jacques 75014 Paris</addrLine> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Fauchais, Anne Laure" sort="Fauchais, Anne Laure" uniqKey="Fauchais A" first="Anne-Laure" last="Fauchais">Anne-Laure Fauchais</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-300906" status="VALID"> <orgName>CHU Limoges</orgName> <desc> <address> <addrLine>Centre Hospitalier Universitaire Dupuytren - 2 avenue Martin Luther King 87042 LIMOGES </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.chu-limoges.fr/</ref> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Deroux, Alban" sort="Deroux, Alban" uniqKey="Deroux A" first="Alban" last="Deroux">Alban Deroux</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-257328" status="VALID"> <orgName>Centre Hospitalier Universitaire [Grenoble]</orgName> <orgName type="acronym">CHU</orgName> <desc> <address> <addrLine>CS 1021738043 Grenoble cedex 9 </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.centre-hospitalier-universitaire-grenoble.fr/</ref> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Dellal, Azeddine" sort="Dellal, Azeddine" uniqKey="Dellal A" first="Azeddine" last="Dellal">Azeddine Dellal</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-409419" status="VALID"> <orgName>Groupe Hospitalier Intercommunal Le Raincy-Montfermeil</orgName> <date type="start">2009-01-01</date> <desc> <address> <addrLine>10 Rue du Général Leclerc, 93370 Montfermeil</addrLine> <country key="FR"></country> </address> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Costedoat Chalumeau, Nathalie" sort="Costedoat Chalumeau, Nathalie" uniqKey="Costedoat Chalumeau N" first="Nathalie" last="Costedoat-Chalumeau">Nathalie Costedoat-Chalumeau</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-446175" status="OLD"> <idno type="IdRef">196443806</idno> <idno type="RNSR">201420738K</idno> <orgName>Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité</orgName> <orgName type="acronym">CRESS (U1153 / UMR_A_1125 / UMR_S_1153)</orgName> <date type="start">2014-01-01</date> <date type="end">2019-12-31</date> <desc> <address> <addrLine>Hôtel-Dieu - 1 place du Parvis Notre-Dame - 75004 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.cress-umr1153.fr/</ref> </desc> <listRelation> <relation name="UMR_A_1125" active="#struct-92114" type="direct"></relation> <relation name="UMR_S_1153" active="#struct-300301" type="direct"></relation> <relation active="#struct-301664" type="direct"></relation> <relation active="#struct-303171" type="direct"></relation> <relation name="U1153" active="#struct-303623" type="direct"></relation> </listRelation> <tutelles><tutelle name="UMR_A_1125" active="#struct-92114" type="direct"><org type="institution" xml:id="struct-92114" status="OLD"> <orgName>Institut National de la Recherche Agronomique</orgName> <orgName type="acronym">INRA</orgName> <date type="start">1946-05-18</date> <date type="end">2019-12-31</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.inra.fr</ref> </desc> </org></tutelle><tutelle name="UMR_S_1153" active="#struct-300301" type="direct"><org type="institution" xml:id="struct-300301" status="VALID"> <idno type="ISNI">0000000121514068</idno> <idno type="IdRef">027542084</idno> <orgName>Université Paris Diderot - Paris 7</orgName> <orgName type="acronym">UPD7</orgName> <desc> <address> <addrLine>5 rue Thomas-Mann - 75205 Paris cedex 13</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-paris-diderot.fr</ref> </desc> </org></tutelle><tutelle active="#struct-301664" type="direct"><org type="institution" xml:id="struct-301664" status="OLD"> <idno type="IdRef">026404788</idno> <idno type="ISNI">0000 0001 2188 0914 </idno> <orgName>Université Paris Descartes - Paris 5</orgName> <orgName type="acronym">UPD5</orgName> <date type="start">1971-01-01</date> <date type="end">2019-12-31</date> <desc> <address> <addrLine>12, rue de l'École de Médecine - 75270 Paris cedex 06</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.parisdescartes.fr/</ref> </desc> </org></tutelle><tutelle active="#struct-303171" type="direct"><org type="regroupinstitution" xml:id="struct-303171" status="VALID"> <orgName>Université Sorbonne Paris Cité</orgName> <orgName type="acronym">USPC</orgName> <date type="start">2010</date> <desc> <address> <addrLine>Université Sorbonne Paris Cité | 100-104, avenue de France | 75013 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.sorbonne-paris-cite.fr/fr</ref> </desc> </org></tutelle><tutelle name="U1153" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Denis, Guillaume" sort="Denis, Guillaume" uniqKey="Denis G" first="Guillaume" last="Denis">Guillaume Denis</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-13338" status="VALID"> <idno type="IdRef">067103510</idno> <idno type="RNSR">199814201Z</idno> <orgName>Laboratoire d’Électrotechnique et d’Électronique de Puissance - EA 2697</orgName> <orgName type="acronym">L2EP</orgName> <desc> <address> <addrLine>Laboratoire L2EP - Université de Lille (Campus Cité Scientifique) - Bâtiment P2 - 59655 Villeneuve d’Ascq</addrLine> <country key="FR"></country> </address> <ref type="url">http://l2ep.univ-lille1.fr/</ref> </desc> <listRelation> <relation active="#struct-120930" type="direct"></relation> <relation active="#struct-301511" type="direct"></relation> <relation active="#struct-374570" type="direct"></relation> <relation active="#struct-1003434" type="direct"></relation> <relation active="#struct-302628" type="indirect"></relation> </listRelation> <tutelles><tutelle active="#struct-120930" type="direct"><org type="institution" xml:id="struct-120930" status="VALID"> <orgName>Ecole Centrale de Lille</orgName> <desc> <address> <addrLine>Cité Scientifique - CS 20048 59651 Villeneuve d'Ascq Cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.ec-lille.fr/</ref> </desc> </org></tutelle><tutelle active="#struct-301511" type="direct"><org type="institution" xml:id="struct-301511" status="VALID"> <orgName>Haute Etude d'Ingénieurs</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-374570" type="direct"><org type="institution" xml:id="struct-374570" status="VALID"> <idno type="IdRef">223446556</idno> <orgName>Université de Lille</orgName> <date type="start">2018-01-01</date> <desc> <address> <addrLine>Lille</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.univ-lille.fr/</ref> </desc> </org></tutelle><tutelle active="#struct-1003434" type="direct"><org type="institution" xml:id="struct-1003434" status="VALID"> <orgName>Arts et Métiers Sciences et Technologies</orgName> <date type="start">2020-03-04</date> <desc> <address> <addrLine>151 boulevard de l'Hôpital 75013 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">https://artsetmetiers.fr/</ref> </desc> <listRelation> <relation active="#struct-302628" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-302628" type="indirect"><org type="regroupinstitution" xml:id="struct-302628" status="VALID"> <orgName>HESAM Université</orgName> <orgName type="acronym">HESAM</orgName> <date type="start">2010</date> <desc> <address> <addrLine>15, rue Soufflot75005 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.hesam.eu</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Sellam, Jeremie" sort="Sellam, Jeremie" uniqKey="Sellam J" first="Jeremie" last="Sellam">Jeremie Sellam</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-413221" status="VALID"> <orgName>Sorbonne Université</orgName> <orgName type="acronym">SU</orgName> <date type="start">2018-01-01</date> <desc> <address> <addrLine>21 rue de l’École de médecine - 75006 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.sorbonne-universite.fr/</ref> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Arlet, Jean Benoit" sort="Arlet, Jean Benoit" uniqKey="Arlet J" first="Jean-Benoît" last="Arlet">Jean-Benoît Arlet</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-204525" status="VALID"> <orgName>Service de Médecine Interne [CHU HEGP]</orgName> <desc> <address> <addrLine>20, rue Leblanc 75015 Paris</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300068" type="direct"></relation> <relation active="#struct-300119" type="direct"></relation> <relation active="#struct-353414" type="indirect"></relation> <relation active="#struct-341272" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-300119" type="direct"><org type="institution" xml:id="struct-300119" status="VALID"> <orgName>Hôpital Européen Georges Pompidou [APHP]</orgName> <orgName type="acronym">HEGP</orgName> <desc> <address> <addrLine>20, rue Leblanc, 75015 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://hopital-georgespompidou.aphp.fr/</ref> </desc> <listRelation> <relation active="#struct-353414" type="direct"></relation> <relation active="#struct-300068" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-353414" type="indirect"><org type="regroupinstitution" xml:id="struct-353414" status="VALID"> <orgName>Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest</orgName> <orgName type="acronym">HUPO</orgName> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://hopitaux-parisouest.aphp.fr/</ref> </desc> </org></tutelle><tutelle active="#struct-341272" type="direct"><org type="institution" xml:id="struct-341272" status="INCOMING"> <orgName>Centre de référence des syndromes drépanocytaires majeurs</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Lavigne, Christian" sort="Lavigne, Christian" uniqKey="Lavigne C" first="Christian" last="Lavigne">Christian Lavigne</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-186833" status="VALID"> <orgName>Service de médecine interne et gérontologie clinique [Angers]</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-74911" type="direct"></relation> <relation active="#struct-151939" type="direct"></relation> <relation active="#struct-301358" type="indirect"></relation> </listRelation> <tutelles><tutelle active="#struct-74911" type="direct"><org type="institution" xml:id="struct-74911" status="VALID"> <idno type="IdRef">026402920</idno> <idno type="ISNI">0000000122483363</idno> <orgName>Université d'Angers</orgName> <orgName type="acronym">UA</orgName> <date type="start">1971-10-25</date> <desc> <address> <addrLine>Université d'Angers - 40 Rue de Rennes, BP 73532 - 49035 Angers CEDEX 01</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-angers.fr/</ref> </desc> </org></tutelle><tutelle active="#struct-151939" type="direct"><org type="institution" xml:id="struct-151939" status="VALID"> <orgName>Centre Hospitalier Universitaire d'Angers</orgName> <orgName type="acronym">CHU Angers</orgName> <desc> <address> <addrLine>4 rue Larrey - 49933 Angers cedex 9</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.chu-angers.fr/</ref> </desc> <listRelation> <relation active="#struct-301358" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-301358" type="indirect"><org type="regroupinstitution" xml:id="struct-301358" status="OLD"> <idno type="IdRef">187401039</idno> <orgName>PRES Université Nantes Angers Le Mans</orgName> <orgName type="acronym">UNAM</orgName> <date type="start">2008-12-31</date> <date type="end">2016-01-01</date> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Angers</settlement><region type="region" nuts="2">Pays de la Loire</region></placeName><orgName type="university">Université d'Angers</orgName></affiliation></author><author><name sortKey="Urbanski, Geoffrey" sort="Urbanski, Geoffrey" uniqKey="Urbanski G" first="Geoffrey" last="Urbanski">Geoffrey Urbanski</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-186833" status="VALID"> <orgName>Service de médecine interne et gérontologie clinique [Angers]</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-74911" type="direct"></relation> <relation active="#struct-151939" type="direct"></relation> <relation active="#struct-301358" type="indirect"></relation> </listRelation> <tutelles><tutelle active="#struct-74911" type="direct"><org type="institution" xml:id="struct-74911" status="VALID"> <idno type="IdRef">026402920</idno> <idno type="ISNI">0000000122483363</idno> <orgName>Université d'Angers</orgName> <orgName type="acronym">UA</orgName> <date type="start">1971-10-25</date> <desc> <address> <addrLine>Université d'Angers - 40 Rue de Rennes, BP 73532 - 49035 Angers CEDEX 01</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-angers.fr/</ref> </desc> </org></tutelle><tutelle active="#struct-151939" type="direct"><org type="institution" xml:id="struct-151939" status="VALID"> <orgName>Centre Hospitalier Universitaire d'Angers</orgName> <orgName type="acronym">CHU Angers</orgName> <desc> <address> <addrLine>4 rue Larrey - 49933 Angers cedex 9</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.chu-angers.fr/</ref> </desc> <listRelation> <relation active="#struct-301358" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-301358" type="indirect"><org type="regroupinstitution" xml:id="struct-301358" status="OLD"> <idno type="IdRef">187401039</idno> <orgName>PRES Université Nantes Angers Le Mans</orgName> <orgName type="acronym">UNAM</orgName> <date type="start">2008-12-31</date> <date type="end">2016-01-01</date> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Angers</settlement><region type="region" nuts="2">Pays de la Loire</region></placeName><orgName type="university">Université d'Angers</orgName></affiliation></author><author><name sortKey="Fischer Dumont, Dominique" sort="Fischer Dumont, Dominique" uniqKey="Fischer Dumont D" first="Dominique" last="Fischer-Dumont">Dominique Fischer-Dumont</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-116551" status="OLD"> <orgName>Hôpital avicenne</orgName> <date type="end">2019-12-31</date> <desc> <address> <addrLine>125, rue de Stalingrad 93000 Bobigny</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300068" type="direct"></relation> <relation active="#struct-15786" type="direct"></relation> <relation active="#struct-300210" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-15786" type="direct"><org type="institution" xml:id="struct-15786" status="VALID"> <orgName>Université Paris 13</orgName> <orgName type="acronym">UP13</orgName> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.univ-paris13.fr/</ref> </desc> </org></tutelle><tutelle active="#struct-300210" type="direct"><org type="institution" xml:id="struct-300210" status="VALID"> <orgName>Hôpital Avicenne</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName><orgName type="university">Université Paris 13</orgName></affiliation></author><author><name sortKey="Diallo, Abdou" sort="Diallo, Abdou" uniqKey="Diallo A" first="Abdou" last="Diallo">Abdou Diallo</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-26729" status="OLD"> <orgName>Hôpital Lariboisière</orgName> <date type="end">2019-12-31</date> <desc> <address> <addrLine>2, rue Ambroise - Paré 75475 Paris Cedex 10</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300068" type="direct"></relation> <relation active="#struct-300128" type="direct"></relation> <relation active="#struct-300301" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-300128" type="direct"><org type="institution" xml:id="struct-300128" status="VALID"> <orgName>Hôpital Lariboisière</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-300301" type="direct"><org type="institution" xml:id="struct-300301" status="VALID"> <idno type="ISNI">0000000121514068</idno> <idno type="IdRef">027542084</idno> <orgName>Université Paris Diderot - Paris 7</orgName> <orgName type="acronym">UPD7</orgName> <desc> <address> <addrLine>5 rue Thomas-Mann - 75205 Paris cedex 13</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-paris-diderot.fr</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Fain, Olivier" sort="Fain, Olivier" uniqKey="Fain O" first="Olivier" last="Fain">Olivier Fain</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-413221" status="VALID"> <orgName>Sorbonne Université</orgName> <orgName type="acronym">SU</orgName> <date type="start">2018-01-01</date> <desc> <address> <addrLine>21 rue de l’École de médecine - 75006 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.sorbonne-universite.fr/</ref> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Mekinian, Arsene" sort="Mekinian, Arsene" uniqKey="Mekinian A" first="Arsène" last="Mékinian">Arsène Mékinian</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-413221" status="VALID"> <orgName>Sorbonne Université</orgName> <orgName type="acronym">SU</orgName> <date type="start">2018-01-01</date> <desc> <address> <addrLine>21 rue de l’École de médecine - 75006 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.sorbonne-universite.fr/</ref> </desc> </hal:affiliation><country>France</country></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">HAL</idno><idno type="RBID">Hal:hal-02171337</idno><idno type="halId">hal-02171337</idno><idno type="halUri">https://hal.sorbonne-universite.fr/hal-02171337</idno><idno type="url">https://hal.sorbonne-universite.fr/hal-02171337</idno><idno type="doi">10.1016/j.autrev.2018.06.015</idno><date when="2019">2019</date><idno type="wicri:Area/Hal/Corpus">000030</idno><idno type="wicri:Area/Hal/Curation">000030</idno><idno type="wicri:Area/Hal/Checkpoint">000020</idno><idno type="wicri:explorRef" wicri:stream="Hal" wicri:step="Checkpoint">000020</idno></publicationStmt><sourceDesc><biblStruct><analytic><title xml:lang="en">Arthritis in primary Sjögren's syndrome: Characteristics, outcome and treatment from French multicenter retrospective study</title><author><name sortKey="Mirouse, Adrien" sort="Mirouse, Adrien" uniqKey="Mirouse A" first="Adrien" last="Mirouse">Adrien Mirouse</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-541912" status="VALID"> <idno type="RNSR">200918542V</idno> <orgName>Centre de Recherche Saint-Antoine</orgName> <orgName type="acronym">CR Saint-Antoine</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation name="U938" active="#struct-303623" type="direct"></relation> <relation active="#struct-413221" type="direct"></relation> </listRelation> <tutelles><tutelle name="U938" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle><tutelle active="#struct-413221" type="direct"><org type="institution" xml:id="struct-413221" status="VALID"> <orgName>Sorbonne Université</orgName> <orgName type="acronym">SU</orgName> <date type="start">2018-01-01</date> <desc> <address> <addrLine>21 rue de l’École de médecine - 75006 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.sorbonne-universite.fr/</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Seror, Raphaele" sort="Seror, Raphaele" uniqKey="Seror R" first="Raphaele" last="Séror">Raphaele Séror</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-18212" status="VALID"> <orgName>Service de rhumatologie</orgName> <desc> <address> <addrLine>Le Kremlin-Bicêtre</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-92966" type="direct"></relation> <relation active="#struct-300068" type="direct"></relation> <relation active="#struct-300148" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-92966" type="direct"><org type="institution" xml:id="struct-92966" status="VALID"> <orgName>Université Paris-Sud - Paris 11</orgName> <orgName type="acronym">UP11</orgName> <desc> <address> <addrLine>Bâtiment 300 - 91405 Orsay cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.u-psud.fr/</ref> </desc> </org></tutelle><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-300148" type="direct"><org type="institution" xml:id="struct-300148" status="VALID"> <orgName>Hôpital Bicêtre</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Vicaut, Eric" sort="Vicaut, Eric" uniqKey="Vicaut E" first="Eric" last="Vicaut">Eric Vicaut</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-26729" status="OLD"> <orgName>Hôpital Lariboisière</orgName> <date type="end">2019-12-31</date> <desc> <address> <addrLine>2, rue Ambroise - Paré 75475 Paris Cedex 10</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300068" type="direct"></relation> <relation active="#struct-300128" type="direct"></relation> <relation active="#struct-300301" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-300128" type="direct"><org type="institution" xml:id="struct-300128" status="VALID"> <orgName>Hôpital Lariboisière</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-300301" type="direct"><org type="institution" xml:id="struct-300301" status="VALID"> <idno type="ISNI">0000000121514068</idno> <idno type="IdRef">027542084</idno> <orgName>Université Paris Diderot - Paris 7</orgName> <orgName type="acronym">UPD7</orgName> <desc> <address> <addrLine>5 rue Thomas-Mann - 75205 Paris cedex 13</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-paris-diderot.fr</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Mariette, Xavier" sort="Mariette, Xavier" uniqKey="Mariette X" first="Xavier" last="Mariette">Xavier Mariette</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-312432" status="VALID"> <orgName>AP-HP Hôpital Bicêtre (Le Kremlin-Bicêtre)</orgName> <desc> <address> <addrLine>78 Rue du Général Leclerc 94270 Le Kremlin-Bicêtre</addrLine> <country key="FR"></country> </address> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Dougados, Maxime" sort="Dougados, Maxime" uniqKey="Dougados M" first="Maxime" last="Dougados">Maxime Dougados</name><affiliation wicri:level="1"><hal:affiliation type="department" xml:id="struct-18258" status="VALID"> <orgName>Service de rhumatologie [CHU Cochin]</orgName> <desc> <address> <addrLine>27 rue du Faubourg Saint-Jacques 75014 Paris</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300123" type="direct"></relation> <relation active="#struct-300068" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300123" type="direct"><org type="institution" xml:id="struct-300123" status="VALID"> <orgName>CHU Cochin [AP-HP]</orgName> <desc> <address> <addrLine>27 Rue du Faubourg Saint-Jacques 75014 Paris</addrLine> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Fauchais, Anne Laure" sort="Fauchais, Anne Laure" uniqKey="Fauchais A" first="Anne-Laure" last="Fauchais">Anne-Laure Fauchais</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-300906" status="VALID"> <orgName>CHU Limoges</orgName> <desc> <address> <addrLine>Centre Hospitalier Universitaire Dupuytren - 2 avenue Martin Luther King 87042 LIMOGES </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.chu-limoges.fr/</ref> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Deroux, Alban" sort="Deroux, Alban" uniqKey="Deroux A" first="Alban" last="Deroux">Alban Deroux</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-257328" status="VALID"> <orgName>Centre Hospitalier Universitaire [Grenoble]</orgName> <orgName type="acronym">CHU</orgName> <desc> <address> <addrLine>CS 1021738043 Grenoble cedex 9 </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.centre-hospitalier-universitaire-grenoble.fr/</ref> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Dellal, Azeddine" sort="Dellal, Azeddine" uniqKey="Dellal A" first="Azeddine" last="Dellal">Azeddine Dellal</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-409419" status="VALID"> <orgName>Groupe Hospitalier Intercommunal Le Raincy-Montfermeil</orgName> <date type="start">2009-01-01</date> <desc> <address> <addrLine>10 Rue du Général Leclerc, 93370 Montfermeil</addrLine> <country key="FR"></country> </address> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Costedoat Chalumeau, Nathalie" sort="Costedoat Chalumeau, Nathalie" uniqKey="Costedoat Chalumeau N" first="Nathalie" last="Costedoat-Chalumeau">Nathalie Costedoat-Chalumeau</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-446175" status="OLD"> <idno type="IdRef">196443806</idno> <idno type="RNSR">201420738K</idno> <orgName>Centre de Recherche Épidémiologie et Statistique Sorbonne Paris Cité</orgName> <orgName type="acronym">CRESS (U1153 / UMR_A_1125 / UMR_S_1153)</orgName> <date type="start">2014-01-01</date> <date type="end">2019-12-31</date> <desc> <address> <addrLine>Hôtel-Dieu - 1 place du Parvis Notre-Dame - 75004 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.cress-umr1153.fr/</ref> </desc> <listRelation> <relation name="UMR_A_1125" active="#struct-92114" type="direct"></relation> <relation name="UMR_S_1153" active="#struct-300301" type="direct"></relation> <relation active="#struct-301664" type="direct"></relation> <relation active="#struct-303171" type="direct"></relation> <relation name="U1153" active="#struct-303623" type="direct"></relation> </listRelation> <tutelles><tutelle name="UMR_A_1125" active="#struct-92114" type="direct"><org type="institution" xml:id="struct-92114" status="OLD"> <orgName>Institut National de la Recherche Agronomique</orgName> <orgName type="acronym">INRA</orgName> <date type="start">1946-05-18</date> <date type="end">2019-12-31</date> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.inra.fr</ref> </desc> </org></tutelle><tutelle name="UMR_S_1153" active="#struct-300301" type="direct"><org type="institution" xml:id="struct-300301" status="VALID"> <idno type="ISNI">0000000121514068</idno> <idno type="IdRef">027542084</idno> <orgName>Université Paris Diderot - Paris 7</orgName> <orgName type="acronym">UPD7</orgName> <desc> <address> <addrLine>5 rue Thomas-Mann - 75205 Paris cedex 13</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-paris-diderot.fr</ref> </desc> </org></tutelle><tutelle active="#struct-301664" type="direct"><org type="institution" xml:id="struct-301664" status="OLD"> <idno type="IdRef">026404788</idno> <idno type="ISNI">0000 0001 2188 0914 </idno> <orgName>Université Paris Descartes - Paris 5</orgName> <orgName type="acronym">UPD5</orgName> <date type="start">1971-01-01</date> <date type="end">2019-12-31</date> <desc> <address> <addrLine>12, rue de l'École de Médecine - 75270 Paris cedex 06</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.parisdescartes.fr/</ref> </desc> </org></tutelle><tutelle active="#struct-303171" type="direct"><org type="regroupinstitution" xml:id="struct-303171" status="VALID"> <orgName>Université Sorbonne Paris Cité</orgName> <orgName type="acronym">USPC</orgName> <date type="start">2010</date> <desc> <address> <addrLine>Université Sorbonne Paris Cité | 100-104, avenue de France | 75013 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.sorbonne-paris-cite.fr/fr</ref> </desc> </org></tutelle><tutelle name="U1153" active="#struct-303623" type="direct"><org type="institution" xml:id="struct-303623" status="VALID"> <idno type="IdRef">026388278</idno> <orgName>Institut National de la Santé et de la Recherche Médicale</orgName> <orgName type="acronym">INSERM</orgName> <desc> <address> <addrLine>101, rue de Tolbiac, 75013 Paris </addrLine> <country key="FR"></country> </address> <ref type="url">http://www.inserm.fr</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Denis, Guillaume" sort="Denis, Guillaume" uniqKey="Denis G" first="Guillaume" last="Denis">Guillaume Denis</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-13338" status="VALID"> <idno type="IdRef">067103510</idno> <idno type="RNSR">199814201Z</idno> <orgName>Laboratoire d’Électrotechnique et d’Électronique de Puissance - EA 2697</orgName> <orgName type="acronym">L2EP</orgName> <desc> <address> <addrLine>Laboratoire L2EP - Université de Lille (Campus Cité Scientifique) - Bâtiment P2 - 59655 Villeneuve d’Ascq</addrLine> <country key="FR"></country> </address> <ref type="url">http://l2ep.univ-lille1.fr/</ref> </desc> <listRelation> <relation active="#struct-120930" type="direct"></relation> <relation active="#struct-301511" type="direct"></relation> <relation active="#struct-374570" type="direct"></relation> <relation active="#struct-1003434" type="direct"></relation> <relation active="#struct-302628" type="indirect"></relation> </listRelation> <tutelles><tutelle active="#struct-120930" type="direct"><org type="institution" xml:id="struct-120930" status="VALID"> <orgName>Ecole Centrale de Lille</orgName> <desc> <address> <addrLine>Cité Scientifique - CS 20048 59651 Villeneuve d'Ascq Cedex</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.ec-lille.fr/</ref> </desc> </org></tutelle><tutelle active="#struct-301511" type="direct"><org type="institution" xml:id="struct-301511" status="VALID"> <orgName>Haute Etude d'Ingénieurs</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-374570" type="direct"><org type="institution" xml:id="struct-374570" status="VALID"> <idno type="IdRef">223446556</idno> <orgName>Université de Lille</orgName> <date type="start">2018-01-01</date> <desc> <address> <addrLine>Lille</addrLine> <country key="FR"></country> </address> <ref type="url">https://www.univ-lille.fr/</ref> </desc> </org></tutelle><tutelle active="#struct-1003434" type="direct"><org type="institution" xml:id="struct-1003434" status="VALID"> <orgName>Arts et Métiers Sciences et Technologies</orgName> <date type="start">2020-03-04</date> <desc> <address> <addrLine>151 boulevard de l'Hôpital 75013 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">https://artsetmetiers.fr/</ref> </desc> <listRelation> <relation active="#struct-302628" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-302628" type="indirect"><org type="regroupinstitution" xml:id="struct-302628" status="VALID"> <orgName>HESAM Université</orgName> <orgName type="acronym">HESAM</orgName> <date type="start">2010</date> <desc> <address> <addrLine>15, rue Soufflot75005 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.hesam.eu</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Sellam, Jeremie" sort="Sellam, Jeremie" uniqKey="Sellam J" first="Jeremie" last="Sellam">Jeremie Sellam</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-413221" status="VALID"> <orgName>Sorbonne Université</orgName> <orgName type="acronym">SU</orgName> <date type="start">2018-01-01</date> <desc> <address> <addrLine>21 rue de l’École de médecine - 75006 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.sorbonne-universite.fr/</ref> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Arlet, Jean Benoit" sort="Arlet, Jean Benoit" uniqKey="Arlet J" first="Jean-Benoît" last="Arlet">Jean-Benoît Arlet</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-204525" status="VALID"> <orgName>Service de Médecine Interne [CHU HEGP]</orgName> <desc> <address> <addrLine>20, rue Leblanc 75015 Paris</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300068" type="direct"></relation> <relation active="#struct-300119" type="direct"></relation> <relation active="#struct-353414" type="indirect"></relation> <relation active="#struct-341272" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-300119" type="direct"><org type="institution" xml:id="struct-300119" status="VALID"> <orgName>Hôpital Européen Georges Pompidou [APHP]</orgName> <orgName type="acronym">HEGP</orgName> <desc> <address> <addrLine>20, rue Leblanc, 75015 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://hopital-georgespompidou.aphp.fr/</ref> </desc> <listRelation> <relation active="#struct-353414" type="direct"></relation> <relation active="#struct-300068" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-353414" type="indirect"><org type="regroupinstitution" xml:id="struct-353414" status="VALID"> <orgName>Hôpitaux Universitaires Paris Ouest - Hôpitaux Universitaires Île de France Ouest</orgName> <orgName type="acronym">HUPO</orgName> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://hopitaux-parisouest.aphp.fr/</ref> </desc> </org></tutelle><tutelle active="#struct-341272" type="direct"><org type="institution" xml:id="struct-341272" status="INCOMING"> <orgName>Centre de référence des syndromes drépanocytaires majeurs</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Lavigne, Christian" sort="Lavigne, Christian" uniqKey="Lavigne C" first="Christian" last="Lavigne">Christian Lavigne</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-186833" status="VALID"> <orgName>Service de médecine interne et gérontologie clinique [Angers]</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-74911" type="direct"></relation> <relation active="#struct-151939" type="direct"></relation> <relation active="#struct-301358" type="indirect"></relation> </listRelation> <tutelles><tutelle active="#struct-74911" type="direct"><org type="institution" xml:id="struct-74911" status="VALID"> <idno type="IdRef">026402920</idno> <idno type="ISNI">0000000122483363</idno> <orgName>Université d'Angers</orgName> <orgName type="acronym">UA</orgName> <date type="start">1971-10-25</date> <desc> <address> <addrLine>Université d'Angers - 40 Rue de Rennes, BP 73532 - 49035 Angers CEDEX 01</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-angers.fr/</ref> </desc> </org></tutelle><tutelle active="#struct-151939" type="direct"><org type="institution" xml:id="struct-151939" status="VALID"> <orgName>Centre Hospitalier Universitaire d'Angers</orgName> <orgName type="acronym">CHU Angers</orgName> <desc> <address> <addrLine>4 rue Larrey - 49933 Angers cedex 9</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.chu-angers.fr/</ref> </desc> <listRelation> <relation active="#struct-301358" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-301358" type="indirect"><org type="regroupinstitution" xml:id="struct-301358" status="OLD"> <idno type="IdRef">187401039</idno> <orgName>PRES Université Nantes Angers Le Mans</orgName> <orgName type="acronym">UNAM</orgName> <date type="start">2008-12-31</date> <date type="end">2016-01-01</date> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Angers</settlement><region type="region" nuts="2">Pays de la Loire</region></placeName><orgName type="university">Université d'Angers</orgName></affiliation></author><author><name sortKey="Urbanski, Geoffrey" sort="Urbanski, Geoffrey" uniqKey="Urbanski G" first="Geoffrey" last="Urbanski">Geoffrey Urbanski</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-186833" status="VALID"> <orgName>Service de médecine interne et gérontologie clinique [Angers]</orgName> <desc> <address> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-74911" type="direct"></relation> <relation active="#struct-151939" type="direct"></relation> <relation active="#struct-301358" type="indirect"></relation> </listRelation> <tutelles><tutelle active="#struct-74911" type="direct"><org type="institution" xml:id="struct-74911" status="VALID"> <idno type="IdRef">026402920</idno> <idno type="ISNI">0000000122483363</idno> <orgName>Université d'Angers</orgName> <orgName type="acronym">UA</orgName> <date type="start">1971-10-25</date> <desc> <address> <addrLine>Université d'Angers - 40 Rue de Rennes, BP 73532 - 49035 Angers CEDEX 01</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-angers.fr/</ref> </desc> </org></tutelle><tutelle active="#struct-151939" type="direct"><org type="institution" xml:id="struct-151939" status="VALID"> <orgName>Centre Hospitalier Universitaire d'Angers</orgName> <orgName type="acronym">CHU Angers</orgName> <desc> <address> <addrLine>4 rue Larrey - 49933 Angers cedex 9</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.chu-angers.fr/</ref> </desc> <listRelation> <relation active="#struct-301358" type="direct"></relation> </listRelation> </org></tutelle><tutelle active="#struct-301358" type="indirect"><org type="regroupinstitution" xml:id="struct-301358" status="OLD"> <idno type="IdRef">187401039</idno> <orgName>PRES Université Nantes Angers Le Mans</orgName> <orgName type="acronym">UNAM</orgName> <date type="start">2008-12-31</date> <date type="end">2016-01-01</date> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Angers</settlement><region type="region" nuts="2">Pays de la Loire</region></placeName><orgName type="university">Université d'Angers</orgName></affiliation></author><author><name sortKey="Fischer Dumont, Dominique" sort="Fischer Dumont, Dominique" uniqKey="Fischer Dumont D" first="Dominique" last="Fischer-Dumont">Dominique Fischer-Dumont</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-116551" status="OLD"> <orgName>Hôpital avicenne</orgName> <date type="end">2019-12-31</date> <desc> <address> <addrLine>125, rue de Stalingrad 93000 Bobigny</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300068" type="direct"></relation> <relation active="#struct-15786" type="direct"></relation> <relation active="#struct-300210" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-15786" type="direct"><org type="institution" xml:id="struct-15786" status="VALID"> <orgName>Université Paris 13</orgName> <orgName type="acronym">UP13</orgName> <desc> <address> <country key="FR"></country> </address> <ref type="url">http://www.univ-paris13.fr/</ref> </desc> </org></tutelle><tutelle active="#struct-300210" type="direct"><org type="institution" xml:id="struct-300210" status="VALID"> <orgName>Hôpital Avicenne</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country><placeName><settlement type="city">Paris</settlement><region type="region" nuts="2">Île-de-France</region></placeName><orgName type="university">Université Paris 13</orgName></affiliation></author><author><name sortKey="Diallo, Abdou" sort="Diallo, Abdou" uniqKey="Diallo A" first="Abdou" last="Diallo">Abdou Diallo</name><affiliation wicri:level="1"><hal:affiliation type="laboratory" xml:id="struct-26729" status="OLD"> <orgName>Hôpital Lariboisière</orgName> <date type="end">2019-12-31</date> <desc> <address> <addrLine>2, rue Ambroise - Paré 75475 Paris Cedex 10</addrLine> <country key="FR"></country> </address> </desc> <listRelation> <relation active="#struct-300068" type="direct"></relation> <relation active="#struct-300128" type="direct"></relation> <relation active="#struct-300301" type="direct"></relation> </listRelation> <tutelles><tutelle active="#struct-300068" type="direct"><org type="regroupinstitution" xml:id="struct-300068" status="VALID"> <orgName>Assistance publique - Hôpitaux de Paris (AP-HP)</orgName> <orgName type="acronym">APHP</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-300128" type="direct"><org type="institution" xml:id="struct-300128" status="VALID"> <orgName>Hôpital Lariboisière</orgName> <desc> <address> <country key="FR"></country> </address> </desc> </org></tutelle><tutelle active="#struct-300301" type="direct"><org type="institution" xml:id="struct-300301" status="VALID"> <idno type="ISNI">0000000121514068</idno> <idno type="IdRef">027542084</idno> <orgName>Université Paris Diderot - Paris 7</orgName> <orgName type="acronym">UPD7</orgName> <desc> <address> <addrLine>5 rue Thomas-Mann - 75205 Paris cedex 13</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.univ-paris-diderot.fr</ref> </desc> </org></tutelle></tutelles></hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Fain, Olivier" sort="Fain, Olivier" uniqKey="Fain O" first="Olivier" last="Fain">Olivier Fain</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-413221" status="VALID"> <orgName>Sorbonne Université</orgName> <orgName type="acronym">SU</orgName> <date type="start">2018-01-01</date> <desc> <address> <addrLine>21 rue de l’École de médecine - 75006 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.sorbonne-universite.fr/</ref> </desc> </hal:affiliation><country>France</country></affiliation></author><author><name sortKey="Mekinian, Arsene" sort="Mekinian, Arsene" uniqKey="Mekinian A" first="Arsène" last="Mékinian">Arsène Mékinian</name><affiliation wicri:level="1"><hal:affiliation type="institution" xml:id="struct-413221" status="VALID"> <orgName>Sorbonne Université</orgName> <orgName type="acronym">SU</orgName> <date type="start">2018-01-01</date> <desc> <address> <addrLine>21 rue de l’École de médecine - 75006 Paris</addrLine> <country key="FR"></country> </address> <ref type="url">http://www.sorbonne-universite.fr/</ref> </desc> </hal:affiliation><country>France</country></affiliation></author></analytic><idno type="DOI">10.1016/j.autrev.2018.06.015</idno><series><title level="j">Autoimmunity Reviews</title><idno type="ISSN">1568-9972</idno><imprint><date type="datePub">2019</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="mix" xml:lang="en"><term>DMARDS</term><term>Primary Sjögren's syndrome</term><term>Rituximab</term><term>Synovitis</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en"> <p>OBJECTIVE: To describe the characteristics and the outcome of primary Sjögren Syndrome (pSS) associated arthritis and to compare the efficacy of different therapeutic regimen.METHODS: We conducted a retrospective study using Club Rhumatisme and Inflammation (CRI) and French Internal Medicine Society (SNFMI) networks. All patients with a diagnosis of pSS and at least one episode of clinical and/or echographic synovitis were included. Patients with synovitis (cases) were compared to pSS patients without synovitis (controls).RESULTS: 57 patients (93% women) were included with a median age of 54 years [45-63]. Patients with synovitis had more frequently lymph node enlargement (12.3% vs. 1.8%, p = .007) and a higher ESSDAI score (8 [6-12] vs. 2 [1-4], p < .0001). There was no difference concerning CRP levels, rheumatoid factor and cyclic citrullinated peptide (CCP)-antibodies positivity. Among 57 patients with synovitis, 101 various treatment courses have been used during the follow-up of 40 [22.5-77] months. First treatment course consisted in steroids alone (3.5%), steroids in association (79%) with hydroxychloroquine (HCQ) (49%), methotrexate (MTX) (35%), rituximab (RTX) (5.3%) or other immunosuppressive drugs (7%). HCQ, MTX, and RTX were associated with a significant reduction of tender and swollen joint count, and a significant steroids-sparing effect. No difference could be shown for the joint response between these treatment regimens.CONCLUSION: pSS articular manifestations may include synovitis which could mimic rheumatoid arthritis but differ by the absence of structural damage. Even if the use of HCQ, MTX, and RTX seem to be effective for joint involvement, the best regimen remains to be determined.</p> </div></front></TEI><hal api="V3"> <titleStmt> <title xml:lang="en">Arthritis in primary Sjögren's syndrome: Characteristics, outcome and treatment from French multicenter retrospective study</title> <author role="aut"> <persName> <forename type="first">Adrien</forename> <surname>Mirouse</surname> </persName> <idno type="halauthorid">1598075</idno> <affiliation ref="#struct-541912"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Raphaele</forename> <surname>Séror</surname> </persName> <idno type="halauthorid">11562010</idno> <affiliation ref="#struct-18212"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Eric</forename> <surname>Vicaut</surname> </persName> <email type="md5">0f71a011b2d2584198715ca4afbd1a68</email> <email type="domain">lrb.aphp.fr</email> <idno type="halauthorid">651912</idno> <affiliation ref="#struct-26729"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Xavier</forename> <surname>Mariette</surname> </persName> <email type="md5">00ea111c8153c0ee7167a0ab2a15897c</email> <email type="domain">bct.aphp.fr</email> <idno type="halauthorid">417928</idno> <affiliation ref="#struct-312432"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Maxime</forename> <surname>Dougados</surname> </persName> <email type="md5">21068e5fbe0089f66ef7c8640f94f50c</email> <email type="domain">cch.aphp.fr</email> <idno type="halauthorid">191437</idno> <affiliation ref="#struct-18258"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Anne-Laure</forename> <surname>Fauchais</surname> </persName> <email type="md5">5e4ecff62d5b0f71a325197b54afb720</email> <email type="domain">chu-limoges.fr</email> <idno type="halauthorid">422840</idno> <affiliation ref="#struct-300906"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Alban</forename> <surname>Deroux</surname> </persName> <email type="md5">c07d3c078eff503b91c2087e7dd41598</email> <email type="domain">chu-grenoble.fr</email> <idno type="halauthorid">1143288</idno> <affiliation ref="#struct-257328"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Azeddine</forename> <surname>Dellal</surname> </persName> <idno type="halauthorid">11523781</idno> <affiliation ref="#struct-409419"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Nathalie</forename> <surname>Costedoat-Chalumeau</surname> </persName> <idno type="halauthorid">822653</idno> <affiliation ref="#struct-446175"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Guillaume</forename> <surname>Denis</surname> </persName> <idno type="halauthorid">508550</idno> <affiliation ref="#struct-13338"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Jeremie</forename> <surname>Sellam</surname> </persName> <idno type="halauthorid">1390434</idno> <affiliation ref="#struct-413221"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Jean-Benoît</forename> <surname>Arlet</surname> </persName> <email type="md5">9a4c0fe2432747cb85008ea300c1d48f</email> <email type="domain">egp.aphp.fr</email> <idno type="halauthorid">769794</idno> <affiliation ref="#struct-204525"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Christian</forename> <surname>Lavigne</surname> </persName> <idno type="halauthorid">1299310</idno> <affiliation ref="#struct-186833"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Geoffrey</forename> <surname>Urbanski</surname> </persName> <idno type="halauthorid">11197141</idno> <affiliation ref="#struct-186833"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Dominique</forename> <surname>Fischer-Dumont</surname> </persName> <idno type="halauthorid">11523782</idno> <affiliation ref="#struct-116551"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Abdou</forename> <surname>Diallo</surname> </persName> <idno type="halauthorid">1434878</idno> <affiliation ref="#struct-26729"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Olivier</forename> <surname>Fain</surname> </persName> <idno type="halauthorid">555165</idno> <affiliation ref="#struct-413221"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Arsène</forename> <surname>Mékinian</surname> </persName> <idno type="halauthorid">11394852</idno> <affiliation ref="#struct-413221"></affiliation> </author> <editor role="depositor"> <persName> <forename>Gestionnaire</forename> <surname>HAL-SU</surname> </persName> <email type="md5">20ce03d813b4e6b0eba84db23565c63b</email> <email type="domain">sorbonne-universite.fr</email> </editor> </titleStmt> <editionStmt> <edition n="v1" type="current"> <date type="whenSubmitted">2019-08-29 11:33:34</date> <date type="whenModified">2020-03-25 16:36:12</date> <date type="whenReleased">2019-08-29 11:43:38</date> <date type="whenProduced">2019</date> <date type="whenEndEmbargoed">2019-08-29</date> <ref type="file" target="https://hal.sorbonne-universite.fr/hal-02171337/document"> <date notBefore="2019-08-29"></date> </ref> <ref type="file" subtype="author" n="1" target="https://hal.sorbonne-universite.fr/hal-02171337/file/Arthritis_Sjogren_24102017_revu%20%281%29.pdf"> <date notBefore="2019-08-29"></date> </ref> </edition> <respStmt> <resp>contributor</resp> <name key="662159"> <persName> <forename>Gestionnaire</forename> <surname>HAL-SU</surname> </persName> <email type="md5">20ce03d813b4e6b0eba84db23565c63b</email> <email type="domain">sorbonne-universite.fr</email> </name> </respStmt> </editionStmt> <publicationStmt> <distributor>CCSD</distributor> <idno type="halId">hal-02171337</idno> <idno type="halUri">https://hal.sorbonne-universite.fr/hal-02171337</idno> <idno type="halBibtex">mirouse:hal-02171337</idno> <idno type="halRefHtml">Autoimmunity Reviews, Elsevier, 2019, 18 (1), pp.9-14. ⟨10.1016/j.autrev.2018.06.015⟩</idno> <idno type="halRef">Autoimmunity Reviews, Elsevier, 2019, 18 (1), pp.9-14. ⟨10.1016/j.autrev.2018.06.015⟩</idno> </publicationStmt> <seriesStmt> <idno type="stamp" n="SORBONNE-UNIVERSITE">Sorbonne Université</idno> <idno type="stamp" n="UNIV-PSUD">Université Paris Sud - Paris XI</idno> <idno type="stamp" n="EC-LILLE">Ecole Centrale de Lille</idno> <idno type="stamp" n="ENSAM">Arts et Métiers Technology Institute </idno> <idno type="stamp" n="INRA">INRA - Institut national de la recherche agronomique</idno> <idno type="stamp" n="SANTE_PUB_INSERM" corresp="INSERM">Santé Publique à l'Inserm</idno> <idno type="stamp" n="U938" corresp="SORBONNE-UNIVERSITE">Centre de recherche Saint-Antoine - UMR S938</idno> <idno type="stamp" n="UNAM">l'unam - université nantes angers le mans</idno> <idno type="stamp" n="APHP" corresp="INSERM">AP-HP</idno> <idno type="stamp" n="SORBONNE-UNIV" corresp="SORBONNE-UNIVERSITE">Sorbonne Université 01/01/2018</idno> <idno type="stamp" n="UNIV-PARIS13">Université Paris-Nord - Paris XIII </idno> <idno type="stamp" n="AGREENIUM">Archive ouverte en agrobiosciences</idno> <idno type="stamp" n="UNIV-PARIS5">Université Paris Descartes (Paris 5)</idno> <idno type="stamp" n="UNIV-PSUD-SACLAY" corresp="UNIV-PARIS-SACLAY">Université Paris Sud pour Paris Saclay</idno> <idno type="stamp" n="UNIV-LILLE">Université de Lille</idno> <idno type="stamp" n="CHU-UNIV-PARIS5">Les centres hospitaliers de Paris Descartes</idno> <idno type="stamp" n="UNIV-HESAM-ENSAM" corresp="UNIV-HESAM">Ecole Nationale Supérieure d'Arts et Métiers</idno> <idno type="stamp" n="UNIV-PARIS7">Université Denis Diderot - Paris VII</idno> <idno type="stamp" n="SU-MEDECINE" corresp="SORBONNE-UNIVERSITE">Faculté de Médecine de Sorbonne Université</idno> <idno type="stamp" n="UNIV-ANGERS">Université d'Angers</idno> <idno type="stamp" n="USPC">Université Sorbonne Paris Cité</idno> <idno type="stamp" n="UNIV-PARIS-SACLAY">Université Paris-Saclay</idno> <idno type="stamp" n="UNIV-HESAM">HESAM Université</idno> <idno type="stamp" n="INSERM">INSERM - Institut national de la santé et de la recherche médicale</idno> <idno type="stamp" n="IBHGC" corresp="UNIV-PARIS13">Institut de Biomécanique Humaine Georges Charpak</idno> <idno type="stamp" n="SORBONNE-PARIS-NORD">Université Sorbonne Paris Nord</idno> <idno type="stamp" n="INRAE">Institut National de Recherche en Agriculture, Alimentation et Environnement</idno> </seriesStmt> <notesStmt> <note type="audience" n="2">International</note> <note type="popular" n="0">No</note> <note type="peer" n="1">Yes</note> </notesStmt> <sourceDesc> <biblStruct> <analytic> <title xml:lang="en">Arthritis in primary Sjögren's syndrome: Characteristics, outcome and treatment from French multicenter retrospective study</title> <author role="aut"> <persName> <forename type="first">Adrien</forename> <surname>Mirouse</surname> </persName> <idno type="halauthorid">1598075</idno> <affiliation ref="#struct-541912"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Raphaele</forename> <surname>Séror</surname> </persName> <idno type="halauthorid">11562010</idno> <affiliation ref="#struct-18212"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Eric</forename> <surname>Vicaut</surname> </persName> <email type="md5">0f71a011b2d2584198715ca4afbd1a68</email> <email type="domain">lrb.aphp.fr</email> <idno type="halauthorid">651912</idno> <affiliation ref="#struct-26729"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Xavier</forename> <surname>Mariette</surname> </persName> <email type="md5">00ea111c8153c0ee7167a0ab2a15897c</email> <email type="domain">bct.aphp.fr</email> <idno type="halauthorid">417928</idno> <affiliation ref="#struct-312432"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Maxime</forename> <surname>Dougados</surname> </persName> <email type="md5">21068e5fbe0089f66ef7c8640f94f50c</email> <email type="domain">cch.aphp.fr</email> <idno type="halauthorid">191437</idno> <affiliation ref="#struct-18258"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Anne-Laure</forename> <surname>Fauchais</surname> </persName> <email type="md5">5e4ecff62d5b0f71a325197b54afb720</email> <email type="domain">chu-limoges.fr</email> <idno type="halauthorid">422840</idno> <affiliation ref="#struct-300906"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Alban</forename> <surname>Deroux</surname> </persName> <email type="md5">c07d3c078eff503b91c2087e7dd41598</email> <email type="domain">chu-grenoble.fr</email> <idno type="halauthorid">1143288</idno> <affiliation ref="#struct-257328"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Azeddine</forename> <surname>Dellal</surname> </persName> <idno type="halauthorid">11523781</idno> <affiliation ref="#struct-409419"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Nathalie</forename> <surname>Costedoat-Chalumeau</surname> </persName> <idno type="halauthorid">822653</idno> <affiliation ref="#struct-446175"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Guillaume</forename> <surname>Denis</surname> </persName> <idno type="halauthorid">508550</idno> <affiliation ref="#struct-13338"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Jeremie</forename> <surname>Sellam</surname> </persName> <idno type="halauthorid">1390434</idno> <affiliation ref="#struct-413221"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Jean-Benoît</forename> <surname>Arlet</surname> </persName> <email type="md5">9a4c0fe2432747cb85008ea300c1d48f</email> <email type="domain">egp.aphp.fr</email> <idno type="halauthorid">769794</idno> <affiliation ref="#struct-204525"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Christian</forename> <surname>Lavigne</surname> </persName> <idno type="halauthorid">1299310</idno> <affiliation ref="#struct-186833"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Geoffrey</forename> <surname>Urbanski</surname> </persName> <idno type="halauthorid">11197141</idno> <affiliation ref="#struct-186833"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Dominique</forename> <surname>Fischer-Dumont</surname> </persName> <idno type="halauthorid">11523782</idno> <affiliation ref="#struct-116551"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Abdou</forename> <surname>Diallo</surname> </persName> <idno type="halauthorid">1434878</idno> <affiliation ref="#struct-26729"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Olivier</forename> <surname>Fain</surname> </persName> <idno type="halauthorid">555165</idno> <affiliation ref="#struct-413221"></affiliation> </author> <author role="aut"> <persName> <forename type="first">Arsène</forename> <surname>Mékinian</surname> </persName> <idno type="halauthorid">11394852</idno> <affiliation ref="#struct-413221"></affiliation> </author> </analytic> <monogr> <idno type="halJournalId" status="VALID">10938</idno> <idno type="issn">1568-9972</idno> <title level="j">Autoimmunity Reviews</title> <imprint> <publisher>Elsevier</publisher> <biblScope unit="volume">18</biblScope> <biblScope unit="issue">1</biblScope> <biblScope unit="pp">9-14</biblScope> <date type="datePub">2019</date> <date type="dateEpub">2018-11-05</date> </imprint> </monogr> <idno type="doi">10.1016/j.autrev.2018.06.015</idno> <idno type="pubmed">30408585</idno> </biblStruct> </sourceDesc> <profileDesc> <langUsage> <language ident="en">English</language> </langUsage> <textClass> <keywords scheme="author"> <term xml:lang="en">Primary Sjögren's syndrome</term> <term xml:lang="en">DMARDS</term> <term xml:lang="en">Synovitis</term> <term xml:lang="en">Rituximab</term> </keywords> <classCode scheme="halDomain" n="sdv.mhep.rsoa">Life Sciences [q-bio]/Human health and pathology/Rhumatology and musculoskeletal system</classCode> <classCode scheme="halDomain" n="sdv.spee">Life Sciences [q-bio]/Santé publique et épidémiologie</classCode> <classCode scheme="halDomain" n="sdv.sp.pharma">Life Sciences [q-bio]/Pharmaceutical sciences/Pharmacology</classCode> <classCode scheme="halTypology" n="ART">Journal articles</classCode> </textClass> <abstract xml:lang="en"> <p>OBJECTIVE: To describe the characteristics and the outcome of primary Sjögren Syndrome (pSS) associated arthritis and to compare the efficacy of different therapeutic regimen.METHODS: We conducted a retrospective study using Club Rhumatisme and Inflammation (CRI) and French Internal Medicine Society (SNFMI) networks. All patients with a diagnosis of pSS and at least one episode of clinical and/or echographic synovitis were included. Patients with synovitis (cases) were compared to pSS patients without synovitis (controls).RESULTS: 57 patients (93% women) were included with a median age of 54 years [45-63]. Patients with synovitis had more frequently lymph node enlargement (12.3% vs. 1.8%, p = .007) and a higher ESSDAI score (8 [6-12] vs. 2 [1-4], p < .0001). There was no difference concerning CRP levels, rheumatoid factor and cyclic citrullinated peptide (CCP)-antibodies positivity. Among 57 patients with synovitis, 101 various treatment courses have been used during the follow-up of 40 [22.5-77] months. First treatment course consisted in steroids alone (3.5%), steroids in association (79%) with hydroxychloroquine (HCQ) (49%), methotrexate (MTX) (35%), rituximab (RTX) (5.3%) or other immunosuppressive drugs (7%). HCQ, MTX, and RTX were associated with a significant reduction of tender and swollen joint count, and a significant steroids-sparing effect. No difference could be shown for the joint response between these treatment regimens.CONCLUSION: pSS articular manifestations may include synovitis which could mimic rheumatoid arthritis but differ by the absence of structural damage. Even if the use of HCQ, MTX, and RTX seem to be effective for joint involvement, the best regimen remains to be determined.</p> </abstract> </profileDesc> </hal></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Sante/explor/ChloroquineV1/Data/Hal/Checkpoint
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000020 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Hal/Checkpoint/biblio.hfd -nk 000020 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Sante
|area= ChloroquineV1
|flux= Hal
|étape= Checkpoint
|type= RBID
|clé= Hal:hal-02171337
|texte= Arthritis in primary Sjögren's syndrome: Characteristics, outcome and treatment from French multicenter retrospective study
}}
| This area was generated with Dilib version V0.6.33. |  |