Polymorphism of HLA class II genes in Berbers from Southern Tunisia
Identifieur interne : 000581 ( Main/Exploration ); précédent : 000580; suivant : 000582Polymorphism of HLA class II genes in Berbers from Southern Tunisia
Auteurs : K. Fadhlaoui-Zid [Tunisie] ; S. Buhler [Suisse] ; A. Dridi [Tunisie] ; A. Benammar El Gaaied [Tunisie] ; Alicia Sanchez-Mazas [Suisse]Source :
- Tissue Antigens [ 0001-2815 ] ; 2010-11.
Descripteurs français
- KwdFr :
- Afrique du Nord, Allèles, Antigènes HLA-DQ (génétique), Antigènes HLA-DR (génétique), Arabes (génétique), Chaines HLA-DRB1, Chaines bêta des antigènes HLA-DQ, Déséquilibre de liaison, Fréquence d'allèle, Groupes ethniques (génétique), Gènes MHC de classe II, Haplotypes, Humains, Polymorphisme génétique, Tunisie.
- Wicri :
- geographic : Tunisie.
- topic : Afrique du Nord.
- MESH :
English descriptors
- KwdEn :
- Africa, Northern, Alleles, Arabs (genetics), Berbers, Ethnic Groups (genetics), Gene Frequency, Genes, MHC Class II, HLA, HLA-DQ Antigens (genetics), HLA-DQ beta-Chains, HLA-DR Antigens (genetics), HLA-DRB1 Chains, Haplotypes, Humans, Linkage Disequilibrium, North Africa, Polymorphism, Genetic, Tunisia, human genetic diversity.
- MESH :
- chemical , genetics : HLA-DQ Antigens, HLA-DR Antigens.
- geographic : Africa, Northern, HLA-DQ beta-Chains, HLA-DRB1 Chains, Tunisia.
- genetics : Arabs, Ethnic Groups.
- Alleles, Gene Frequency, Genes, MHC Class II, Haplotypes, Humans, Linkage Disequilibrium, Polymorphism, Genetic.
Abstract
In this study, the HLA‐DRB1 and ‐DQB1 molecular diversity of two Berber‐speaking populations of Southern Tunisia was analysed. Genetic comparisons indicate that both populations exhibit peculiar profiles for HLA‐DRB1, as they diverge significantly from most other North Africans, while being highly diversified. At the opposite, they are much less differentiated from neighbouring populations according to the HLA‐DQB1 polymorphism. Overall, the HLA class II genetic structure of Arab and Berber‐speaking populations from Tunisia, and of North Africa as a whole, is complex and cannot be simply explained by geographic or linguistic differentiations. The present North African genetic pool has probably been shaped by both genetic drift and the contribution of genetically heterogeneous populations during the history of settlement of North Africa.
Url:
DOI: 10.1111/j.1399-0039.2010.01534.x
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 001960
- to stream Istex, to step Curation: 001179
- to stream Istex, to step Checkpoint: 000406
- to stream PubMed, to step Corpus: 000012
- to stream PubMed, to step Curation: 000012
- to stream PubMed, to step Checkpoint: 000012
- to stream Ncbi, to step Merge: 000085
- to stream Ncbi, to step Curation: 000085
- to stream Ncbi, to step Checkpoint: 000085
- to stream Main, to step Merge: 000584
- to stream Main, to step Curation: 000581
Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Polymorphism of HLA class II genes in Berbers from Southern Tunisia</title><author><name sortKey="Fadhlaoui Id, K" sort="Fadhlaoui Id, K" uniqKey="Fadhlaoui Id K" first="K." last="Fadhlaoui-Zid">K. Fadhlaoui-Zid</name></author><author><name sortKey="Buhler, S" sort="Buhler, S" uniqKey="Buhler S" first="S." last="Buhler">S. Buhler</name></author><author><name sortKey="Dridi, A" sort="Dridi, A" uniqKey="Dridi A" first="A." last="Dridi">A. Dridi</name></author><author><name sortKey="Benammar El Gaaied, A" sort="Benammar El Gaaied, A" uniqKey="Benammar El Gaaied A" first="A." last="Benammar El Gaaied">A. Benammar El Gaaied</name></author><author><name sortKey="Sanchez Azas, Alicia" sort="Sanchez Azas, Alicia" uniqKey="Sanchez Azas A" first="Alicia" last="Sanchez-Mazas">Alicia Sanchez-Mazas</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:02A8AE72F5BF1D0D320B9FA2DD77D91C4E77F3B8</idno><date when="2010" year="2010">2010</date><idno type="doi">10.1111/j.1399-0039.2010.01534.x</idno><idno type="url">https://api.istex.fr/document/02A8AE72F5BF1D0D320B9FA2DD77D91C4E77F3B8/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">001960</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">001960</idno><idno type="wicri:Area/Istex/Curation">001179</idno><idno type="wicri:Area/Istex/Checkpoint">000406</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">000406</idno><idno type="wicri:doubleKey">0001-2815:2010:Fadhlaoui Id K:polymorphism:of:hla</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:20670354</idno><idno type="wicri:Area/PubMed/Corpus">000012</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">000012</idno><idno type="wicri:Area/PubMed/Curation">000012</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">000012</idno><idno type="wicri:Area/PubMed/Checkpoint">000012</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">000012</idno><idno type="wicri:Area/Ncbi/Merge">000085</idno><idno type="wicri:Area/Ncbi/Curation">000085</idno><idno type="wicri:Area/Ncbi/Checkpoint">000085</idno><idno type="wicri:Area/Main/Merge">000584</idno><idno type="wicri:Area/Main/Curation">000581</idno><idno type="wicri:Area/Main/Exploration">000581</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Polymorphism of HLA class II genes in Berbers from Southern Tunisia</title><author><name sortKey="Fadhlaoui Id, K" sort="Fadhlaoui Id, K" uniqKey="Fadhlaoui Id K" first="K." last="Fadhlaoui-Zid">K. Fadhlaoui-Zid</name><affiliation wicri:level="1"><country xml:lang="fr">Tunisie</country><wicri:regionArea>Laboratory of Genetics, Immunology and Human Pathologies Faculty of Science of Tunis, University Tunis El Manar</wicri:regionArea><wicri:noRegion>University Tunis El Manar</wicri:noRegion></affiliation></author><author><name sortKey="Buhler, S" sort="Buhler, S" uniqKey="Buhler S" first="S." last="Buhler">S. Buhler</name><affiliation wicri:level="4"><country xml:lang="fr">Suisse</country><wicri:regionArea>Laboratory of Anthropology, Genetics and Peopling History (AGP Lab), Department of Anthropology, University of Geneva, Geneva</wicri:regionArea><orgName type="university">Université de Genève</orgName><placeName><settlement type="city">Genève</settlement><region nuts="3" type="region">Canton de Genève</region></placeName></affiliation><affiliation wicri:level="1"><country wicri:rule="url">Suisse</country></affiliation></author><author><name sortKey="Dridi, A" sort="Dridi, A" uniqKey="Dridi A" first="A." last="Dridi">A. Dridi</name><affiliation wicri:level="3"><country xml:lang="fr">Tunisie</country><wicri:regionArea>Center of Blood Transfusion, Tunis</wicri:regionArea><placeName><settlement type="city">Tunis</settlement><region nuts="2">Gouvernorat de Tunis</region></placeName></affiliation></author><author><name sortKey="Benammar El Gaaied, A" sort="Benammar El Gaaied, A" uniqKey="Benammar El Gaaied A" first="A." last="Benammar El Gaaied">A. Benammar El Gaaied</name><affiliation wicri:level="1"><country xml:lang="fr">Tunisie</country><wicri:regionArea>Laboratory of Genetics, Immunology and Human Pathologies Faculty of Science of Tunis, University Tunis El Manar</wicri:regionArea><wicri:noRegion>University Tunis El Manar</wicri:noRegion></affiliation></author><author><name sortKey="Sanchez Azas, Alicia" sort="Sanchez Azas, Alicia" uniqKey="Sanchez Azas A" first="Alicia" last="Sanchez-Mazas">Alicia Sanchez-Mazas</name><affiliation wicri:level="4"><country xml:lang="fr">Suisse</country><wicri:regionArea>Laboratory of Anthropology, Genetics and Peopling History (AGP Lab), Department of Anthropology, University of Geneva, Geneva</wicri:regionArea><orgName type="university">Université de Genève</orgName><placeName><settlement type="city">Genève</settlement><region nuts="3" type="region">Canton de Genève</region></placeName></affiliation></author></analytic><monogr></monogr><series><title level="j">Tissue Antigens</title><idno type="ISSN">0001-2815</idno><idno type="eISSN">1399-0039</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2010-11">2010-11</date><biblScope unit="volume">76</biblScope><biblScope unit="issue">5</biblScope><biblScope unit="page" from="416">416</biblScope><biblScope unit="page" to="420">420</biblScope></imprint><idno type="ISSN">0001-2815</idno></series><idno type="istex">02A8AE72F5BF1D0D320B9FA2DD77D91C4E77F3B8</idno><idno type="DOI">10.1111/j.1399-0039.2010.01534.x</idno><idno type="ArticleID">TAN1534</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0001-2815</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Africa, Northern</term><term>Alleles</term><term>Arabs (genetics)</term><term>Berbers</term><term>Ethnic Groups (genetics)</term><term>Gene Frequency</term><term>Genes, MHC Class II</term><term>HLA</term><term>HLA-DQ Antigens (genetics)</term><term>HLA-DQ beta-Chains</term><term>HLA-DR Antigens (genetics)</term><term>HLA-DRB1 Chains</term><term>Haplotypes</term><term>Humans</term><term>Linkage Disequilibrium</term><term>North Africa</term><term>Polymorphism, Genetic</term><term>Tunisia</term><term>human genetic diversity</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Afrique du Nord</term><term>Allèles</term><term>Antigènes HLA-DQ (génétique)</term><term>Antigènes HLA-DR (génétique)</term><term>Arabes (génétique)</term><term>Chaines HLA-DRB1</term><term>Chaines bêta des antigènes HLA-DQ</term><term>Déséquilibre de liaison</term><term>Fréquence d'allèle</term><term>Groupes ethniques (génétique)</term><term>Gènes MHC de classe II</term><term>Haplotypes</term><term>Humains</term><term>Polymorphisme génétique</term><term>Tunisie</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>HLA-DQ Antigens</term><term>HLA-DR Antigens</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Africa, Northern</term><term>HLA-DQ beta-Chains</term><term>HLA-DRB1 Chains</term><term>Tunisia</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Tunisie</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Afrique du Nord</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Arabs</term><term>Ethnic Groups</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Antigènes HLA-DQ</term><term>Antigènes HLA-DR</term><term>Arabes</term><term>Groupes ethniques</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Alleles</term><term>Gene Frequency</term><term>Genes, MHC Class II</term><term>Haplotypes</term><term>Humans</term><term>Linkage Disequilibrium</term><term>Polymorphism, Genetic</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Afrique du Nord</term><term>Allèles</term><term>Chaines HLA-DRB1</term><term>Chaines bêta des antigènes HLA-DQ</term><term>Déséquilibre de liaison</term><term>Fréquence d'allèle</term><term>Gènes MHC de classe II</term><term>Haplotypes</term><term>Humains</term><term>Polymorphisme génétique</term><term>Tunisie</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In this study, the HLA‐DRB1 and ‐DQB1 molecular diversity of two Berber‐speaking populations of Southern Tunisia was analysed. Genetic comparisons indicate that both populations exhibit peculiar profiles for HLA‐DRB1, as they diverge significantly from most other North Africans, while being highly diversified. At the opposite, they are much less differentiated from neighbouring populations according to the HLA‐DQB1 polymorphism. Overall, the HLA class II genetic structure of Arab and Berber‐speaking populations from Tunisia, and of North Africa as a whole, is complex and cannot be simply explained by geographic or linguistic differentiations. The present North African genetic pool has probably been shaped by both genetic drift and the contribution of genetically heterogeneous populations during the history of settlement of North Africa.</div></front></TEI><affiliations><list><country><li>Suisse</li><li>Tunisie</li></country><region><li>Canton de Genève</li><li>Gouvernorat de Tunis</li></region><settlement><li>Genève</li><li>Tunis</li></settlement><orgName><li>Université de Genève</li></orgName></list><tree><country name="Tunisie"><noRegion><name sortKey="Fadhlaoui Id, K" sort="Fadhlaoui Id, K" uniqKey="Fadhlaoui Id K" first="K." last="Fadhlaoui-Zid">K. Fadhlaoui-Zid</name></noRegion><name sortKey="Benammar El Gaaied, A" sort="Benammar El Gaaied, A" uniqKey="Benammar El Gaaied A" first="A." last="Benammar El Gaaied">A. Benammar El Gaaied</name><name sortKey="Dridi, A" sort="Dridi, A" uniqKey="Dridi A" first="A." last="Dridi">A. Dridi</name></country><country name="Suisse"><region name="Canton de Genève"><name sortKey="Buhler, S" sort="Buhler, S" uniqKey="Buhler S" first="S." last="Buhler">S. Buhler</name></region><name sortKey="Buhler, S" sort="Buhler, S" uniqKey="Buhler S" first="S." last="Buhler">S. Buhler</name><name sortKey="Sanchez Azas, Alicia" sort="Sanchez Azas, Alicia" uniqKey="Sanchez Azas A" first="Alicia" last="Sanchez-Mazas">Alicia Sanchez-Mazas</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Linguistique/explor/TamazightV2/Data/Main/Exploration
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000581 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Main/Exploration/biblio.hfd -nk 000581 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Linguistique
|area= TamazightV2
|flux= Main
|étape= Exploration
|type= RBID
|clé= ISTEX:02A8AE72F5BF1D0D320B9FA2DD77D91C4E77F3B8
|texte= Polymorphism of HLA class II genes in Berbers from Southern Tunisia
}}
| This area was generated with Dilib version V0.6.33. |  |