TamazightV2, PubMed, Corpus, bibRecord, 000012

Polymorphism of HLA class II genes in Berbers from Southern Tunisia.

Identifieur interne : 000012 ( PubMed/Corpus ); précédent : 000011; suivant : 000013

Polymorphism of HLA class II genes in Berbers from Southern Tunisia.

Auteurs : K. Fadhlaoui-Zid ; S. Buhler ; A. Dridi ; A. Benammar El Gaaied ; Alicia Sanchez-Mazas

Source :

Tissue antigens [ 1399-0039 ] ; 2010.

RBID : pubmed:20670354

English descriptors

KwdEn :
- Africa, Northern, Alleles, Arabs (genetics), Ethnic Groups (genetics), Gene Frequency, Genes, MHC Class II, HLA-DQ Antigens (genetics), HLA-DQ beta-Chains, HLA-DR Antigens (genetics), HLA-DRB1 Chains, Haplotypes, Humans, Linkage Disequilibrium, Polymorphism, Genetic, Tunisia.
MESH :
- chemical , genetics : HLA-DQ Antigens, HLA-DR Antigens.
- geographic : Africa, Northern, HLA-DQ beta-Chains, HLA-DRB1 Chains, Tunisia.
- genetics : Arabs, Ethnic Groups.
- Alleles, Gene Frequency, Genes, MHC Class II, Haplotypes, Humans, Linkage Disequilibrium, Polymorphism, Genetic.

Abstract

In this study, the HLA-DRB1 and -DQB1 molecular diversity of two Berber-speaking populations of Southern Tunisia was analysed. Genetic comparisons indicate that both populations exhibit peculiar profiles for HLA-DRB1, as they diverge significantly from most other North Africans, while being highly diversified. At the opposite, they are much less differentiated from neighbouring populations according to the HLA-DQB1 polymorphism. Overall, the HLA class II genetic structure of Arab and Berber-speaking populations from Tunisia, and of North Africa as a whole, is complex and cannot be simply explained by geographic or linguistic differentiations. The present North African genetic pool has probably been shaped by both genetic drift and the contribution of genetically heterogeneous populations during the history of settlement of North Africa.

DOI: 10.1111/j.1399-0039.2010.01534.x
PubMed: 20670354

Links to Exploration step

pubmed:20670354

Le document en format XML

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<author><name sortKey="Fadhlaoui Zid, K" sort="Fadhlaoui Zid, K" uniqKey="Fadhlaoui Zid K" first="K" last="Fadhlaoui-Zid">K. Fadhlaoui-Zid</name>
<affiliation><nlm:affiliation>Laboratory of Genetics, Immunology and Human Pathologies Faculty of Science of Tunis, University Tunis El Manar, Tunisia.</nlm:affiliation>
</affiliation>
</author>
<author><name sortKey="Buhler, S" sort="Buhler, S" uniqKey="Buhler S" first="S" last="Buhler">S. Buhler</name>
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<author><name sortKey="Dridi, A" sort="Dridi, A" uniqKey="Dridi A" first="A" last="Dridi">A. Dridi</name>
</author>
<author><name sortKey="Benammar El Gaaied, A" sort="Benammar El Gaaied, A" uniqKey="Benammar El Gaaied A" first="A" last="Benammar El Gaaied">A. Benammar El Gaaied</name>
</author>
<author><name sortKey="Sanchez Mazas, Alicia" sort="Sanchez Mazas, Alicia" uniqKey="Sanchez Mazas A" first="Alicia" last="Sanchez-Mazas">Alicia Sanchez-Mazas</name>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">Polymorphism of HLA class II genes in Berbers from Southern Tunisia.</title>
<author><name sortKey="Fadhlaoui Zid, K" sort="Fadhlaoui Zid, K" uniqKey="Fadhlaoui Zid K" first="K" last="Fadhlaoui-Zid">K. Fadhlaoui-Zid</name>
<affiliation><nlm:affiliation>Laboratory of Genetics, Immunology and Human Pathologies Faculty of Science of Tunis, University Tunis El Manar, Tunisia.</nlm:affiliation>
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<author><name sortKey="Benammar El Gaaied, A" sort="Benammar El Gaaied, A" uniqKey="Benammar El Gaaied A" first="A" last="Benammar El Gaaied">A. Benammar El Gaaied</name>
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<author><name sortKey="Sanchez Mazas, Alicia" sort="Sanchez Mazas, Alicia" uniqKey="Sanchez Mazas A" first="Alicia" last="Sanchez-Mazas">Alicia Sanchez-Mazas</name>
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<series><title level="j">Tissue antigens</title>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Africa, Northern</term>
<term>Alleles</term>
<term>Arabs (genetics)</term>
<term>Ethnic Groups (genetics)</term>
<term>Gene Frequency</term>
<term>Genes, MHC Class II</term>
<term>HLA-DQ Antigens (genetics)</term>
<term>HLA-DQ beta-Chains</term>
<term>HLA-DR Antigens (genetics)</term>
<term>HLA-DRB1 Chains</term>
<term>Haplotypes</term>
<term>Humans</term>
<term>Linkage Disequilibrium</term>
<term>Polymorphism, Genetic</term>
<term>Tunisia</term>
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<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>HLA-DQ Antigens</term>
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<keywords scheme="MESH" type="geographic" xml:lang="en"><term>Africa, Northern</term>
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<term>HLA-DRB1 Chains</term>
<term>Tunisia</term>
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<keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Arabs</term>
<term>Ethnic Groups</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Alleles</term>
<term>Gene Frequency</term>
<term>Genes, MHC Class II</term>
<term>Haplotypes</term>
<term>Humans</term>
<term>Linkage Disequilibrium</term>
<term>Polymorphism, Genetic</term>
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<front><div type="abstract" xml:lang="en">In this study, the HLA-DRB1 and -DQB1 molecular diversity of two Berber-speaking populations of Southern Tunisia was analysed. Genetic comparisons indicate that both populations exhibit peculiar profiles for HLA-DRB1, as they diverge significantly from most other North Africans, while being highly diversified. At the opposite, they are much less differentiated from neighbouring populations according to the HLA-DQB1 polymorphism. Overall, the HLA class II genetic structure of Arab and Berber-speaking populations from Tunisia, and of North Africa as a whole, is complex and cannot be simply explained by geographic or linguistic differentiations. The present North African genetic pool has probably been shaped by both genetic drift and the contribution of genetically heterogeneous populations during the history of settlement of North Africa.</div>
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<Month>11</Month>
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<DateCompleted><Year>2011</Year>
<Month>02</Month>
<Day>24</Day>
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<DateRevised><Year>2011</Year>
<Month>11</Month>
<Day>17</Day>
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<Issue>5</Issue>
<PubDate><Year>2010</Year>
<Month>Nov</Month>
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<Title>Tissue antigens</Title>
<ISOAbbreviation>Tissue Antigens</ISOAbbreviation>
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<ArticleTitle>Polymorphism of HLA class II genes in Berbers from Southern Tunisia.</ArticleTitle>
<Pagination><MedlinePgn>416-20</MedlinePgn>
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<Abstract><AbstractText>In this study, the HLA-DRB1 and -DQB1 molecular diversity of two Berber-speaking populations of Southern Tunisia was analysed. Genetic comparisons indicate that both populations exhibit peculiar profiles for HLA-DRB1, as they diverge significantly from most other North Africans, while being highly diversified. At the opposite, they are much less differentiated from neighbouring populations according to the HLA-DQB1 polymorphism. Overall, the HLA class II genetic structure of Arab and Berber-speaking populations from Tunisia, and of North Africa as a whole, is complex and cannot be simply explained by geographic or linguistic differentiations. The present North African genetic pool has probably been shaped by both genetic drift and the contribution of genetically heterogeneous populations during the history of settlement of North Africa.</AbstractText>
<CopyrightInformation>© 2010 John Wiley & Sons A/S.</CopyrightInformation>
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<Author ValidYN="Y"><LastName>Dridi</LastName>
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<NlmUniqueID>0331072</NlmUniqueID>
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<MeshHeading><DescriptorName UI="D005802" MajorTopicYN="Y">Genes, MHC Class II</DescriptorName>
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<QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName>
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<MeshHeading><DescriptorName UI="D059866" MajorTopicYN="N">HLA-DQ beta-Chains</DescriptorName>
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<MeshHeading><DescriptorName UI="D059811" MajorTopicYN="N">HLA-DRB1 Chains</DescriptorName>
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<MeshHeading><DescriptorName UI="D006239" MajorTopicYN="N">Haplotypes</DescriptorName>
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<MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D015810" MajorTopicYN="N">Linkage Disequilibrium</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D011110" MajorTopicYN="Y">Polymorphism, Genetic</DescriptorName>
</MeshHeading>
<MeshHeading><DescriptorName UI="D014416" MajorTopicYN="N" Type="Geographic">Tunisia</DescriptorName>
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Polymorphism of HLA class II genes in Berbers from Southern Tunisia.

Polymorphism of HLA class II genes in Berbers from Southern Tunisia.

Source :

English descriptors

Abstract

Links to Exploration step

Le document en format XML

Pour manipuler ce document sous Unix (Dilib)

Pour mettre un lien sur cette page dans le réseau Wicri

Pour générer des pages wiki