Polymorphism of HLA class II genes in Berbers from Southern Tunisia.
Identifieur interne : 000085 ( Ncbi/Curation ); précédent : 000084; suivant : 000086Polymorphism of HLA class II genes in Berbers from Southern Tunisia.
Auteurs : K. Fadhlaoui-Zid [Tunisie] ; S. Buhler ; A. Dridi ; A. Benammar El Gaaied ; Alicia Sanchez-MazasSource :
- Tissue antigens [ 1399-0039 ] ; 2010.
Descripteurs français
- KwdFr :
- Afrique du Nord, Allèles, Antigènes HLA-DQ (génétique), Antigènes HLA-DR (génétique), Arabes (génétique), Chaines HLA-DRB1, Chaines bêta des antigènes HLA-DQ, Déséquilibre de liaison, Fréquence d'allèle, Groupes ethniques (génétique), Gènes MHC de classe II, Haplotypes, Humains, Polymorphisme génétique, Tunisie.
- MESH :
- Wicri :
- geographic : Tunisie.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : HLA-DQ Antigens, HLA-DR Antigens.
- geographic : Africa, Northern, HLA-DQ beta-Chains, HLA-DRB1 Chains, Tunisia.
- genetics : Arabs, Ethnic Groups.
- Alleles, Gene Frequency, Genes, MHC Class II, Haplotypes, Humans, Linkage Disequilibrium, Polymorphism, Genetic.
Abstract
In this study, the HLA-DRB1 and -DQB1 molecular diversity of two Berber-speaking populations of Southern Tunisia was analysed. Genetic comparisons indicate that both populations exhibit peculiar profiles for HLA-DRB1, as they diverge significantly from most other North Africans, while being highly diversified. At the opposite, they are much less differentiated from neighbouring populations according to the HLA-DQB1 polymorphism. Overall, the HLA class II genetic structure of Arab and Berber-speaking populations from Tunisia, and of North Africa as a whole, is complex and cannot be simply explained by geographic or linguistic differentiations. The present North African genetic pool has probably been shaped by both genetic drift and the contribution of genetically heterogeneous populations during the history of settlement of North Africa.
DOI: 10.1111/j.1399-0039.2010.01534.x
PubMed: 20670354
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pubmed:20670354Le document en format XML
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<author><name sortKey="Benammar El Gaaied, A" sort="Benammar El Gaaied, A" uniqKey="Benammar El Gaaied A" first="A" last="Benammar El Gaaied">A. Benammar El Gaaied</name>
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<term>Ethnic Groups (genetics)</term>
<term>Gene Frequency</term>
<term>Genes, MHC Class II</term>
<term>HLA-DQ Antigens (genetics)</term>
<term>HLA-DQ beta-Chains</term>
<term>HLA-DR Antigens (genetics)</term>
<term>HLA-DRB1 Chains</term>
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<term>Linkage Disequilibrium</term>
<term>Polymorphism, Genetic</term>
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<term>Allèles</term>
<term>Antigènes HLA-DQ (génétique)</term>
<term>Antigènes HLA-DR (génétique)</term>
<term>Arabes (génétique)</term>
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<term>Chaines bêta des antigènes HLA-DQ</term>
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<term>Fréquence d'allèle</term>
<term>Groupes ethniques (génétique)</term>
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<term>Haplotypes</term>
<term>Humains</term>
<term>Polymorphisme génétique</term>
<term>Tunisie</term>
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<term>Antigènes HLA-DR</term>
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<term>Groupes ethniques</term>
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<term>Gene Frequency</term>
<term>Genes, MHC Class II</term>
<term>Haplotypes</term>
<term>Humans</term>
<term>Linkage Disequilibrium</term>
<term>Polymorphism, Genetic</term>
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<term>Allèles</term>
<term>Chaines HLA-DRB1</term>
<term>Chaines bêta des antigènes HLA-DQ</term>
<term>Déséquilibre de liaison</term>
<term>Fréquence d'allèle</term>
<term>Gènes MHC de classe II</term>
<term>Haplotypes</term>
<term>Humains</term>
<term>Polymorphisme génétique</term>
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<front><div type="abstract" xml:lang="en">In this study, the HLA-DRB1 and -DQB1 molecular diversity of two Berber-speaking populations of Southern Tunisia was analysed. Genetic comparisons indicate that both populations exhibit peculiar profiles for HLA-DRB1, as they diverge significantly from most other North Africans, while being highly diversified. At the opposite, they are much less differentiated from neighbouring populations according to the HLA-DQB1 polymorphism. Overall, the HLA class II genetic structure of Arab and Berber-speaking populations from Tunisia, and of North Africa as a whole, is complex and cannot be simply explained by geographic or linguistic differentiations. The present North African genetic pool has probably been shaped by both genetic drift and the contribution of genetically heterogeneous populations during the history of settlement of North Africa.</div>
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