Polymorphism of HLA class II genes in Berbers from Southern Tunisia.
Identifieur interne : 000085 ( Ncbi/Checkpoint ); précédent : 000084; suivant : 000086Polymorphism of HLA class II genes in Berbers from Southern Tunisia.
Auteurs : K. Fadhlaoui-Zid [Tunisie] ; S. Buhler ; A. Dridi ; A. Benammar El Gaaied ; Alicia Sanchez-MazasSource :
- Tissue antigens [ 1399-0039 ] ; 2010.
Descripteurs français
- KwdFr :
- Afrique du Nord, Allèles, Antigènes HLA-DQ (génétique), Antigènes HLA-DR (génétique), Arabes (génétique), Chaines HLA-DRB1, Chaines bêta des antigènes HLA-DQ, Déséquilibre de liaison, Fréquence d'allèle, Groupes ethniques (génétique), Gènes MHC de classe II, Haplotypes, Humains, Polymorphisme génétique, Tunisie.
- MESH :
- Wicri :
- geographic : Tunisie.
English descriptors
- KwdEn :
- MESH :
- chemical , genetics : HLA-DQ Antigens, HLA-DR Antigens.
- geographic : Africa, Northern, HLA-DQ beta-Chains, HLA-DRB1 Chains, Tunisia.
- genetics : Arabs, Ethnic Groups.
- Alleles, Gene Frequency, Genes, MHC Class II, Haplotypes, Humans, Linkage Disequilibrium, Polymorphism, Genetic.
Abstract
In this study, the HLA-DRB1 and -DQB1 molecular diversity of two Berber-speaking populations of Southern Tunisia was analysed. Genetic comparisons indicate that both populations exhibit peculiar profiles for HLA-DRB1, as they diverge significantly from most other North Africans, while being highly diversified. At the opposite, they are much less differentiated from neighbouring populations according to the HLA-DQB1 polymorphism. Overall, the HLA class II genetic structure of Arab and Berber-speaking populations from Tunisia, and of North Africa as a whole, is complex and cannot be simply explained by geographic or linguistic differentiations. The present North African genetic pool has probably been shaped by both genetic drift and the contribution of genetically heterogeneous populations during the history of settlement of North Africa.
DOI: 10.1111/j.1399-0039.2010.01534.x
PubMed: 20670354
Affiliations:
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Fadhlaoui-Zid</name><affiliation wicri:level="1"><nlm:affiliation>Laboratory of Genetics, Immunology and Human Pathologies Faculty of Science of Tunis, University Tunis El Manar, Tunisia.</nlm:affiliation><country xml:lang="fr">Tunisie</country><wicri:regionArea>Laboratory of Genetics, Immunology and Human Pathologies Faculty of Science of Tunis, University Tunis El Manar</wicri:regionArea><wicri:noRegion>University Tunis El Manar</wicri:noRegion></affiliation></author><author><name sortKey="Buhler, S" sort="Buhler, S" uniqKey="Buhler S" first="S" last="Buhler">S. Buhler</name></author><author><name sortKey="Dridi, A" sort="Dridi, A" uniqKey="Dridi A" first="A" last="Dridi">A. Dridi</name></author><author><name sortKey="Benammar El Gaaied, A" sort="Benammar El Gaaied, A" uniqKey="Benammar El Gaaied A" first="A" last="Benammar El Gaaied">A. Benammar El Gaaied</name></author><author><name sortKey="Sanchez Mazas, Alicia" sort="Sanchez Mazas, Alicia" uniqKey="Sanchez Mazas A" first="Alicia" last="Sanchez-Mazas">Alicia Sanchez-Mazas</name></author></analytic><series><title level="j">Tissue antigens</title><idno type="eISSN">1399-0039</idno><imprint><date when="2010" type="published">2010</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Africa, Northern</term><term>Alleles</term><term>Arabs (genetics)</term><term>Ethnic Groups (genetics)</term><term>Gene Frequency</term><term>Genes, MHC Class II</term><term>HLA-DQ Antigens (genetics)</term><term>HLA-DQ beta-Chains</term><term>HLA-DR Antigens (genetics)</term><term>HLA-DRB1 Chains</term><term>Haplotypes</term><term>Humans</term><term>Linkage Disequilibrium</term><term>Polymorphism, Genetic</term><term>Tunisia</term></keywords><keywords scheme="KwdFr" xml:lang="fr"><term>Afrique du Nord</term><term>Allèles</term><term>Antigènes HLA-DQ (génétique)</term><term>Antigènes HLA-DR (génétique)</term><term>Arabes (génétique)</term><term>Chaines HLA-DRB1</term><term>Chaines bêta des antigènes HLA-DQ</term><term>Déséquilibre de liaison</term><term>Fréquence d'allèle</term><term>Groupes ethniques (génétique)</term><term>Gènes MHC de classe II</term><term>Haplotypes</term><term>Humains</term><term>Polymorphisme génétique</term><term>Tunisie</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>HLA-DQ Antigens</term><term>HLA-DR Antigens</term></keywords><keywords scheme="MESH" type="geographic" xml:lang="en"><term>Africa, Northern</term><term>HLA-DQ beta-Chains</term><term>HLA-DRB1 Chains</term><term>Tunisia</term></keywords><keywords scheme="MESH" qualifier="genetics" xml:lang="en"><term>Arabs</term><term>Ethnic Groups</term></keywords><keywords scheme="MESH" qualifier="génétique" xml:lang="fr"><term>Antigènes HLA-DQ</term><term>Antigènes HLA-DR</term><term>Arabes</term><term>Groupes ethniques</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Alleles</term><term>Gene Frequency</term><term>Genes, MHC Class II</term><term>Haplotypes</term><term>Humans</term><term>Linkage Disequilibrium</term><term>Polymorphism, Genetic</term></keywords><keywords scheme="MESH" xml:lang="fr"><term>Afrique du Nord</term><term>Allèles</term><term>Chaines HLA-DRB1</term><term>Chaines bêta des antigènes HLA-DQ</term><term>Déséquilibre de liaison</term><term>Fréquence d'allèle</term><term>Gènes MHC de classe II</term><term>Haplotypes</term><term>Humains</term><term>Polymorphisme génétique</term><term>Tunisie</term></keywords><keywords scheme="Wicri" type="geographic" xml:lang="fr"><term>Tunisie</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In this study, the HLA-DRB1 and -DQB1 molecular diversity of two Berber-speaking populations of Southern Tunisia was analysed. Genetic comparisons indicate that both populations exhibit peculiar profiles for HLA-DRB1, as they diverge significantly from most other North Africans, while being highly diversified. At the opposite, they are much less differentiated from neighbouring populations according to the HLA-DQB1 polymorphism. Overall, the HLA class II genetic structure of Arab and Berber-speaking populations from Tunisia, and of North Africa as a whole, is complex and cannot be simply explained by geographic or linguistic differentiations. The present North African genetic pool has probably been shaped by both genetic drift and the contribution of genetically heterogeneous populations during the history of settlement of North Africa.</div></front></TEI><affiliations><list><country><li>Tunisie</li></country></list><tree><noCountry><name sortKey="Benammar El Gaaied, A" sort="Benammar El Gaaied, A" uniqKey="Benammar El Gaaied A" first="A" last="Benammar El Gaaied">A. Benammar El Gaaied</name><name sortKey="Buhler, S" sort="Buhler, S" uniqKey="Buhler S" first="S" last="Buhler">S. Buhler</name><name sortKey="Dridi, A" sort="Dridi, A" uniqKey="Dridi A" first="A" last="Dridi">A. Dridi</name><name sortKey="Sanchez Mazas, Alicia" sort="Sanchez Mazas, Alicia" uniqKey="Sanchez Mazas A" first="Alicia" last="Sanchez-Mazas">Alicia Sanchez-Mazas</name></noCountry><country name="Tunisie"><noRegion><name sortKey="Fadhlaoui Zid, K" sort="Fadhlaoui Zid, K" uniqKey="Fadhlaoui Zid K" first="K" last="Fadhlaoui-Zid">K. Fadhlaoui-Zid</name></noRegion></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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