A Psychobiological Perspective on Genetic Determinants of Hypothalamus‐Pituitary‐Adrenal Axis Activity
Identifieur interne : 001B38 ( Main/Merge ); précédent : 001B37; suivant : 001B39A Psychobiological Perspective on Genetic Determinants of Hypothalamus‐Pituitary‐Adrenal Axis Activity
Auteurs : Stefan Wüst [Allemagne] ; Ilona S. Federenko [Allemagne] ; Elisabeth F. C. Van Rossum [Allemagne] ; Jan W. Koper [Allemagne] ; Robert Kumsta [Allemagne] ; Sonja Entringer [Allemagne] ; Dirk H. Hellhammer [Allemagne]Source :
- Annals of the New York Academy of Sciences [ 0077-8923 ] ; 2004-12.
English descriptors
- KwdEn :
- Animals, Genetics, HPA, Humans, Hypothalamo-Hypophyseal System (physiology), Pituitary-Adrenal System (physiology), Polymorphism, Genetic (physiology), Psychophysiology, Receptors, Glucocorticoid (genetics), Receptors, Glucocorticoid (physiology), Stress, Psychological (physiopathology), Twin Studies as Topic, genes, glucocorticoids, heritability, hypothalamus‐pituitary‐adrenal axis, stress, twins.
- MESH :
- chemical , genetics : Receptors, Glucocorticoid.
- physiology : Hypothalamo-Hypophyseal System, Pituitary-Adrenal System, Polymorphism, Genetic, Receptors, Glucocorticoid.
- physiopathology : Stress, Psychological.
- Animals, Genetics, Humans, Psychophysiology, Twin Studies as Topic.
Abstract
Abstract: From the perspective of psychobiological stress research we present a brief overview of findings documenting a significant impact of genetic factors on the activity of the hypothalamus‐pituitary‐adrenal (HPA) axis. Quantitative genetic studies in twins as well as association studies, primarily on polymorphisms in the glucocorticoid receptor gene, are depicted. Recent findings suggest that the collaboration of psychobiology and molecular genetics is a promising interdisciplinary approach that will significantly contribute to the understanding of the mechanisms underlying the link between stress, the HPA axis, and HPA‐related clinical states.
Url:
DOI: 10.1196/annals.1314.005
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<front><div type="abstract">Abstract: From the perspective of psychobiological stress research we present a brief overview of findings documenting a significant impact of genetic factors on the activity of the hypothalamus‐pituitary‐adrenal (HPA) axis. Quantitative genetic studies in twins as well as association studies, primarily on polymorphisms in the glucocorticoid receptor gene, are depicted. Recent findings suggest that the collaboration of psychobiology and molecular genetics is a promising interdisciplinary approach that will significantly contribute to the understanding of the mechanisms underlying the link between stress, the HPA axis, and HPA‐related clinical states.</div>
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<sourceDesc><biblStruct><analytic><title xml:lang="en">A psychobiological perspective on genetic determinants of hypothalamus-pituitary-adrenal axis activity.</title>
<author><name sortKey="Wust, Stefan" sort="Wust, Stefan" uniqKey="Wust S" first="Stefan" last="Wüst">Stefan Wüst</name>
<affiliation wicri:level="4"><nlm:affiliation>Department of Psychobiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany. wuest@uni-trier.de</nlm:affiliation>
<country xml:lang="fr">Allemagne</country>
<wicri:regionArea>Department of Psychobiology, University of Trier, Johanniterufer 15, 54290 Trier</wicri:regionArea>
<wicri:noRegion>54290 Trier</wicri:noRegion>
<orgName type="university">Université de Trèves</orgName>
<placeName><settlement type="city">Trèves (Allemagne)</settlement>
<region type="land" nuts="1">Rhénanie-Palatinat</region>
</placeName>
</affiliation>
</author>
<author><name sortKey="Federenko, Ilona S" sort="Federenko, Ilona S" uniqKey="Federenko I" first="Ilona S" last="Federenko">Ilona S. Federenko</name>
</author>
<author><name sortKey="Van Rossum, Elisabeth F C" sort="Van Rossum, Elisabeth F C" uniqKey="Van Rossum E" first="Elisabeth F C" last="Van Rossum">Elisabeth F C. Van Rossum</name>
</author>
<author><name sortKey="Koper, Jan W" sort="Koper, Jan W" uniqKey="Koper J" first="Jan W" last="Koper">Jan W. Koper</name>
</author>
<author><name sortKey="Kumsta, Robert" sort="Kumsta, Robert" uniqKey="Kumsta R" first="Robert" last="Kumsta">Robert Kumsta</name>
</author>
<author><name sortKey="Entringer, Sonja" sort="Entringer, Sonja" uniqKey="Entringer S" first="Sonja" last="Entringer">Sonja Entringer</name>
</author>
<author><name sortKey="Hellhammer, Dirk H" sort="Hellhammer, Dirk H" uniqKey="Hellhammer D" first="Dirk H" last="Hellhammer">Dirk H. Hellhammer</name>
</author>
</analytic>
<series><title level="j">Annals of the New York Academy of Sciences</title>
<idno type="ISSN">0077-8923</idno>
<imprint><date when="2004" type="published">2004</date>
</imprint>
</series>
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<profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term>
<term>Genetics</term>
<term>Humans</term>
<term>Hypothalamo-Hypophyseal System (physiology)</term>
<term>Pituitary-Adrenal System (physiology)</term>
<term>Polymorphism, Genetic (physiology)</term>
<term>Psychophysiology</term>
<term>Receptors, Glucocorticoid (genetics)</term>
<term>Receptors, Glucocorticoid (physiology)</term>
<term>Stress, Psychological (physiopathology)</term>
<term>Twin Studies as Topic</term>
</keywords>
<keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Receptors, Glucocorticoid</term>
</keywords>
<keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Hypothalamo-Hypophyseal System</term>
<term>Pituitary-Adrenal System</term>
<term>Polymorphism, Genetic</term>
<term>Receptors, Glucocorticoid</term>
</keywords>
<keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Stress, Psychological</term>
</keywords>
<keywords scheme="MESH" xml:lang="en"><term>Animals</term>
<term>Genetics</term>
<term>Humans</term>
<term>Psychophysiology</term>
<term>Twin Studies as Topic</term>
</keywords>
</textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en">From the perspective of psychobiological stress research we present a brief overview of findings documenting a significant impact of genetic factors on the activity of the hypothalamus-pituitary-adrenal (HPA) axis. Quantitative genetic studies in twins as well as association studies, primarily on polymorphisms in the glucocorticoid receptor gene, are depicted. Recent findings suggest that the collaboration of psychobiology and molecular genetics is a promising interdisciplinary approach that will significantly contribute to the understanding of the mechanisms underlying the link between stress, the HPA axis, and HPA-related clinical states.</div>
</front>
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