A psychobiological perspective on genetic determinants of hypothalamus-pituitary-adrenal axis activity.
Identifieur interne : 000726 ( PubMed/Corpus ); précédent : 000725; suivant : 000727A psychobiological perspective on genetic determinants of hypothalamus-pituitary-adrenal axis activity.
Auteurs : Stefan Wüst ; Ilona S. Federenko ; Elisabeth F C. Van Rossum ; Jan W. Koper ; Robert Kumsta ; Sonja Entringer ; Dirk H. HellhammerSource :
- Annals of the New York Academy of Sciences [ 0077-8923 ] ; 2004.
English descriptors
- KwdEn :
- Animals, Genetics, Humans, Hypothalamo-Hypophyseal System (physiology), Pituitary-Adrenal System (physiology), Polymorphism, Genetic (physiology), Psychophysiology, Receptors, Glucocorticoid (genetics), Receptors, Glucocorticoid (physiology), Stress, Psychological (physiopathology), Twin Studies as Topic.
- MESH :
- chemical , genetics : Receptors, Glucocorticoid.
- physiology : Hypothalamo-Hypophyseal System, Pituitary-Adrenal System, Polymorphism, Genetic, Receptors, Glucocorticoid.
- physiopathology : Stress, Psychological.
- Animals, Genetics, Humans, Psychophysiology, Twin Studies as Topic.
Abstract
From the perspective of psychobiological stress research we present a brief overview of findings documenting a significant impact of genetic factors on the activity of the hypothalamus-pituitary-adrenal (HPA) axis. Quantitative genetic studies in twins as well as association studies, primarily on polymorphisms in the glucocorticoid receptor gene, are depicted. Recent findings suggest that the collaboration of psychobiology and molecular genetics is a promising interdisciplinary approach that will significantly contribute to the understanding of the mechanisms underlying the link between stress, the HPA axis, and HPA-related clinical states.
DOI: 10.1196/annals.1314.005
PubMed: 15677395
Links to Exploration step
pubmed:15677395Le document en format XML
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Koper</name></author><author><name sortKey="Kumsta, Robert" sort="Kumsta, Robert" uniqKey="Kumsta R" first="Robert" last="Kumsta">Robert Kumsta</name></author><author><name sortKey="Entringer, Sonja" sort="Entringer, Sonja" uniqKey="Entringer S" first="Sonja" last="Entringer">Sonja Entringer</name></author><author><name sortKey="Hellhammer, Dirk H" sort="Hellhammer, Dirk H" uniqKey="Hellhammer D" first="Dirk H" last="Hellhammer">Dirk H. 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Federenko</name></author><author><name sortKey="Van Rossum, Elisabeth F C" sort="Van Rossum, Elisabeth F C" uniqKey="Van Rossum E" first="Elisabeth F C" last="Van Rossum">Elisabeth F C. Van Rossum</name></author><author><name sortKey="Koper, Jan W" sort="Koper, Jan W" uniqKey="Koper J" first="Jan W" last="Koper">Jan W. Koper</name></author><author><name sortKey="Kumsta, Robert" sort="Kumsta, Robert" uniqKey="Kumsta R" first="Robert" last="Kumsta">Robert Kumsta</name></author><author><name sortKey="Entringer, Sonja" sort="Entringer, Sonja" uniqKey="Entringer S" first="Sonja" last="Entringer">Sonja Entringer</name></author><author><name sortKey="Hellhammer, Dirk H" sort="Hellhammer, Dirk H" uniqKey="Hellhammer D" first="Dirk H" last="Hellhammer">Dirk H. Hellhammer</name></author></analytic><series><title level="j">Annals of the New York Academy of Sciences</title><idno type="ISSN">0077-8923</idno><imprint><date when="2004" type="published">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Animals</term><term>Genetics</term><term>Humans</term><term>Hypothalamo-Hypophyseal System (physiology)</term><term>Pituitary-Adrenal System (physiology)</term><term>Polymorphism, Genetic (physiology)</term><term>Psychophysiology</term><term>Receptors, Glucocorticoid (genetics)</term><term>Receptors, Glucocorticoid (physiology)</term><term>Stress, Psychological (physiopathology)</term><term>Twin Studies as Topic</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Receptors, Glucocorticoid</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Hypothalamo-Hypophyseal System</term><term>Pituitary-Adrenal System</term><term>Polymorphism, Genetic</term><term>Receptors, Glucocorticoid</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Stress, Psychological</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Genetics</term><term>Humans</term><term>Psychophysiology</term><term>Twin Studies as Topic</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">From the perspective of psychobiological stress research we present a brief overview of findings documenting a significant impact of genetic factors on the activity of the hypothalamus-pituitary-adrenal (HPA) axis. Quantitative genetic studies in twins as well as association studies, primarily on polymorphisms in the glucocorticoid receptor gene, are depicted. Recent findings suggest that the collaboration of psychobiology and molecular genetics is a promising interdisciplinary approach that will significantly contribute to the understanding of the mechanisms underlying the link between stress, the HPA axis, and HPA-related clinical states.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">15677395</PMID><DateCreated><Year>2005</Year><Month>01</Month><Day>28</Day></DateCreated><DateCompleted><Year>2005</Year><Month>04</Month><Day>19</Day></DateCompleted><DateRevised><Year>2007</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0077-8923</ISSN><JournalIssue CitedMedium="Print"><Volume>1032</Volume><PubDate><Year>2004</Year><Month>Dec</Month></PubDate></JournalIssue><Title>Annals of the New York Academy of Sciences</Title><ISOAbbreviation>Ann. N. Y. Acad. Sci.</ISOAbbreviation></Journal><ArticleTitle>A psychobiological perspective on genetic determinants of hypothalamus-pituitary-adrenal axis activity.</ArticleTitle><Pagination><MedlinePgn>52-62</MedlinePgn></Pagination><Abstract><AbstractText>From the perspective of psychobiological stress research we present a brief overview of findings documenting a significant impact of genetic factors on the activity of the hypothalamus-pituitary-adrenal (HPA) axis. Quantitative genetic studies in twins as well as association studies, primarily on polymorphisms in the glucocorticoid receptor gene, are depicted. Recent findings suggest that the collaboration of psychobiology and molecular genetics is a promising interdisciplinary approach that will significantly contribute to the understanding of the mechanisms underlying the link between stress, the HPA axis, and HPA-related clinical states.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Wüst</LastName><ForeName>Stefan</ForeName><Initials>S</Initials><AffiliationInfo><Affiliation>Department of Psychobiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany. wuest@uni-trier.de</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Federenko</LastName><ForeName>Ilona S</ForeName><Initials>IS</Initials></Author><Author ValidYN="Y"><LastName>van Rossum</LastName><ForeName>Elisabeth F C</ForeName><Initials>EF</Initials></Author><Author ValidYN="Y"><LastName>Koper</LastName><ForeName>Jan W</ForeName><Initials>JW</Initials></Author><Author ValidYN="Y"><LastName>Kumsta</LastName><ForeName>Robert</ForeName><Initials>R</Initials></Author><Author ValidYN="Y"><LastName>Entringer</LastName><ForeName>Sonja</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Hellhammer</LastName><ForeName>Dirk H</ForeName><Initials>DH</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D016454">Review</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>United States</Country><MedlineTA>Ann N Y Acad Sci</MedlineTA><NlmUniqueID>7506858</NlmUniqueID><ISSNLinking>0077-8923</ISSNLinking></MedlineJournalInfo><ChemicalList><Chemical><RegistryNumber>0</RegistryNumber><NameOfSubstance UI="D011965">Receptors, Glucocorticoid</NameOfSubstance></Chemical></ChemicalList><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000818" MajorTopicYN="N">Animals</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D005823" MajorTopicYN="Y">Genetics</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D006801" MajorTopicYN="N">Humans</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D007030" MajorTopicYN="N">Hypothalamo-Hypophyseal System</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D010913" MajorTopicYN="N">Pituitary-Adrenal System</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="Y">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011110" MajorTopicYN="N">Polymorphism, Genetic</DescriptorName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D011603" MajorTopicYN="N">Psychophysiology</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D011965" MajorTopicYN="N">Receptors, Glucocorticoid</DescriptorName><QualifierName UI="Q000235" MajorTopicYN="N">genetics</QualifierName><QualifierName UI="Q000502" MajorTopicYN="N">physiology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D013315" MajorTopicYN="N">Stress, Psychological</DescriptorName><QualifierName UI="Q000503" MajorTopicYN="N">physiopathology</QualifierName></MeshHeading><MeshHeading><DescriptorName UI="D018433" MajorTopicYN="N">Twin Studies as Topic</DescriptorName></MeshHeading></MeshHeadingList><NumberOfReferences>74</NumberOfReferences></MedlineCitation><PubmedData><History><PubMedPubDate PubStatus="pubmed"><Year>2005</Year><Month>1</Month><Day>29</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2005</Year><Month>4</Month><Day>20</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2005</Year><Month>1</Month><Day>29</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">15677395</ArticleId><ArticleId IdType="pii">1032/1/52</ArticleId><ArticleId IdType="doi">10.1196/annals.1314.005</ArticleId></ArticleIdList></PubmedData></pubmed></record>Pour manipuler ce document sous Unix (Dilib)
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