A Psychobiological Perspective on Genetic Determinants of Hypothalamus‐Pituitary‐Adrenal Axis Activity
Identifieur interne : 000F94 ( Istex/Corpus ); précédent : 000F93; suivant : 000F95A Psychobiological Perspective on Genetic Determinants of Hypothalamus‐Pituitary‐Adrenal Axis Activity
Auteurs : Stefan Wüst ; Ilona S. Federenko ; Elisabeth F. C. Van Rossum ; Jan W. Koper ; Robert Kumsta ; Sonja Entringer ; Dirk H. HellhammerSource :
- Annals of the New York Academy of Sciences [ 0077-8923 ] ; 2004-12.
English descriptors
- KwdEn :
Abstract
Abstract: From the perspective of psychobiological stress research we present a brief overview of findings documenting a significant impact of genetic factors on the activity of the hypothalamus‐pituitary‐adrenal (HPA) axis. Quantitative genetic studies in twins as well as association studies, primarily on polymorphisms in the glucocorticoid receptor gene, are depicted. Recent findings suggest that the collaboration of psychobiology and molecular genetics is a promising interdisciplinary approach that will significantly contribute to the understanding of the mechanisms underlying the link between stress, the HPA axis, and HPA‐related clinical states.
Url:
DOI: 10.1196/annals.1314.005
Links to Exploration step
ISTEX:CDFBF3C6BE150D30B772AACA1337563895414EC1Le document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">A Psychobiological Perspective on Genetic Determinants of Hypothalamus‐Pituitary‐Adrenal Axis Activity</title><author><name sortKey="Wust, Stefan" sort="Wust, Stefan" uniqKey="Wust S" first="Stefan" last="Wüst">Stefan Wüst</name><affiliation><mods:affiliation>Department of Psychobiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: wuest@uni‐trier.de</mods:affiliation></affiliation></author><author><name sortKey="Federenko, Ilona S" sort="Federenko, Ilona S" uniqKey="Federenko I" first="Ilona S." last="Federenko">Ilona S. Federenko</name><affiliation><mods:affiliation>Department of Psychobiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany</mods:affiliation></affiliation></author><author><name sortKey="Van Rossum, Elisabeth F C" sort="Van Rossum, Elisabeth F C" uniqKey="Van Rossum E" first="Elisabeth F. C." last="Van Rossum">Elisabeth F. C. Van Rossum</name><affiliation><mods:affiliation>Department of Psychobiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany</mods:affiliation></affiliation></author><author><name sortKey="Koper, Jan W" sort="Koper, Jan W" uniqKey="Koper J" first="Jan W." last="Koper">Jan W. Koper</name><affiliation><mods:affiliation>Department of Psychobiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany</mods:affiliation></affiliation></author><author><name sortKey="Kumsta, Robert" sort="Kumsta, Robert" uniqKey="Kumsta R" first="Robert" last="Kumsta">Robert Kumsta</name><affiliation><mods:affiliation>Department of Psychobiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany</mods:affiliation></affiliation></author><author><name sortKey="Entringer, Sonja" sort="Entringer, Sonja" uniqKey="Entringer S" first="Sonja" last="Entringer">Sonja Entringer</name><affiliation><mods:affiliation>Department of Psychobiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany</mods:affiliation></affiliation></author><author><name sortKey="Hellhammer, Dirk H" sort="Hellhammer, Dirk H" uniqKey="Hellhammer D" first="Dirk H." last="Hellhammer">Dirk H. Hellhammer</name><affiliation><mods:affiliation>Department of Psychobiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany</mods:affiliation></affiliation></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:CDFBF3C6BE150D30B772AACA1337563895414EC1</idno><date when="2004" year="2004">2004</date><idno type="doi">10.1196/annals.1314.005</idno><idno type="url">https://api.istex.fr/document/CDFBF3C6BE150D30B772AACA1337563895414EC1/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000F94</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000F94</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">A Psychobiological Perspective on Genetic Determinants of Hypothalamus‐Pituitary‐Adrenal Axis Activity</title><author><name sortKey="Wust, Stefan" sort="Wust, Stefan" uniqKey="Wust S" first="Stefan" last="Wüst">Stefan Wüst</name><affiliation><mods:affiliation>Department of Psychobiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany</mods:affiliation></affiliation><affiliation><mods:affiliation>E-mail: wuest@uni‐trier.de</mods:affiliation></affiliation></author><author><name sortKey="Federenko, Ilona S" sort="Federenko, Ilona S" uniqKey="Federenko I" first="Ilona S." last="Federenko">Ilona S. Federenko</name><affiliation><mods:affiliation>Department of Psychobiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany</mods:affiliation></affiliation></author><author><name sortKey="Van Rossum, Elisabeth F C" sort="Van Rossum, Elisabeth F C" uniqKey="Van Rossum E" first="Elisabeth F. C." last="Van Rossum">Elisabeth F. C. Van Rossum</name><affiliation><mods:affiliation>Department of Psychobiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany</mods:affiliation></affiliation></author><author><name sortKey="Koper, Jan W" sort="Koper, Jan W" uniqKey="Koper J" first="Jan W." last="Koper">Jan W. Koper</name><affiliation><mods:affiliation>Department of Psychobiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany</mods:affiliation></affiliation></author><author><name sortKey="Kumsta, Robert" sort="Kumsta, Robert" uniqKey="Kumsta R" first="Robert" last="Kumsta">Robert Kumsta</name><affiliation><mods:affiliation>Department of Psychobiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany</mods:affiliation></affiliation></author><author><name sortKey="Entringer, Sonja" sort="Entringer, Sonja" uniqKey="Entringer S" first="Sonja" last="Entringer">Sonja Entringer</name><affiliation><mods:affiliation>Department of Psychobiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany</mods:affiliation></affiliation></author><author><name sortKey="Hellhammer, Dirk H" sort="Hellhammer, Dirk H" uniqKey="Hellhammer D" first="Dirk H." last="Hellhammer">Dirk H. Hellhammer</name><affiliation><mods:affiliation>Department of Psychobiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany</mods:affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Annals of the New York Academy of Sciences</title><idno type="ISSN">0077-8923</idno><idno type="eISSN">1749-6632</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2004-12">2004-12</date><biblScope unit="volume">1032</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="52">52</biblScope><biblScope unit="page" to="62">62</biblScope></imprint><idno type="ISSN">0077-8923</idno></series><idno type="istex">CDFBF3C6BE150D30B772AACA1337563895414EC1</idno><idno type="DOI">10.1196/annals.1314.005</idno><idno type="ArticleID">NYAS52</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0077-8923</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>HPA</term><term>genes</term><term>glucocorticoids</term><term>heritability</term><term>hypothalamus‐pituitary‐adrenal axis</term><term>stress</term><term>twins</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract">Abstract: From the perspective of psychobiological stress research we present a brief overview of findings documenting a significant impact of genetic factors on the activity of the hypothalamus‐pituitary‐adrenal (HPA) axis. Quantitative genetic studies in twins as well as association studies, primarily on polymorphisms in the glucocorticoid receptor gene, are depicted. Recent findings suggest that the collaboration of psychobiology and molecular genetics is a promising interdisciplinary approach that will significantly contribute to the understanding of the mechanisms underlying the link between stress, the HPA axis, and HPA‐related clinical states.</div></front></TEI><istex><corpusName>wiley</corpusName><author><json:item><name>STEFAN WÜST</name><affiliations><json:string>Department of Psychobiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany</json:string><json:string>E-mail: wuest@uni‐trier.de</json:string></affiliations></json:item><json:item><name>ILONA S. FEDERENKO</name><affiliations><json:string>Department of Psychobiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany</json:string></affiliations></json:item><json:item><name>ELISABETH F.C. van ROSSUM</name><affiliations><json:string>Department of Psychobiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany</json:string></affiliations></json:item><json:item><name>JAN W. KOPER</name><affiliations><json:string>Department of Psychobiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany</json:string></affiliations></json:item><json:item><name>ROBERT KUMSTA</name><affiliations><json:string>Department of Psychobiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany</json:string></affiliations></json:item><json:item><name>SONJA ENTRINGER</name><affiliations><json:string>Department of Psychobiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany</json:string></affiliations></json:item><json:item><name>DIRK H. HELLHAMMER</name><affiliations><json:string>Department of Psychobiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany</json:string></affiliations></json:item></author><subject><json:item><lang><json:string>eng</json:string></lang><value>hypothalamus‐pituitary‐adrenal axis</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>HPA</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>stress</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>glucocorticoids</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>genes</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>heritability</value></json:item><json:item><lang><json:string>eng</json:string></lang><value>twins</value></json:item></subject><articleId><json:string>NYAS52</json:string></articleId><language><json:string>eng</json:string></language><originalGenre><json:string>article</json:string></originalGenre><abstract>Abstract: From the perspective of psychobiological stress research we present a brief overview of findings documenting a significant impact of genetic factors on the activity of the hypothalamus‐pituitary‐adrenal (HPA) axis. Quantitative genetic studies in twins as well as association studies, primarily on polymorphisms in the glucocorticoid receptor gene, are depicted. Recent findings suggest that the collaboration of psychobiology and molecular genetics is a promising interdisciplinary approach that will significantly contribute to the understanding of the mechanisms underlying the link between stress, the HPA axis, and HPA‐related clinical states.</abstract><qualityIndicators><score>5.657</score><pdfVersion>1.3</pdfVersion><pdfPageSize>432 x 648 pts</pdfPageSize><refBibsNative>true</refBibsNative><abstractCharCount>658</abstractCharCount><pdfWordCount>4601</pdfWordCount><pdfCharCount>28683</pdfCharCount><pdfPageCount>11</pdfPageCount><abstractWordCount>88</abstractWordCount></qualityIndicators><title>A Psychobiological Perspective on Genetic Determinants of Hypothalamus‐Pituitary‐Adrenal Axis Activity</title><refBibs><json:item><author><json:item><name>G.P. Chrousos</name></json:item></author><host><volume>851</volume><pages><last>335</last><first>311</first></pages><author></author><title>The 1997 Hans Selye Memorial Lecture. Ann. N.Y. Acad. Sci</title></host><title>Stressors, stress, and neuroendocrine integration of the adaptive response</title></json:item><json:item><author><json:item><name>J. Galon</name></json:item></author><host><volume>16</volume><pages><last>71</last><first>61</first></pages><author></author><title>Faseb J</title></host><title>Gene profiling reveals unknown enhancing and suppressive actions of glucocorticoids on immune cells</title></json:item><json:item><author><json:item><name>A. Buske‐Kirschbaum</name></json:item></author><host><volume>59</volume><pages><last>426</last><first>419</first></pages><author></author><title>Psychosom. Med</title></host><title>Attenuated free cortisol response to psychosocial stress in children with atopic dermatitis</title></json:item><json:item><author><json:item><name>R. Yehuda</name></json:item></author><host><volume>821</volume><pages><last>75</last><first>57</first></pages><author></author><title>Ann. N Y Acad. Sci</title></host><title>Sensitization of the hypothalamic‐pituitary‐adrenal axis in posttraumatic stress disorder</title></json:item><json:item><author><json:item><name>P. Bjorntorp</name></json:item></author><host><volume>892</volume><pages><last>307</last><first>297</first></pages><author></author><title>Ann. N Y Acad. Sci</title></host><title>Hypothalamic origin of the metabolic syndrome X</title></json:item><json:item><author><json:item><name>G. P. Chrousos</name></json:item></author><host><volume>106</volume><pages><last>91</last><first>275</first></pages><author></author><title>J. Allergy Clin. Immunol</title></host><title>Stress, chronic inflammation, and emotional and physical well‐being: concurrent effects and chronic sequelae</title></json:item><json:item><author><json:item><name>F. Holsboer</name></json:item></author><host><volume>23</volume><pages><last>501</last><first>477</first></pages><author></author><title>Neuropsychopharmacology</title></host><title>The corticosteroid receptor hypothesis of depression</title></json:item><json:item><author><json:item><name>J.K. Belanoff</name></json:item></author><host><volume>35</volume><pages><last>45</last><first>127</first></pages><author></author><title>J. Psychiatr. Res</title></host><title>Corticosteroids and cognition</title></json:item><json:item><author><json:item><name>J.W. Chu</name></json:item></author><host><volume>86</volume><pages><last>3573</last><first>3568</first></pages><author></author><title>J. Clin. Endocrinol. Metab</title></host><title>Successful long‐term treatment of refractory Cushing's disease with high‐dose mifepristone (RU 486)</title></json:item><json:item><author><json:item><name>J.W. Mason</name></json:item></author><host><volume>30</volume><pages><last>607</last><first>576</first></pages><author></author><title>Psychosom. Med</title></host><title>A review of psychoendocrine research on the pituitary‐adrenal cortical system</title></json:item><json:item><author><json:item><name>J.D. Maxwell</name></json:item></author><host><volume>6</volume><pages><last>297</last><first>294</first></pages><author></author><title>J. Med. Genet</title></host><title>Plasma corticosteroids in healthy twin pairs</title></json:item><json:item><author><json:item><name>A.W. Meikle</name></json:item></author><host><volume>37</volume><pages><last>517</last><first>514</first></pages><author></author><title>Metabolism</title></host><title>Heritability of variation of plasma cortisol levels</title></json:item><json:item><author><json:item><name>P. Linkowski</name></json:item></author><host><volume>264</volume><pages><last>181</last><first>173</first></pages><author></author><title>Am. J. Physiol</title></host><title>Twin study of the 24‐h cortisol profile: evidence for genetic control of the human circadian clock</title></json:item><json:item><author><json:item><name>S. Wüst</name></json:item></author><host><volume>7</volume><pages><last>85</last><first>77</first></pages><author></author><title>Noise & Health</title></host><title>The cortisol awakening response ‐ normal values and confounds</title></json:item><json:item><author><json:item><name>S. Wust</name></json:item></author><host><volume>25</volume><pages><last>720</last><first>707</first></pages><author></author><title>Psychoneuroendocrinology</title></host><title>Genetic factors, perceived chronic stress, and the free cortisol response to awakening</title></json:item><json:item><author><json:item><name>M. Bartels</name></json:item></author><host><volume>28</volume><pages><last>137</last><first>121</first></pages><author></author><title>Psychoneuroendocrinology</title></host><title>Heritability of cortisol levels: review and simultaneous analysis of twin studies</title></json:item><json:item><author><json:item><name>M. Bartels</name></json:item></author><host><volume>33</volume><pages><last>433</last><first>421</first></pages><author></author><title>Behav. Genet</title></host><title>Heritability of daytime cortisol levels in children</title></json:item><json:item><author><json:item><name>J.I. Nurnberger Jr.</name></json:item></author><host><volume>7</volume><pages><last>176</last><first>163</first></pages><author></author><title>Psychoneuroendocrinology</title></host><title>Behavioral, biochemical and neuroendocrine responses to amphetamine in normal twins and ‘well‐state’ bipolar patients</title></json:item><json:item><author><json:item><name>C. Kirschbaum</name></json:item></author><host><volume>28</volume><pages><last>81</last><first>76</first></pages><author></author><title>Neuropsychobiology</title></host><title>The “Trier Social Stress Test” ‐ a tool for investigating psychobiology stress responses in a laboratory setting</title></json:item><json:item><author><json:item><name>G.C. Inglis</name></json:item></author><host><volume>84</volume><pages><last>4137</last><first>4132</first></pages><author></author><title>J. Clin. Endocrinol. Metab</title></host><title>Familial pattern of corticosteroids and their metabolism in adult human subjects‐the Scottish Adult Twin Study</title></json:item><json:item><author><json:item><name>J.C. Froehlich</name></json:item></author><host><volume>24</volume><pages><last>277</last><first>265</first></pages><author></author><title>Alcoholism: Clin. Exp. Res</title></host><title>Analysis of heritability of hormonal responses to alcohol in twins: beta‐endorphin as a potential biomarker of genetic risk for alcoholism</title></json:item><json:item><host><author></author><title>Federenko, I.S., M. Nagamine, D.H. Hellhamer, et al. 2004. The heritability of hypothalamus pituitary adrenal axis responses to psychosocial stress is context dependent. J. Clin. Endocrinol. Metab. In press.</title></host></json:item><json:item><author><json:item><name>H.M. Reichardt</name></json:item></author><host><volume>146</volume><pages><last>6</last><first>1</first></pages><author></author><title>Mol. Cell. Endocrinol</title></host><title>Glucocorticoid signalling–multiple variations of a common theme</title></json:item><json:item><author><json:item><name>C.M. Bamberger</name></json:item></author><host><volume>17</volume><pages><last>261</last><first>245</first></pages><author></author><title>Endocr. Rev</title></host><title>Molecular determinants of glucocorticoid receptor function and tissue sensitivity to glucocorticoids</title></json:item><json:item><author><json:item><name>G.P. Chrousos</name></json:item></author><host><volume>154</volume><pages><last>43</last><first>39</first></pages><author></author><title>Potential clinical implications. Am. J. Respir. Crit. Care Med</title></host><title>Molecular mechanisms of glucocorticoid resistance/hypersensitivity</title></json:item><json:item><author><json:item><name>M.J. Schaaf</name></json:item></author><host><volume>83</volume><pages><last>48</last><first>37</first></pages><author></author><title>J. Steroid Biochem. Mol. Biol</title></host><title>Molecular mechanisms of glucocorticoid action and resistance</title></json:item><json:item><author><json:item><name>R.H. DeRijk</name></json:item></author><host><volume>81</volume><pages><last>122</last><first>103</first></pages><author></author><title>J. Steroid Biochem. Mol. Biol</title></host><title>Glucocorticoid receptor variants: clinical implications</title></json:item><json:item><author><json:item><name>J.C. Murray</name></json:item></author><host><volume>15</volume><pages><first>6765</first></pages><author></author><title>Nucleic Acids Res</title></host><title>RFLP for the glucocorticoid receptor (GRL) located at 5q11‐5q13</title></json:item><json:item><author><json:item><name>E.F.C. van Rossum</name></json:item></author><host><volume>59</volume><pages><last>592</last><first>585</first></pages><author></author><title>Clin. Endocrinol. (Oxf)</title></host><title>Identification of the BclI polymorphism in the glucocorticoid receptor gene: association with sensitivity to glucocorticoids in vivo, and body mass index</title></json:item><json:item><author><json:item><name>I. Fleury</name></json:item></author><host><volume>49</volume><pages><last>1531</last><first>1528</first></pages><author></author><title>Clin. Chem</title></host><title>Characterization of the BclI polymorphism in the glucocorticoid receptor gene</title></json:item><json:item><author><json:item><name>J.U. Weaver</name></json:item></author><host><volume>9</volume><pages><last>300</last><first>295</first></pages><author></author><title>J. Mol. Endocrinol</title></host><title>An association between a BcI1 restriction fragment length polymorphism of the glucocorticoid receptor locus and hyperinsulinaemia in obese women</title></json:item><json:item><author><json:item><name>B. Buemann</name></json:item></author><host><volume>5</volume><pages><last>192</last><first>186</first></pages><author></author><title>Obes. Res</title></host><title>Abdominal visceral fat is associated with a BclI restriction fragment length polymorphism at the glucocorticoid receptor gene locus</title></json:item><json:item><author><json:item><name>M. Panarelli</name></json:item></author><host><volume>83</volume><pages><last>1852</last><first>1846</first></pages><author></author><title>J. Clin. Endocrinol. Metab</title></host><title>Glucocorticoid receptor polymorphism, skin vasoconstriction, and other metabolic intermediate phenotypes in normal human subjects</title></json:item><json:item><author><json:item><name>R. Rosmond</name></json:item></author><host><volume>8</volume><pages><last>218</last><first>211</first></pages><author></author><title>Obes. Res</title></host><title>A glucocorticoid receptor gene marker is associated with abdominal obesity, leptin, and dysregulation of the hypothalamic‐pituitary‐adrenal axis</title></json:item><json:item><author><json:item><name>O. Ukkola</name></json:item></author><host><volume>157</volume><pages><last>224</last><first>221</first></pages><author></author><title>Atherosclerosis</title></host><title>Glucocorticoid receptor Bcl I variant is associated with an increased atherogenic profile in response to long‐term overfeeding</title></json:item><json:item><author><json:item><name>A. Tremblay</name></json:item></author><host><volume>88</volume><pages><last>3145</last><first>3141</first></pages><author></author><title>J. Clin. Endocrinol. Metab</title></host><title>Long‐term adiposity changes are related to a glucocorticoid receptor polymorphism in young females</title></json:item><json:item><author><json:item><name>A. Stevens</name></json:item></author><host><volume>89</volume><pages><last>897</last><first>892</first></pages><author></author><title>J. Clin. Endocrinol. Metab</title></host><title>Glucocorticoid sensitivity is determined by a specific glucocorticoid receptor haplotype</title></json:item><json:item><author><json:item><name>J.W. Koper</name></json:item></author><host><volume>99</volume><pages><last>668</last><first>663</first></pages><author></author><title>Hum. Genet</title></host><title>Lack of association between five polymorphisms in the human glucocorticoid receptor gene and glucocorticoid resistance</title></json:item><json:item><author><json:item><name>R.C. Lin</name></json:item></author><host><volume>319</volume><pages><last>1338</last><first>1337</first></pages><author></author><title>Brit. Med. J</title></host><title>High penetrance, overweight, and glucocorticoid receptor variant: case‐control study</title></json:item><json:item><author><json:item><name>A.M. Di Blasio</name></json:item></author><host><volume>59</volume><pages><last>74</last><first>68</first></pages><author></author><title>Clin. Endocrinol. (Oxf)</title></host><title>The relation between two polymorphisms in the glucocorticoid receptor gene and body mass index, blood pressure and cholesterol in obese patients</title></json:item><json:item><author><json:item><name>M.G. Dobson</name></json:item></author><host><volume>86</volume><pages><last>2274</last><first>2270</first></pages><author></author><title>J. Clin. Endocrinol. Metab</title></host><title>The N363S polymorphism of the glucocorticoid receptor: potential contribution to central obesity in men and lack of association with other risk factors for coronary heart disease and diabetes mellitus</title></json:item><json:item><author><json:item><name>R. Roussel</name></json:item></author><host><volume>59</volume><pages><last>241</last><first>237</first></pages><author></author><title>Clin. Endocrinol. (Oxf)</title></host><title>The N363S polymorphism in the glucocorticoid receptor gene is associated with overweight in subjects with type 2 diabetes mellitus</title></json:item><json:item><author><json:item><name>N.A. Huizenga</name></json:item></author><host><volume>83</volume><pages><last>151</last><first>144</first></pages><author></author><title>J. Clin. Endocrinol. Metab</title></host><title>A polymorphism in the glucocorticoid receptor gene may be associated with and increased sensitivity to glucocorticoids in vivo</title></json:item><json:item><author><json:item><name>E.F. van Rossum</name></json:item></author><host><volume>51</volume><pages><last>3134</last><first>3128</first></pages><author></author><title>Diabetes</title></host><title>A polymorphism in the glucocorticoid receptor gene, which decreases sensitivity to glucocorticoids in vivo, is associated with low insulin and cholesterol levels</title></json:item><json:item><host><author></author><title>van Rossum, E.F.C. et al. The ER22/23EK polymorphism in the glucocorticoid receptor gene is associated with better survival and low C‐reactive protein levels in elderly men. Am. J. Med. In press.</title></host></json:item><json:item><author><json:item><name>S. Wüst</name></json:item></author><host><volume>89</volume><pages><last>573</last><first>565</first></pages><author></author><title>J. Clin. Endocrinol. Metab</title></host><title>Common polymorphisms in the glucocorticoid receptor gene are associated with adrenocortical responses to psychosocial stress</title></json:item><json:item><author><json:item><name>S.D. Detera‐Wadleigh</name></json:item></author><host><volume>19</volume><pages><first>1960</first></pages><author></author><title>Nucleic Acids Res</title></host><title>A TthIII1 polymorphism on the 5’ flanking region of the glucocorticoid receptor gene (GRL)</title></json:item><json:item><author><json:item><name>R. Rosmond</name></json:item></author><host><volume>49</volume><pages><last>1199</last><first>1197</first></pages><author></author><title>Metabolism</title></host><title>A polymorphism of the 5′‐flanking region of the glucocorticoid receptor gene locus is associated with basal cortisol secretion in men</title></json:item><json:item><author><json:item><name>R.H. DeRijk</name></json:item></author><host><volume>28</volume><pages><last>2388</last><first>2383</first></pages><author></author><title>J. Rheumatol</title></host><title>A human glucocorticoid receptor gene variant that increases the stability of the glucocorticoid receptor beta‐isoform mRNA is associated with rheumatoid arthritis</title></json:item><json:item><author><json:item><name>P.J. Bray</name></json:item></author><host><volume>21</volume><pages><last>568</last><first>557</first></pages><author></author><title>Hum. Mutat</title></host><title>Variations of the human glucocorticoid receptor gene (NR3C1): pathological and in vitro mutations and polymorphisms</title></json:item><json:item><author><json:item><name>R. Rosmond</name></json:item></author><host><volume>50</volume><pages><last>1062</last><first>1059</first></pages><author></author><title>Metabolism</title></host><title>A polymorphism in the regulatory region of the corticotropin‐releasing hormone gene in relation to cortisol secretion, obesity, and gene‐gene interaction</title></json:item><json:item><author><json:item><name>T.C. Baghai</name></json:item></author><host><volume>328</volume><pages><last>303</last><first>299</first></pages><author></author><title>Neurosci. Lett</title></host><title>Hypothalamic‐pituitary‐adrenocortical axis dysregulation in patients with major depression is influenced by the insertion/deletion polymorphism in the angiotensin I‐converting enzyme gene</title></json:item><json:item><author><json:item><name>C.G. Baerwald</name></json:item></author><host><volume>59</volume><pages><last>34</last><first>29</first></pages><author></author><title>Z. Rheumatol</title></host><title>Corticotropin releasing hormone (CRH) promoter polymorphisms in various ethnic groups of patients with rheumatoid arthritis</title></json:item><json:item><author><json:item><name>C.G. Baerwald</name></json:item></author><host><volume>97</volume><pages><last>698</last><first>697</first></pages><author></author><title>Hum. Genet</title></host><title>A new XmnI polymorphism in the regulatory region of the corticotropin releasing hormone gene</title></json:item><json:item><author><json:item><name>J.W. Smoller</name></json:item></author><host><volume>54</volume><pages><last>1381</last><first>1376</first></pages><author></author><title>Biol. Psychiatry</title></host><title>Association of a genetic marker at the corticotropin‐releasing hormone locus with behavioral inhibition</title></json:item><json:item><author><json:item><name>B.G. Challis</name></json:item></author><host><volume>28</volume><pages><last>446</last><first>442</first></pages><author></author><title>Int. J. Obes. Relat. Metab. Disord</title></host><title>Genetic variation in the corticotrophin‐releasing factor receptors: identification of single‐nucleotide polymorphisms and association studies with obesity in UK Caucasians</title></json:item><json:item><author><json:item><name>S.M. Villafuerte</name></json:item></author><host><volume>114</volume><pages><last>226</last><first>222</first></pages><author></author><title>Am. J. Med. Genet</title></host><title>Gene‐based SNP genetic association study of the corticotropin‐releasing hormone receptor‐2 (CRHR2) in major depression</title></json:item><json:item><author><json:item><name>E. Brunner</name></json:item></author><host><volume>58</volume><pages><last>762</last><first>756</first></pages><author></author><title>Clin. Endocrinol. (Oxf)</title></host><title>Hereditary corticosteroid‐binding globulin deficiency due to a missense mutation (Asp367Asn, CBG Lyon) in a Brazilian kindred</title></json:item><json:item><author><json:item><name>R. Rosmond</name></json:item></author><host><volume>51</volume><pages><last>644</last><first>642</first></pages><author></author><title>Metabolism</title></host><title>Polymorphisms in exon 3 of the proopiomelanocortin gene in relation to serum leptin, salivary cortisol, and obesity in Swedish men</title></json:item><json:item><author><json:item><name>M. Ludwig</name></json:item></author><host><volume>64</volume><pages><last>230</last><first>227</first></pages><author></author><title>J. Steroid Biochem. Mol. Biol</title></host><title>Common polymorphisms in genes encoding the human mineralocorticoid receptor and the human amiloride‐sensitive sodium channel</title></json:item><json:item><author><json:item><name>M.C. Zennaro</name></json:item></author><host><volume>15</volume><pages><last>1598</last><first>1586</first></pages><author></author><title>Mol. Endocrinol</title></host><title>A new human MR splice variant is a ligand‐independent transactivator modulating corticosteroid action</title></json:item><json:item><author><json:item><name>N. Hiroi</name></json:item></author><host><volume>48</volume><pages><last>134</last><first>129</first></pages><author></author><title>Clin. Endocrinol. (Oxf)</title></host><title>Human ACTH hypersensitivity syndrome associated with abnormalities of the ACTH receptor gene</title></json:item><json:item><author><json:item><name>R. Rosmond</name></json:item></author><host><volume>44</volume><pages><last>1338</last><first>1335</first></pages><author></author><title>Diabetologia</title></host><title>A missense mutation in the human melanocortin‐4 receptor gene in relation to abdominal obesity and salivary cortisol</title></json:item><json:item><author><json:item><name>R. Rosmond</name></json:item></author><host><volume>251</volume><pages><last>257</last><first>252</first></pages><author></author><title>J. Intern. Med</title></host><title>A C‐1291G polymorphism in the alpha2A‐adrenergic receptor gene (ADRA2A) promoter is associated with cortisol escape from dexamethasone and elevated glucose levels</title></json:item><json:item><author><json:item><name>R. Rosmond</name></json:item></author><host><volume>26</volume><pages><last>941</last><first>938</first></pages><author></author><title>Int. J. Obes. Relat. Metab. Disord</title></host><title>Allelic variants in the GABA(A)alpha6 receptor subunit gene (GABRA6) is associated with abdominal obesity and cortisol secretion</title></json:item><json:item><author><json:item><name>R. Rosmond</name></json:item></author><host><volume>10</volume><pages><last>589</last><first>585</first></pages><author></author><title>Obes. Res</title></host><title>5‐Ht2a receptor gene promoter polymorphism in relation to abdominal obesity and cortisol</title></json:item><json:item><author><json:item><name>R. Rosmond</name></json:item></author><host><volume>86</volume><pages><last>2180</last><first>2178</first></pages><author></author><title>J. Clin. Endocrinol. Metab</title></host><title>G‐308A polymorphism of the tumor necrosis factor alpha gene promoter and salivary cortisol secretion</title></json:item><json:item><author><json:item><name>G. Villuendas</name></json:item></author><host><volume>87</volume><pages><last>1141</last><first>1134</first></pages><author></author><title>J. Clin. Endocrinol. Metab</title></host><title>The −597 G–>A and −174 G–>C polymorphisms in the promoter of the IL‐6 gene are associated with hyperandrogenism</title></json:item><json:item><author><json:item><name>G.S. Wand</name></json:item></author><host><volume>26</volume><pages><last>114</last><first>106</first></pages><author></author><title>Neuropsychopharmacology</title></host><title>The mu‐opioid receptor gene polymorphism (A118G) alters HPA axis activation induced by opioid receptor blockade</title></json:item><json:item><author><json:item><name>C.A. Hernandez‐Avila</name></json:item></author><host><volume>118B</volume><pages><last>65</last><first>60</first></pages><author></author><title>Am. J. Med. Genet</title></host><title>Association between the cortisol response to opioid blockade and the Asn40Asp polymorphism at the mu‐opioid receptor locus (OPRM1)</title></json:item><json:item><author><json:item><name>E. Caramelli</name></json:item></author><host><volume>27</volume><pages><last>61</last><first>47</first></pages><author></author><title>Endocr. Res</title></host><title>Lack of mutations of type 1 11beta‐hydroxysteroid dehydrogenase gene in patients with abdominal obesity</title></json:item><json:item><author><json:item><name>E. Lovati</name></json:item></author><host><volume>84</volume><pages><last>3749</last><first>3745</first></pages><author></author><title>J. Clin. Endocrinol. Metab</title></host><title>Molecular basis of human salt sensitivity: the role of the 11beta‐hydroxysteroid dehydrogenase type 2</title></json:item><json:item><author><json:item><name>E. Davies</name></json:item></author><host><volume>54</volume><pages><last>817</last><first>813</first></pages><author></author><title>Clin. Endocrinol. (Oxf)</title></host><title>An influence of variation in the aldosterone synthase gene (CYP11B2) on corticosteroid responses to ACTH in normal human subjects</title></json:item><json:item><author><json:item><name>N. Weintrob</name></json:item></author><host><volume>143</volume><pages><last>403</last><first>397</first></pages><author></author><title>Eur. J. Endocrinol</title></host><title>Genotype‐phenotype associations in non‐classical steroid 21‐hydroxylase deficiency</title></json:item></refBibs><genre><json:string>article</json:string></genre><host><volume>1032</volume><publisherId><json:string>NYAS</json:string></publisherId><pages><total>11</total><last>62</last><first>52</first></pages><issn><json:string>0077-8923</json:string></issn><issue>1</issue><genre><json:string>journal</json:string></genre><language><json:string>unknown</json:string></language><eissn><json:string>1749-6632</json:string></eissn><title>Annals of the New York Academy of Sciences</title><doi><json:string>10.1111/(ISSN)1749-6632</json:string></doi></host><categories><wos><json:string>science</json:string><json:string>multidisciplinary sciences</json:string></wos><scienceMetrix><json:string>general</json:string><json:string>general science & technology</json:string><json:string>general science & technology</json:string></scienceMetrix></categories><publicationDate>2004</publicationDate><copyrightDate>2004</copyrightDate><doi><json:string>10.1196/annals.1314.005</json:string></doi><id>CDFBF3C6BE150D30B772AACA1337563895414EC1</id><score>1.8182752</score><fulltext><json:item><extension>pdf</extension><original>true</original><mimetype>application/pdf</mimetype><uri>https://api.istex.fr/document/CDFBF3C6BE150D30B772AACA1337563895414EC1/fulltext/pdf</uri></json:item><json:item><extension>zip</extension><original>false</original><mimetype>application/zip</mimetype><uri>https://api.istex.fr/document/CDFBF3C6BE150D30B772AACA1337563895414EC1/fulltext/zip</uri></json:item><istex:fulltextTEI uri="https://api.istex.fr/document/CDFBF3C6BE150D30B772AACA1337563895414EC1/fulltext/tei"><teiHeader><fileDesc><titleStmt><title level="a" type="main" xml:lang="en">A Psychobiological Perspective on Genetic Determinants of Hypothalamus‐Pituitary‐Adrenal Axis Activity</title></titleStmt><publicationStmt><authority>ISTEX</authority><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><availability><p>WILEY</p></availability><date>2004</date></publicationStmt><sourceDesc><biblStruct type="inbook"><analytic><title level="a" type="main" xml:lang="en">A Psychobiological Perspective on Genetic Determinants of Hypothalamus‐Pituitary‐Adrenal Axis Activity</title><author xml:id="author-1"><persName><forename type="first">STEFAN</forename><surname>WÜST</surname></persName><email>wuest@uni‐trier.de</email><affiliation>Department of Psychobiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany</affiliation></author><author xml:id="author-2"><persName><forename type="first">ILONA S.</forename><surname>FEDERENKO</surname></persName><affiliation>Department of Psychobiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany</affiliation></author><author xml:id="author-3"><persName><forename type="first">ELISABETH F.C.</forename><surname>van ROSSUM</surname></persName><affiliation>Department of Psychobiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany</affiliation></author><author xml:id="author-4"><persName><forename type="first">JAN W.</forename><surname>KOPER</surname></persName><affiliation>Department of Psychobiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany</affiliation></author><author xml:id="author-5"><persName><forename type="first">ROBERT</forename><surname>KUMSTA</surname></persName><affiliation>Department of Psychobiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany</affiliation></author><author xml:id="author-6"><persName><forename type="first">SONJA</forename><surname>ENTRINGER</surname></persName><affiliation>Department of Psychobiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany</affiliation></author><author xml:id="author-7"><persName><forename type="first">DIRK H.</forename><surname>HELLHAMMER</surname></persName><affiliation>Department of Psychobiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany</affiliation></author></analytic><monogr><title level="j">Annals of the New York Academy of Sciences</title><idno type="pISSN">0077-8923</idno><idno type="eISSN">1749-6632</idno><idno type="DOI">10.1111/(ISSN)1749-6632</idno><imprint><publisher>Blackwell Publishing Ltd</publisher><pubPlace>Oxford, UK</pubPlace><date type="published" when="2004-12"></date><biblScope unit="volume">1032</biblScope><biblScope unit="issue">1</biblScope><biblScope unit="page" from="52">52</biblScope><biblScope unit="page" to="62">62</biblScope></imprint></monogr><idno type="istex">CDFBF3C6BE150D30B772AACA1337563895414EC1</idno><idno type="DOI">10.1196/annals.1314.005</idno><idno type="ArticleID">NYAS52</idno></biblStruct></sourceDesc></fileDesc><profileDesc><creation><date>2004</date></creation><langUsage><language ident="en">en</language></langUsage><abstract><p>Abstract: From the perspective of psychobiological stress research we present a brief overview of findings documenting a significant impact of genetic factors on the activity of the hypothalamus‐pituitary‐adrenal (HPA) axis. Quantitative genetic studies in twins as well as association studies, primarily on polymorphisms in the glucocorticoid receptor gene, are depicted. Recent findings suggest that the collaboration of psychobiology and molecular genetics is a promising interdisciplinary approach that will significantly contribute to the understanding of the mechanisms underlying the link between stress, the HPA axis, and HPA‐related clinical states.</p></abstract><textClass xml:lang="en"><keywords scheme="keyword"><list><head>keywords</head><item><term>hypothalamus‐pituitary‐adrenal axis</term></item><item><term>HPA</term></item><item><term>stress</term></item><item><term>glucocorticoids</term></item><item><term>genes</term></item><item><term>heritability</term></item><item><term>twins</term></item></list></keywords></textClass></profileDesc><revisionDesc><change when="2004-12">Published</change></revisionDesc></teiHeader></istex:fulltextTEI><json:item><extension>txt</extension><original>false</original><mimetype>text/plain</mimetype><uri>https://api.istex.fr/document/CDFBF3C6BE150D30B772AACA1337563895414EC1/fulltext/txt</uri></json:item></fulltext><metadata><istex:metadataXml wicri:clean="Wiley, elements deleted: body"><istex:xmlDeclaration>version="1.0" encoding="UTF-8" standalone="yes"</istex:xmlDeclaration><istex:document><component version="2.0" type="serialArticle" xml:lang="en"><header><publicationMeta level="product"><publisherInfo><publisherName>Blackwell Publishing Ltd</publisherName><publisherLoc>Oxford, UK</publisherLoc></publisherInfo><doi origin="wiley" registered="yes">10.1111/(ISSN)1749-6632</doi><issn type="print">0077-8923</issn><issn type="electronic">1749-6632</issn><idGroup><id type="product" value="NYAS"></id><id type="publisherDivision" value="ST"></id></idGroup><titleGroup><title type="main" sort="ANNALS OF NEW YORK ACADEMY SCIENCES">Annals of the New York Academy of Sciences</title></titleGroup></publicationMeta><publicationMeta level="part" position="12001"><doi origin="wiley">10.1111/nyas.2004.1032.issue-1</doi><titleGroup><title type="main">Biobehavioral Stress Response: Protective and Damaging Effects</title></titleGroup><numberingGroup><numbering type="journalVolume" number="1032">1032</numbering><numbering type="journalIssue">1</numbering></numberingGroup><coverDate startDate="2004-12">December 2004</coverDate></publicationMeta><publicationMeta level="unit" type="article" position="6" status="forIssue"><doi origin="wiley">10.1196/annals.1314.005</doi><idGroup><id type="unit" value="NYAS52"></id></idGroup><countGroup><count type="pageTotal" number="11"></count></countGroup><titleGroup><title type="tocHeading1">Biobehavioral Stress Response: Protective and Damaging Effects: Part II. Understanding the Effects of Genes on Stress and Stress on Gene Expression over the Course of Development</title></titleGroup><eventGroup><event type="firstOnline" date="2006-01-12"></event><event type="publishedOnlineFinalForm" date="2009-07-08"></event><event type="xmlConverted" agent="Converter:BPG_TO_WML3G version:2.3.2 mode:FullText source:FullText result:FullText" date="2010-02-27"></event><event type="xmlConverted" agent="Converter:WILEY_ML3G_TO_WILEY_ML3GV2 version:4.0.1" date="2014-03-19"></event><event type="xmlConverted" agent="Converter:WML3G_To_WML3G version:4.1.7 mode:FullText,remove_FC" date="2014-10-14"></event></eventGroup><numberingGroup><numbering type="pageFirst" number="52">52</numbering><numbering type="pageLast" number="62">62</numbering></numberingGroup><correspondenceTo>Address for correspondence: Stefan Wüst, Ph.D., Department of Psychobiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany. Voice: +49‐651‐2013688; fax: +49‐651‐2013690. <email normalForm="wuest@uni-trier.de">wuest@uni‐trier.de</email></correspondenceTo><linkGroup><link type="toTypesetVersion" href="file:NYAS.NYAS52.pdf"></link></linkGroup></publicationMeta><contentMeta><countGroup><count type="figureTotal" number="2"></count><count type="tableTotal" number="0"></count><count type="formulaTotal" number="0"></count><count type="referenceTotal" number="74"></count><count type="linksCrossRef" number="78"></count></countGroup><titleGroup><title type="main">A Psychobiological Perspective on Genetic Determinants of Hypothalamus‐Pituitary‐Adrenal Axis Activity</title></titleGroup><creators><creator creatorRole="author" xml:id="cr1" affiliationRef="#a1" corresponding="yes"><personName><givenNames>STEFAN</givenNames><familyName>WÜST</familyName></personName></creator><creator creatorRole="author" xml:id="cr2" affiliationRef="#a1"><personName><givenNames>ILONA S.</givenNames><familyName>FEDERENKO</familyName></personName></creator><creator creatorRole="author" xml:id="cr3" affiliationRef="#a1"><personName><givenNames>ELISABETH F.C.</givenNames><familyNamePrefix>van</familyNamePrefix><familyName>ROSSUM</familyName></personName></creator><creator creatorRole="author" xml:id="cr4" affiliationRef="#a1"><personName><givenNames>JAN W.</givenNames><familyName>KOPER</familyName></personName></creator><creator creatorRole="author" xml:id="cr5" affiliationRef="#a1"><personName><givenNames>ROBERT</givenNames><familyName>KUMSTA</familyName></personName></creator><creator creatorRole="author" xml:id="cr6" affiliationRef="#a1"><personName><givenNames>SONJA</givenNames><familyName>ENTRINGER</familyName></personName></creator><creator creatorRole="author" xml:id="cr7" affiliationRef="#a1"><personName><givenNames>DIRK H.</givenNames><familyName>HELLHAMMER</familyName></personName></creator></creators><affiliationGroup><affiliation xml:id="a1" countryCode="DE"><unparsedAffiliation>Department of Psychobiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany</unparsedAffiliation></affiliation></affiliationGroup><keywordGroup xml:lang="en"><keyword xml:id="k1">hypothalamus‐pituitary‐adrenal axis</keyword><keyword xml:id="k2">HPA</keyword><keyword xml:id="k3">stress</keyword><keyword xml:id="k4">glucocorticoids</keyword><keyword xml:id="k5">genes</keyword><keyword xml:id="k6">heritability</keyword><keyword xml:id="k7">twins</keyword></keywordGroup><abstractGroup><abstract type="main" xml:lang="en"><p><b>A<sc>bstract</sc>: </b> From the perspective of psychobiological stress research we present a brief overview of findings documenting a significant impact of genetic factors on the activity of the hypothalamus‐pituitary‐adrenal (HPA) axis. Quantitative genetic studies in twins as well as association studies, primarily on polymorphisms in the glucocorticoid receptor gene, are depicted. Recent findings suggest that the collaboration of psychobiology and molecular genetics is a promising interdisciplinary approach that will significantly contribute to the understanding of the mechanisms underlying the link between stress, the HPA axis, and HPA‐related clinical states.</p></abstract></abstractGroup></contentMeta></header></component></istex:document></istex:metadataXml><mods version="3.6"><titleInfo lang="en"><title>A Psychobiological Perspective on Genetic Determinants of Hypothalamus‐Pituitary‐Adrenal Axis Activity</title></titleInfo><titleInfo type="alternative" contentType="CDATA" lang="en"><title>A Psychobiological Perspective on Genetic Determinants of Hypothalamus‐Pituitary‐Adrenal Axis Activity</title></titleInfo><name type="personal"><namePart type="given">STEFAN</namePart><namePart type="family">WÜST</namePart><affiliation>Department of Psychobiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany</affiliation><affiliation>E-mail: wuest@uni‐trier.de</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">ILONA S.</namePart><namePart type="family">FEDERENKO</namePart><affiliation>Department of Psychobiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">ELISABETH F.C.</namePart><namePart type="family">van ROSSUM</namePart><affiliation>Department of Psychobiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">JAN W.</namePart><namePart type="family">KOPER</namePart><affiliation>Department of Psychobiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">ROBERT</namePart><namePart type="family">KUMSTA</namePart><affiliation>Department of Psychobiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">SONJA</namePart><namePart type="family">ENTRINGER</namePart><affiliation>Department of Psychobiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><name type="personal"><namePart type="given">DIRK H.</namePart><namePart type="family">HELLHAMMER</namePart><affiliation>Department of Psychobiology, University of Trier, Johanniterufer 15, 54290 Trier, Germany</affiliation><role><roleTerm type="text">author</roleTerm></role></name><typeOfResource>text</typeOfResource><genre type="article" displayLabel="article"></genre><originInfo><publisher>Blackwell Publishing Ltd</publisher><place><placeTerm type="text">Oxford, UK</placeTerm></place><dateIssued encoding="w3cdtf">2004-12</dateIssued><copyrightDate encoding="w3cdtf">2004</copyrightDate></originInfo><language><languageTerm type="code" authority="rfc3066">en</languageTerm><languageTerm type="code" authority="iso639-2b">eng</languageTerm></language><physicalDescription><internetMediaType>text/html</internetMediaType><extent unit="figures">2</extent><extent unit="references">74</extent></physicalDescription><abstract>Abstract: From the perspective of psychobiological stress research we present a brief overview of findings documenting a significant impact of genetic factors on the activity of the hypothalamus‐pituitary‐adrenal (HPA) axis. Quantitative genetic studies in twins as well as association studies, primarily on polymorphisms in the glucocorticoid receptor gene, are depicted. Recent findings suggest that the collaboration of psychobiology and molecular genetics is a promising interdisciplinary approach that will significantly contribute to the understanding of the mechanisms underlying the link between stress, the HPA axis, and HPA‐related clinical states.</abstract><subject lang="en"><genre>keywords</genre><topic>hypothalamus‐pituitary‐adrenal axis</topic><topic>HPA</topic><topic>stress</topic><topic>glucocorticoids</topic><topic>genes</topic><topic>heritability</topic><topic>twins</topic></subject><relatedItem type="host"><titleInfo><title>Annals of the New York Academy of Sciences</title></titleInfo><genre type="journal">journal</genre><identifier type="ISSN">0077-8923</identifier><identifier type="eISSN">1749-6632</identifier><identifier type="DOI">10.1111/(ISSN)1749-6632</identifier><identifier type="PublisherID">NYAS</identifier><part><date>2004</date><detail type="title"><title>Biobehavioral Stress Response: Protective and Damaging Effects</title></detail><detail type="volume"><caption>vol.</caption><number>1032</number></detail><detail type="issue"><caption>no.</caption><number>1</number></detail><extent unit="pages"><start>52</start><end>62</end><total>11</total></extent></part></relatedItem><identifier type="istex">CDFBF3C6BE150D30B772AACA1337563895414EC1</identifier><identifier type="DOI">10.1196/annals.1314.005</identifier><identifier type="ArticleID">NYAS52</identifier><recordInfo><recordContentSource>WILEY</recordContentSource><recordOrigin>Blackwell Publishing Ltd</recordOrigin></recordInfo></mods></metadata><serie></serie></istex></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Rhénanie/explor/UnivTrevesV1/Data/Istex/Corpus
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000F94 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Istex/Corpus/biblio.hfd -nk 000F94 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Rhénanie
|area= UnivTrevesV1
|flux= Istex
|étape= Corpus
|type= RBID
|clé= ISTEX:CDFBF3C6BE150D30B772AACA1337563895414EC1
|texte= A Psychobiological Perspective on Genetic Determinants of Hypothalamus‐Pituitary‐Adrenal Axis Activity
}}
| This area was generated with Dilib version V0.6.31. |  |