Effects of handedness and gender on macro- and microstructure of the corpus callosum and its subregions: a combined high-resolution and diffusion-tensor MRI study.
Identifieur interne : 000726 ( PubMed/Checkpoint ); précédent : 000725; suivant : 000727Effects of handedness and gender on macro- and microstructure of the corpus callosum and its subregions: a combined high-resolution and diffusion-tensor MRI study.
Auteurs : René Westerhausen [Allemagne] ; Frank Kreuder ; Sarah Dos Santos Sequeira ; Christof Walter ; Wolfgang Woerner ; Ralf Arne Wittling ; Elisabeth Schweiger ; Werner WittlingSource :
- Brain research. Cognitive brain research [ 0926-6410 ] ; 2004.
English descriptors
- KwdEn :
- Adult, Analysis of Variance, Anisotropy, Brain Mapping, Corpus Callosum (anatomy & histology), Corpus Callosum (physiology), Diffusion Magnetic Resonance Imaging (methods), Female, Functional Laterality (physiology), Humans, Image Processing, Computer-Assisted (methods), Magnetic Resonance Imaging (methods), Male, Reaction Time (physiology), Sex Characteristics.
- MESH :
- anatomy & histology : Corpus Callosum.
- methods : Diffusion Magnetic Resonance Imaging, Image Processing, Computer-Assisted, Magnetic Resonance Imaging.
- physiology : Corpus Callosum, Functional Laterality, Reaction Time.
- Adult, Analysis of Variance, Anisotropy, Brain Mapping, Female, Humans, Male, Sex Characteristics.
Abstract
The corpus callosum (CC) represents the major commissural tract connecting the two cerebral hemispheres and is supposed to play crucial integrative role in functional hemispheric specialization. The present study examined whether interindividual variations in macro- and microstructure of the human CC are associated with handedness and gender. Therefore, a combined diffusion-tensor (DTI) and high-resolution morphological MRI study was performed on 34 right- and 33 left-handed subjects of both sexes. The mid-sagittal surface areas and quantitative measures of molecular diffusion (relative anisotropy, mean diffusion) of the total CC and its subregions (genu, truncus, posterior third) were determined. Analysis revealed a larger total callosal area in right- as compared to left-handed subjects and in males as compared to females. Throughout all callosal subregions, anisotropy was found to be increased in left-handed as well as in male subjects, while the mean diffusion was diminished only in left-handers. For the posterior third of the CC, a significant negative correlation (r=-0.34) between anisotropy and area was detected in right-handed subjects. Summarized, significant alterations in the molecular diffusion and in the size of the CC with respect to gender and handedness were revealed in the present study. These findings can be interpreted as handedness- and gender-related differences in macro- and microstructure of the callosal pathways. It was demonstrated that the inspection of the callosal microstructure using DTI yields empirical evidence on interhemispheric connectivity that goes well beyond the information revealed by anatomical measurements alone. Thus, DTI has proven to be a useful additional method in cognitive neuroscience.
DOI: 10.1016/j.cogbrainres.2004.07.002
PubMed: 15511657
Affiliations:
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Cognitive brain research</title><idno type="ISSN">0926-6410</idno><imprint><date when="2004" type="published">2004</date></imprint></series></biblStruct></sourceDesc></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Analysis of Variance</term><term>Anisotropy</term><term>Brain Mapping</term><term>Corpus Callosum (anatomy & histology)</term><term>Corpus Callosum (physiology)</term><term>Diffusion Magnetic Resonance Imaging (methods)</term><term>Female</term><term>Functional Laterality (physiology)</term><term>Humans</term><term>Image Processing, Computer-Assisted (methods)</term><term>Magnetic Resonance Imaging (methods)</term><term>Male</term><term>Reaction Time (physiology)</term><term>Sex Characteristics</term></keywords><keywords scheme="MESH" qualifier="anatomy & histology" xml:lang="en"><term>Corpus Callosum</term></keywords><keywords scheme="MESH" qualifier="methods" xml:lang="en"><term>Diffusion Magnetic Resonance Imaging</term><term>Image Processing, Computer-Assisted</term><term>Magnetic Resonance Imaging</term></keywords><keywords scheme="MESH" qualifier="physiology" xml:lang="en"><term>Corpus Callosum</term><term>Functional Laterality</term><term>Reaction Time</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Analysis of Variance</term><term>Anisotropy</term><term>Brain Mapping</term><term>Female</term><term>Humans</term><term>Male</term><term>Sex Characteristics</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">The corpus callosum (CC) represents the major commissural tract connecting the two cerebral hemispheres and is supposed to play crucial integrative role in functional hemispheric specialization. The present study examined whether interindividual variations in macro- and microstructure of the human CC are associated with handedness and gender. Therefore, a combined diffusion-tensor (DTI) and high-resolution morphological MRI study was performed on 34 right- and 33 left-handed subjects of both sexes. The mid-sagittal surface areas and quantitative measures of molecular diffusion (relative anisotropy, mean diffusion) of the total CC and its subregions (genu, truncus, posterior third) were determined. Analysis revealed a larger total callosal area in right- as compared to left-handed subjects and in males as compared to females. Throughout all callosal subregions, anisotropy was found to be increased in left-handed as well as in male subjects, while the mean diffusion was diminished only in left-handers. For the posterior third of the CC, a significant negative correlation (r=-0.34) between anisotropy and area was detected in right-handed subjects. Summarized, significant alterations in the molecular diffusion and in the size of the CC with respect to gender and handedness were revealed in the present study. These findings can be interpreted as handedness- and gender-related differences in macro- and microstructure of the callosal pathways. It was demonstrated that the inspection of the callosal microstructure using DTI yields empirical evidence on interhemispheric connectivity that goes well beyond the information revealed by anatomical measurements alone. Thus, DTI has proven to be a useful additional method in cognitive neuroscience.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">15511657</PMID><DateCreated><Year>2004</Year><Month>10</Month><Day>29</Day></DateCreated><DateCompleted><Year>2005</Year><Month>03</Month><Day>07</Day></DateCompleted><DateRevised><Year>2006</Year><Month>11</Month><Day>15</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Print">0926-6410</ISSN><JournalIssue CitedMedium="Print"><Volume>21</Volume><Issue>3</Issue><PubDate><Year>2004</Year><Month>Nov</Month></PubDate></JournalIssue><Title>Brain research. Cognitive brain research</Title><ISOAbbreviation>Brain Res Cogn Brain Res</ISOAbbreviation></Journal><ArticleTitle>Effects of handedness and gender on macro- and microstructure of the corpus callosum and its subregions: a combined high-resolution and diffusion-tensor MRI study.</ArticleTitle><Pagination><MedlinePgn>418-26</MedlinePgn></Pagination><Abstract><AbstractText>The corpus callosum (CC) represents the major commissural tract connecting the two cerebral hemispheres and is supposed to play crucial integrative role in functional hemispheric specialization. The present study examined whether interindividual variations in macro- and microstructure of the human CC are associated with handedness and gender. Therefore, a combined diffusion-tensor (DTI) and high-resolution morphological MRI study was performed on 34 right- and 33 left-handed subjects of both sexes. The mid-sagittal surface areas and quantitative measures of molecular diffusion (relative anisotropy, mean diffusion) of the total CC and its subregions (genu, truncus, posterior third) were determined. Analysis revealed a larger total callosal area in right- as compared to left-handed subjects and in males as compared to females. Throughout all callosal subregions, anisotropy was found to be increased in left-handed as well as in male subjects, while the mean diffusion was diminished only in left-handers. For the posterior third of the CC, a significant negative correlation (r=-0.34) between anisotropy and area was detected in right-handed subjects. Summarized, significant alterations in the molecular diffusion and in the size of the CC with respect to gender and handedness were revealed in the present study. These findings can be interpreted as handedness- and gender-related differences in macro- and microstructure of the callosal pathways. It was demonstrated that the inspection of the callosal microstructure using DTI yields empirical evidence on interhemispheric connectivity that goes well beyond the information revealed by anatomical measurements alone. Thus, DTI has proven to be a useful additional method in cognitive neuroscience.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Westerhausen</LastName><ForeName>René</ForeName><Initials>R</Initials><AffiliationInfo><Affiliation>Center for Neuropsychological Research, University of Trier, Johanniterufer 15, D-54290 Trier, Germany. westerhausen@znf.uni-trier.de</Affiliation></AffiliationInfo></Author><Author ValidYN="Y"><LastName>Kreuder</LastName><ForeName>Frank</ForeName><Initials>F</Initials></Author><Author ValidYN="Y"><LastName>Dos Santos Sequeira</LastName><ForeName>Sarah</ForeName><Initials>S</Initials></Author><Author ValidYN="Y"><LastName>Walter</LastName><ForeName>Christof</ForeName><Initials>C</Initials></Author><Author ValidYN="Y"><LastName>Woerner</LastName><ForeName>Wolfgang</ForeName><Initials>W</Initials></Author><Author ValidYN="Y"><LastName>Wittling</LastName><ForeName>Ralf Arne</ForeName><Initials>RA</Initials></Author><Author ValidYN="Y"><LastName>Schweiger</LastName><ForeName>Elisabeth</ForeName><Initials>E</Initials></Author><Author ValidYN="Y"><LastName>Wittling</LastName><ForeName>Werner</ForeName><Initials>W</Initials></Author></AuthorList><Language>eng</Language><PublicationTypeList><PublicationType UI="D003160">Comparative Study</PublicationType><PublicationType UI="D016428">Journal Article</PublicationType><PublicationType UI="D013485">Research Support, Non-U.S. Gov't</PublicationType></PublicationTypeList></Article><MedlineJournalInfo><Country>Netherlands</Country><MedlineTA>Brain Res Cogn Brain Res</MedlineTA><NlmUniqueID>9214304</NlmUniqueID><ISSNLinking>0926-6410</ISSNLinking></MedlineJournalInfo><CitationSubset>IM</CitationSubset><MeshHeadingList><MeshHeading><DescriptorName UI="D000328" MajorTopicYN="N">Adult</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D000704" MajorTopicYN="N">Analysis of Variance</DescriptorName></MeshHeading><MeshHeading><DescriptorName UI="D016880" 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PubStatus="pubmed"><Year>2004</Year><Month>10</Month><Day>30</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="medline"><Year>2005</Year><Month>3</Month><Day>8</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate><PubMedPubDate PubStatus="entrez"><Year>2004</Year><Month>10</Month><Day>30</Day><Hour>9</Hour><Minute>0</Minute></PubMedPubDate></History><PublicationStatus>ppublish</PublicationStatus><ArticleIdList><ArticleId IdType="pubmed">15511657</ArticleId><ArticleId IdType="pii">S0926-6410(04)00190-9</ArticleId><ArticleId IdType="doi">10.1016/j.cogbrainres.2004.07.002</ArticleId></ArticleIdList></PubmedData></pubmed><affiliations><list><country><li>Allemagne</li></country><region><li>Rhénanie-Palatinat</li></region><settlement><li>Trèves (Allemagne)</li></settlement><orgName><li>Université de Trèves</li></orgName></list><tree><noCountry><name sortKey="Dos Santos Sequeira, Sarah" sort="Dos Santos Sequeira, Sarah" uniqKey="Dos Santos Sequeira S" first="Sarah" last="Dos Santos Sequeira">Sarah Dos Santos Sequeira</name><name sortKey="Kreuder, Frank" sort="Kreuder, Frank" uniqKey="Kreuder F" first="Frank" last="Kreuder">Frank Kreuder</name><name sortKey="Schweiger, Elisabeth" sort="Schweiger, Elisabeth" uniqKey="Schweiger E" first="Elisabeth" last="Schweiger">Elisabeth Schweiger</name><name sortKey="Walter, Christof" sort="Walter, Christof" uniqKey="Walter C" first="Christof" last="Walter">Christof Walter</name><name sortKey="Wittling, Ralf Arne" sort="Wittling, Ralf Arne" uniqKey="Wittling R" first="Ralf Arne" last="Wittling">Ralf Arne Wittling</name><name sortKey="Wittling, Werner" sort="Wittling, Werner" uniqKey="Wittling W" first="Werner" last="Wittling">Werner Wittling</name><name sortKey="Woerner, Wolfgang" sort="Woerner, Wolfgang" uniqKey="Woerner W" first="Wolfgang" last="Woerner">Wolfgang Woerner</name></noCountry><country name="Allemagne"><region name="Rhénanie-Palatinat"><name sortKey="Westerhausen, Rene" 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