| Ident. | Authors (with country if any) | Title |
|---|
| 000014 (2020) |
Shan Ying [Canada] ; Denys A. Khaperskyy [Canada] | UV damage induces G3BP1-dependent stress granule formation that is not driven by mTOR inhibition-mediated translation arrest. |
| 000016 (2020) |
Elizabeth K. Brauer [Canada] ; Nimrat Manes [Canada] ; Christopher Bonner [Canada] ; Rajagopal Subramaniam [Canada] | Two 14-3-3 proteins contribute to nitrogen sensing through the TOR and glutamine synthetase-dependent pathways in Fusarium graminearum. |
| 000044 (2020) |
Jie Zeng [Canada] ; Nhan Huynh [Canada] ; Brian Phelps [Canada] ; Kirst King-Jones [Canada] | Snail synchronizes endocycling in a TOR-dependent manner to coordinate entry and escape from endoreplication pausing during the Drosophila critical weight checkpoint. |
| 000114 (2020) |
Sarah A. Cook [États-Unis] ; William A. Comrie [États-Unis] ; M Cecilia Poli [États-Unis, Chili] ; Morgan Similuk [États-Unis] ; Andrew J. Oler [États-Unis] ; Aiman J. Faruqi [États-Unis] ; Douglas B. Kuhns [États-Unis] ; Sheng Yang [États-Unis] ; Alexander Vargas-Hernández [États-Unis] ; Alexandre F. Carisey [États-Unis] ; Benjamin Fournier [France] ; D Eric Anderson [États-Unis] ; Susan Price [États-Unis] ; Margery Smelkinson [États-Unis] ; Wadih Abou Chahla [France] ; Lisa R. Forbes [États-Unis] ; Emily M. Mace [États-Unis] ; Tram N. Cao [États-Unis] ; Zeynep H. Coban-Akdemir [États-Unis] ; Shalini N. Jhangiani [États-Unis] ; Donna M. Muzny [États-Unis] ; Richard A. Gibbs [États-Unis] ; James R. Lupski [États-Unis] ; Jordan S. Orange [États-Unis] ; Geoffrey D E. Cuvelier [Canada] ; Moza Al Hassani [Émirats arabes unis] ; Nawal Al Kaabi [Émirats arabes unis] ; Zain Al Yafei [Émirats arabes unis] ; Soma Jyonouchi [États-Unis] ; Nikita Raje [États-Unis] ; Jason W. Caldwell [États-Unis] ; Yanping Huang [États-Unis] ; Janis K. Burkhardt [États-Unis] ; Sylvain Latour [France] ; Baoyu Chen [États-Unis] ; Gehad Elghazali [Émirats arabes unis] ; V Koneti Rao [États-Unis] ; Ivan K. Chinn [États-Unis] ; Michael J. Lenardo [États-Unis] | HEM1 deficiency disrupts mTORC2 and F-actin control in inherited immunodysregulatory disease. |
| 000120 (2020) |
David Dilworth [Canada] ; Fade Gong [États-Unis] ; Kyle Miller [États-Unis] ; Christopher J. Nelson [Canada] | FKBP25 participates in DNA double-strand break repair. |
| 000147 (2020) |
Affan Ali Sher [Canada] ; Ang Gao [Canada] ; Kevin M. Coombs [Canada] | Autophagy Modulators Profoundly Alter the Astrocyte Cellular Proteome. |
| 000186 (2019) |
Mirtha William [Canada] ; Louis-Philippe Leroux [Canada] ; Visnu Chaparro [Canada] ; Tyson E. Graber [Canada] ; Tommy Alain [Canada] ; Maritza Jaramillo [Canada] | Translational repression of Ccl5 and Cxcl10 by 4E-BP1 and 4E-BP2 restrains the ability of mouse macrophages to induce migration of activated T cells. |
| 000195 (2019) |
Mengnan Xu [République populaire de Chine] ; Shekoufeh Almasi [Canada] ; Yiming Yang [Canada] ; Chi Yan [Canada] ; Andra Mihaela Sterea [Canada] ; Alia Kazim Rizvi Syeda [Canada] ; Bing Shen [République populaire de Chine] ; Clements Richard Derek [Canada] ; Peng Huang [République populaire de Chine] ; Shashi Gujar [Canada] ; Jun Wang [Canada] ; Wei-Xing Zong [États-Unis] ; Mohamed Trebak [États-Unis] ; Yassine El Hiani [Canada] ; Xian-Ping Dong [République populaire de Chine] | The lysosomal TRPML1 channel regulates triple negative breast cancer development by promoting mTORC1 and purinergic signaling pathways. |
| 000205 (2019) |
Han Dong [États-Unis] ; Nicholas M. Adams [États-Unis] ; Yichi Xu [États-Unis] ; Jin Cao [États-Unis] ; David S J. Allan [États-Unis] ; James R. Carlyle [Canada] ; Xi Chen [États-Unis] ; Joseph C. Sun [États-Unis] ; Laurie H. Glimcher [États-Unis] | The IRE1 endoplasmic reticulum stress sensor activates natural killer cell immunity in part by regulating c-Myc. |
| 000210 (2019) |
Khashayar Esfahani [Canada] ; Tho-Alfakar Al-Aubodah [Canada] ; Pamela Thebault [Canada] ; Réjean Lapointe [Canada] ; Marie Hudson [Canada] ; Nathalie A. Johnson [Canada] ; Dana Baran [Canada] ; Najwa Bhulaiga [Canada] ; Tomoko Takano [Canada] ; Jean-François Cailhier [Canada] ; Ciriaco A. Piccirillo [Canada] ; Wilson H. Miller [Canada] | Targeting the mTOR pathway uncouples the efficacy and toxicity of PD-1 blockade in renal transplantation. |
| 000239 (2019) |
Yuwei Jiang [Canada] ; Matthew D. Berg [Canada] ; Julie Genereaux [Canada] ; Khadija Ahmed [Canada] ; Martin L. Duennwald [Canada] ; Christopher J. Brandl [Canada] ; Patrick Lajoie [Canada] | Sfp1 links TORC1 and cell growth regulation to the yeast SAGA-complex component Tra1 in response to polyQ proteotoxicity. |
| 000283 (2019) |
Zoe E. Gillespie [Canada] ; Chenxuan Wang [Canada] ; Flaviu Vadan [Canada] ; Topaza Y. Yu [Canada] ; Juan Ausi [Canada] ; Anthony Kusalik [Canada] ; Christopher H. Eskiw [Canada] | Metformin induces the AP-1 transcription factor network in normal dermal fibroblasts. |
| 000303 (2019) |
Visnu Chaparro [Canada] ; Louis-Philippe Leroux [Canada] ; Aude Zimmermann [Canada] ; Armando Jardim [Canada] ; Brent Johnston [Canada] ; Albert Descoteaux [Canada] ; Maritza Jaramillo [Canada] | Leishmania donovani Lipophosphoglycan Increases Macrophage-Dependent Chemotaxis of CXCR6-Expressing Cells via CXCL16 Induction. |
| 000307 (2019) |
Eric S. Pringle [Canada] ; Carolyn-Ann Robinson [Canada] ; Craig Mccormick [Canada] | Kaposi's Sarcoma-Associated Herpesvirus Lytic Replication Interferes with mTORC1 Regulation of Autophagy and Viral Protein Synthesis. |
| 000311 (2019) |
Julie Parenteau [Canada] ; Laurine Maignon [Canada] ; Mélodie Berthoumieux [Canada] ; Mathieu Catala [Canada] ; Vanessa Gagnon [Canada] ; Sherif Abou Elela [Canada] | Introns are mediators of cell response to starvation. |
| 000312 (2019) |
Saeedah Musaed Almutairi [Canada, Arabie saoudite] ; Alaa Kassim Ali [Canada] ; William He [Canada] ; Doo-Seok Yang [Canada] ; Peyman Ghorbani [Canada] ; Lisheng Wang [Canada] ; Morgan D. Fullerton [Canada] ; Seung-Hwan Lee [Canada] | Interleukin-18 up-regulates amino acid transporters and facilitates amino acid-induced mTORC1 activation in natural killer cells. |
| 000317 (2019) |
Ali Zahedi-Amiri [Canada] ; Glen L. Sequiera [Canada] ; Sanjiv Dhingra [Canada] ; Kevin M. Coombs [Canada] | Influenza a virus-triggered autophagy decreases the pluripotency of human-induced pluripotent stem cells. |
| 000319 (2019) |
Yasbanoo Moayedi [Canada] ; Carlos A. Gomez [États-Unis] ; Chun Po S. Fan [Canada] ; Robert J H. Miller [États-Unis] ; Paul E. Bunce [Canada] ; Maxime Tremblay-Gravel [États-Unis] ; Farid Foroutan [Canada] ; Cedric Manlhiot [Canada] ; James Yee [États-Unis] ; Michael A. Shullo [États-Unis] ; Kiran K. Khush [États-Unis] ; Heather J. Ross [Canada] ; Jose G. Montoya [États-Unis] ; Jeffrey J. Teuteberg [États-Unis] | Infectious complications after heart transplantation in patients screened with gene expression profiling. |
| 000325 (2019) |
David C. Fajgenbaum ; Ruth-Anne Langan ; Alberto Sada Japp [États-Unis] ; Helen L. Partridge ; Sheila K. Pierson ; Amrit Singh [Canada] ; Daniel J. Arenas ; Jason R. Ruth [États-Unis] ; Christopher S. Nabel [États-Unis] ; Katie Stone [États-Unis] ; Mariko Okumura [États-Unis] ; Anthony Schwarer [Australie] ; Fábio Freire Jose ; Nelson Hamerschlak [Brésil] ; Gerald B. Wertheim [États-Unis] ; Michael B. Jordan [États-Unis] ; Adam D. Cohen [États-Unis] ; Vera Krymskaya ; Arthur Rubenstein ; Michael R. Betts [États-Unis] ; Taku Kambayashi [États-Unis] ; Frits Van Rhee [États-Unis] ; Thomas S. Uldrick [États-Unis] | Identifying and targeting pathogenic PI3K/AKT/mTOR signaling in IL-6-blockade-refractory idiopathic multicentric Castleman disease. |
| 000329 (2019) |
Khadija Ahmed [Canada] ; David E. Carter [Canada] ; Patrick Lajoie [Canada] | Hyperactive TORC1 sensitizes yeast cells to endoplasmic reticulum stress by compromising cell wall integrity. |
| 000337 (2019) |
Tanveer Sharif [Canada] ; Emma Martell [Canada] ; Cathleen Dai [Canada] ; Mohammad Saleh Ghassemi-Rad [Canada] ; Mark Robert Hanes [Canada] ; Patrick J. Murphy [Canada] ; Nandini N. Margam [Canada] ; Hirendrasinh B. Parmar [Canada] ; Carman A. Giacomantonio [Canada] ; Roy Duncan [Canada] ; Patrick W K. Lee [Canada] ; Shashi Gujar [Canada] | HDAC6 differentially regulates autophagy in stem-like versus differentiated cancer cells. |
| 000338 (2019) |
Christopher Mogg [Canada] ; Christopher Bonner [Canada] ; Li Wang [Canada] ; Johann Schernthaner [Canada] ; Myron Smith [Canada] ; Darrell Desveaux [Canada] ; Rajagopal Subramaniam [Canada] | Genomic Identification of the TOR Signaling Pathway as a Target of the Plant Alkaloid Antofine in the Phytopathogen Fusarium graminearum. |
| 000354 (2019) |
Jean-Pierre Routy [Canada] ; Stéphane Isnard [Canada] ; Vikram Mehraj [Canada] ; Mario Ostrowski [Canada] ; Nicolas Chomont [Canada] ; Petronela Ancuta [Canada] ; Rosalie Ponte [Canada] ; Delphine Planas [Canada] ; Franck P. Dupuy [Canada] ; Jonathan B. Angel [Canada] | Effect of metformin on the size of the HIV reservoir in non-diabetic ART-treated individuals: single-arm non-randomised Lilac pilot study protocol. |
| 000360 (2019) |
Kara M. Ruicci [Canada] ; Paul Plantinga [Canada] ; Nicole Pinto [Canada] ; Mohammed I. Khan [Canada] ; William Stecho [Canada] ; Sandeep S. Dhaliwal [Canada] ; John Yoo [Canada] ; Kevin Fung [Canada] ; Danielle Macneil [Canada] ; Joe S. Mymryk [Canada] ; John W. Barrett [Canada] ; Christopher J. Howlett [Canada] ; Anthony C. Nichols [Canada] | Disruption of the RICTOR/mTORC2 complex enhances the response of head and neck squamous cell carcinoma cells to PI3K inhibition. |
| 000373 (2019) |
Patricia Lakin-Thomas [Canada] | Circadian rhythms, metabolic oscillators, and the target of rapamycin (TOR) pathway: the Neurospora connection. |
| 000396 (2019) |
Truc T. Losier [Canada] ; Mercy Akuma [Canada] ; Olivia C. Mckee-Muir [Canada] ; Nicholas D. Leblond [Canada] ; Yujin Suk [Canada] ; Reham M. Alsaadi [Canada] ; Zhihao Guo [Canada] ; Ryan Reshke [Canada] ; Subash Sad [Canada] ; François-Xavier Campbell-Valois [Canada] ; Derrick J. Gibbings [Canada] ; Morgan D. Fullerton [Canada] ; Ryan C. Russell [Canada] | AMPK Promotes Xenophagy through Priming of Autophagic Kinases upon Detection of Bacterial Outer Membrane Vesicles. |
| 000410 (2019) |
Angela C. Zhou [Canada] ; Nathália V. Batista [Canada] ; Tania H. Watts [Canada] | 4-1BB Regulates Effector CD8 T Cell Accumulation in the Lung Tissue through a TRAF1-, mTOR-, and Antigen-Dependent Mechanism to Enhance Tissue-Resident Memory T Cell Formation during Respiratory Influenza Infection. |
| 000411 (2019) |
Denise Rageot [Suisse] ; Thomas Bohnacker [Suisse] ; Erhan Keles [Suisse] ; Jacob A. Mcphail [Canada] ; Reece M. Hoffmann [Canada] ; Anna Melone [Suisse] ; Chiara Borsari [Suisse] ; Rohitha Sriramaratnam [Suisse] ; Alexander M. Sele [Suisse] ; Florent Beaufils [Suisse] ; Paul Hebeisen [Suisse] ; Doriano Fabbro [Suisse] ; Petra Hillmann [Suisse] ; John E. Burke [Canada] ; Matthias P. Wymann [Suisse] | (S)-4-(Difluoromethyl)-5-(4-(3-methylmorpholino)-6-morpholino-1,3,5-triazin-2-yl)pyridin-2-amine (PQR530), a Potent, Orally Bioavailable, and Brain-Penetrable Dual Inhibitor of Class I PI3K and mTOR Kinase. |
| 000433 (2018) |
Laura Hulea [Canada] ; Simon-Pierre Gravel [Canada] ; Masahiro Morita [Japon] ; Marie Cargnello [France] ; Oro Uchenunu [Canada] ; Young Kyuen Im [Canada] ; Camille Lehuédé [Canada] ; Eric H. Ma [Canada] ; Matthew Leibovitch [Canada] ; Shannon Mclaughlan [Canada] ; Marie-José Blouin [Canada] ; Maxime Parisotto [Canada] ; Vasilios Papavasiliou [Canada] ; Cynthia Lavoie [Canada] ; Ola Larsson [Suède] ; Michael Ohh [Canada] ; Tiago Ferreira [Canada] ; Celia Greenwood [Canada] ; Gaëlle Bridon [Canada] ; Daina Avizonis [Canada] ; Gerardo Ferbeyre [Canada] ; Peter Siegel [Canada] ; Russell G. Jones [Canada] ; William Muller [Canada] ; Josie Ursini-Siegel [Canada] ; Julie St-Pierre [Canada] ; Michael Pollak [Canada] ; Ivan Topisirovic [Canada] | Translational and HIF-1α-Dependent Metabolic Reprogramming Underpin Metabolic Plasticity and Responses to Kinase Inhibitors and Biguanides. |
| 000441 (2018) |
Fatemeh Khadir [Iran, Canada] ; Christopher R. Shaler [Canada] ; Ahmad Oryan [Iran] ; Patrick T. Rudak [Canada] ; Delfina M. Mazzuca [Canada] ; Tahereh Taheri [Iran] ; Jimmy D. Dikeakos [Canada] ; S M Mansour Haeryfar [Canada] ; Sima Rafati [Iran] | Therapeutic control of leishmaniasis by inhibitors of the mammalian target of rapamycin. |
| 000446 (2018) |
David S. Hui [Hong Kong] ; Nelson Lee [Canada] ; Paul K. Chan [Hong Kong] ; John H. Beigel [États-Unis] | The role of adjuvant immunomodulatory agents for treatment of severe influenza. |
| 000461 (2018) |
Louis-Philippe Leroux [Canada] ; Julie Lorent [Suède] ; Tyson E. Graber [Canada] ; Visnu Chaparro [Canada] ; Laia Masvidal [Suède] ; Maria Aguirre [Canada] ; Bruno D. Fonseca [Canada] ; Léon C. Van Kempen [Canada, Pays-Bas] ; Tommy Alain [Canada] ; Ola Larsson [Suède] ; Maritza Jaramillo [Canada] | The Protozoan Parasite Toxoplasma gondii Selectively Reprograms the Host Cell Translatome. |
| 000476 (2018) |
Shekoufeh Almasi ; Barry E. Kennedy ; Mariam El-Aghil ; Andra M. Sterea ; Shashi Gujar [Canada] ; Santiago Partida-Sánchez [États-Unis] ; Yassine El Hiani [Canada] | TRPM2 channel-mediated regulation of autophagy maintains mitochondrial function and promotes gastric cancer cell survival via the JNK-signaling pathway. |
| 000506 (2018) |
Elizabeth I. Vink [États-Unis] ; Sora Lee [États-Unis] ; James R. Smiley [Canada] ; Ian Mohr [États-Unis] | Remodeling mTORC1 Responsiveness to Amino Acids by the Herpes Simplex Virus UL46 and Us3 Gene Products Supports Replication during Nutrient Insufficiency. |
| 000512 (2018) |
Julie Barsalou [Canada] ; Annaliesse Blincoe [Canada] ; Isabel Fernandez [Canada] ; Dorothée Dal-Soglio [Canada] ; Lorie Marchitto [Canada] ; Silvia Selleri [Canada] ; Elie Haddad [Canada] ; Aissa Benyoucef [Canada] ; Fabien Touzot [Canada] | Rapamycin as an Adjunctive Therapy for NLRC4 Associated Macrophage Activation Syndrome. |
| 000539 (2018) |
Gabriel Castro-Falc N [États-Unis] ; Grant S. Seiler [États-Unis] ; Özlem Demir [États-Unis] ; Manoj K. Rathinaswamy [Canada] ; David Hamelin [Canada] ; Reece M. Hoffmann [Canada] ; Stefanie L. Makowski [États-Unis] ; Anne-Catrin Letzel [États-Unis] ; Seth J. Field [États-Unis] ; John E. Burke [Canada] ; Rommie E. Amaro [États-Unis] ; Chambers C. Hughes [États-Unis] | Neolymphostin A Is a Covalent Phosphoinositide 3-Kinase (PI3K)/Mammalian Target of Rapamycin (mTOR) Dual Inhibitor That Employs an Unusual Electrophilic Vinylogous Ester. |
| 000611 (2018) |
Chao Wang [Canada] ; Maria I. Edilova [Canada] ; Lisa E. Wagar [Canada] ; Shariq Mujib [Canada] ; Meromit Singer [États-Unis] ; Nicole F. Bernard [Canada] ; Thérèse Croughs [France] ; Michael M. Lederman [États-Unis] ; Irini Sereti [États-Unis] ; Margaret A. Fischl [États-Unis] ; Elisabeth Kremmer [Allemagne] ; Mario Ostrowski [Canada] ; Jean-Pierre Routy [Canada] ; Tania H. Watts [Canada] | Effect of IL-7 Therapy on Phospho-Ribosomal Protein S6 and TRAF1 Expression in HIV-Specific CD8 T Cells in Patients Receiving Antiretroviral Therapy. |
| 000613 (2018) |
Kara M. Ruicci [Canada] ; Nicole Pinto [Canada] ; Mohammed I. Khan [Canada] ; John Yoo [Canada] ; Kevin Fung [Canada] ; Danielle Macneil [Canada] ; Joe S. Mymryk [Canada] ; John W. Barrett [Canada] ; Anthony C. Nichols [Canada] | ERK-TSC2 signalling in constitutively-active HRAS mutant HNSCC cells promotes resistance to PI3K inhibition. |
| 000619 (2018) |
Denise Rageot [Suisse] ; Thomas Bohnacker [Suisse] ; Anna Melone [Suisse] ; Jean-Baptiste Langlois [Suisse] ; Chiara Borsari [Suisse] ; Petra Hillmann [Suisse] ; Alexander M. Sele [Suisse] ; Florent Beaufils [Suisse] ; Marketa Zvelebil [Suisse] ; Paul Hebeisen [Suisse] ; Wolfgang Löscher [Allemagne] ; John Burke [Canada] ; Doriano Fabbro [Suisse] ; Matthias P. Wymann [Suisse] | Discovery and Preclinical Characterization of 5-[4,6-Bis({3-oxa-8-azabicyclo[3.2.1]octan-8-yl})-1,3,5-triazin-2-yl]-4-(difluoromethyl)pyridin-2-amine (PQR620), a Highly Potent and Selective mTORC1/2 Inhibitor for Cancer and Neurological Disorders. |
| 000628 (2018) |
Sneha A. Thomas [Canada] ; Devki Nandan [Canada] ; Jennifer Kass [Canada] ; Neil E. Reiner [Canada] | Countervailing, time-dependent effects on host autophagy promotes intracellular survival of Leishmania. |
| 000629 (2018) |
Iva Lu I [Autriche] ; Manoj K. Rathinaswamy [Canada] ; Linda Truebestein [Autriche] ; David J. Hamelin [Canada] ; John E. Burke [Canada] ; Thomas A. Leonard [Autriche] | Conformational sampling of membranes by Akt controls its activation and inactivation. |
| 000631 (2018) |
Charlene Ranadheera [Canada] ; Kevin M. Coombs [Canada] ; Darwyn Kobasa [Canada] | Comprehending a Killer: The Akt/mTOR Signaling Pathways Are Temporally High-Jacked by the Highly Pathogenic 1918 Influenza Virus. |
| 000634 (2018) |
Andrew Sulaiman [Canada, République populaire de Chine] ; Sarah Mcgarry [Canada] ; Ka Mien Lam [Canada] ; Sara El-Sahli [Canada] ; Jason Chambers [Canada] ; Shelby Kaczmarek [Canada] ; Li Li [Canada, République populaire de Chine] ; Christina Addison [Canada] ; Jim Dimitroulakos [Canada] ; Angel Arnaout [Canada] ; Carolyn Nessim [Canada] ; Zemin Yao [Canada, République populaire de Chine] ; Guang Ji [Canada, République populaire de Chine] ; Haiyan Song [Canada, République populaire de Chine] ; Sheng Liu [République populaire de Chine] ; Ying Xie [République populaire de Chine] ; Suresh Gadde [Canada] ; Xuguang Li [Canada] ; Lisheng Wang [Canada, République populaire de Chine] | Co-inhibition of mTORC1, HDAC and ESR1α retards the growth of triple-negative breast cancer and suppresses cancer stem cells. |
| 000637 (2018) |
Bram Stynen [Canada] ; Diala Abd-Rabbo [Canada] ; Jacqueline Kowarzyk [Canada] ; Leonor Miller-Fleming [Royaume-Uni] ; Simran Kaur Aulakh [Royaume-Uni] ; Philippe Garneau [Canada] ; Markus Ralser [Allemagne] ; Stephen W. Michnick [Canada] | Changes of Cell Biochemical States Are Revealed in Protein Homomeric Complex Dynamics. |
| 000644 (2018) |
Shima Shahbaz [Canada] ; Najmeh Bozorgmehr [Canada] ; Petya Koleva [Canada] ; Afshin Namdar [Canada] ; Juan Jovel [Canada] ; Roy A. Fava [États-Unis] ; Shokrollah Elahi [Canada] | CD71+VISTA+ erythroid cells promote the development and function of regulatory T cells through TGF-β. |
| 000647 (2018) |
Huy-Dung Hoang [Canada] ; Tyson E. Graber [Canada] ; Tommy Alain [Canada] | Battling for Ribosomes: Translational Control at the Forefront of the Antiviral Response. |
| 000665 (2018) |
Chadi Zakaria [Canada] ; Polen Sean [Canada] ; Huy-Dung Hoang [Canada] ; Louis-Phillipe Leroux [Canada] ; Margaret Watson [Canada] ; Samuel Tekeste Workenhe [Canada] ; Jaclyn Hearnden [Canada] ; Dana Pearl [Canada] ; Vinh Tai Truong [Canada] ; Nathaniel Robichaud [Canada] ; Akiko Yanagiya [Canada] ; Soroush Tahmasebi [Canada] ; Seyed Mehdi Jafarnejad [Canada] ; Jian-Jun Jia [Canada] ; Adrian Pelin [Canada] ; Jean-Simon Diallo [Canada] ; Fabrice Le Boeuf [Canada] ; John Cameron Bell [Canada] ; Karen Louise Mossman [Canada] ; Tyson Ernst Graber [Canada] ; Maritza Jaramillo [Canada] ; Nahum Sonenberg [Canada] ; Tommy Alain [Canada] | Active-site mTOR inhibitors augment HSV1-dICP0 infection in cancer cells via dysregulated eIF4E/4E-BP axis. |
| 000676 (2018) |
Lalanthi Ratnayake [Canada] ; Keyur K. Adhvaryu [Canada] ; Elizabeth Kafes [Canada] ; Kamyar Motavaze [Canada] ; Patricia Lakin-Thomas [Canada] | A component of the TOR (Target Of Rapamycin) nutrient-sensing pathway plays a role in circadian rhythmicity in Neurospora crassa. |
| 000685 (2017) |
Walaa Eid [Canada] ; Kristin Dauner [Canada] ; Kevin C. Courtney [Canada] ; Annemarie Gagnon [Canada] ; Robin J. Parks [Canada] ; Alexander Sorisky [Canada] ; Xiaohui Zha [Canada] | mTORC1 activates SREBP-2 by suppressing cholesterol trafficking to lysosomes in mammalian cells. |
| 000688 (2017) |
Kristin Dauner ; Walaa Eid [Canada] ; Riya Raghupathy ; John F. Presley [Canada] ; Xiaohui Zha [Canada] | mTOR complex 1 activity is required to maintain the canonical endocytic recycling pathway against lysosomal delivery. |
| 000736 (2017) |
Adam G. Peres [Canada] ; Robert Zamboni [Canada] ; Irah L. King [Canada] ; Joaquín Madrenas [Canada, États-Unis] | Suppression of CYP1 members of the AHR response by pathogen-associated molecular patterns. |
