Serveur d'exploration sur la rapamycine et les champignons - Exploration (Accueil)

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Les termes de plus forte occurence

1836rapamycin
1271cells
1222cell
1208target
1172protein
1002these
889results
882signaling
872pathway
818kinase
783growth
781here
748also
744yeast
730expression
692but
690role
687response
679induced
663complex
646activity
631were
631mtor
607both
601tor
598dependent
594study
592mammalian
588activation
581treatment
577however
572associated
553inhibition
538cellular
530show
530regulation
527proteins
520function
508through
504human
504autophagy
499mediated
482increased
476gene
466pathways
461cerevisiae
460may
448infection
445saccharomyces
435factor
434control
419genes
416during
415including
404specific
404other
399found
394inhibitor
389mechanism
389important
387mechanisms
385required
380transcription
378via
377effects
374levels
360torc
360suggest
358activated
357stress
357phosphorylation
354after
352virus
350involved
349nutrient
347data
345regulated
341well
341effect
338regulates
334conserved
330type
330related
325reduced
320analysis
315studies
315showed
314thus
311known
311functions
309identified
308novel
308findings
306binding
304addition
298model
295conditions
289under
287demonstrate
285acid
284when
284induction
283responses
282akt
281survival
281drug
280mtorc
277sensitive
274high
273cancer
271potential
271essential
268patients
266proliferation
265factors
262regulator
261further
260report
260different
257immune
257disease
256key
256furthermore
256amino
255methods
254metabolism
252than
252development
251regulatory
251inhibited
247vitro
245several
245new
245molecular
243while
241only
240inhibitors
238vivo
238observed
237membrane
237all
236plays
236although
235intracellular
234significantly
233revealed
233increase
232regulate
231starvation
231production
230viral
229synthesis
229most
228suggesting
228process
228like
227against
226many
226could
224major
223resistance
223decreased
221upon
221together
220genetic
219therapeutic
219present
219host
218demonstrated
217anti
216formation
211treated
210mutant
208therapy
208targets
208enhanced
208downstream
206processes
204receptor
204cycle
203provide
203inhibits
203independent
201nitrogen
200signal
200previously
200infected
200critical
199tumor
199level
198changes
196mice
195highly
194whereas
194system
194metabolic
194mechanistic
193kinases
193background
191shown
189multiple
189eukaryotic
189dna
188moreover
187roles
187functional
186induces
186distinct
184first
182rna
182clinical
181recent
181evidence
180replication
180nuclear
180deletion
179degradation
179controls
179complexes
178conclusions
177various
177conclusion
176therefore
176compared
175immunosuppressive
174mutants
174inhibit
173transplantation
173indicate
172presence
171within
171components
169transcriptional
168translation
168investigated
167small
167death
166unknown
163regulating
163promotes
163did
162transplant
162induce
162family
162drugs
161similar
160phosphatase
160contrast
158three
157interaction
156negative
156manner
155understood
155remains
155non
155diseases
155apoptosis
154number
154identify
154due
153primary
152review
152had
150signals
150domain
149significant
149localization
148normal
148central
146requires
146mutations
145whether
145loss
145early
143time
142wild
141mrna
140targeting
140species
139ribosomal
139low
139homeostasis
139active
139ability
138respectively
138resistant
138progression
138positive
138either
138autophagic
137sensitivity
137recently
137containing
137caused
136sirolimus
136mitochondrial
136following
135reported
135accumulation
134causes
133understanding
133underlying
133single
133direct
133cause
132budding
131leads
131interactions
130indicating
130increases
129promote
128reveal
128long
127play
127phase
127nutrients
127higher
127effector
127because
126suppression
125strains
125approach
125agents
124inhibiting
124form
123taken
123mouse
123genome
123finally
122without
122leading
122large
122inflammatory
122developed
122activator
121directly
121component
119subunit
119phosphatidylinositol
119atg
119acids
118part
118differentiation
117there
117signalling
117repression
116inactivation
115those
115initiation
115effective
115availability
114strain
114common
113recipients
113controlled
113characterized
113activates
112renal
112glucose
112down
112does
112activities
111site
111reduction
111overexpression
111absence
110derived
110combination
110association
108suppressed
108specifically
108impaired
108encoding
108affect
108action
107organisms
107might
107environmental
106remain
106oxidative
106infections
106find
105pathogen
105determined
105damage
104sensing
104lines
104expressed
104current
103targeted
103fkbp
103examined
102chain
101terminal
101regulators
101activate
100resulted
100kidney
100interestingly
99result
99plasma
99phenotype
99macrophages
98suggests
98immunosuppression
98decrease
97wide
97variety
97rate
97physiological
97biogenesis
96liver
96increasing
96eif
96defects
96bacterial
95will
95serine
95lacking
95innate
95events
95chronic
95arrest
94transduction
94stimulated
94state
94risk
94resulting
94rapid
94mutation
94models
94general
94depletion
94amp
93potent
93investigate
93implicated
93immunity
93autophagosome
92strategy
92network
92molecules
92little
92dose
92aging
92agent
92activating
91phosphorylated
91linked
91extracellular
91confirmed
90promoting
90machinery
90largely
90impact
90acute
89upstream
89structure
89poorly
89mediates
89limited
89life
89fission
89ampk
88unclear
88support
88over
88fungal
88biological
88additional
87yet
87work
87ribosome
87responsible
87lipid
87enhance
86tissue
86surface
86suggested
86provides
86natural
86crucial
86combined
85stimulation
85selective
85likely
85global
85eukaryotes
85enhances
85cytoplasmic
85controlling
85biosynthesis
84translational
84sources
84post
84organ
84double
84cytokine
83thereby
83patient

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