1232 | Humans (MeSH) |
939 | Animals (MeSH) |
687 | Sirolimus (pharmacology) |
520 | Saccharomyces cerevisiae Proteins (metabolism) |
505 | Signal Transduction (MeSH) |
495 | Mice (MeSH) |
488 | Saccharomyces cerevisiae (metabolism) |
485 | Saccharomyces cerevisiae (genetics) |
470 | TOR Serine-Threonine Kinases (metabolism) |
380 | Saccharomyces cerevisiae Proteins (genetics) |
372 | Female (MeSH) |
354 | Male (MeSH) |
258 | Phosphorylation (MeSH) |
227 | Transcription Factors (metabolism) |
222 | Signal Transduction (drug effects) |
219 | Saccharomyces cerevisiae (drug effects) |
217 | Gene Expression Regulation, Fungal (MeSH) |
196 | Protein-Serine-Threonine Kinases (metabolism) |
196 | Cell Line, Tumor (MeSH) |
194 | Cell Line (MeSH) |
189 | Mechanistic Target of Rapamycin Complex 1 (MeSH) |
188 | Mutation (MeSH) |
185 | Phosphatidylinositol 3-Kinases (metabolism) |
182 | TOR Serine-Threonine Kinases (genetics) |
177 | Middle Aged (MeSH) |
177 | Mice, Inbred C57BL (MeSH) |
175 | Multiprotein Complexes (metabolism) |
175 | Cells, Cultured (MeSH) |
169 | Adult (MeSH) |
162 | TOR Serine-Threonine Kinases (antagonists & inhibitors) |
161 | Autophagy (MeSH) |
160 | Molecular Sequence Data (MeSH) |
160 | Amino Acid Sequence (MeSH) |
159 | Autophagy (drug effects) |
143 | Transcription Factors (genetics) |
142 | Antifungal Agents (pharmacology) |
137 | Models, Biological (MeSH) |
137 | Fungal Proteins (metabolism) |
135 | Signal Transduction (physiology) |
134 | Protein Kinases (metabolism) |
132 | Proto-Oncogene Proteins c-akt (metabolism) |
129 | TOR Serine-Threonine Kinases (MeSH) |
129 | Saccharomyces cerevisiae (enzymology) |
127 | Sirolimus (therapeutic use) |
127 | Immunosuppressive Agents (therapeutic use) |
123 | Protein Binding (MeSH) |
122 | Immunosuppressive Agents (pharmacology) |
118 | Fungal Proteins (genetics) |
116 | Nitrogen (metabolism) |
116 | Mechanistic Target of Rapamycin Complex 1 (metabolism) |
115 | Saccharomyces cerevisiae (growth & development) |
113 | Saccharomyces cerevisiae (cytology) |
107 | Signal Transduction (genetics) |
106 | Carrier Proteins (metabolism) |
103 | Saccharomyces cerevisiae (physiology) |
101 | Time Factors (MeSH) |
100 | Cell Proliferation (drug effects) |
99 | Protein-Serine-Threonine Kinases (genetics) |
95 | Disease Models, Animal (MeSH) |
91 | Gene Deletion (MeSH) |
90 | Aged (MeSH) |
89 | Phosphatidylinositol 3-Kinases (genetics) |
89 | Mice, Knockout (MeSH) |
87 | Blotting, Western (MeSH) |
86 | DNA-Binding Proteins (metabolism) |
85 | Saccharomyces cerevisiae Proteins (MeSH) |
84 | Transcription, Genetic (MeSH) |
79 | Multiprotein Complexes (genetics) |
78 | Sirolimus (MeSH) |
78 | Autophagy (physiology) |
78 | Apoptosis (drug effects) |
76 | Phosphorylation (drug effects) |
75 | Mitochondria (metabolism) |
75 | Immunosuppressive Agents (adverse effects) |
75 | Adaptor Proteins, Signal Transducing (metabolism) |
73 | Phosphotransferases (Alcohol Group Acceptor) (metabolism) |
73 | Mice, Inbred BALB C (MeSH) |
73 | Base Sequence (MeSH) |
72 | Cell Cycle Proteins (metabolism) |
71 | Sirolimus (metabolism) |
70 | Saccharomyces cerevisiae Proteins (physiology) |
69 | Saccharomyces cerevisiae Proteins (chemistry) |
69 | Phenotype (MeSH) |
69 | Cell Proliferation (MeSH) |
69 | Carrier Proteins (genetics) |
68 | Genes, Fungal (MeSH) |
68 | Gene Expression Regulation, Fungal (drug effects) |
67 | Protein Kinases (genetics) |
66 | Virus Replication (MeSH) |
64 | Kidney Transplantation (adverse effects) |
64 | Cell Nucleus (metabolism) |
63 | Gene Expression Profiling (MeSH) |
63 | Autophagy (genetics) |
62 | Protein Biosynthesis (MeSH) |
62 | Phosphoproteins (metabolism) |
61 | Gene Expression Regulation (MeSH) |
60 | Schizosaccharomyces pombe Proteins (metabolism) |
60 | Reactive Oxygen Species (metabolism) |
60 | Host-Pathogen Interactions (MeSH) |
60 | Amino Acids (metabolism) |
59 | Treatment Outcome (MeSH) |
59 | RNA, Messenger (metabolism) |
59 | Protein Kinase Inhibitors (pharmacology) |
58 | Antineoplastic Agents (pharmacology) |
57 | Tacrolimus (pharmacology) |
57 | Schizosaccharomyces (genetics) |
57 | RNA, Messenger (genetics) |
56 | Sirolimus (administration & dosage) |
56 | Repressor Proteins (metabolism) |
56 | Mechanistic Target of Rapamycin Complex 2 (MeSH) |
55 | Membrane Proteins (metabolism) |
55 | Mechanistic Target of Rapamycin Complex 1 (genetics) |
55 | Intracellular Signaling Peptides and Proteins (metabolism) |
54 | Saccharomyces cerevisiae Proteins (antagonists & inhibitors) |
54 | Protein Transport (MeSH) |
54 | Glucose (metabolism) |
54 | Flow Cytometry (MeSH) |
53 | Virus Replication (drug effects) |
52 | Risk Factors (MeSH) |
51 | Rats (MeSH) |
51 | Phosphoinositide-3 Kinase Inhibitors (MeSH) |
51 | Mechanistic Target of Rapamycin Complex 2 (metabolism) |
51 | Cell Membrane (metabolism) |
50 | Schizosaccharomyces (metabolism) |
50 | Cell Survival (drug effects) |
49 | Stress, Physiological (MeSH) |
49 | Ribosomal Protein S6 Kinases, 70-kDa (metabolism) |
49 | Polyenes (pharmacology) |
49 | Phosphatidylinositol 3-Kinases (MeSH) |
49 | HeLa Cells (MeSH) |
49 | Enzyme Activation (MeSH) |
49 | Cell Cycle Proteins (MeSH) |
48 | Kidney Transplantation (MeSH) |
48 | HEK293 Cells (MeSH) |
47 | Vacuoles (metabolism) |
47 | Tacrolimus Binding Proteins (MeSH) |
47 | Sequence Homology, Amino Acid (MeSH) |
47 | Retrospective Studies (MeSH) |
46 | Microtubule-Associated Proteins (metabolism) |
46 | Macrophages (microbiology) |
46 | Gene Expression (MeSH) |
46 | Cyclic AMP-Dependent Protein Kinases (metabolism) |
45 | Sirolimus (adverse effects) |
45 | Phosphotransferases (Alcohol Group Acceptor) (genetics) |
45 | Mutation (genetics) |
45 | Cell Cycle Proteins (genetics) |
45 | AMP-Activated Protein Kinases (metabolism) |
44 | Signal Transduction (immunology) |
44 | Schizosaccharomyces pombe Proteins (genetics) |
44 | Enzyme Inhibitors (pharmacology) |
43 | Sirolimus (analogs & derivatives) |
43 | Mice, Transgenic (MeSH) |
43 | Lysosomes (metabolism) |
43 | DNA-Binding Proteins (genetics) |
43 | Antibiotics, Antineoplastic (pharmacology) |
42 | RNA Interference (MeSH) |
42 | Proto-Oncogene Proteins c-akt (genetics) |
42 | Dose-Response Relationship, Drug (MeSH) |
42 | Adaptor Proteins, Signal Transducing (genetics) |
41 | Cell Survival (MeSH) |
40 | Macrophages (metabolism) |
40 | Apoptosis (MeSH) |
39 | Xenograft Model Antitumor Assays (MeSH) |
39 | Protein-Serine-Threonine Kinases (MeSH) |
39 | Protein Structure, Tertiary (MeSH) |
39 | Promoter Regions, Genetic (MeSH) |
39 | Phagosomes (metabolism) |
39 | Microscopy, Fluorescence (MeSH) |
38 | Transcription, Genetic (drug effects) |
38 | TOR Serine-Threonine Kinases (physiology) |
38 | TOR Serine-Threonine Kinases (immunology) |
38 | Saccharomyces cerevisiae (MeSH) |
38 | Phosphoprotein Phosphatases (metabolism) |
38 | Multiprotein Complexes (MeSH) |
38 | Immunosuppressive Agents (administration & dosage) |
37 | Young Adult (MeSH) |
37 | T-Lymphocytes (immunology) |
37 | Recombinant Fusion Proteins (metabolism) |
37 | Down-Regulation (MeSH) |
37 | Adolescent (MeSH) |
36 | Transfection (MeSH) |
36 | Ribosomes (metabolism) |
36 | Drug Therapy, Combination (MeSH) |
36 | Cytoplasm (metabolism) |
36 | Cytokines (metabolism) |
35 | Models, Molecular (MeSH) |
35 | Membrane Proteins (genetics) |
35 | Cyclosporine (pharmacology) |
35 | CD8-Positive T-Lymphocytes (immunology) |
35 | Adaptor Proteins, Signal Transducing (MeSH) |
34 | Sequence Alignment (MeSH) |
34 | Monomeric GTP-Binding Proteins (metabolism) |
34 | Monomeric GTP-Binding Proteins (genetics) |
34 | Heat-Shock Proteins (metabolism) |
34 | Graft Rejection (prevention & control) |
34 | Cloning, Molecular (MeSH) |
33 | T-Lymphocytes, Regulatory (immunology) |
32 | Viral Load (MeSH) |
32 | Oxidative Stress (MeSH) |
32 | Oligonucleotide Array Sequence Analysis (MeSH) |
31 | Reverse Transcriptase Polymerase Chain Reaction (MeSH) |
31 | Repressor Proteins (genetics) |
31 | Protein Phosphatase 2 (metabolism) |
31 | Immunocompromised Host (MeSH) |
30 | Trans-Activators (metabolism) |
30 | Recombinant Fusion Proteins (genetics) |
30 | Polymerase Chain Reaction (MeSH) |
30 | Phosphatidylinositol 3-Kinases (physiology) |
30 | Mice, Nude (MeSH) |
30 | Lymphocyte Activation (MeSH) |
30 | Immunoblotting (MeSH) |
30 | Graft Rejection (immunology) |
30 | Gene Expression Regulation, Neoplastic (MeSH) |
30 | Binding Sites (MeSH) |
29 | Macrophages (immunology) |
29 | Intracellular Signaling Peptides and Proteins (genetics) |
29 | Cell Differentiation (MeSH) |
29 | Antiviral Agents (therapeutic use) |
29 | Anti-Bacterial Agents (pharmacology) |
28 | Transcription Factors (physiology) |
28 | Mechanistic Target of Rapamycin Complex 2 (genetics) |
28 | Homeostasis (MeSH) |
28 | Glutamine (metabolism) |
28 | Enzyme Activation (drug effects) |
28 | Candida albicans (genetics) |
27 | Transcription Factors (antagonists & inhibitors) |
27 | Nuclear Proteins (metabolism) |
27 | Mitogen-Activated Protein Kinases (metabolism) |
27 | Microtubule-Associated Proteins (genetics) |
27 | Microbial Sensitivity Tests (MeSH) |
27 | Intracellular Signaling Peptides and Proteins (MeSH) |
27 | Green Fluorescent Proteins (metabolism) |
27 | Genotype (MeSH) |
27 | Gene Expression Regulation (drug effects) |
26 | Up-Regulation (MeSH) |
26 | Temperature (MeSH) |
26 | Sirolimus (chemistry) |
26 | Schizosaccharomyces (enzymology) |
26 | Ribosomal Proteins (genetics) |
26 | Real-Time Polymerase Chain Reaction (MeSH) |
26 | Protein-Serine-Threonine Kinases (physiology) |
26 | Mitochondria (drug effects) |
26 | Immunohistochemistry (MeSH) |
26 | Glycogen Synthase Kinase 3 (metabolism) |
26 | Gene Knockdown Techniques (MeSH) |
26 | Follow-Up Studies (MeSH) |
26 | Everolimus (MeSH) |
26 | Drug Synergism (MeSH) |
26 | Disease Progression (MeSH) |
26 | Child (MeSH) |
25 | Tumor Cells, Cultured (MeSH) |
25 | T-Lymphocytes (metabolism) |
25 | Sarcoma, Kaposi (virology) |
25 | Proto-Oncogene Proteins c-akt (antagonists & inhibitors) |
25 | Proteins (metabolism) |
25 | Protein-Serine-Threonine Kinases (antagonists & inhibitors) |
25 | Prospective Studies (MeSH) |
25 | Polyomavirus Infections (virology) |
25 | Phosphoprotein Phosphatases (genetics) |
25 | Mechanistic Target of Rapamycin Complex 1 (antagonists & inhibitors) |
25 | Immunoprecipitation (MeSH) |
25 | Gene Knockout Techniques (MeSH) |
25 | Fungal Proteins (chemistry) |
25 | Enzyme-Linked Immunosorbent Assay (MeSH) |
25 | Cytomegalovirus Infections (virology) |
25 | Cell Wall (metabolism) |
25 | Carrier Proteins (chemistry) |
25 | Candida albicans (drug effects) |
25 | Caloric Restriction (MeSH) |
25 | Antineoplastic Agents (therapeutic use) |
25 | Amino Acid Transport Systems (metabolism) |
25 | Adenine (analogs & derivatives) |
24 | Yeasts (metabolism) |
24 | Protein Processing, Post-Translational (MeSH) |
24 | Protein Kinases (physiology) |
24 | Morpholines (pharmacology) |
24 | Macrophages (drug effects) |
24 | Immunity, Innate (MeSH) |
24 | Fibroblasts (virology) |
24 | Cell Differentiation (drug effects) |
24 | Bacterial Proteins (metabolism) |
24 | Autophagy-Related Proteins (MeSH) |
23 | Yeasts (genetics) |
23 | Proteomics (MeSH) |
23 | Multiprotein Complexes (antagonists & inhibitors) |
23 | Kinetics (MeSH) |
23 | Forkhead Transcription Factors (metabolism) |
23 | DNA Damage (MeSH) |
23 | Conserved Sequence (MeSH) |
23 | Cell Cycle (MeSH) |
23 | CD4-Positive T-Lymphocytes (immunology) |
23 | Autophagosomes (metabolism) |
23 | Actins (metabolism) |
22 | Virulence (MeSH) |
22 | Tumor Suppressor Proteins (metabolism) |
22 | Tacrolimus Binding Protein 1A (metabolism) |
22 | Tacrolimus (therapeutic use) |
22 | Swine (MeSH) |
22 | Protein Transport (drug effects) |
22 | Prognosis (MeSH) |
22 | Graft Survival (drug effects) |
22 | Endoplasmic Reticulum (metabolism) |
22 | Drug Resistance, Fungal (genetics) |
22 | Drug Resistance, Fungal (MeSH) |
22 | B-Lymphocytes (immunology) |
22 | Alleles (MeSH) |
22 | Adenine (pharmacology) |
21 | Transcriptome (MeSH) |
21 | Structure-Activity Relationship (MeSH) |
21 | RNA-Binding Proteins (metabolism) |
21 | Protein Phosphatase 2 (genetics) |
21 | Protein Phosphatase 2 (MeSH) |
21 | Protein Biosynthesis (drug effects) |
21 | NF-kappa B (metabolism) |
21 | Immunosuppression (MeSH) |
21 | GATA Transcription Factors (metabolism) |
21 | Everolimus (therapeutic use) |
21 | Down-Regulation (drug effects) |
21 | Cyclic AMP-Dependent Protein Kinases (genetics) |
21 | Candida albicans (metabolism) |
21 | Autophagy (immunology) |
21 | Aged, 80 and over (MeSH) |
20 | Transcriptional Activation (MeSH) |
20 | Tacrolimus (metabolism) |
20 | T-Lymphocytes (drug effects) |
20 | Streptomyces (metabolism) |
20 | Schizosaccharomyces (growth & development) |
20 | Schizosaccharomyces (cytology) |
20 | Ribosomal Proteins (metabolism) |
20 | Postoperative Complications (virology) |
20 | Polyenes (metabolism) |
20 | Lymphocyte Activation (immunology) |
20 | Kidney Transplantation (immunology) |
20 | Gene Expression Regulation, Fungal (physiology) |
20 | Fungal Proteins (physiology) |
20 | Fibroblasts (metabolism) |
20 | DNA, Fungal (genetics) |
20 | Culture Media (MeSH) |
20 | Cell Differentiation (immunology) |
20 | Carbon (metabolism) |
20 | Breast Neoplasms (pathology) |
20 | Biological Transport (MeSH) |
19 | ras Proteins (metabolism) |
19 | Two-Hybrid System Techniques (MeSH) |
19 | Tumor Virus Infections (virology) |
19 | Tumor Suppressor Proteins (genetics) |
19 | Sequence Analysis, DNA (MeSH) |
19 | Schizosaccharomyces (drug effects) |
19 | Saccharomyces cerevisiae (chemistry) |
19 | Reproducibility of Results (MeSH) |
19 | RNA, Small Interfering (metabolism) |
19 | Protein Conformation (MeSH) |
19 | Protein Binding (drug effects) |
19 | Phosphatidylinositol 3-Kinases (chemistry) |
19 | Neoplasms (drug therapy) |
19 | Models, Genetic (MeSH) |
19 | MicroRNAs (genetics) |
19 | Mice, SCID (MeSH) |
19 | Incidence (MeSH) |
19 | Immunosuppression (methods) |
19 | Graft Survival (MeSH) |
19 | Genome, Fungal (MeSH) |
19 | Epithelial Cells (virology) |
19 | Dendritic Cells (immunology) |
19 | Chromones (pharmacology) |
19 | Chlorocebus aethiops (MeSH) |
19 | Cell Proliferation (genetics) |
19 | Cell Division (MeSH) |
19 | Cell Cycle (genetics) |
19 | Cell Cycle (drug effects) |
18 | Wortmannin (MeSH) |
18 | Sphingolipids (metabolism) |
18 | Species Specificity (MeSH) |
18 | Rats, Sprague-Dawley (MeSH) |
18 | RNA, Small Interfering (genetics) |
18 | RNA, Fungal (genetics) |
18 | Phosphotransferases (Alcohol Group Acceptor) (physiology) |
18 | Peptidylprolyl Isomerase (metabolism) |
18 | Peptidylprolyl Isomerase (MeSH) |
18 | Neoplasms (pathology) |
18 | Mycophenolic Acid (therapeutic use) |
18 | Molecular Structure (MeSH) |
18 | MAP Kinase Signaling System (MeSH) |
18 | Hyphae (growth & development) |
18 | Histones (metabolism) |
18 | Genes, Reporter (MeSH) |
18 | Gene Regulatory Networks (MeSH) |
18 | Gene Expression Regulation, Fungal (genetics) |
18 | Epstein-Barr Virus Infections (virology) |
18 | Endosomes (metabolism) |
18 | Candida albicans (growth & development) |
18 | Calcineurin (metabolism) |
18 | Breast Neoplasms (metabolism) |
18 | Blotting, Northern (MeSH) |
18 | Androstadienes (pharmacology) |
17 | Vesicular Transport Proteins (metabolism) |
17 | Transplantation, Homologous (MeSH) |
17 | T-Lymphocytes, Regulatory (drug effects) |
17 | Substrate Specificity (MeSH) |
17 | RNA-Binding Proteins (genetics) |
17 | RNA, Small Interfering (MeSH) |
17 | Phosphatidylinositol 3-Kinase (metabolism) |
17 | PTEN Phosphohydrolase (metabolism) |
17 | Mutagenesis, Site-Directed (MeSH) |
17 | Macrophages (cytology) |
17 | Lymphocyte Activation (drug effects) |
17 | Liver (metabolism) |
17 | Ligands (MeSH) |
17 | Infant (MeSH) |
17 | Hepatocytes (metabolism) |
17 | Hep G2 Cells (MeSH) |
17 | HIV Infections (virology) |
17 | Gene Silencing (MeSH) |
17 | Gene Expression (drug effects) |
17 | Forkhead Transcription Factors (genetics) |
17 | Fermentation (MeSH) |
17 | Energy Metabolism (MeSH) |
17 | Child, Preschool (MeSH) |
17 | Cell Membrane (drug effects) |
17 | Caffeine (pharmacology) |
17 | Antiviral Agents (pharmacology) |
17 | Active Transport, Cell Nucleus (MeSH) |
16 | Yeasts (physiology) |
16 | Tuberous Sclerosis Complex 2 Protein (MeSH) |
16 | Transcription Factors (MeSH) |
16 | Trans-Activators (genetics) |
16 | Survival Analysis (MeSH) |
16 | Stress, Physiological (genetics) |
16 | Schizosaccharomyces (physiology) |
16 | Proteins (genetics) |
16 | Protein Kinases (chemistry) |
16 | Promoter Regions, Genetic (genetics) |
16 | Plasmids (metabolism) |
16 | Phylogeny (MeSH) |
16 | Phagosomes (drug effects) |
16 | Nuclear Proteins (genetics) |
16 | Neoplasms (genetics) |
16 | Mycophenolic Acid (analogs & derivatives) |
16 | Mutagenesis (MeSH) |
16 | Molecular Targeted Therapy (MeSH) |
16 | Microscopy, Electron, Transmission (MeSH) |
16 | Liver Transplantation (MeSH) |
16 | Liver Neoplasms (pathology) |
16 | Kidney Failure, Chronic (surgery) |
16 | Kidney Diseases (virology) |
16 | Intracellular Membranes (metabolism) |
16 | Inflammation (metabolism) |
16 | Inflammation (immunology) |
16 | HIV Infections (drug therapy) |
16 | Golgi Apparatus (metabolism) |
16 | Genes, Fungal (genetics) |
16 | Epithelial Cells (metabolism) |
16 | Drug Interactions (MeSH) |
16 | DNA Primers (MeSH) |
16 | Cytokines (immunology) |
16 | Chromatin (metabolism) |
16 | Carcinoma, Hepatocellular (pathology) |
16 | Calcineurin Inhibitors (MeSH) |
16 | Beclin-1 (MeSH) |
16 | Autophagy-Related Proteins (metabolism) |
16 | AMP-Activated Protein Kinases (genetics) |
15 | Viral Proteins (metabolism) |
15 | Ubiquitination (MeSH) |
15 | Tacrolimus Binding Protein 1A (genetics) |
15 | T-Lymphocytes, Regulatory (metabolism) |
15 | T-Lymphocytes (virology) |
15 | Survival Rate (MeSH) |
15 | Ribosomal Protein S6 Kinases (metabolism) |
15 | Recombinant Proteins (metabolism) |
15 | Rabbits (MeSH) |
15 | RNA, Fungal (metabolism) |
15 | Proteolysis (MeSH) |
15 | Protein Subunits (metabolism) |
15 | Phosphoproteins (genetics) |
15 | Monocytes (metabolism) |
15 | Microbial Viability (MeSH) |
15 | MCF-7 Cells (MeSH) |
15 | Lymphoproliferative Disorders (virology) |
15 | Longevity (drug effects) |
15 | Liver Transplantation (adverse effects) |
15 | Liver Neoplasms (metabolism) |
15 | Hepacivirus (drug effects) |
15 | HIV Infections (immunology) |
15 | Graft Survival (immunology) |
15 | Evolution, Molecular (MeSH) |
15 | Everolimus (pharmacology) |
15 | Eukaryotic Initiation Factor-4E (metabolism) |
15 | Drug Resistance, Neoplasm (drug effects) |
15 | Drug Resistance, Neoplasm (MeSH) |
15 | Cytokines (genetics) |
15 | Cell Movement (drug effects) |
15 | Cell Division (drug effects) |
15 | Cell Cycle (physiology) |
15 | Calcium (metabolism) |
15 | Apoptosis Regulatory Proteins (metabolism) |
15 | Apoptosis (genetics) |
14 | Virus Activation (drug effects) |
14 | Vacuoles (drug effects) |
14 | Up-Regulation (drug effects) |
14 | Tissue Donors (MeSH) |