Ident. | Authors (with country if any) | Title |
---|
000001 (2020) |
Denis Anatolievich Putilin [Ukraine] ; Sergey Yuryevich Evchenko [Ukraine] ; Larisa Yaroslavivna Fedoniuk [Ukraine] ; Olexandr Stepanovich Tokarskyy [Ukraine] ; Oleksandr Mikhailovich Kamyshny [Ukraine] ; Liudmyla Mikhailivna Migenko [Ukraine] ; Serhiy Mikhailovich Andreychyn [Ukraine] ; Iryna Ihorivna Hanberher [Ukraine] ; Tetyana Oleksandrivna Bezruk [Ukraine] | The Influence of Metformin to the Transcriptional Activity of the mTOR and FOX3 Genes in Parapancreatic Adipose Tissue of Streptozotocin-Induced Diabetic Rats. |
000003 (2020) |
Muhammad Shahidan Muhammad Sakri [Malaisie] ; Wan Faiziah Wan Abdul Rahman [Malaisie] ; Tengku Ahmad Damitri Al-Astani Tengku Din [Malaisie] ; Fauziah Mohd Idris [Malaisie] ; Hasnan Jaafar [Malaisie] | Microvessel density and vascular endothelial growth factor receptors in breast carcinoma under the influence of rapamycin and platelet factor 4. |
000004 (2020) |
Xiujie Cui [République populaire de Chine] ; Xiao Wang [République populaire de Chine] ; Xiaoqing Zhou [République populaire de Chine] ; Jihui Jia [République populaire de Chine] ; Hanxiang Chen [République populaire de Chine] ; Weiming Zhao | miR-106a Regulates Cell Proliferation and Autophagy by Targeting LKB1 in HPV-16-Associated Cervical Cancer. |
000005 (2020) |
Po-Chien Chou [États-Unis] ; Swati Rajput [États-Unis] ; Xiaoyun Zhao [République populaire de Chine] ; Chadni Patel [États-Unis] ; Danielle Albaciete [États-Unis] ; Won Jun Oh [États-Unis] ; Heineken Queen Daguplo [États-Unis] ; Nikhil Patel [États-Unis] ; Bing Su [République populaire de Chine] ; Guy Werlen [États-Unis] ; Estela Jacinto [États-Unis] | mTORC2 Is Involved in the Induction of RSK Phosphorylation by Serum or Nutrient Starvation. |
000006 (2020) |
Manish Kumar Johri [Inde] ; Hiren Vasantrai Lashkari [Inde] ; Divya Gupta [Inde] ; Dhiviya Vedagiri [Inde] ; Krishnan Harinivas Harshan [Inde] | mTORC1 restricts hepatitis C virus RNA replication through ULK1-mediated suppression of miR-122 and facilitates post-replication events. |
000007 (2020) |
Derek Strassheim [États-Unis] ; Vijaya Karoor [États-Unis] ; Hala Nijmeh [États-Unis] ; Philip Weston [États-Unis] ; Martin Lapel [États-Unis] ; Jerome Schaack [États-Unis] ; Timothy Sullivan [États-Unis] ; Edward C. Dempsey [États-Unis] ; Kurt R. Stenmark [États-Unis] ; Evgenia Gerasimovskaya [États-Unis] | c-Jun, Foxo3a, and c-Myc Transcription Factors are Key Regulators of ATP-Mediated Angiogenic Responses in Pulmonary Artery Vasa Vasorum Endothelial Cells. |
000008 (2020) |
Shuliang Chen [États-Unis] ; Muriel Mari [Pays-Bas] ; Smriti Parashar [États-Unis] ; Dongmei Liu [États-Unis] ; Yixian Cui [États-Unis] ; Fulvio Reggiori [Pays-Bas] ; Peter J. Novick [États-Unis] ; Susan Ferro-Novick [États-Unis] | Vps13 is required for the packaging of the ER into autophagosomes during ER-phagy. |
000010 (2020) |
Gyeong Joon Moon [Corée du Sud] ; Minsang Shin [Corée du Sud] ; Sang Ryong Kim [Corée du Sud] | Upregulation of Neuronal Rheb(S16H) for Hippocampal Protection in the Adult Brain. |
000012 (2020) |
Luc Colas [France] ; Emmanuel F. Mongodin [États-Unis] ; Emmanuel Montassier [France] ; Mélanie Chesneau [France] ; Pierrick Guerif [France] ; Lauren Hittle [États-Unis] ; Magali Giral [France] ; Jonathan S. Bromberg [États-Unis] ; Sophie Brouard [France] | Unique and specific Proteobacteria diversity in urinary microbiota of tolerant kidney transplanted recipients. |
000014 (2020) |
Shan Ying [Canada] ; Denys A. Khaperskyy [Canada] | UV damage induces G3BP1-dependent stress granule formation that is not driven by mTOR inhibition-mediated translation arrest. |
000016 (2020) |
Elizabeth K. Brauer [Canada] ; Nimrat Manes [Canada] ; Christopher Bonner [Canada] ; Rajagopal Subramaniam [Canada] | Two 14-3-3 proteins contribute to nitrogen sensing through the TOR and glutamine synthetase-dependent pathways in Fusarium graminearum. |
000020 (2020) |
Tiffany J. Rios-Fuller [États-Unis] ; Melanie Mahe [États-Unis] ; Beth Walters [États-Unis] ; Dounia Abbadi [États-Unis] ; Sandra Pérez-Baos [États-Unis] ; Abhilash Gadi [États-Unis] ; John J. Andrews [États-Unis] ; Olga Katsara [États-Unis] ; C Theresa Vincent [États-Unis, Suède] ; Robert J. Schneider [États-Unis] | Translation Regulation by eIF2α Phosphorylation and mTORC1 Signaling Pathways in Non-Communicable Diseases (NCDs). |
000021 (2020) |
Paolo Fagone [Italie] ; Rosella Ciurleo [Italie] ; Salvo Danilo Lombardo [Autriche] ; Carmelo Iacobello [Italie] ; Concetta Ilenia Palermo [Italie] ; Yehuda Shoenfeld [Russie] ; Klaus Bendtzen [Danemark] ; Placido Bramanti [Italie] ; Ferdinando Nicoletti [Italie] | Transcriptional landscape of SARS-CoV-2 infection dismantles pathogenic pathways activated by the virus, proposes unique sex-specific differences and predicts tailored therapeutic strategies. |
000022 (2020) |
Ljubica Vucicevic [Serbie] ; Maja Misirkic [Serbie] ; Darko Ciric [Serbie] ; Tamara Martinovic [Serbie] ; Maja Jovanovic [Serbie] ; Aleksandra Isakovic [Serbie] ; Ivanka Markovic [Serbie] ; Jasna Saponjic [Serbie] ; Marc Foretz [France] ; Yoana Rabanal-Ruiz [Royaume-Uni, Espagne] ; Viktor I. Korolchuk [Royaume-Uni] ; Vladimir Trajkovic [Serbie] | Transcriptional block of AMPK-induced autophagy promotes glutamate excitotoxicity in nutrient-deprived SH-SY5Y neuroblastoma cells. |
000023 (2020) |
Keunsoo Kang [Corée du Sud] ; Hoo Hyun Kim [Corée du Sud] ; Yoonjung Choi [Corée du Sud] | Tiotropium is Predicted to be a Promising Drug for COVID-19 Through Transcriptome-Based Comprehensive Molecular Pathway Analysis. |
000026 (2020) |
Debalina Bhattacharya [Inde] ; Moumita Dutta [Inde] ; Mainak Mukhopadhyay [Inde] ; Maitree Bhattacharyya [Inde] ; Subhankar Chowdhury [Inde] ; Parimal Karmakar [Inde] | The protective role of metformin in autophagic status in peripheral blood mononuclear cells of type 2 diabetic patients. |
000032 (2020) |
Loukman Omarjee [France] ; Anne Janin [France] ; Frédérique Perrot [France] ; Bruno Laviolle [France] ; Olivier Meilhac [France] ; Guillaume Mahe [France] | Targeting T-cell senescence and cytokine storm with rapamycin to prevent severe progression in COVID-19. |
000034 (2020) |
Duy Vuong Nguyen [France] ; Thomas Roret [France] ; Antonio Fernandez-Gonzalez [France] ; Annegret Kohler [France] ; Mélanie Morel-Rouhier [France] ; Eric Gelhaye [France] ; Rodnay Sormani [France] | Target Of Rapamycin pathway in the white-rot fungus Phanerochaete chrysosporium. |
000036 (2020) |
Shamsul Morshed [Japon] ; Tasnuva Sharmin [Japon] ; Takashi Ushimaru [Japon] | TORC1 regulates ESCRT-0 complex formation on the vacuolar membrane and microautophagy induction in yeast. |
000037 (2020) |
Manuel Méndez-G Mez [Mexique] ; Elda Castro-Mercado [Mexique] ; César Arturo Pe A-Uribe [Mexique] ; Homero Reyes-De La Cruz [Mexique] ; José L Pez-Bucio [Mexique] ; Ernesto García-Pineda [Mexique] | TARGET OF RAPAMYCIN signaling plays a role in Arabidopsis growth promotion by Azospirillum brasilense Sp245. |
000038 (2020) |
Prabhu S. Arunachalam [États-Unis] ; Florian Wimmers [États-Unis] ; Chris Ka Pun Mok [Hong Kong] ; Ranawaka A P M. Perera [Hong Kong] ; Madeleine Scott [États-Unis] ; Thomas Hagan [États-Unis] ; Natalia Sigal [États-Unis] ; Yupeng Feng [États-Unis] ; Laurel Bristow [États-Unis] ; Owen Tak-Yin Tsang [Hong Kong] ; Dhananjay Wagh [États-Unis] ; John Coller [États-Unis] ; Kathryn L. Pellegrini [États-Unis] ; Dmitri Kazmin [États-Unis] ; Ghina Alaaeddine [États-Unis] ; Wai Shing Leung [Hong Kong] ; Jacky Man Chun Chan [Hong Kong] ; Thomas Shiu Hong Chik [Hong Kong] ; Chris Yau Chung Choi [Hong Kong] ; Christopher Huerta [États-Unis] ; Michele Paine Mccullough [États-Unis] ; Huibin Lv [Hong Kong] ; Evan Anderson [États-Unis] ; Srilatha Edupuganti [États-Unis] ; Amit A. Upadhyay [États-Unis] ; Steve E. Bosinger [États-Unis] ; Holden Terry Maecker [États-Unis] ; Purvesh Khatri [États-Unis] ; Nadine Rouphael [États-Unis] ; Malik Peiris [Hong Kong] ; Bali Pulendran [États-Unis] | Systems biological assessment of immunity to mild versus severe COVID-19 infection in humans. |
000039 (2020) |
Elizabeth G. Graham-Gurysh [États-Unis] ; Ananya B. Murthy [États-Unis] ; Kathryn M. Moore [États-Unis] ; Shawn D. Hingtgen [États-Unis] ; Eric M. Bachelder [États-Unis] ; Kristy M. Ainslie [États-Unis] | Synergistic drug combinations for a precision medicine approach to interstitial glioblastoma therapy. |
000041 (2020) |
Laura C. Geben [États-Unis] ; Bret C. Mobley [États-Unis] ; Asa A. Brockman [États-Unis] ; Devang Pastakia [États-Unis] ; Rob Naftel [États-Unis] ; Rebecca A. Ihrie [États-Unis] ; Adam J. Esbenshade [États-Unis] | Sustained response to erlotinib and rapamycin in a patient with pediatric anaplastic oligodendroglioma. |
000044 (2020) |
Jie Zeng [Canada] ; Nhan Huynh [Canada] ; Brian Phelps [Canada] ; Kirst King-Jones [Canada] | Snail synchronizes endocycling in a TOR-dependent manner to coordinate entry and escape from endoreplication pausing during the Drosophila critical weight checkpoint. |
000047 (2020) |
Rachel M. Wise [États-Unis] ; Mark A A. Harrison [États-Unis] ; Brianne N. Sullivan [États-Unis] ; Sara Al-Ghadban [États-Unis] ; Sarah J. Aleman [États-Unis] ; Amber T. Vinluan [États-Unis] ; Emily R. Monaco [États-Unis] ; Umberto M. Donato [États-Unis] ; India A. Pursell [États-Unis] ; Bruce A. Bunnell [États-Unis] | Short-Term Rapamycin Preconditioning Diminishes Therapeutic Efficacy of Human Adipose-Derived Stem Cells in a Murine Model of Multiple Sclerosis. |
000048 (2020) |
You-Sun Shim [Corée du Sud] ; Solji Lee [Corée du Sud] ; Hwan-Woo Park [Corée du Sud] ; Seok-Rae Park [Corée du Sud] | Sestrin2 Mediates IL-4-induced IgE Class Switching by Enhancing Germline ε Transcription in B Cells. |
000050 (2020) |
Takuo Yamai [Japon] ; Hayato Hikita [Japon] ; Makoto Fukuoka [Japon] ; Keisuke Fukutomi [Japon] ; Kazuhiro Murai [Japon] ; Tasuku Nakabori [Japon] ; Ryoko Yamada [Japon] ; Kei Miyakawa [Japon] ; Kohei Watashi [Japon] ; Akihide Ryo [Japon] ; Takahiro Kodama [Japon] ; Ryotaro Sakamori [Japon] ; Tomohide Tatsumi [Japon] ; Tetsuo Takehara [Japon] | SIRT1 enhances hepatitis virus B transcription independent of hepatic autophagy. |
000052 (2020) |
Wen-Jie Shu [République populaire de Chine] ; Runfa Chen [République populaire de Chine] ; Zhao-Hong Yin [République populaire de Chine] ; Feng Li [République populaire de Chine] ; Heng Zhang [République populaire de Chine] ; Hai-Ning Du [République populaire de Chine] | Rph1 coordinates transcription of ribosomal protein genes and ribosomal RNAs to control cell growth under nutrient stress conditions. |
000053 (2020) |
Fatemeh Hosseini Heydarabadi [Iran] ; Asghar Abdoli [Iran] ; Safoora Gharibzadeh [Iran] ; Mohammad Sayyah [Iran] ; Rouzbeh Bashar [Iran] ; Farzaneh Sheikholeslami [Iran] | Role of autophagy in nerve cell apoptosis in mice infected with street rabies virus. |
000059 (2020) |
Alakananda Basu [États-Unis] | Regulation of Autophagy by Protein Kinase C-ε in Breast Cancer Cells. |
000060 (2020) |
Fatemeh Azizian-Farsani [Iran] ; Navid Abedpoor [Iran] ; Mohammad Hasan Sheikhha [Iran] ; Ali Osmay Gure [Turquie] ; Mohammad Hossein Nasr-Esfahani [Iran] ; Kamran Ghaedi [Iran] | Receptor for Advanced Glycation End Products Acts as a Fuel to Colorectal Cancer Development. |
000061 (2020) |
Lucero Romero-Aguilar [Mexique] ; Guadalupe Guerra-Sánchez [Mexique] ; Eda P. Tenorio [Mexique] ; Miguel Tapia-Rodriguez [Mexique] ; Genaro Matus-Ortega [Mexique] ; Oscar Flores-Herrera [Mexique] ; James González [Mexique] ; Juan Pablo Pardo [Mexique] | Rapamycin induces morphological and physiological changes without increase in lipid content in Ustilago maydis. |
000062 (2020) |
Amjad Husain [Inde] ; Siddappa N. Byrareddy [États-Unis] | Rapamycin as a potential repurpose drug candidate for the treatment of COVID-19. |
000063 (2020) |
Ling Xu [République populaire de Chine] ; Cuili Zhang [République populaire de Chine] ; Dan He [République populaire de Chine] ; Nan Jiang [République populaire de Chine] ; Ying Bai [République populaire de Chine] ; Yi Xin [République populaire de Chine] | Rapamycin and MCC950 modified gut microbiota in experimental autoimmune encephalomyelitis mouse by brain gut axis. |
000066 (2020) |
Amitha Muraleedharan [Israël] ; Noa Rotem-Dai [Israël] ; Itai Strominger [Israël] ; Nikhil Ponnoor Anto [Israël] ; Noah Isakov [Israël] ; Alon Monsonego [Israël] ; Etta Livneh [Israël] | Protein kinase C eta is activated in reactive astrocytes of an Alzheimer's disease mouse model: Evidence for its immunoregulatory function in primary astrocytes. |
000070 (2020) |
Bin Qian [République populaire de Chine] ; Xinyu Liu [République populaire de Chine] ; Ziyuan Ye [République populaire de Chine] ; Qikun Zhou [République populaire de Chine] ; Peng Liu [République populaire de Chine] ; Ziyi Yin [République populaire de Chine] ; Wenhao Wang [République populaire de Chine] ; Xiaobo Zheng [République populaire de Chine] ; Haifeng Zhang [République populaire de Chine] ; Zhengguang Zhang [République populaire de Chine] | Phosphatase-associated protein MoTip41 interacts with the phosphatase MoPpe1 to mediate crosstalk between TOR and cell wall integrity signalling during infection by the rice blast fungus Magnaporthe oryzae. |
000072 (2020) |
Samuel M. Gonçalves [Portugal] ; Cláudio Duarte-Oliveira [Portugal] ; Cláudia F. Campos [Portugal] ; Vishukumar Aimanianda [France] ; Rob Ter Horst [Pays-Bas] ; Luis Leite [Portugal] ; Toine Mercier [Belgique] ; Paulo Pereira [Portugal] ; Miguel Fernández-García [Espagne] ; Daniela Antunes [Portugal] ; Cláudia S. Rodrigues [Portugal] ; Catarina Barbosa-Matos [Portugal] ; Joana Gaifem [Portugal] ; Inês Mesquita [Portugal] ; Ant Nio Marques [Portugal] ; Nuno S. Os Rio [Portugal] ; Egídio Torrado [Portugal] ; Fernando Rodrigues [Portugal] ; Sandra Costa [Portugal] ; Leo Ab Joosten [Pays-Bas] ; Katrien Lagrou [Belgique] ; Johan Maertens [Belgique] ; João F. Lacerda [Portugal] ; Ant Nio Campos [Portugal] ; Gordon D. Brown [Royaume-Uni] ; Axel A. Brakhage [Allemagne] ; Coral Barbas [Espagne] ; Ricardo Silvestre [Portugal] ; Frank L. Van De Veerdonk [Pays-Bas] ; Georgios Chamilos [Grèce] ; Mihai G. Netea [Pays-Bas, Allemagne] ; Jean-Paul Latgé [France] ; Cristina Cunha [Portugal] ; Agostinho Carvalho [Portugal] | Phagosomal removal of fungal melanin reprograms macrophage metabolism to promote antifungal immunity. |
000073 (2020) |
Gagan K. Gupta [États-Unis] ; Amber L. Collier [États-Unis] ; Dasom Lee [États-Unis] ; Richard A. Hoefer [États-Unis] ; Vasilena Zheleva [États-Unis] ; Lauren L. Siewertsz Van Reesema [États-Unis] ; Angela M. Tang-Tan [États-Unis] ; Mary L. Guye [États-Unis] ; David Z. Chang [États-Unis] ; Janet S. Winston [États-Unis] ; Billur Samli [États-Unis] ; Rick J. Jansen [États-Unis] ; Emanuel F. Petricoin [États-Unis] ; Matthew P. Goetz [États-Unis] ; Harry D. Bear [États-Unis] ; Amy H. Tang [États-Unis] | Perspectives on Triple-Negative Breast Cancer: Current Treatment Strategies, Unmet Needs, and Potential Targets for Future Therapies. |
000075 (2020) |
Tasnuva Sharmin [Japon] ; Shamsul Morshed [Japon] ; Takashi Ushimaru [Japon] | PP2A promotes ESCRT-0 complex formation on vacuolar membranes and microautophagy induction after TORC1 inactivation. |
000077 (2020) |
Elena Jiménez-Gutiérrez [Espagne] ; Estíbaliz Alegría-Carrasco [Espagne] ; Ángela Sellers-Moya [Espagne] ; María Molina [Espagne] ; Humberto Martín [Espagne] | Not just the wall: the other ways to turn the yeast CWI pathway on. |
000079 (2020) |
Samreen Fatima [Inde] ; Shashank Shivaji Kamble [Inde] ; Ved Prakash Dwivedi [Inde] ; Debapriya Bhattacharya [Inde] ; Santosh Kumar [Inde] ; Anand Ranganathan [Inde] ; Luc Van Kaer [États-Unis] ; Sujata Mohanty [Inde] ; Gobardhan Das [Inde] | Mycobacterium tuberculosis programs mesenchymal stem cells to establish dormancy and persistence. |
000080 (2020) |
Nicola Ferreira [Australie] ; Christopher E. Andoniou [Australie] ; Kara L. Perks [Australie] ; Judith A. Ermer [Australie] ; Danielle L. Rudler [Australie] ; Giulia Rossetti [Australie] ; Ambika Periyakaruppiah [Australie] ; Jamie K Y. Wong [Australie] ; Oliver Rackham [Australie] ; Peter G. Noakes [Australie] ; Mariapia A. Degli-Esposti [Australie] ; Aleksandra Filipovska [Australie] | Murine cytomegalovirus infection exacerbates complex IV deficiency in a model of mitochondrial disease. |
000081 (2020) |
Edson Mario De Andrade Silva [Brésil] ; Sara Pereira Menezes Reis [Brésil] ; Caio Suzart Argolo [Brésil] ; Dayane Santos Gomes [Brésil] ; Ceslaine Santos Barbosa [Brésil] ; Karina Peres Gramacho [Brésil] ; Lidiane Figueredo Ribeiro [Brésil] ; Raner José Santana Silva [Brésil] ; Fabienne Micheli [France] | Moniliophthora perniciosa development: key genes involved in stress-mediated cell wall organization and autophagy. |
000082 (2020) |
Jana Vojtova [République tchèque] ; Jiri Hasek [République tchèque] | Mmi1, the Yeast Ortholog of Mammalian Translationally Controlled Tumor Protein (TCTP), Negatively Affects Rapamycin-Induced Autophagy in Post-Diauxic Growth Phase. |
000083 (2020) |
Evelyn Zacharewicz [Australie] ; Ming Kalanon [Australie] ; Robyn M. Murphy [Australie] ; Aaron P. Russell [Australie] ; Séverine Lamon [Australie] | MicroRNA-99b-5p downregulates protein synthesis in human primary myotubes. |
000084 (2020) |
Wipawee Saenwongsa [Thaïlande] ; Arnone Nithichanon [Thaïlande] ; Malinee Chittaganpitch [Thaïlande] ; Kampaew Buayai [Thaïlande] ; Chidchamai Kewcharoenwong [Thaïlande] ; Boonyarat Thumrongwilainet [Thaïlande] ; Patcharavadee Butta [Thaïlande] ; Tanapat Palaga [Thaïlande] ; Yoshimasa Takahashi [Japon] ; Manabu Ato [Japon] ; Ganjana Lertmemongkolchai [Thaïlande] | Metformin-induced suppression of IFN-α via mTORC1 signalling following seasonal vaccination is associated with impaired antibody responses in type 2 diabetes. |
000088 (2020) |
Paramarjan Piranavan [États-Unis] ; Manjeet Bhamra [États-Unis] ; Andras Perl [États-Unis] | Metabolic Targets for Treatment of Autoimmune Diseases. |
000089 (2020) |
Shun-Fa Yang [Taïwan] ; Yong-Syuan Chen [Taïwan] ; Hsiang-Wen Chien [Taïwan] ; Kai Wang [Taïwan] ; Chia-Liang Lin [Taïwan] ; Hui-Ling Chiou [Taïwan] ; Chia-Yi Lee [Taïwan] ; Pei-Ni Chen [Taïwan] ; Yi-Hsien Hsieh [Taïwan] | Melatonin attenuates epidermal growth factor-induced cathepsin S expression in ARPE-19 cells: Implications for proliferative vitreoretinopathy. |
000091 (2020) |
John C. Charpentier [États-Unis] ; Di Chen [États-Unis] ; Philip E. Lapinski [États-Unis] ; Jackson Turner [États-Unis] ; Irina Grigorova [États-Unis] ; Joel A. Swanson [États-Unis] ; Philip D. King [États-Unis] | Macropinocytosis drives T cell growth by sustaining the activation of mTORC1. |
000094 (2020) |
Aparna Godavarthy ; Ryan Kelly ; John Jimah ; Miguel Beckford ; Tiffany Caza ; David Fernandez ; Nick Huang [États-Unis] ; Manuel Duarte ; Joshua Lewis ; Hind J. Fadel [États-Unis] ; Eric M. Poeschla [États-Unis] ; Katalin Banki [États-Unis] ; Andras Perl [États-Unis] | Lupus-associated endogenous retroviral LTR polymorphism and epigenetic imprinting promote HRES-1/RAB4 expression and mTOR activation. |
000098 (2020) |
Rami Bou Khalil [Liban] | Lithium chloride combination with rapamycin for the treatment of COVID-19 pneumonia. |