In Vitro Screening for the Tumoricidal Properties of International Medicinal Herbs
Identifieur interne : 000893 ( Ncbi/Curation ); précédent : 000892; suivant : 000894In Vitro Screening for the Tumoricidal Properties of International Medicinal Herbs
Auteurs : Elizabeth A. Mazzio ; Karam F. A. SolimanSource :
- Phytotherapy research : PTR [ 0951-418X ] ; 2009.
Abstract
There is growing use of anticancer complementary and alternative medicines (CAMs) worldwide. The purpose of the current study is to assess a sizeable variety of natural and plant sources of diverse origin, to ascertain prospective research directives for cancer treatment and potential new chemotherapy drug sources. In this study, 374 natural extracts (10 μg/mL-5 mg/mL) were evaluated for dose-dependent tumoricidal effects using immortal neuroblastoma of spontaneous malignant origin. The findings indicate no pattern of tumoricidal effects by diverse plants with similar families/genus under the classes Pinopsida, Equisetopsida, Lycopodiosida, Filicosida, Liliopsida Monocotyledons or Magnoliopsida Dicotyledons. The results indicate that many of the most commonly used CAMs exhibited relatively weak tumoricidal effects including cats claw, astragalus, ginseng, echinacea, mistletoe, milk thistle, slippery elm, cayenne, chamomile, don quai, meadowsweet, motherwort and shepherd's purse. The data demonstrate that the most potent plant extracts were randomly dispersed within the plantae kingdom (LC50 = 31-490 μg/mL) in order of the lowest LC50
Url:
DOI: 10.1002/ptr.2636
PubMed: 18844256
PubMed Central: 2650746
Links toward previous steps (curation, corpus...)
- to stream Pmc, to step Corpus: Pour aller vers cette notice dans l'étape Curation :000A69
- to stream Pmc, to step Curation: Pour aller vers cette notice dans l'étape Curation :000A68
- to stream Pmc, to step Checkpoint: Pour aller vers cette notice dans l'étape Curation :001042
- to stream Ncbi, to step Merge: Pour aller vers cette notice dans l'étape Curation :000893
Links to Exploration step
PMC:2650746Le document en format XML
<record><TEI><teiHeader><fileDesc><titleStmt><title xml:lang="en"><italic>In Vitro</italic>
Screening for the Tumoricidal Properties of International Medicinal Herbs</title>
<author><name sortKey="Mazzio, Elizabeth A" sort="Mazzio, Elizabeth A" uniqKey="Mazzio E" first="Elizabeth A." last="Mazzio">Elizabeth A. Mazzio</name>
</author>
<author><name sortKey="Soliman, Karam F A" sort="Soliman, Karam F A" uniqKey="Soliman K" first="Karam F. A." last="Soliman">Karam F. A. Soliman</name>
</author>
</titleStmt>
<publicationStmt><idno type="wicri:source">PMC</idno>
<idno type="pmid">18844256</idno>
<idno type="pmc">2650746</idno>
<idno type="url">http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2650746</idno>
<idno type="RBID">PMC:2650746</idno>
<idno type="doi">10.1002/ptr.2636</idno>
<date when="2009">2009</date>
<idno type="wicri:Area/Pmc/Corpus">000A69</idno>
<idno type="wicri:Area/Pmc/Curation">000A68</idno>
<idno type="wicri:Area/Pmc/Checkpoint">001042</idno>
<idno type="wicri:Area/Ncbi/Merge">000893</idno>
<idno type="wicri:Area/Ncbi/Curation">000893</idno>
</publicationStmt>
<sourceDesc><biblStruct><analytic><title xml:lang="en" level="a" type="main"><italic>In Vitro</italic>
Screening for the Tumoricidal Properties of International Medicinal Herbs</title>
<author><name sortKey="Mazzio, Elizabeth A" sort="Mazzio, Elizabeth A" uniqKey="Mazzio E" first="Elizabeth A." last="Mazzio">Elizabeth A. Mazzio</name>
</author>
<author><name sortKey="Soliman, Karam F A" sort="Soliman, Karam F A" uniqKey="Soliman K" first="Karam F. A." last="Soliman">Karam F. A. Soliman</name>
</author>
</analytic>
<series><title level="j">Phytotherapy research : PTR</title>
<idno type="ISSN">0951-418X</idno>
<idno type="eISSN">1099-1573</idno>
<imprint><date when="2009">2009</date>
</imprint>
</series>
</biblStruct>
</sourceDesc>
</fileDesc>
<profileDesc><textClass></textClass>
</profileDesc>
</teiHeader>
<front><div type="abstract" xml:lang="en"><p id="P1">There is growing use of anticancer complementary and alternative medicines (CAMs) worldwide. The purpose of the current study is to assess a sizeable variety of natural and plant sources of diverse origin, to ascertain prospective research directives for cancer treatment and potential new chemotherapy drug sources. In this study, 374 natural extracts (10 μg/mL-5 mg/mL) were evaluated for dose-dependent tumoricidal effects using immortal neuroblastoma of spontaneous malignant origin. The findings indicate no pattern of tumoricidal effects by diverse plants with similar families/genus under the classes Pinopsida, Equisetopsida, Lycopodiosida, Filicosida, Liliopsida Monocotyledons or Magnoliopsida Dicotyledons. The results indicate that many of the most commonly used CAMs exhibited relatively weak tumoricidal effects including cats claw, astragalus, ginseng, echinacea, mistletoe, milk thistle, slippery elm, cayenne, chamomile, don quai, meadowsweet, motherwort and shepherd's purse. The data demonstrate that the most potent plant extracts were randomly dispersed within the plantae kingdom (LC<sub>50</sub>
= 31-490 μg/mL) in order of the lowest LC<sub>50</sub>
<italic>Dioscorea villosa</italic>
(Dioscoreaceae) > <italic>Sanguinaria canadensis</italic>
(Papaveraceae) > <italic>Dipsacus asper</italic>
(Dipsacaceae) > <italic>Populus balsamifera</italic>
(Salicaceae) > <italic>Boswellia carteri</italic>
(Burseraceae) > <italic>Cyamopsis psoralioides</italic>
(Fabaceae) > <italic>Rhamnus cathartica</italic>
(Rhamnaceae) > <italic>Larrea tridentate</italic>
(Zygophyllaceae) > <italic>Dichroa febrifuga</italic>
(Hydrangeaceae) > <italic>Batschia canescens</italic>
(Boraginaceae) > <italic>Kochia scoparia</italic>
(Chenopodiaceae) > <italic>Solanum xanthocarpum</italic>
(Solanaceae) > <italic>Opoponax</italic>
chironium (Umbelliferae) > <italic>Caulophyllum thalictroides</italic>
(Berberidaceae) > <italic>Dryopteris crassirhizoma</italic>
(Dryopteridaceae) > <italic>Garcinia cambogia</italic>
(Clusiaceae) > <italic>Vitex agnus-castus</italic>
(Verbenaceae) > <italic>Calamus draco</italic>
(Arecaceae). These findings show tumoricidal effect by extracts of wild yam root, bloodroot, teasel root, bakuchi seed, dichroa root, kanta kari, garcinia fruit, mace, dragons blood and the biblically referenced herbs: balm of gilead bud, frankincense and myrrh gum.</p>
</div>
</front>
</TEI>
</record>
Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Bois/explor/OrangerV1/Data/Ncbi/Curation
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000893 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd -nk 000893 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien |wiki= Wicri/Bois |area= OrangerV1 |flux= Ncbi |étape= Curation |type= RBID |clé= PMC:2650746 |texte= In Vitro Screening for the Tumoricidal Properties of International Medicinal Herbs }}
Pour générer des pages wiki
HfdIndexSelect -h $EXPLOR_AREA/Data/Ncbi/Curation/RBID.i -Sk "pubmed:18844256" \ | HfdSelect -Kh $EXPLOR_AREA/Data/Ncbi/Curation/biblio.hfd \ | NlmPubMed2Wicri -a OrangerV1
![]() | This area was generated with Dilib version V0.6.25. | ![]() |