In Vitro Screening for the Tumoricidal Properties of International Medicinal Herbs
Identifieur interne : 001042 ( Pmc/Checkpoint ); précédent : 001041; suivant : 001043In Vitro Screening for the Tumoricidal Properties of International Medicinal Herbs
Auteurs : Elizabeth A. Mazzio ; Karam F. A. SolimanSource :
- Phytotherapy research : PTR [ 0951-418X ] ; 2009.
Abstract
There is growing use of anticancer complementary and alternative medicines (CAMs) worldwide. The purpose of the current study is to assess a sizeable variety of natural and plant sources of diverse origin, to ascertain prospective research directives for cancer treatment and potential new chemotherapy drug sources. In this study, 374 natural extracts (10 μg/mL-5 mg/mL) were evaluated for dose-dependent tumoricidal effects using immortal neuroblastoma of spontaneous malignant origin. The findings indicate no pattern of tumoricidal effects by diverse plants with similar families/genus under the classes Pinopsida, Equisetopsida, Lycopodiosida, Filicosida, Liliopsida Monocotyledons or Magnoliopsida Dicotyledons. The results indicate that many of the most commonly used CAMs exhibited relatively weak tumoricidal effects including cats claw, astragalus, ginseng, echinacea, mistletoe, milk thistle, slippery elm, cayenne, chamomile, don quai, meadowsweet, motherwort and shepherd's purse. The data demonstrate that the most potent plant extracts were randomly dispersed within the plantae kingdom (LC50 = 31-490 μg/mL) in order of the lowest LC50
Url:
DOI: 10.1002/ptr.2636
PubMed: 18844256
PubMed Central: 2650746
Affiliations:
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Screening for the Tumoricidal Properties of International Medicinal Herbs</title>
<author><name sortKey="Mazzio, Elizabeth A" sort="Mazzio, Elizabeth A" uniqKey="Mazzio E" first="Elizabeth A." last="Mazzio">Elizabeth A. Mazzio</name>
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<author><name sortKey="Soliman, Karam F A" sort="Soliman, Karam F A" uniqKey="Soliman K" first="Karam F. A." last="Soliman">Karam F. A. Soliman</name>
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Screening for the Tumoricidal Properties of International Medicinal Herbs</title>
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<front><div type="abstract" xml:lang="en"><p id="P1">There is growing use of anticancer complementary and alternative medicines (CAMs) worldwide. The purpose of the current study is to assess a sizeable variety of natural and plant sources of diverse origin, to ascertain prospective research directives for cancer treatment and potential new chemotherapy drug sources. In this study, 374 natural extracts (10 μg/mL-5 mg/mL) were evaluated for dose-dependent tumoricidal effects using immortal neuroblastoma of spontaneous malignant origin. The findings indicate no pattern of tumoricidal effects by diverse plants with similar families/genus under the classes Pinopsida, Equisetopsida, Lycopodiosida, Filicosida, Liliopsida Monocotyledons or Magnoliopsida Dicotyledons. The results indicate that many of the most commonly used CAMs exhibited relatively weak tumoricidal effects including cats claw, astragalus, ginseng, echinacea, mistletoe, milk thistle, slippery elm, cayenne, chamomile, don quai, meadowsweet, motherwort and shepherd's purse. The data demonstrate that the most potent plant extracts were randomly dispersed within the plantae kingdom (LC<sub>50</sub>
= 31-490 μg/mL) in order of the lowest LC<sub>50</sub>
<italic>Dioscorea villosa</italic>
(Dioscoreaceae) > <italic>Sanguinaria canadensis</italic>
(Papaveraceae) > <italic>Dipsacus asper</italic>
(Dipsacaceae) > <italic>Populus balsamifera</italic>
(Salicaceae) > <italic>Boswellia carteri</italic>
(Burseraceae) > <italic>Cyamopsis psoralioides</italic>
(Fabaceae) > <italic>Rhamnus cathartica</italic>
(Rhamnaceae) > <italic>Larrea tridentate</italic>
(Zygophyllaceae) > <italic>Dichroa febrifuga</italic>
(Hydrangeaceae) > <italic>Batschia canescens</italic>
(Boraginaceae) > <italic>Kochia scoparia</italic>
(Chenopodiaceae) > <italic>Solanum xanthocarpum</italic>
(Solanaceae) > <italic>Opoponax</italic>
chironium (Umbelliferae) > <italic>Caulophyllum thalictroides</italic>
(Berberidaceae) > <italic>Dryopteris crassirhizoma</italic>
(Dryopteridaceae) > <italic>Garcinia cambogia</italic>
(Clusiaceae) > <italic>Vitex agnus-castus</italic>
(Verbenaceae) > <italic>Calamus draco</italic>
(Arecaceae). These findings show tumoricidal effect by extracts of wild yam root, bloodroot, teasel root, bakuchi seed, dichroa root, kanta kari, garcinia fruit, mace, dragons blood and the biblically referenced herbs: balm of gilead bud, frankincense and myrrh gum.</p>
</div>
</front>
</TEI>
<pmc article-type="research-article" xml:lang="EN"><pmc-comment>The publisher of this article does not allow downloading of the full text in XML form.</pmc-comment>
<pmc-dir>properties manuscript</pmc-dir>
<front><journal-meta><journal-id journal-id-type="nlm-journal-id">8904486</journal-id>
<journal-id journal-id-type="pubmed-jr-id">21098</journal-id>
<journal-id journal-id-type="nlm-ta">Phytother Res</journal-id>
<journal-title>Phytotherapy research : PTR</journal-title>
<issn pub-type="ppub">0951-418X</issn>
<issn pub-type="epub">1099-1573</issn>
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<article-meta><article-id pub-id-type="pmid">18844256</article-id>
<article-id pub-id-type="pmc">2650746</article-id>
<article-id pub-id-type="doi">10.1002/ptr.2636</article-id>
<article-id pub-id-type="manuscript">NIHMS86121</article-id>
<article-categories><subj-group subj-group-type="heading"><subject>Article</subject>
</subj-group>
</article-categories>
<title-group><article-title><italic>In Vitro</italic>
Screening for the Tumoricidal Properties of International Medicinal Herbs</article-title>
</title-group>
<contrib-group><contrib contrib-type="author"><name><surname>Mazzio</surname>
<given-names>Elizabeth A.</given-names>
</name>
</contrib>
<contrib contrib-type="author"><name><surname>Soliman</surname>
<given-names>Karam F. A.</given-names>
</name>
<xref ref-type="corresp" rid="CR1">*</xref>
</contrib>
<aff id="A1">College of Pharmacy and Pharmaceutical Sciences, Florida A & M University, Tallahassee, Florida 32307, USA</aff>
</contrib-group>
<author-notes><corresp id="CR1"><label>*</label>
Correspondence to: Dr Karam F. A. Soliman, College of Pharmacy and Pharmaceutical Sciences, Florida A & M University, Tallahassee, FL 32307, USA. E-mail: <email>karam.soliman@famu.edu</email>
</corresp>
</author-notes>
<pub-date pub-type="nihms-submitted"><day>7</day>
<month>1</month>
<year>2009</year>
</pub-date>
<pub-date pub-type="ppub"><month>3</month>
<year>2009</year>
</pub-date>
<pub-date pub-type="pmc-release"><day>3</day>
<month>3</month>
<year>2009</year>
</pub-date>
<volume>23</volume>
<issue>3</issue>
<fpage>385</fpage>
<lpage>398</lpage>
<permissions><copyright-statement>Copyright © 2008 John Wiley & Sons, Ltd.</copyright-statement>
<copyright-year>2008</copyright-year>
</permissions>
<abstract><p id="P1">There is growing use of anticancer complementary and alternative medicines (CAMs) worldwide. The purpose of the current study is to assess a sizeable variety of natural and plant sources of diverse origin, to ascertain prospective research directives for cancer treatment and potential new chemotherapy drug sources. In this study, 374 natural extracts (10 μg/mL-5 mg/mL) were evaluated for dose-dependent tumoricidal effects using immortal neuroblastoma of spontaneous malignant origin. The findings indicate no pattern of tumoricidal effects by diverse plants with similar families/genus under the classes Pinopsida, Equisetopsida, Lycopodiosida, Filicosida, Liliopsida Monocotyledons or Magnoliopsida Dicotyledons. The results indicate that many of the most commonly used CAMs exhibited relatively weak tumoricidal effects including cats claw, astragalus, ginseng, echinacea, mistletoe, milk thistle, slippery elm, cayenne, chamomile, don quai, meadowsweet, motherwort and shepherd's purse. The data demonstrate that the most potent plant extracts were randomly dispersed within the plantae kingdom (LC<sub>50</sub>
= 31-490 μg/mL) in order of the lowest LC<sub>50</sub>
<italic>Dioscorea villosa</italic>
(Dioscoreaceae) > <italic>Sanguinaria canadensis</italic>
(Papaveraceae) > <italic>Dipsacus asper</italic>
(Dipsacaceae) > <italic>Populus balsamifera</italic>
(Salicaceae) > <italic>Boswellia carteri</italic>
(Burseraceae) > <italic>Cyamopsis psoralioides</italic>
(Fabaceae) > <italic>Rhamnus cathartica</italic>
(Rhamnaceae) > <italic>Larrea tridentate</italic>
(Zygophyllaceae) > <italic>Dichroa febrifuga</italic>
(Hydrangeaceae) > <italic>Batschia canescens</italic>
(Boraginaceae) > <italic>Kochia scoparia</italic>
(Chenopodiaceae) > <italic>Solanum xanthocarpum</italic>
(Solanaceae) > <italic>Opoponax</italic>
chironium (Umbelliferae) > <italic>Caulophyllum thalictroides</italic>
(Berberidaceae) > <italic>Dryopteris crassirhizoma</italic>
(Dryopteridaceae) > <italic>Garcinia cambogia</italic>
(Clusiaceae) > <italic>Vitex agnus-castus</italic>
(Verbenaceae) > <italic>Calamus draco</italic>
(Arecaceae). These findings show tumoricidal effect by extracts of wild yam root, bloodroot, teasel root, bakuchi seed, dichroa root, kanta kari, garcinia fruit, mace, dragons blood and the biblically referenced herbs: balm of gilead bud, frankincense and myrrh gum.</p>
</abstract>
<kwd-group><kwd>herbs</kwd>
<kwd>screening</kwd>
<kwd>cancer</kwd>
<kwd>wild yam</kwd>
<kwd>frankincense</kwd>
<kwd>teasel</kwd>
<kwd>myrrh</kwd>
</kwd-group>
<contract-num rid="RR1">G12 RR003020-255367
||RR</contract-num>
<contract-num rid="RR1">G12 RR003020-140002
||RR</contract-num>
<contract-sponsor id="RR1">National Center for Research Resources : NCRR</contract-sponsor>
</article-meta>
</front>
</pmc>
<affiliations><list></list>
<tree><noCountry><name sortKey="Mazzio, Elizabeth A" sort="Mazzio, Elizabeth A" uniqKey="Mazzio E" first="Elizabeth A." last="Mazzio">Elizabeth A. Mazzio</name>
<name sortKey="Soliman, Karam F A" sort="Soliman, Karam F A" uniqKey="Soliman K" first="Karam F. A." last="Soliman">Karam F. A. Soliman</name>
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