OrangerV1, Main, Exploration, bibRecord, 002054

Effects of banana, orange, and apple on oxidative stress-induced neurotoxicity in PC12 cells.

Identifieur interne : 002054 ( Main/Exploration ); précédent : 002053; suivant : 002055

Effects of banana, orange, and apple on oxidative stress-induced neurotoxicity in PC12 cells.

Auteurs : H J Heo [Corée du Sud] ; S J Choi ; S-G Choi ; D-H Shin ; J M Lee ; C Y Lee

Source :

Journal of food science [ 1750-3841 ] ; 2008.

RBID : pubmed:18298733

English descriptors

KwdEn :
- Animals, Cell Survival, Citrus sinensis (chemistry), Humans, Hydrogen Peroxide, Malus (chemistry), Musa (chemistry), Nerve Degeneration (etiology), Neurons (drug effects), Neurons (physiology), Oxidative Stress (drug effects), PC12 Cells, Rats.
MESH :
- chemical : Hydrogen Peroxide.
- chemistry : Citrus sinensis, Malus, Musa.
- drug effects : Neurons, Oxidative Stress.
- etiology : Nerve Degeneration.
- physiology : Neurons.
- Animals, Cell Survival, Humans, PC12 Cells, Rats.

Abstract

Banana, orange, and apple are the major fruits in Western and Asian diets. In order to find the effects of these fruits, neuron like PC12 cells were exposed to the extracts of these fruits before H(2)O(2) treatment. We found a significant viability of PC12 cells by the MTT reduction test, which indicated that the phenolics of banana, orange, and apple fruits prevented oxidative stress-induced neurotoxicity. Additional tests by lactate dehydrogenase and trypan blue exclusion assays showed that the extracts reduced oxidative stress-induced neuronal cell membrane damage. These results suggest that fresh apples, banana, and orange in our daily diet along with other fruits may protect neuron cells against oxidative stress-induced neurotoxicity and may play an important role in reducing the risk of neurodegenerative disorders such as Alzheimer's disease.

DOI: 10.1111/j.1750-3841.2007.00632.x
PubMed: 18298733

Affiliations:

Corée du Sud

Le document en format XML

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<term>Malus (chemistry)</term>
<term>Musa (chemistry)</term>
<term>Nerve Degeneration (etiology)</term>
<term>Neurons (drug effects)</term>
<term>Neurons (physiology)</term>
<term>Oxidative Stress (drug effects)</term>
<term>PC12 Cells</term>
<term>Rats</term>
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<front><div type="abstract" xml:lang="en">Banana, orange, and apple are the major fruits in Western and Asian diets. In order to find the effects of these fruits, neuron like PC12 cells were exposed to the extracts of these fruits before H(2)O(2) treatment. We found a significant viability of PC12 cells by the MTT reduction test, which indicated that the phenolics of banana, orange, and apple fruits prevented oxidative stress-induced neurotoxicity. Additional tests by lactate dehydrogenase and trypan blue exclusion assays showed that the extracts reduced oxidative stress-induced neuronal cell membrane damage. These results suggest that fresh apples, banana, and orange in our daily diet along with other fruits may protect neuron cells against oxidative stress-induced neurotoxicity and may play an important role in reducing the risk of neurodegenerative disorders such as Alzheimer's disease.</div>
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<name sortKey="Shin, D H" sort="Shin, D H" uniqKey="Shin D" first="D-H" last="Shin">D-H Shin</name>
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Effects of banana, orange, and apple on oxidative stress-induced neurotoxicity in PC12 cells.

Effects of banana, orange, and apple on oxidative stress-induced neurotoxicity in PC12 cells.

Source :

English descriptors

Abstract

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Le document en format XML

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