Effects of banana, orange, and apple on oxidative stress-induced neurotoxicity in PC12 cells.
Identifieur interne : 000A70 ( PubMed/Curation ); précédent : 000A69; suivant : 000A71Effects of banana, orange, and apple on oxidative stress-induced neurotoxicity in PC12 cells.
Auteurs : H J Heo [Corée du Sud] ; S J Choi ; S-G Choi ; D-H Shin ; J M Lee ; C Y LeeSource :
- Journal of food science [ 1750-3841 ] ; 2008.
English descriptors
- KwdEn :
- MESH :
- chemical : Hydrogen Peroxide.
- chemistry : Citrus sinensis, Malus, Musa.
- drug effects : Neurons, Oxidative Stress.
- etiology : Nerve Degeneration.
- physiology : Neurons.
- Animals, Cell Survival, Humans, PC12 Cells, Rats.
Abstract
Banana, orange, and apple are the major fruits in Western and Asian diets. In order to find the effects of these fruits, neuron like PC12 cells were exposed to the extracts of these fruits before H(2)O(2) treatment. We found a significant viability of PC12 cells by the MTT reduction test, which indicated that the phenolics of banana, orange, and apple fruits prevented oxidative stress-induced neurotoxicity. Additional tests by lactate dehydrogenase and trypan blue exclusion assays showed that the extracts reduced oxidative stress-induced neuronal cell membrane damage. These results suggest that fresh apples, banana, and orange in our daily diet along with other fruits may protect neuron cells against oxidative stress-induced neurotoxicity and may play an important role in reducing the risk of neurodegenerative disorders such as Alzheimer's disease.
DOI: 10.1111/j.1750-3841.2007.00632.x
PubMed: 18298733
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In order to find the effects of these fruits, neuron like PC12 cells were exposed to the extracts of these fruits before H(2)O(2) treatment. We found a significant viability of PC12 cells by the MTT reduction test, which indicated that the phenolics of banana, orange, and apple fruits prevented oxidative stress-induced neurotoxicity. Additional tests by lactate dehydrogenase and trypan blue exclusion assays showed that the extracts reduced oxidative stress-induced neuronal cell membrane damage. These results suggest that fresh apples, banana, and orange in our daily diet along with other fruits may protect neuron cells against oxidative stress-induced neurotoxicity and may play an important role in reducing the risk of neurodegenerative disorders such as Alzheimer's disease.</div></front></TEI><pubmed><MedlineCitation Status="MEDLINE" Owner="NLM"><PMID Version="1">18298733</PMID><DateCreated><Year>2008</Year><Month>2</Month><Day>26</Day></DateCreated><DateCompleted><Year>2008</Year><Month>03</Month><Day>28</Day></DateCompleted><DateRevised><Year>2013</Year><Month>11</Month><Day>21</Day></DateRevised><Article PubModel="Print"><Journal><ISSN IssnType="Electronic">1750-3841</ISSN><JournalIssue CitedMedium="Internet"><Volume>73</Volume><Issue>2</Issue><PubDate><Year>2008</Year><Month>Mar</Month></PubDate></JournalIssue><Title>Journal of food science</Title><ISOAbbreviation>J. 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These results suggest that fresh apples, banana, and orange in our daily diet along with other fruits may protect neuron cells against oxidative stress-induced neurotoxicity and may play an important role in reducing the risk of neurodegenerative disorders such as Alzheimer's disease.</AbstractText></Abstract><AuthorList CompleteYN="Y"><Author ValidYN="Y"><LastName>Heo</LastName><ForeName>H J</ForeName><Initials>HJ</Initials><AffiliationInfo><Affiliation>Div. of Applied Life Science, Inst. of Agriculture and Life Sciences, Gyeongsang Natl. 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